Abstract:
:Four-day-old chicks respond to isolation with distress calling. A decrease in distress calling during isolation seems to reflect some general aspect of depressive syndrome and appears to be sensitive to pharmacological manipulation. Diverse clinically active antidepressants are able to counteract this decrease with high selectivity; non-antidepressants have either no influence or further inhibit the distress calling.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Lehr Edoi
10.1007/BF00442235subject
Has Abstractpub_date
1989-01-01 00:00:00pages
145-6issue
2eissn
0033-3158issn
1432-2072journal_volume
97pub_type
杂志文章abstract:RATIONALE:(1S,3aS)-8-(2,3,3,4,5,6-hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one (Ro 64-6198), a non-peptidic agonist for the opioid receptor-like1 (ORL1) receptor, exhibits anxiolytic properties in stressful conditions. OBJECTIVE:The present study was aimed at evaluating whether activation of ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1020-7
更新日期:2002-05-01 00:00:00
abstract:RATIONALE:Understanding factors contributing to individual differences in vulnerability to opioid addiction is essential for developing more effective preventions and treatments, yet few reliable behavioral predictors of subsequent opioid self-administration have been identified in rodents. Sensitivity to the acute eff...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05532-w
更新日期:2020-08-01 00:00:00
abstract:RATIONALE:We previously demonstrated that the addition of the selective norepinephrine reuptake inhibitor reboxetine attenuates olanzapine-induced weight gain. Using the same study sample, we also sought to determine whether reboxetine's weight-attenuating effect was accompanied by a beneficial effect on metabolic and ...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-013-3199-1
更新日期:2013-11-01 00:00:00
abstract:RATIONALE:Temporal differentiation in the free-operant psychophysical procedure is sensitive to the 5-hydroxytryptamine (5-HT)1A receptor agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) and the 5-HT2 receptor agonist 2,5-dimethoxy-4-iodo-amphetamine (DOI); both drugs shift the psychophysical curve leftwards...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-004-1871-1
更新日期:2004-11-01 00:00:00
abstract::While chronic intermittent administration of stimulants often induces behavioral sensitization in adulthood, stimulant sensitization has rarely been reported prior to weaning [around postnatal day (P) 21]. Consistent pairing of drug administration with the test context often facilitates sensitization in adults, yet yo...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050653
更新日期:1998-07-01 00:00:00
abstract:RATIONALE:Increasing concomitant abuse of cocaine and morphine-like opioids has prompted a number of studies aimed at understanding how these drugs interact. OBJECTIVE:The present study was designed to determine if variations in opioid pretreatment time would affect how mu opioid agonists interact with cocaine. METHO...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100732
更新日期:2001-08-01 00:00:00
abstract::A study was performed on the effect of ethanol on the basal and K+-evoked efflux of endogenous GABA from rat hypothalamic fragments. The amount of GABA present in the medium and in the tissue was measured by radioreceptor assay. In vitro addition of ethanol (50 and 100 mM) enhanced the K+-evoked efflux of GABA in a Ca...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00181959
更新日期:1988-01-01 00:00:00
abstract::Four macaques with lesions of dorsolateral frontal cortex and 4 normal monkeys were injected with 1 mg/kg d-amphetamine. Observations of social behaviors and motor activity were conducted over a 1-month period. The results of this experiment show a partial dissociation of effects of amphetamines on behavior of normal ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00428704
更新日期:1976-05-05 00:00:00
abstract:RATIONALE:Sex differences in the dopaminergic response to psychostimulants could have implications for drug abuse risk and other psychopathology involving the dopamine system, but human data are limited and mixed. OBJECTIVES:Here, we sought to investigate sex differences in dopamine release after oral D-amphetamine ad...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-5083-5
更新日期:2019-02-01 00:00:00
abstract::The effects of naltrexone methobromide, a quaternary derivative of the opioid antagonist naltrexone, were investigated on deprivation (24 h)-induced water intake in the unilaterally cannulated rats. Naltrexone methobromide reduced post-deprivational water intake with an ED50 of 7.3 micrograms when tested at 30 min (pe...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00518177
更新日期:1987-01-01 00:00:00
abstract::Chronic treatment of rats with the antipsychotic drug molindone (2.5 mg/kg) did not elicit behavioral supersensitivity to apomorphine (AP) (0.25 mg/kg) or increased striatal 3H-spiroperidol binding, whereas treatment with haloperidol (0.5-1.0 mg/kg) produced manifestations of dopaminergic supersensitivity in both para...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432549
更新日期:1982-01-01 00:00:00
abstract::The effect of long-term treatment with clozapine in schizophrenia and schizoaffective disorder was evaluated in a retrospective study comprising 96 patients treated with the drug during the period 1974-1986 at the Psychiatric Research Center in Uppsala. All patients had previously been treated with different kinds of ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00442567
更新日期:1989-01-01 00:00:00
abstract::The purpose of this study was to determine whether repeated treatment (15 days) with d-amphetamine (AMP) or fenfluramine (FEN), administered after a daily 3 h feeding session (e.g. post-session), would result in tolerance or cross-tolerance to the decrement in food consumption induced by treatment with either drug bef...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00435853
更新日期:1981-01-01 00:00:00
abstract::The purpose of this study was to investigate the developmental differences in seizure susceptibility in mice and the roles of the histaminergic neuron system in inhibition of convulsions in development. First, we studied developmental differences in electrically-induced seizures. Since the 14-day-old mice showed a dif...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244911
更新日期:1993-01-01 00:00:00
abstract:RATIONALE:The dopaminergic system has been proposed to mediate alcohol-induced locomotor activity, yet the mechanisms underlying this behavioral response remain poorly understood. OBJECTIVES:This study was conducted to investigate the role of dopamine D2-like receptors in mediating alcohol-induced behavioral responses...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-016-4264-3
更新日期:2016-06-01 00:00:00
abstract:RATIONALE:We recently demonstrated that blocking specific nicotinic acetylcholine receptors (nAChRs) abolishes the conditioned reinforcing properties of ethanol-associated cues in rat, suggesting nAChRs as promising pharmacological targets for prevention of cue-induced relapse. OBJECTIVES:The present study investigate...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1957-x
更新日期:2010-10-01 00:00:00
abstract::A combined analysis of data from 11 controlled studies of loxapine versus either chlorpromazine or trifluoperazine in acute schizophrenia (5 studies) and chronic schizophrenia (6 studies) showed statistically significant superiority of loxapine on several items and factors of standardized psychiatric rating scales. Up...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00431725
更新日期:1977-01-31 00:00:00
abstract::The binding kinetics of tritiated quinuclidinyl benzilate (QNB) were studied in membrane preparations from human parotid and rabbit submandibular glands. Inhibition of 3H-QNB was then used to compare the anticholinergic activity of lofepramine, desipramine, imipramine and amitriptyline for muscarinic receptor in the s...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00172861
更新日期:1986-01-01 00:00:00
abstract:RATIONALE:Gonadal steroid hormones altered opioid antinociception under some conditions in rodents, and we reported previously that chronic estradiol enhanced kappa but not mu opioid antinociception in ovariectomized rhesus monkeys. Sex differences have also been observed in the antinociceptive effects of opioid agonis...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100912
更新日期:2002-01-01 00:00:00
abstract::The effects of flurazepam (0.0, 0.5, and 3.0 mg/kg) on methylphenidate-induced increases in stereotypy, gnawing, sniffing, and locomotion were evaluated in Swiss-Webster mice in daytime and nighttime experiments. Methylphenidate (50 mg/kg) increased overall stereotypy and stereotyped gnawing behavior; two doses of met...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432374
更新日期:1980-01-01 00:00:00
abstract:RATIONALE:The widespread deficits in cognitive flexibility observed across psychiatric disorders call for improved rodent tests to understand the biology of cognitive flexibility and development of better psychotherapeutics. Current reversal learning paradigms have a forced-choice setup that challenges the interpretati...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05687-6
更新日期:2021-02-01 00:00:00
abstract:RATIONALE:Glucose administration may decrease desire to smoke in abstinent smokers. Moreover, glucose administration has been associated with improved performance on measures of attention in healthy humans but evidence remains modest. OBJECTIVE:The present study aimed to determine whether reported craving and nicotine...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00213-002-1035-0
更新日期:2002-05-01 00:00:00
abstract::The effect of the (+)- and (-)-enantiomers of 3-PPP [conventional and atypical dopamine (DA)-receptor active agent, respectively] were investigated in a commonly used animal model of anxiety: the Vogel licking-conflict test. Low doses (less than or equal to 0.5 mg/kg SC) of both 3-PPP enantiomers resulted in anti-conf...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00210846
更新日期:1987-01-01 00:00:00
abstract:RATIONALE:Several lines of evidence have indicated that the central histaminergic system might be involved in learning and memory OBJECTIVES:The aim of the present study was to ascertain the impact on memory processes of putative histaminergic-cholinergic interactions in the nucleus basalis magnocellularis (NBM) of th...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100892
更新日期:2002-01-01 00:00:00
abstract::The augmentation effect of (-)pindolol as used in combination with SSRI to treat major depression has been ascribed to blocking of dorsal raphe nucleus cell body 5-HT autoreceptors. In this study, the radioligand [carbonyl-11C]WAY-100635 and positron emission tomography were used to establish whether pindolol at a cli...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130051009
更新日期:1999-06-01 00:00:00
abstract:RATIONALE:Buprenorphine is a partial mu opioid agonist under development as a sublingual (SL) medication for opioid dependence treatment in the United States. Because buprenorphine may be abused, tablets combining buprenorphine with naloxone in a 4:1 ratio have been developed to reduce that risk. Low doses of injected ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002130000637
更新日期:2001-03-01 00:00:00
abstract::The effect of the intravenous administration of ergot alkaloids on epileptic responses to intermittent photic stimulation )IPS) has been studied in adolescent baboons, Papio papio, from Senegal. Ergocornine, 1--2 mg/kg, produced marked autonomic and behavioural effects, slowed the EEG, and abolished myoclonic response...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426958
更新日期:1978-04-14 00:00:00
abstract:RATIONALE:Zotepine is an antipsychotic drug with proven efficacy for treatment of acute episodes of schizophrenia. Antipsychotic drugs also require to be effective in prevention of recurrence. OBJECTIVE:This trial was designed to compare the effects of zotepine and placebo in the prevention of recurrence of acute epis...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002130000452
更新日期:2000-06-01 00:00:00
abstract::3,4-Methylenedioxymethamphetamine (MDMA) is a psychoactive phenylisopropylamine which is structurally similar to both amphetamine-related sympathomimetics and the hallucinogen, mescaline. MDMA produces pleasurable effects which include euphoria, and recent reports continue to demonstrate its widespread recreational us...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00212765
更新日期:1988-01-01 00:00:00
abstract::Methaqualone produces a dose- and time-dependent increase in plasma corticosterone concentration in mice. Acute studies showed that this effect is largely independent of methaqualone-induced hypothermia but can be blocked by pretreatment with dexamethasone, thus demonstrating that the adrenal cortex is not being direc...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426541
更新日期:1977-08-31 00:00:00