Abstract：
:The augmentation effect of (-)pindolol as used in combination with SSRI to treat major depression has been ascribed to blocking of dorsal raphe nucleus cell body 5-HT autoreceptors. In this study, the radioligand [carbonyl-11C]WAY-100635 and positron emission tomography were used to establish whether pindolol at a clinical dose level (10 mg s.o.d.) occupies 5-HT1A receptors in the human brain in vivo. Three healthy males were recruited and each subject was used as his own control. The 5-HT1A receptor occupancy was calculated for the frontal and temporal cortex and the raphe nuclei, using and a ratio analysis with the cerebellar cortex as the reference region. Maximal pindolol plasma concentration was reached within 3 h after drug administration. Two hours after pindolol administration, the regional 5-HT1A receptor occupancy was within the range 7-21% in the three subjects. The study confirms that the 5-HT1A-receptor may be a clinically significant target for pindolol.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Andrée B,Thorberg SO,Halldin C,Farde Ldoi
10.1007/s002130051009subject
Has Abstractpub_date
1999-06-01 00:00:00pages
303-5issue
3eissn
0033-3158issn
1432-2072journal_volume
144pub_type
杂志文章abstract：:The effects of a new alpha-2 adrenoceptor antagonist on erectile function was assessed in 12 normal volunteers (mean age 28.7, range 20-42), using a double blind, placebo controlled design with two doses of drug and three testing sessions. The drug was administered by intravenous infusion and erectile responses to ero...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02245569
更新日期：1994-08-01 00:00:00
abstract：INTRODUCTION:The comparative effects of a newly described specific alpha7 nAChR partial agonist, S 24795, and a cholinesterase inhibitor, donepezil, currently used as a symptomatic Alzheimer's disease treatment were studied in two mouse models of aging-related memory deficits. MATERIALS AND METHODS:We employed radial ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-007-1063-x
更新日期：2008-04-01 00:00:00
abstract：:7-Hydroxychlorpromazine (7-OHCPZ) has been identified and quantified in CSF from chlorpromazine (CPZ)-treated schizophrenic patients. The level of the metabolite in CSF was similar to that of CPZ. In serum the amount of 7-OHCPZ was about 30% of CPZ. The concentration of 7-OHCPZ in csf was positively and significantly ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00432774
更新日期：1982-01-01 00:00:00
abstract：RATIONALE:The occurrence of methamphetamine (METH) use by the smoking route is increasing. A nonhuman primate model for examining the reinforcing effects of smoked METH would be valuable for testing potential interventions for treating METH abuse disorders. OBJECTIVE:The purpose of the present study was to examine the...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-006-0479-z
更新日期：2006-10-01 00:00:00
abstract：:The ability of delta 9-tetrahydrocannabinol (THC), cannabinol (CBN), cannabidiol (CBD), 11-OH THC and 8 alpha, 11-diOH THC to antagonise the abdominal constriction response in the mouse induced by formic acid, phenylquinone, 5-hydroxytryptamine, prostaglandin E1 (PGE1) and bradykinin was tested. THC was an effective a...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00432273
更新日期：1979-03-28 00:00:00
abstract：RATIONALE:Environmental stimuli associated with drugs of abuse are believed to play a major role in the motivation to take drugs, drug dependence, and relapse. Previous work from this laboratory demonstrated that the response-contingent presentation of drug-related, visual cues was at least as important as nicotine in ...
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doi：10.1007/s00213-002-1156-5
更新日期：2002-09-01 00:00:00
abstract：:In the rat, the antimuscarinics atropine and scopolamine failed to block the reduction in pentobarbital-induced sleep time produced by either thyrotropin-releasing hormone (TRH) or MK-771 (a TRH analog). Previous reports have indicated that the marked analeptic effect produced by TRH is antagonized by such agents. It ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00431749
更新日期：1981-01-01 00:00:00
abstract：:The authors review the literature regarding the pharmacokinetics of long-acting injectable neuroleptic drugs (LINS). There are important differences between LINS and oral neuroleptics that affect their pharmacokinetics. By avoiding first pass metabolism in gut and liver, LINS result in lower circulating concentrations...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/BF00441937
更新日期：1989-01-01 00:00:00
abstract：:A review and meta-analysis by Hamer et al. (2006) showed that a single session of exercise can attenuate post-exercise blood pressure (BP) responses to stress, but no studies examined the effects among smokers or with brisk walking. Healthy volunteers (n=60), averaging 28 years of age and smoking 15 cigarettes daily, ...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-005-0275-1
更新日期：2006-01-01 00:00:00
abstract：RATIONALE:A previously reported pharmacokinetic interaction between bromperidol and carbamazepine, an inducer of cytochrome P450 (CYP) 3A4, suggests possible involvement of CYP3A4 in the metabolism of bromperidol. OBJECTIVE:We investigated pharmacokinetic interaction between bromperidol and itraconazole, a potent inhi...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130051048
更新日期：1999-07-01 00:00:00
abstract：RATIONALE:Acute cocaine administration produces an initial rewarding state followed by a dysphoric/anxiogenic "crash." OBJECTIVE:The objective of this study was to determine whether individual differences in the relative value of cocaine's positive and negative effects would account for variations in subsequent drug s...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-015-3873-6
更新日期：2015-07-01 00:00:00
abstract：:Seven neuroleptic-free schizophrenic patients received bromocriptine and eight schizophrenic patients received CF 25-397, both ergot derivatives with dopamine agonist activity. Psychosis failed to improve in response to either drug at the relatively low doses administered. Unlike the antipsychotic property of apomorph...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00428312
更新日期：1979-01-01 00:00:00
abstract：:The protective effects of acute and chronic diazepam administration (4 mg/kg) against seizures induced by pentylenetetrazole (PTZ) and picrotoxin were investigated. Considering the incidence of tonic-clonic convulsions, tolerance to the protective effects of diazepam was evident by day 5 if the mice were challenged wi...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427828
更新日期：1983-01-01 00:00:00
abstract：RATIONALE:Previous experiments have shown that d-amphetamine disrupts timing behaviour in rats. It has been proposed that d-amphetamine's effects reflect a reduction in the period of the pacemaker of the hypothetical internal clock. However, some studies have obtained conflicting results. OBJECTIVE:To examine the effe...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130000422
更新日期：2000-06-01 00:00:00
abstract：:Evidence has been provided for impaired neurotransmitter functioning in the brain of elderly subjects. In order to assess central GABAergic transmission, the activity of the hypothalamic GABA system may be investigated by basal growth hormone (GH) response to the GABAergic drug sodium valproate (SV). For this purpose ...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/BF00690918
更新日期：1987-01-01 00:00:00
abstract：:Intact male and ovariectomized female rats were trained to lever press under a random ratio (RR) schedule of food reinforcement. Effects of different doses of pentobarbital (1-16 mg/kg) and progesterone (10-80 mg/kg) on response output were studied. Low doses of pentobarbital increased responding, high doses decreased...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00179930
更新日期：1987-01-01 00:00:00
abstract：:The effects of morphine, ketocyclazocine, cyclazocine, and SKF-10,047 were tested alone and in conjunction with naltrexone or naloxone, in rats responding under a multiple fixed-interval 3-min schedule of food presentation. Under this paradigm, electric shock was delivered on a fixed-ratio schedule for responses occur...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00435274
更新日期：1982-01-01 00:00:00
abstract：:The topography of stereotyped behaviour produced by apomorphine in rats was studied by using either a scoring system, based on observation in a wire cage, or by quantification of horizontal and vertical activities, and of the total distances run in an open field, using an automatic recording system. The latter design ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00172869
更新日期：1986-01-01 00:00:00
abstract：:The relationship between nicotine yield as determined by the FTC method and nicotine absorption was examined in 72 smokers in a more rigorous repetition of a previous study of 33 smokers. For this study, 113 smokers evenly distributed across four FTC "tar" yield ranges were recruited, only 72 demonstrated reasonable c...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/s002130050720
更新日期：1998-10-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:Major depressive disorder (MDD) is associated with an increased risk for cardiovascular disease (CVD). Apart from biological and life style factors, the use of antidepressants and their potentially adverse effects might contribute to the increased CVD risk. Therefore, we compared cardiovascular...
journal_title：Psychopharmacology
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abstract：:Fifty-nine depressed female inpatients were treated with 100 mg amitriptyline (AMT) IM for 4 weeks. Depression ratings and determinations of the parent drug and nortriptyline (NT) were performed weekly. No direct relationship between plasma AMT + NT concentrations and therapeutic response was apparent, but beneficial ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244602
更新日期：1990-01-01 00:00:00
abstract：RATIONALE:Many previous studies have reported that alcohol and cannabis produce additive psychomotor effects in acute combination, but few have explicitly tested whether chronic exposure to cannabis, in the absence of acute administration, alters the effects of alcohol on psychomotor performance. OBJECTIVES:To test wh...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/s00213-001-0955-4
更新日期：2002-03-01 00:00:00
abstract：RATIONALE:The notion that the onset of action of antidepressant drugs (ADs) takes weeks is widely accepted; however, the sequence of events necessary for therapeutic effects still remains obscure. OBJECTIVE:We aimed to evaluate a time-course of ADs-induced alterations in the expression of 95 selected genes in 4 region...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-012-2714-0
更新日期：2012-10-01 00:00:00
abstract：:The effects of benzodiazepine (BZ) antagonists on operant behavior were examined in rats chronically administered a low dose of diazepam (DZ). The low maintenance dose of DZ (5 mg/kg twice daily) was selected as more closely associated with its anxiolytic effects than the higher treatment doses previously used to stud...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244103
更新日期：1990-01-01 00:00:00
abstract：RATIONALE:Gonadal steroid hormones altered opioid antinociception under some conditions in rodents, and we reported previously that chronic estradiol enhanced kappa but not mu opioid antinociception in ovariectomized rhesus monkeys. Sex differences have also been observed in the antinociceptive effects of opioid agonis...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130100912
更新日期：2002-01-01 00:00:00
abstract：RATIONALE:Executive function impairment, as classically assessed using the Wisconsin Card Sort Test or intradimensional/extradimensional tests, is a key feature of schizophrenia but remains inadequately treated by existing therapies. Recently, however, erythropoietin has been shown to improve attentional set-shifting p...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-010-1990-9
更新日期：2010-12-01 00:00:00
abstract：:Muscimol, a structural analog of GABA, significantly potentiated pilocarpine-induced analgesia in rats, but failed to alter pilocarpine-induced catalepsy. It also failed to affect pilocarpine-elicited increase in homovanillic acid levels in the striatum. These findings suggest that the potentiation of pilocarpine-indu...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00432756
更新日期：1981-01-01 00:00:00
abstract：:Parenteral administration of the adenosine deaminase (ADA) inhibitor erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) results in a profound decrease in spontaneous motor activity in mice and rats. The inhibition of cortical ADA activity measured ex vivo parallels the decrease in spontaneous motor activity in a time-depend...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427798
更新日期：1983-01-01 00:00:00
abstract：RATIONALE:Although many studies have investigated the effects of gestational and lactational cocaine use on maternal behavior, few studies have examined the effects of prior adult cocaine use on maternal behavior. METHODS:In the current study, intraperitoneal cocaine or saline was administered to adult female rats for...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-010-1777-z
更新日期：2010-03-01 00:00:00
abstract：:Antipsychotic drugs, such as haloperidol and risperidone, are used in long-term treatment of psychiatric patients and thus increase the risk of obesity and other metabolic dysfunctions. Available evidence suggests that these drugs have pro-inflammatory effect, which contributes to the establishment of endocrine distur...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-015-4079-7
更新日期：2016-05-01 00:00:00
