Blockade of photically induced epilepsy by 'dopamine agonist' ergot alkaloids.


:The effect of the intravenous administration of ergot alkaloids on epileptic responses to intermittent photic stimulation )IPS) has been studied in adolescent baboons, Papio papio, from Senegal. Ergocornine, 1--2 mg/kg, produced marked autonomic and behavioural effects, slowed the EEG, and abolished myoclonic responses to IPS for 30--90 min. Ergometrine, 1 mg/kg, activated the EEG and blocked the induction of myoclonic responses for 1--3 h. Bromocriptine, 0.5--4 mg/kg, did not consistently prevent myoclonic responses to IPS. After pretreatment with a subconvulsant dose of allylglycine (180--200 mg/kg), lysergic acid diethylamide, 0.1 mg/kg, retained the capacity to block myoclonic responses to IPS, and ergocornine 1 mg/kg reduced such responses. The convulsant effect of allylglycine was enhanced, however, so that prolonged seizure sequences began 19--96 min after ergocornine administration. The protective action of ergot alkaloids against epileptic responses induced by sensory stimulation is interpreted in terms of effects at several sites, including dopaminergic and serotoninergic synapses.




Anlezark G,Meldrum B




Has Abstract


1978-04-14 00:00:00












  • Effects of dopamine and serotonin-releasing agents on methamphetamine discrimination and self-administration in rats.

    abstract::To analyze the involvement of dopamine (DA) and serotonin (5-HT) release in the stimulus properties of methamphetamine, two amphetamine analogs that selectively release either brain DA (phentermine) or 5-HT (fenfluramine) were tested for their ability to substitute for methamphetamine in rats discriminating methamphet...


    pub_type: 杂志文章


    authors: Munzar P,Baumann MH,Shoaib M,Goldberg SR

    更新日期:1999-01-01 00:00:00

  • Increased salivary cortisol after waking in depression.

    abstract:RATIONALE:Cortisol hypersecretion is regarded as important in the pathophysiology of major depression. However, recent studies in community-based samples have been inconclusive. OBJECTIVE:To determine whether acutely depressed, medication-free subjects show an exaggerated release of cortisol in saliva in relation to a...


    pub_type: 杂志文章


    authors: Bhagwagar Z,Hafizi S,Cowen PJ

    更新日期:2005-10-01 00:00:00

  • Cognitive effects of lithium treatment in normal volunteers.

    abstract::Patients taking lithium often report difficulties in concentration, memory, learning, and attention and many of these complaints are verified on psychometric testing. Laboratory tests of cognitive functions in healthy volunteers on chronic lithium demonstrate that disruptions in memory-learning processes are apparent ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Weingartner H,Rudorfer MV,Linnoila M

    更新日期:1985-01-01 00:00:00

  • No effects of enhanced central norepinephrine on finger-sequence learning and attention.

    abstract:RATIONALE:When paired with training, substances that increase monoaminergic transmission in the brain support motor and language learning in healthy subjects and in rehabilitation after brain lesions. OBJECTIVES:To test the hypotheses that enhancement of central norepinephrine by the selective norepinephrine reuptake ...


    pub_type: 杂志文章,随机对照试验


    authors: Plewnia C,Hoppe J,Gerloff C

    更新日期:2006-08-01 00:00:00

  • Synergistic interaction between nicotine and social rewards in adolescent male rats.

    abstract:RATIONALE:Smoking typically begins during adolescence and is largely reinforced by social cues. During adolescence in rats, sensitivity to both social cues and drugs of abuse is enhanced. OBJECTIVES:We have previously demonstrated in adolescent male rats that a low dose of cocaine interacts with social reward to produ...


    pub_type: 杂志文章


    authors: Thiel KJ,Sanabria F,Neisewander JL

    更新日期:2009-06-01 00:00:00

  • Ethanol-induced changes of dopaminergic function in three strains of mice characterized by a different population of opiate receptors.

    abstract::The effects of ethanol have been studied in three strains of mice (DBA 2J, albino, and C57 BL/6J) having different populations of opiate receptors. Acute ethanol treatment induces a significant increase in striatal dopamine metabolism only in the mouse strains (C57 and albino) that are rich in enkephalinergic receptor...


    pub_type: 杂志文章


    authors: Barbaccia ML,Reggiani A,Spano PF,Trabucchi M

    更新日期:1981-01-01 00:00:00

  • Contributions of hippocampus and neocortex to the expression of ethanol effects.

    abstract::The distinctive effects of ethanol on behavior suggest that certain parts of the CNS may be especially sensitive to it. One of the primary candidates is the hippocampal formation. Damage to this structure mimics acute ethanol treatment across a wide variety of behavioral tasks and processes. The possibility of a hippo...


    pub_type: 杂志文章


    authors: Devenport LD,Hale RL

    更新日期:1989-01-01 00:00:00

  • Opposing neural effects of naltrexone on food reward and aversion: implications for the treatment of obesity.

    abstract:RATIONALE:Opioid antagonism reduces the consumption of palatable foods in humans but the neural substrates implicated in these effects are less well understood. OBJECTIVES:The aim of the present study was to examine the effects of the opioid antagonist, naltrexone, on neural response to rewarding and aversive sight an...


    pub_type: 杂志文章,随机对照试验


    authors: Murray E,Brouwer S,McCutcheon R,Harmer CJ,Cowen PJ,McCabe C

    更新日期:2014-11-01 00:00:00

  • Presynaptic regulation of extracellular dopamine levels in the medial prefrontal cortex and striatum during tyrosine depletion.

    abstract:RATIONALE:Available neurochemical probes that lower brain dopamine (DA) levels in man are limited by their tolerability and efficacy. For instance, the acute lowering of brain tyrosine is well tolerated, but only modestly lowers brain DA levels. Modification of tyrosine depletion to robustly lower DA levels would provi...


    pub_type: 杂志文章


    authors: Brodnik Z,Double M,Jaskiw GE

    更新日期:2013-05-01 00:00:00

  • Buprenorphine versus methadone in the treatment of opioid-dependent cocaine users.

    abstract::This study compared the efficacy of buprenorphine to methadone for decreasing cocaine use in patients with combined opioid and cocaine use. Participants (n = 51) were enrolled in a 26-week treatment program and randomly assigned to either buprenorphine or methadone. Dosing was double-blind and double-dummy. Patients w...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Strain EC,Stitzer ML,Liebson IA,Bigelow GE

    更新日期:1994-12-01 00:00:00

  • Inhibiting 5alpha-reductase in the amygdala attenuates antianxiety and antidepressive behavior of naturally receptive and hormone-primed ovariectomized rats.

    abstract:RATIONALE:Greater incidence of anxiety and depressive disorders of women compared to men may be due in part to progesterone (P) and its neuroactive metabolite, 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP), acting in limbic regions, such as the amygdala. OBJECTIVE:If P's metabolism via 5alpha-reduction to 3alpha...


    pub_type: 杂志文章


    authors: Walf AA,Sumida K,Frye CA

    更新日期:2006-06-01 00:00:00

  • Neonatal neurosteroid administration results in development-specific alterations in prepulse inhibition and locomotor activity: neurosteroids alter prepulse inhibition and locomotor activity.

    abstract:RATIONALE:Early life exposure to stress and to GABAA receptor modulators have well-defined and persistent behavioral effects. A single neonatal injection of the GABAergic neurosteroid allopregnanolone (3alpha-hydroxy,5alpha-pregnane-20-one, 10 mg/kg, i.p.) alters the localization of prefrontal cortex (PFC) interneurons...


    pub_type: 杂志文章


    authors: Gizerian SS,Moy SS,Lieberman JA,Grobin AC

    更新日期:2006-06-01 00:00:00

  • Human studies on the benzodiazepine receptor antagonist beta-carboline ZK 93 426: antagonism of lormetazepam's psychotropic effects.

    abstract::The effects of lormetazepam (0.03 mg/kg IV) a benzodiazepine (BZ) derivative in combination with ZK 93 426 (0.04 mg/kg IV) a beta-carboline, benzodiazepine receptor antagonist were evaluated in humans. Independently, the effects of ZK 93 426 on its own were investigated. A psychometric test battery to evaluate sedatio...


    pub_type: 临床试验,杂志文章


    authors: Duka T,Goerke D,Dorow R,Höller L,Fichte K

    更新日期:1988-01-01 00:00:00

  • 5-Methoxy-N,N-dimethyltryptamine: spinal cord and brainstem mediation of excitatory effects on acoustic startle.

    abstract::The effects of different doses (0.03, 0.06, 0.12, 0.25, 1.0, 2.0, 4.0, and 8.0 mg/kg body weight) of 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) were tested on the acoustic startle reflex in rats. Beginning at 0.12 mg/kg, 5-MeODMT increased startle monotonically up to the highest dose used. 5-MeODMT still increased st...


    pub_type: 杂志文章


    authors: Davis M,Astrachan DI,Gendelman PM,Gendelman DS

    更新日期:1980-01-01 00:00:00

  • Prenatal exposure to escitalopram and/or stress in rats: a prenatal stress model of maternal depression and its treatment.

    abstract:RATIONALE:A rigorously investigated model of stress and antidepressant administration during pregnancy is needed to evaluate possible effects on the mother. OBJECTIVE:The objective of this study was to develop a model of clinically relevant prenatal exposure to an antidepressant and stress during pregnancy to evaluate...


    pub_type: 杂志文章


    authors: Bourke CH,Capello CF,Rogers SM,Yu ML,Boss-Williams KA,Weiss JM,Stowe ZN,Owens MJ

    更新日期:2013-07-01 00:00:00

  • Intrinsic connections between thalamic sub-regions and the lateral prefrontal cortex are differentially impacted by acute methylphenidate.

    abstract:BACKGROUND:The thalamus is a major target of dopaminergic projections and is densely connected with the prefrontal cortex. A better understanding of how dopamine changes thalamo-cortical communication may shed light on how dopamine supports cognitive function. Methylphenidate has been shown to facilitate cognitive proc...


    pub_type: 杂志文章,随机对照试验


    authors: Gorka AX,Lago TR,Balderston N,Torrisi S,Fuchs B,Grillon C,Ernst M

    更新日期:2020-06-01 00:00:00

  • Role of neuro-immunological factors in the pathophysiology of mood disorders.

    abstract::Mood disorders, despite the widespread availability of monoamine-based antidepressant treatments, are associated with persistently high rates of disability, together with elevated rates of mortality due to suicide, cardiovascular disease, and other causes. The development of more effective treatments has been hindered...


    pub_type: 杂志文章,评审


    authors: Bhattacharya A,Derecki NC,Lovenberg TW,Drevets WC

    更新日期:2016-05-01 00:00:00

  • Enhancement of cocaine's abuse liability in methadone maintenance patients.

    abstract::The present study was conducted to determine whether methadone maintenance alters the pharmacodynamic effects of single doses of cocaine. Twenty-two current users of IV cocaine who were not seeking treatment for their illicit cocaine use participated while living on a research unit. Eleven were maintained on methadone...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Preston KL,Sullivan JT,Strain EC,Bigelow GE

    更新日期:1996-01-01 00:00:00

  • Family history of alcoholism interacts with alcohol to affect brain regions involved in behavioral inhibition.

    abstract:RATIONALE:Impulsive behavior is associated with both alcohol use disorders and a family history of alcoholism (FHA). One operational definition of impulsive behavior is the stop-signal task (SST) which measures the time needed to stop a ballistic hand movement. OBJECTIVE:Employ functional magnetic resonance imaging (f...


    pub_type: 杂志文章,随机对照试验


    authors: Kareken DA,Dzemidzic M,Wetherill L,Eiler W 2nd,Oberlin BG,Harezlak J,Wang Y,O'Connor SJ

    更新日期:2013-07-01 00:00:00

  • Marijuana, alcohol, and combined drug effects on the time course of glare recovery.

    abstract::The time course of light adaptation after intense light exposure is significantly delayed by alcohol, marijuana, and a combined dose of alcohol and marijuana. These effects were found in a double blind experiment, using 10 subjects. The experimental treatments were placebo, 0.75 ml/kg of 95% ethanol, 8 and 15 mg of de...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Adams AJ,Brown B,Haegerstrom-Portnoy G,Flom MC,Jones RT

    更新日期:1978-01-31 00:00:00

  • Humoral-endorphin blood levels in autistic, schizophrenic and healthy subjects.

    abstract::Basal morning humoral (H)-endorphin blood levels were assessed in ten autistic patients, 12 chronic schizophrenic patients and 11 healthy control subjects. Four autistic patients and four schizophrenic patients were drug free for at least 6 months while all other psychiatric patients were under treatment with antidopa...


    pub_type: 杂志文章


    authors: Weizman R,Weizman A,Tyano S,Szekely G,Weissman BA,Sarne Y

    更新日期:1984-01-01 00:00:00

  • Effects of three therapeutic doses of codeine/paracetamol on driving performance, a psychomotor vigilance test, and subjective feelings.

    abstract:RATIONALE:Some recent pharmacoepidemiological studies revealed an elevated risk of driving accidents after opioid analgesics uses. Among analgesics, codeine is often associated with paracetamol in numerous pharmaceutical specialties. OBJECTIVES:The objective of this study was to evaluate the dose-effect relationship o...


    pub_type: 杂志文章,随机对照试验


    authors: Amato JN,Marie S,Lelong-Boulouard V,Paillet-Loilier M,Berthelon C,Coquerel A,Denise P,Bocca ML

    更新日期:2013-07-01 00:00:00

  • Caffeine withdrawal increases cerebral blood flow velocity and alters quantitative electroencephalography (EEG) activity.

    abstract:RATIONALE:Cessation of daily caffeine consumption produces a withdrawal syndrome comprised of subjective symptoms and functional impairment. Few controlled studies have examined the physiological effects of caffeine withdrawal. OBJECTIVE:The present study examined the effect of caffeine withdrawal on cerebral blood fl...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Jones HE,Herning RI,Cadet JL,Griffiths RR

    更新日期:2000-01-01 00:00:00

  • The D2 antagonist sulpiride modulates the neural processing of both rewarding and aversive stimuli in healthy volunteers.

    abstract:RATIONALE:Animal studies indicate that dopamine pathways in the ventral striatum code for the motivational salience of both rewarding and aversive stimuli, but evidence for this mechanism in humans is less established. We have developed a functional magnetic resonance imaging (fMRI) model which permits examination of t...


    pub_type: 杂志文章,随机对照试验


    authors: McCabe C,Huber A,Harmer CJ,Cowen PJ

    更新日期:2011-09-01 00:00:00

  • Reversible metabolism of haloperidol and reduced haloperidol in Chinese schizophrenic patients.

    abstract::Haloperidol disposition has been associated with reversible metabolism: it is reversibly reduced to its metabolite, reduced haloperidol, which has less pharmacologic activity than the parent compound. To characterize the interconversion process, six healthy male schizophrenics were administered a single dose of 10 mg ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Jann MW,Lam YW,Chang WH

    更新日期:1990-01-01 00:00:00

  • Modulation of the effects of alcohol on driving-related psychomotor skills by chronic exposure to cannabis.

    abstract:RATIONALE:Many previous studies have reported that alcohol and cannabis produce additive psychomotor effects in acute combination, but few have explicitly tested whether chronic exposure to cannabis, in the absence of acute administration, alters the effects of alcohol on psychomotor performance. OBJECTIVES:To test wh...


    pub_type: 临床试验,杂志文章


    authors: Wright A,Terry P

    更新日期:2002-03-01 00:00:00

  • A naturalistic study of grey matter volume increase after early treatment in anti-psychotic naïve, newly diagnosed schizophrenia.

    abstract:BACKGROUND:Anti-psychotic treatment appears to be associated with striatal volume increase, but how early this change occurs is still unknown. METHODS:A single prospective cohort of 20 anti-psychotic-naïve patients, newly diagnosed with schizophrenia, underwent magnetic resonance imaging brain scan at baseline. This w...


    pub_type: 杂志文章


    authors: Deng MY,McAlonan GM,Cheung C,Chiu CP,Law CW,Cheung V,Sham PC,Chen EY,Chua SE

    更新日期:2009-10-01 00:00:00

  • High-dose methadone produces superior opioid blockade and comparable withdrawal suppression to lower doses in opioid-dependent humans.

    abstract:RATIONALE:The efficacy of methadone for treating heroin dependence derives, in part, from suppression of opiate withdrawal and attenuation of the effects of heroin. OBJECTIVES:The purpose of this double-blind, within-subject, inpatient study was to determine whether larger doses of methadone, which are more effective ...


    pub_type: 杂志文章


    authors: Donny EC,Walsh SL,Bigelow GE,Eissenberg T,Stitzer ML

    更新日期:2002-05-01 00:00:00

  • Assessment of a combination of physostigmine and scopolamine as pretreatment against the behavioural effects of organophosphates in the common marmoset (Callithrix jacchus).

    abstract:RATIONALE:There is a requirement to ensure that UK armed forces are provided with the best possible medical countermeasures to prevent or mitigate the effects of exposure to nerve agents. When pretreatments are under consideration, it is of particular importance to ensure that they do not in themselves give rise to adv...


    pub_type: 杂志文章


    authors: Muggleton NG,Bowditch AP,Crofts HS,Scott EA,Pearce PC

    更新日期:2003-03-01 00:00:00

  • Effect of cocaine sensitization prior to pregnancy on maternal care and aggression in the rat.

    abstract:RATIONALE:Although many studies have investigated the effects of gestational and lactational cocaine use on maternal behavior, few studies have examined the effects of prior adult cocaine use on maternal behavior. METHODS:In the current study, intraperitoneal cocaine or saline was administered to adult female rats for...


    pub_type: 杂志文章


    authors: Nephew BC,Febo M

    更新日期:2010-03-01 00:00:00