Randomized, controlled, double-blind trial of taranabant for smoking cessation.

Abstract:

RATIONALE:It has been proposed that cannabinoid-1 receptor inverse agonists might be effective for smoking cessation. We evaluated this hypothesis with the cannabinoid-1 receptor inverse agonist taranabant. METHODS:Adults who smoked > or =10 cigarettes a day for >1 year and had an expired CO level of > or =10 ppm participated in a randomized, double-blind, 8-week, study of taranabant (N = 159) or placebo (N = 158). Taranabant was titrated from 2 mg once daily to 8 mg once daily. Patients received smoking cessation counseling. The primary efficacy endpoint was continuous abstinence, defined as no cigarettes assessed by daily patient self-report and verified by breath CO level (<10 ppm) and plasma cotinine test (<10 ng/ml), during the last 4 weeks of the 8-week treatment period. RESULTS:The percentage of patients achieving continuous abstinence was 7.5% for taranabant 2-8 mg and 6.3% for placebo (odds ratio = 1.2 [90% confidence interval (CI), 0.6, 2.5], P = 0.678). Change from baseline in body weight in the taranabant 2-8-mg group was -1.5 (90% CI, -1.8, -1.3) versus 0.6 kg (90% CI, 0.4, 0.9) in the placebo group. Compared to placebo, taranabant 2-8 mg was associated with an increased incidence of psychiatric-related adverse events (e.g., depression, 8.2% versus 2.5%, P = 0.048), gastrointestinal-related adverse events (e.g., nausea, 49.7% versus 19.0%, P < 0.001), and flushing/hot flash adverse events (10.7% versus 1.9%, P = 0.002). CONCLUSIONS:Taranabant 2-8 mg did not improve smoking cessation and was associated with increased incidences of psychiatric-related, gastrointestinal-related, and flushing adverse events (ClinicalTrials.gov NCT00109135).

journal_title

Psychopharmacology

authors

Morrison MF,Ceesay P,Gantz I,Kaufman KD,Lines CR

doi

10.1007/s00213-010-1790-2

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

245-53

issue

3

eissn

0033-3158

issn

1432-2072

journal_volume

209

pub_type

杂志文章,多中心研究,随机对照试验
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    更新日期:2005-12-01 00:00:00

  • MK-801 can facilitate passive avoidance memory when retention is not present in control animals, and can fail to facilitate when it is present.

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    pub_type: 杂志文章

    doi:10.1007/BF02244300

    authors: Weiskrantz L,Mondadori C

    更新日期:1991-01-01 00:00:00

  • Motivational properties of ethanol in mice selectively bred for ethanol-induced locomotor differences.

    abstract::Ethanol-induced locomotor stimulation has been proposed to be positively correlated with the rewarding effects of ethanol (Wise and Bozarth 1987). The present experiments provided a test of this hypothesis using a genetic model. Three behavioral indices of the motivational effects of ethanol (drinking, taste condition...

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    pub_type: 杂志文章

    doi:10.1007/BF02245064

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    更新日期:1994-10-01 00:00:00

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    pub_type: 杂志文章

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    authors: Hill MN,Froese LM,Morrish AC,Sun JC,Floresco SB

    更新日期:2006-08-01 00:00:00

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    pub_type: 杂志文章

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    authors: Glover EM,Davis M

    更新日期:2008-06-01 00:00:00

  • Alprazolam, caffeine and their interaction: relating DRL performance to pharmacokinetics.

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    pub_type: 杂志文章

    doi:10.1007/BF02246346

    authors: Lau CE,Wang J

    更新日期:1996-07-01 00:00:00

  • Anxiogenic drugs beta-CCE and FG 7142 increase extracellular dopamine levels in nucleus accumbens.

    abstract::Two experiments were conducted to study the effects of anxiogenic drugs on dopamine release and metabolism in nucleus accumbens. Microdialysis probes were implanted into the nucleus accumbens, and rats were tested the day after implantation. In the first experiment, groups of rats received injections of saline, 1.25 o...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF02245888

    authors: McCullough LD,Salamone JD

    更新日期:1992-01-01 00:00:00

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    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-013-3271-x

    authors: Baladi MG,Newman AH,France CP

    更新日期:2014-02-01 00:00:00

  • Are adolescents more vulnerable to drug addiction than adults? Evidence from animal models.

    abstract:BACKGROUND AND RATIONALE:Epidemiological evidence suggests that people who begin experimenting with drugs of abuse during early adolescence are more likely to develop substance use disorders (SUDs), but this correlation does not guarantee causation. Animal models, in which age of onset can be tightly controlled, offer ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章,评审

    doi:10.1007/s00213-009-1585-5

    authors: Schramm-Sapyta NL,Walker QD,Caster JM,Levin ED,Kuhn CM

    更新日期:2009-09-01 00:00:00

  • Preclinical pharmacology of F-98214-TA, a novel potent serotonin and norepinephrine uptake inhibitor with antidepressant and anxiolytic properties.

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    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-005-0087-3

    authors: Artaiz I,Zazpe A,Innerárity A,Del Olmo E,Díaz A,Ruiz-Ortega JA,Castro E,Pena R,Labeaga L,Pazos A,Orjales A

    更新日期:2005-11-01 00:00:00

  • Prenatal maternal phenobarbital increases reactivity and retards habituation of mature offspring to environmental stimuli.

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    pub_type: 杂志文章

    doi:10.1007/BF00432745

    authors: Middaugh LD,Simpson LW,Thomas TN,Zemp JW

    更新日期:1981-01-01 00:00:00

  • Behavioral performance effects of nifedipine in normotensive and renovascular hypertensive baboons.

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    pub_type: 杂志文章

    doi:10.1007/BF02245802

    authors: Turkkan JS,Hienz RD

    更新日期:1990-01-01 00:00:00

  • Infusions of cholecystokinin octapeptide into the ventral tegmental area potentiate amphetamine conditioned place preferences.

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    pub_type: 杂志文章

    doi:10.1007/BF00445571

    authors: Pettit HO,Mueller K

    更新日期:1989-01-01 00:00:00

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    journal_title:Psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00213-012-2698-9

    authors: Gass JC,Wray JM,Hawk LW,Mahoney MC,Tiffany ST

    更新日期:2012-09-01 00:00:00

  • Effects of carbamazepine on cerebrospinal fluid somatostatin.

    abstract::This paper reports the reduction of the concentration of the neuropeptide somatostatin in the CSF of patients with affective illness during treatment with the anticonvulsant carbamazepine. None of the other psychotropic agents used in this study similarly affected CSF somatostatin, although zimelidine appeared to incr...

    journal_title:Psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF00428416

    authors: Rubinow DR,Post RM,Gold PW,Ballenger JC,Reichlin S

    更新日期:1985-01-01 00:00:00

  • Physostigmine alters onset but not duration of REM sleep in man.

    abstract::Physostigmine (1.0mg) or placebo were administered intravenously over 1-h period to seven male normal volunteers beginning 35 min after sleep onset. The results indicate that physostigmine induced the onset of REM sleep but did not significantly alter the duration of individual REM sleep periods. Physostigmine signifi...

    journal_title:Psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF00426799

    authors: Gillin JC,Sitaram N,Mendelson WB,Wyatt RJ

    更新日期:1978-06-15 00:00:00

  • Attenuation of pilocarpine-induced hypothermia in response to chronic administration of choline.

    abstract::Chronic treatment of rats with choline caused a decrease in the hypothermic response to pilocarpine. The action of choline on the muscarinic receptors is consistent with electrophysiological and binding studies, supporting a direct muscarinic action for choline. Administration of direct muscarinic agonists has been sh...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00427955

    authors: Pomara N,Block R,Demetriou S,Fucek F,Stanley M,Gershon S

    更新日期:1983-01-01 00:00:00

  • An IL-6 receptor antagonist attenuates postpartum anhedonia, but has no effect on anhedonia precipitated by subchronic stress in female rats.

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    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-019-05194-3

    authors: Gomez J,Haas NA,Schwarz JM

    更新日期:2019-10-01 00:00:00

  • Effects of venlafaxine in the sleep architecture of rats.

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    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s002130050194

    authors: Salin-Pascual RJ,Moro-Lopez ML

    更新日期:1997-02-01 00:00:00

  • 8-OH-DPAT-induced place preference and place aversion: effects of PCPA and dopamine antagonists.

    abstract::Low doses of 8-OH-DPAT (62.5-250 micrograms/kg) were reinforcing in the place preference conditioning procedure, while a higher dose (1 mg/kg) supported a conditioned place aversion. The 5-HT synthesis inhibitor PCPA, and the DA antagonists pimozide and sulpiride, had no effect when administered alone, but abolished t...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF02244082

    authors: Papp M,Willner P

    更新日期:1991-01-01 00:00:00

  • Profile of acute tolerance to three sedative anxiolytics.

    abstract::Acute tolerance, defined as a decreasing drug effect relative to drug-plasma levels (DPL) over a period of minutes to a few hours, is pronounced following single doses of diazepam or pentobarbital. Both of these lipid-soluble drugs produce an early peak behavioral impairment and subsequent rapid recovery component tha...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00427800

    authors: Ellinwood EH Jr,Linnoila M,Easler ME,Molter DW

    更新日期:1983-01-01 00:00:00

  • The pharmacology of impulsive behaviour in rats II: the effects of amphetamine, haloperidol, imipramine, chlordiazepoxide and other drugs on fixed consecutive number schedules (FCN 8 and FCN 32).

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    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s002130050673

    authors: Evenden JL

    更新日期:1998-08-01 00:00:00

  • Effects of the dopamine/norepinephrine releaser phenmetrazine on cocaine self-administration and cocaine-primed reinstatement in rats.

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    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-015-3875-4

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    更新日期:2015-07-01 00:00:00

  • Post-retrieval extinction training enhances or hinders the extinction of morphine-induced conditioned place preference in rats dependent on the retrieval-extinction interval.

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    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-011-2545-4

    authors: Ma X,Zhang JJ,Yu LC

    更新日期:2012-05-01 00:00:00

  • Alcohol-induced behavioral changes in zebrafish: The role of dopamine D2-like receptors.

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    pub_type: 杂志文章

    doi:10.1007/s00213-016-4264-3

    authors: Tran S,Facciol A,Gerlai R

    更新日期:2016-06-01 00:00:00

  • Orbitofrontal and caudate volumes in cannabis users: a multi-site mega-analysis comparing dependent versus non-dependent users.

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    pub_type: 杂志文章

    doi:10.1007/s00213-017-4606-9

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    更新日期:2017-07-01 00:00:00

  • Neonatal neurosteroid administration results in development-specific alterations in prepulse inhibition and locomotor activity: neurosteroids alter prepulse inhibition and locomotor activity.

    abstract:RATIONALE:Early life exposure to stress and to GABAA receptor modulators have well-defined and persistent behavioral effects. A single neonatal injection of the GABAergic neurosteroid allopregnanolone (3alpha-hydroxy,5alpha-pregnane-20-one, 10 mg/kg, i.p.) alters the localization of prefrontal cortex (PFC) interneurons...

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    pub_type: 杂志文章

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    更新日期:2006-06-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1007/BF00427106

    authors: Barbaccia ML,Reggiani A,Spano PF,Trabucchi M

    更新日期:1981-01-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1007/BF02245214

    authors: Laviola G,Terranova ML,Sedowofia K,Clayton R,Manning A

    更新日期:1994-01-01 00:00:00

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    abstract::The effects of caffeine (1-100 mg/kg, IP), (-)N-((R)-1-methyl-2-phenylethyl)-adenosine (PIA) (0.01-1 mg/kg, IP), and of the two drugs in combination were studied in mice responding under a mult FR30 FI600 s schedule of food presentation. The lowest dose of caffeine, 1 mg/kg, had no effect on responding under either co...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00432506

    authors: Glowa JR,Sobel E,Malaspina S,Dews PB

    更新日期:1985-01-01 00:00:00