Atypical antipsychotics: are some more atypical than others?

abstract：RATIONALE:There is a close relationship between arousal and pupil diameter, decrease in the level of arousal being accompanied by constriction of the pupil (miosis), probably reflecting the attenuation of sympathetic outflow as sedation sets in. Paradoxically, sedation induced by benzodiazepines is not accompanied by m...

journal_title：Psychopharmacology

authors： Hou RH,Samuels ER,Langley RW,Szabadi E,Bradshaw CM

更新日期：2007-11-01 00:00:00

abstract：RATIONALE AND OBJECTIVE:Drug-associated memories are hypothesized to underlie the high risk of relapse in addiction. Recent studies show that post-retrieval extinction training erases fear memories by reconsolidation blockade. Here, we examine the efficacy of this non-invasive procedure in rats with drug-associated mem...

journal_title：Psychopharmacology

authors： Ma X,Zhang JJ,Yu LC

更新日期：2012-05-01 00:00:00

abstract：:Central dopaminergic transmission has been implicated in memory processes. The present experiments examined the effects of several direct acting dopaminergic agents on performance of a delayed-non-match-to-sample radial arm maze task. Preadministration of apomorphine (D1-D2 agonist; 0.25, 0.5, and 1.0 mg/kg), quinpiro...

journal_title：Psychopharmacology

authors： Chrobak JJ,Napier TC

更新日期：1992-01-01 00:00:00

abstract：:The present report investigated several parametric and pharmacological aspects of the enhanced self-grooming behavior of rats following systemic administration of the selective D1 dopamine (DA) receptor agonist SKF 38393. The amount of time that rats spent grooming themselves was measured continuously for 30 min follo...

journal_title：Psychopharmacology

authors： Wachtel SR,Brooderson RJ,White FJ

更新日期：1992-01-01 00:00:00

abstract：:The intracerebroventricular administration of carbachol chloride induced a characteristic wet dog shake response in rats. Neither 5,6-dihydroxytryptamine, a serotonergic depletor, nor DL-p-chlorophenylalanine, an inhibitor of 5-HT synthesis, affected wet dog shakes induced by carbachol. Putative antiserotonergic drugs...

journal_title：Psychopharmacology

authors： Turski L,Turski W,Czuczwar SJ,Kleinrok Z

更新日期：1981-01-01 00:00:00

abstract：:Male Sprague-Dawley rats weighing 116--241 g were injected i.p. with ketamine hydrochloride, 80 mg per kilo of body weight. Immediately after loss of righting reflex, scopolamine, physostigmine, and mecamylamine were administered i.p. to different groups of rats. Control animals received sterile saline by the same rou...

journal_title：Psychopharmacology

authors： Figallo EM,Wingard LB Jr

更新日期：1979-03-14 00:00:00

abstract：:The effects of 6-OHDA lesions of dopamine terminals within the amygdala were investigated on i) (+) amphetamine-induced locomotor hyperactivity and ii) the acquisition of intravenous self-administration of (+) amphetamine. The lesioned rats exhibited increased locomotor activity in response to (+) amphetamine (0.75 an...

journal_title：Psychopharmacology

authors： Deminière JM,Taghzouti K,Tassin JP,Le Moal M,Simon H

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Stress, a powerful precipitant of drug seeking during abstinence, may also accelerate the return to pathological patterns of intake after initial instances of drug reuse. OBJECTIVE:To explore the effect of stress on a learning process underlying relapse, this study assessed the effect of yohimbine on reacqui...

journal_title：Psychopharmacology

authors： Campbell AT,Kwiatkowski D,Boughner E,Leri F

更新日期：2012-07-01 00:00:00

abstract：RATIONALE:Acute ethanol administration induces hypothermia in genetically susceptible animals. Tolerance to this effect may develop with repeated administration. Allopregnanolone is an endogenously produced neuroactive steroid that acts at the GABA-A receptor. We postulated that allopregnanolone would induce hypothermi...

journal_title：Psychopharmacology

authors： Palmer AA,Moyer MR,Crabbe JC,Phillips TJ

更新日期：2002-07-01 00:00:00

abstract：RATIONALE:Central cannabinoid systems have been implicated in appetite regulation through the hyperphagic effects of exogenous and endogenous cannabinoids. These effects may involve activation of reward systems and be mediated in part by opioidergic processes. OBJECTIVE:Cannabinoid-opioid interactions in feeding were ...

journal_title：Psychopharmacology

authors： Kirkham TC,Williams CM

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Anti-psychotic treatment appears to be associated with striatal volume increase, but how early this change occurs is still unknown. METHODS:A single prospective cohort of 20 anti-psychotic-naïve patients, newly diagnosed with schizophrenia, underwent magnetic resonance imaging brain scan at baseline. This w...

journal_title：Psychopharmacology

authors： Deng MY,McAlonan GM,Cheung C,Chiu CP,Law CW,Cheung V,Sham PC,Chen EY,Chua SE

更新日期：2009-10-01 00:00:00

abstract：INTRODUCTION:Recently we demonstrated that genetic or pharmacological suppression of the central ghrelin signaling system, involving the growth hormone secretagogue receptor 1A (GHS-R1A), lead to a reduced reward profile from alcohol. As the target circuits for ghrelin in the brain include a mesolimbic reward pathway t...

journal_title：Psychopharmacology

authors： Jerlhag E,Egecioglu E,Dickson SL,Engel JA

更新日期：2010-09-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:Dopamine (DA) agonists reliably disrupt prepulse inhibition (PPI) of the startle reflex in animals but less so in humans despite cross-species similarities in the neural regulation of PPI. This study examines whether individual variation in baseline PPI may account for the inconsistencies in DA...

journal_title：Psychopharmacology

authors： Bitsios P,Giakoumaki SG,Frangou S

更新日期：2005-10-01 00:00:00

abstract：:The behavioral profile of corticotropin-releasing factor (CRF) in mediating anxiogenic-like and aversive responses to stressors may be particularly relevant for dependence and withdrawal in drug-experienced organisms. Moreover, stressful aspects of drug exposure in the drug naive organism may also induce CRF system ac...

journal_title：Psychopharmacology

authors： Heinrichs SC,Klaassen A,Koob GF,Schulteis G,Ahmed S,De Souza EB

更新日期：1998-04-01 00:00:00

abstract：:Ten behavioural variables were recorded by means of an automatic holeboard apparatus. The behaviour of rats placed for the first time in the apparatus was recorded for 10 min. The suppression of this exploratory behaviour by the dopamine agonist apomorphine (0.01-0.1 mg/kg) was shown to be reversible in a surmountable...

journal_title：Psychopharmacology

authors： Ståhle L,Ungerstedt U

更新日期：1989-01-01 00:00:00

abstract：RATIONALE:Results from clinical studies have shown that topiramate effectively reduces alcohol consumption in a population of heavy-drinking alcohol-dependent humans. OBJECTIVES:We undertook this preclinical study in order to establish topiramate's efficacy in a rodent model and to determine whether topiramate's effic...

journal_title：Psychopharmacology

authors： Breslin FJ,Johnson BA,Lynch WJ

更新日期：2010-01-01 00:00:00

abstract：:Recent clinical data suggest that buspirone may enhance the efficacy and/or reduce the latency to therapeutic effect of selective serotonin reuptake inhibitors (SSRIs) in unipolar major depressive disorder. The present study, using the mouse forced swimming test, was performed to investigate further the mechanisms inv...

journal_title：Psychopharmacology

authors： Redrobe JP,Bourin M

更新日期：1998-07-01 00:00:00

abstract：RATIONALE:Performance on progressive ratio schedules has been proposed as a means of assessing the effects of drugs on the value or "efficacy" of reinforcers. A mathematical model affords a basis for quantifying the effects of drugs on progressive ratio schedule performance. According to this model, the relation betwee...

journal_title：Psychopharmacology

authors： Zhang Z,Rickard JF,Asgari K,Body S,Bradshaw CM,Szabadi E

更新日期：2005-05-01 00:00:00

abstract：RATIONALE:Past research has found that exposure to alcohol cues causes a narrowing of attentional scope and enhances the neural responses associated with approach motivation. OBJECTIVE:The current research sought to determine if a manipulated broadened (global) attentional scope would reduce approach-motivated neural ...

journal_title：Psychopharmacology

authors： Ryerson NC,Neal LB,Gable PA

更新日期：2017-04-01 00:00:00

abstract：RATIONALE:Recently, we showed that 2-bromoterguride acted as a dopamine D2 receptor partial agonist, a serotonin 5-HT2A and α2C-adrenergic receptor antagonist, and exhibited antidopaminergic efficacy in amphetamine-induced locomotion (AIL) in rats without inducing catalepsy. OBJECTIVE:To extend our knowledge on the an...

journal_title：Psychopharmacology

authors： Franke RT,Tarland E,Fink H,Pertz HH,Brosda J

更新日期：2016-08-01 00:00:00

abstract：:The purpose of this study was to investigate the developmental differences in seizure susceptibility in mice and the roles of the histaminergic neuron system in inhibition of convulsions in development. First, we studied developmental differences in electrically-induced seizures. Since the 14-day-old mice showed a dif...

journal_title：Psychopharmacology

authors： Yokoyama H,Onodera K,Iinuma K,Watanabe T

更新日期：1993-01-01 00:00:00

abstract：:Serotonin receptors of the 5HT2 type were labeled on platelet membranes using tritiated ketanserin. Blood was collected from the umbilical cord of newborns and venous samples were collected from 6-year-old children as well as junior-high and high school students (ages 13 through 18) to determine age-related changes in...

journal_title：Psychopharmacology

authors： Biegon A,Greuner N

更新日期：1992-01-01 00:00:00

abstract：:The [14C]-2-deoxyglucose method was used to map the in vivo metabolic response of glucose to savoxepine, a novel tetracyclic cyano-dibenzoxepino-azepine. Savoxepine is reported to have higher affinity for dopamine (DA) receptors in the hippocampus than in the striatum and hence should have dose-dependent, anatomically...

journal_title：Psychopharmacology

authors： Cascella NG,Tarazi FI,Shirakawa O,Tamminga CA

更新日期：1994-03-01 00:00:00

abstract：INTRODUCTION:Alterations in protein kinase (PKA) protein levels have been implicated in the regulation of responses to and development of cocaine addiction. However, the contribution of differences in PKA intracellular cascade to the known sex differences in responses to cocaine is not well understood. This study exami...

journal_title：Psychopharmacology

authors： Nazarian A,Sun WL,Zhou L,Kemen LM,Jenab S,Quinones-Jenab V

更新日期：2009-04-01 00:00:00

abstract：RATIONALE:Mice are useful tools for dissecting genetic and environmental factors in relation to the study of attention and impulsivity. The five-choice serial reaction time task (5CSRTT) paradigm has been well established in rats, but its transferability to mice is less well documented. OBJECTIVES:This study aims to s...

journal_title：Psychopharmacology

authors： Sanchez-Roige S,Peña-Oliver Y,Stephens DN

更新日期：2012-01-01 00:00:00

abstract：RATIONALE:The elevated plus-maze and the light/dark box are two established anxiety tests in rodents, which are useful to screen putative anxiogenic effects of drugs. OBJECTIVE:Caffeine is well known to promote anxious behaviour in humans and animal models, but the precise site of action of the drug is still a matter ...

journal_title：Psychopharmacology

authors： El Yacoubi M,Ledent C,Parmentier M,Costentin J,Vaugeois JM

更新日期：2000-02-01 00:00:00

abstract：RATIONALE AND OBJECTIVE:Estradiol decline has been associated with depression and anxiety in post-menopausal women. Agomelatine (Ago) is an agonist of the melatonergic MT1/MT2 receptors and an antagonist of the serotonergic 5-HT2c receptors. The present study aimed to evaluate the effects of combining Ago with 17β-estr...

journal_title：Psychopharmacology

authors： El-Khatib YA,Sayed RH,Sallam NA,Zaki HF,Khattab MM

更新日期：2020-09-01 00:00:00

abstract：RATIONALE:Understanding factors contributing to individual differences in vulnerability to opioid addiction is essential for developing more effective preventions and treatments, yet few reliable behavioral predictors of subsequent opioid self-administration have been identified in rodents. Sensitivity to the acute eff...

journal_title：Psychopharmacology

authors： Swain Y,Muelken P,Skansberg A,Lanzdorf D,Haave Z,LeSage MG,Gewirtz JC,Harris AC

更新日期：2020-08-01 00:00:00

abstract：RATIONALE:Delta-opioid agonists produce a number of behavioral effects, including convulsions, antinociception, locomotor stimulation, and antidepressant-like effects. The development of these compounds as treatments for depression is limited by their convulsive effects. Therefore, determining how to separate the convu...

journal_title：Psychopharmacology

authors： Jutkiewicz EM,Rice KC,Traynor JR,Woods JH

更新日期：2005-11-01 00:00:00

abstract：:Phencyclidine combined with footshock stress produced a greater increase in the homovanillic acid content of prefrontal cortex than either phencyclidine or footshock alone. Phencyclidine decreased both substance P and substance K in the ventral tegmental area. The results suggest that phencyclidine and footshock activ...

journal_title：Psychopharmacology

authors： Bowers MB Jr,Bannon MJ,Hoffman FJ Jr

更新日期：1987-01-01 00:00:00