Effect of transdermal nicotine replacement on alcohol responses and alcohol self-administration.

abstract：RATIONALE:Though interoceptive properties of antidepressants have been described, discriminative stimulus (DS) properties of mirtazapine, which does not affect monoamine reuptake, remain uncharacterized. OBJECTIVES:The objectives of the study are to train rats to recognize a mirtazapine DS, then perform substitution s...

journal_title：Psychopharmacology

authors： Dekeyne A,Millan MJ

更新日期：2009-04-01 00:00:00

abstract：RATIONALE:Pharmacological agents used in the treatment of anxiety have been reported to decrease threat relevant processing in patients and healthy controls, suggesting a potentially relevant mechanism of action. However, the effects of the anxiolytic diazepam have typically been examined at sedative doses, which do no...

journal_title：Psychopharmacology

authors： Murphy SE,Downham C,Cowen PJ,Harmer CJ

更新日期：2008-09-01 00:00:00

abstract：:The binding kinetics of tritiated quinuclidinyl benzilate (QNB) were studied in membrane preparations from human parotid and rabbit submandibular glands. Inhibition of 3H-QNB was then used to compare the anticholinergic activity of lofepramine, desipramine, imipramine and amitriptyline for muscarinic receptor in the s...

journal_title：Psychopharmacology

authors： Batra S,Biörklund A

更新日期：1986-01-01 00:00:00

abstract：:This paper reports the reduction of the concentration of the neuropeptide somatostatin in the CSF of patients with affective illness during treatment with the anticonvulsant carbamazepine. None of the other psychotropic agents used in this study similarly affected CSF somatostatin, although zimelidine appeared to incr...

journal_title：Psychopharmacology

authors： Rubinow DR,Post RM,Gold PW,Ballenger JC,Reichlin S

更新日期：1985-01-01 00:00:00

abstract：:Various doses of the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, MK-801 (0.1-0.5 mg/kg) and ketamine (2.5-10 mg/kg), produced a dose-dependent increase in stereotypic behaviour in naive mice. MK-801 (0.1 mg/kg) and ketamine (2.5 mg/kg) potentiated the stereotypic response of apomorphine (0.1-0.5 ...

journal_title：Psychopharmacology

authors： Verma A,Kulkarni SK

更新日期：1992-01-01 00:00:00

abstract：:Physostigmine (1.0mg) or placebo were administered intravenously over 1-h period to seven male normal volunteers beginning 35 min after sleep onset. The results indicate that physostigmine induced the onset of REM sleep but did not significantly alter the duration of individual REM sleep periods. Physostigmine signifi...

journal_title：Psychopharmacology

authors： Gillin JC,Sitaram N,Mendelson WB,Wyatt RJ

更新日期：1978-06-15 00:00:00

abstract：RATIONALE:Individual differences in the rate of nicotine metabolism (RNM) could be related to dependence and success in stopping smoking. A range of studies have examined RNM measured by the ratio of trans-3'-hydroxycotinine and cotinine in body fluids (the ratio). A systematic review of this literature is needed to dr...

journal_title：Psychopharmacology

authors： West O,Hajek P,McRobbie H

更新日期：2011-11-01 00:00:00

abstract：:This study demonstrates that the selective delta receptor antagonists ICI 174864 and naltrindole (NTI) attenuate alcohol intake in a dose-dependent manner, without altering water intake, in rats selectively bred for alcohol preference. ICI 174864 had a very limited duration of action, as evidenced by the fact that sup...

journal_title：Psychopharmacology

authors： Krishnan-Sarin S,Jing SL,Kurtz DL,Zweifel M,Portoghese PS,Li TK,Froehlich JC

更新日期：1995-07-01 00:00:00

abstract：:Both muscarinic antagonists, such as scopolamine, and benzodiazepine receptor (BZR) agonists, such as diazepam, produce a reliable impairment in the performance of one trial passive avoidance. Such deficits are frequently interpreted as drug-induced amnesia. However, these deficits could also result from a learning im...

journal_title：Psychopharmacology

authors： Cole BJ,Jones GH

更新日期：1995-03-01 00:00:00

abstract：:The effects on memory and psychomotor functions of four antidepressants which differ in sedative and anticholinergic properties were assessed. Amitriptyline (37.5, 70 mg), trazodone (100, 200 mg) viloxazine (100, 200 mg), protriptyline (10, 20 mg) or placebo were administered in a double blind, independent groups desi...

journal_title：Psychopharmacology

authors： Curran HV,Sakulsriprong M,Lader M

更新日期：1988-01-01 00:00:00

abstract：:The effects of chronic desmethylimipramine (DMI) treatment on measures of incentive motivation for cocaine were assessed in order to investigate the predictive validity of the extinction/reinstatement model of drug craving. Rats were trained to respond for cocaine infusions (0.75 mg/kg per 0.1 ml i.v.) or received yok...

journal_title：Psychopharmacology

authors： Fuchs RA,Tran-Nguyen LT,Specio SE,Groff RS,Neisewander JL

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVES:Although cocaine use has been linked to sexual HIV risk behavior for decades, the direct effects of cocaine on sexual desire and sexual decision-making are unexamined. Research suggests delay discounting (devaluation of future outcomes) and probability discounting (devaluation of uncertain outcomes) play rol...

journal_title：Psychopharmacology

authors： Johnson MW,Herrmann ES,Sweeney MM,LeComte RS,Johnson PS

更新日期：2017-02-01 00:00:00

abstract：:Quantitative receptor autoradiography was used to study the effects of the selective serotonin reuptake inhibitors citalopram and fluoxetine and the tricyclic antidepressant imipramine on the regulation of beta 1-adrenergic receptors in the rat brain. Rats were treated with saline, citalopram (10 mg kg-1), fluoxetine ...

journal_title：Psychopharmacology

authors： Pälvimäki EP,Laakso A,Kuoppamäki M,Syvälahti E,Hietala J

更新日期：1994-08-01 00:00:00

abstract：RATIONALE:Pindolol has been reported to shorten the onset of antidepressant action of selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitors (SSRIs) as well as to increase their efficacy. It has been postulated that pindolol enhances the antidepressant effect of SSRIs by blocking somatodendritic 5-HT1A aut...

journal_title：Psychopharmacology

authors： Arborelius L,Linnér L,Wallsten C,Ahlenius S,Svensson TH

更新日期：2000-07-01 00:00:00

abstract：:Systemic administration of RB 101, a complete inhibitor of the enkephalin degrading enzymes, has been reported to induce naltrindole-reversed antidepressant-like effects in the conditioned suppression of motility (CSM) test in mice. The selective CCKB antagonist L-365,260 also elicits the same naltrindole-blocked resp...

journal_title：Psychopharmacology

authors： Smadja C,Maldonado R,Turcaud S,Fournie-Zaluski MC,Roques BP

更新日期：1995-08-01 00:00:00

abstract：BACKGROUND:Acute administration of selective serotonin and noradrenaline re-uptake blockers to healthy volunteers affects the processing of emotional information but it is not known if similar effects occur with antidepressants acting through other pharmacological mechanisms. Mirtazapine is a clinically established ant...

journal_title：Psychopharmacology

authors： Arnone D,Horder J,Cowen PJ,Harmer CJ

更新日期：2009-05-01 00:00:00

abstract：:Response decrements in an operant task produced by either extinction or by the dopamine receptor blocker pimozide were examined in three experiments which employed intermittent reinforcement schedules. In contrast to the congruency between these treatments previously observed following continuous reinforcement trainin...

journal_title：Psychopharmacology

authors： Tombaugh TN,Anisman H,Tombaugh J

更新日期：1980-01-01 00:00:00

abstract：:Supersensitivity to serotonin during migraine attack has been previously observed. Since the attack has been attributed to a critical lowering of morphine-like factors, we can expect serotonin supersensitivity during morphine abstinence. Slight signs of morphine abstinence have also been induced in volunteers after mi...

journal_title：Psychopharmacology

authors： Sicuteri F,Del Bianco PL,Anselmi B

更新日期：1979-10-01 00:00:00

abstract：RATIONALE:Drug development is a high-risk and high failure enterprise, and studies that provide an early read on the pharmacodynamic activity of novel compounds could save time and money, increasing the efficiency of the drug development process. OBJECTIVE:Preclinical and clinical experiments were designed to examine ...

journal_title：Psychopharmacology

authors： Lenz RA,Baker JD,Locke C,Rueter LE,Mohler EG,Wesnes K,Abi-Saab W,Saltarelli MD

更新日期：2012-03-01 00:00:00

abstract：:Central dopaminergic transmission has been implicated in memory processes. The present experiments examined the effects of several direct acting dopaminergic agents on performance of a delayed-non-match-to-sample radial arm maze task. Preadministration of apomorphine (D1-D2 agonist; 0.25, 0.5, and 1.0 mg/kg), quinpiro...

journal_title：Psychopharmacology

authors： Chrobak JJ,Napier TC

更新日期：1992-01-01 00:00:00

abstract：:Spontaneous and amphetamine-elicited locomotor activity in rats is reduced by most clinically effective antipsychotic drugs. We have recently demonstrated that intracerebroventricular infusion of kainic acid (KA), which produces cell loss in the hippocampus and other limbic-cortical brain regions, increases spontaneou...

journal_title：Psychopharmacology

authors： Bardgett ME,Jackson JL,Taylor BM,Csernansky JG

更新日期：1998-02-01 00:00:00

abstract：RATIONALE:Benzodiazepine agonists characteristically increase food intake in humans and non-human subjects, and the underlying mechanisms of this effect are not understood completely. OBJECTIVE:Compounds with selectivity for GABAA receptor subtypes were used to evaluate the role of GABAA receptors containing alpha1 an...

journal_title：Psychopharmacology

authors： Duke AN,Platt DM,Cook JM,Huang S,Yin W,Mattingly BA,Rowlett JK

更新日期：2006-08-01 00:00:00

abstract：RATIONALE:Animal models of alcohol-seeking are useful for understanding alcohol addiction and for treatment development, but throughput in these models is limited by the extensive pretraining required to overcome the aversive taste of ethanol. Work by Augier et al. (Psychopharmacology 231: 4561-4568, 2014) indicates th...

journal_title：Psychopharmacology

authors： Puaud M,Ossowska Z,Barnard J,Milton AL

更新日期：2018-04-01 00:00:00

abstract：RATIONALE:The high prevalence of smoking and low cessation rates among individuals with schizophrenia and similar conditions are not well understood. Behavioral economics has been extensively applied to studying addictive behavior and may contribute to understanding smoking in this subpopulation. OBJECTIVES:This study...

journal_title：Psychopharmacology

authors： MacKillop J,Tidey JW

更新日期：2011-07-01 00:00:00

abstract：:Each morning eight adults with caffeine versus placebo discrimination histories ingested letter-coded capsules containing 100 mg caffeine or placebo and then engaged in a relaxation or vigilance activity. Subjects were first exposed to caffeine and placebo once each with each activity. Then each day for 10 days subjec...

journal_title：Psychopharmacology

authors： Silverman K,Mumford GK,Griffiths RR

更新日期：1994-04-01 00:00:00

abstract：RATIONALE:Studies of ethanol's effects on TSH carried out during the daytime, when its secretion is at its nadir, do not reflect the true action of alcohol on TSH secretion since TSH peak occurs at night. OBJECTIVE:The present study investigated the effects of alcohol on the serum concentrations of TSH in healthy volu...

journal_title：Psychopharmacology

authors： Danel T,Touitou Y

更新日期：2003-11-01 00:00:00

abstract：RATIONALE:Animal models of relapse to drug abuse typically assess the ability of various manipulations to reinstate responding that has ceased due to non-reinforcement (extinction). However, there is a lack of information concerning the reinstatement of responding that has ceased for reasons other than extinction. OBJ...

journal_title：Psychopharmacology

authors： Panlilio LV,Thorndike EB,Schindler CW

更新日期：2003-07-01 00:00:00

abstract：RATIONALE:Acute ethanol administration induces hypothermia in genetically susceptible animals. Tolerance to this effect may develop with repeated administration. Allopregnanolone is an endogenously produced neuroactive steroid that acts at the GABA-A receptor. We postulated that allopregnanolone would induce hypothermi...

journal_title：Psychopharmacology

authors： Palmer AA,Moyer MR,Crabbe JC,Phillips TJ

更新日期：2002-07-01 00:00:00

abstract：:Rats were trained to discriminate fenfluramine (1.0 mg/kg) from saline in a two-lever drug discrimination task. The dose-response curve for this discrimination was orderly with an ED50 of about one-half of the training dose (0.52 mg/kg). In substitution tests, indirect (p-chloroamphetamine) and direct (quipazine, MK-2...

journal_title：Psychopharmacology

authors： White FJ,Appel JB

更新日期：1981-01-01 00:00:00

abstract：RATIONALE:The orexin/hypocretin system has recently been implicated in reward-seeking, especially for highly salient food and drug rewards. We reasoned that this system may be strongly engaged during periods of reward restriction, including food restriction. OBJECTIVES:This study examined the involvement of the orexin...

journal_title：Psychopharmacology

authors： Cason AM,Aston-Jones G

更新日期：2013-03-01 00:00:00