An automated method for studying exploratory and stereotyped behaviour in rats.

abstract：:The effects of clozapine (CLOZ) upon acquired schedule-induced polydipsia in rats were compared to the effects of the dopamine (DA) D1 antagonist SCH 23390 (SCH) and the DA D2 antagonist raclopride (RAC). All three compounds suppressed water consumption, but only SCH and RAC decreased drinking efficiency. SCH was the ...

journal_title：Psychopharmacology

authors： Didriksen M,Olsen GM,Christensen AV

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:It has recently been shown that acute alcohol globally impairs 'prospective memory' (PM)-remembering to do something in the future (Leitz et al. in Psychopharmacology 205:379-387, 2009). In healthy, sober individuals, simulating future events at encoding enhances PM performance. AIMS:We therefore aimed to d...

journal_title：Psychopharmacology

authors： Paraskevaides T,Morgan CJ,Leitz JR,Bisby JA,Rendell PG,Curran HV

更新日期：2010-02-01 00:00:00

abstract：:Rats were treated once with doses of haloperidol or of droperidol below and above the acute ID50 vs the dopamine agonist apomorphine; they were later challenged with an acute dose of apomorphine (0.3 mg/kg, SC) and rated for stereotyped behavioral responses. The two neuroleptics were similar in acute anti-apomorphine ...

journal_title：Psychopharmacology

authors： Campbell A,Baldessarini RJ,Teicher MH,Kula NS

更新日期：1985-01-01 00:00:00

abstract：:We investigated the possibility that repeated electrical stimulation of the basolateral amygdala (kindling) would increase punished behavior, a pre-clinical indicator of anti-anxiety activity. Male Sprague-Dawley rats, prepared with electrodes in the left basolateral nucleus and frontal cortex, were trained to bar-pre...

journal_title：Psychopharmacology

authors： Witkin JM,Lee MA,Walczak DD

更新日期：1988-01-01 00:00:00

abstract：:The aim of the present study was to evaluate the effects of nicotinic acetylcholine receptor (nACh-R) agonists such as (-)-nicotine and related compounds on brain monoamine turnover. A single administration of (-)-nicotine (0.04, 0.2, 1.0, and 5.0 mg/kg SC) increased both noradrenaline (NA) and dopamine (DA) turnover ...

journal_title：Psychopharmacology

authors： Tani Y,Saito K,Tsuneyoshi A,Imoto M,Ohno T

更新日期：1997-02-01 00:00:00

abstract：:The sensitivity of the dopaminergic hypothalamic pituitary system, as indicated by growth hormone (GH) release after apomorphine (0.5 mg SC), was studied in 11 chronic schizophrenic in-patients under long-term neuroleptic (NL) therapy and after 12 and 30 days' drug withdrawal. GH peak levels after a 12-day drug-free p...

journal_title：Psychopharmacology

authors： Müller-Spahn F,Ackenheil M,Albus M,May G,Naber D,Welter D,Zander K

更新日期：1984-01-01 00:00:00

abstract：RATIONALE:New research findings in the field of neuroactive steroids strongly suggest that to understand their role in physiopathology, it is essential to accurately measure their tissue levels. Through his broad chemical expertise and extensive knowledge of steroids, Dr. Robert H. Purdy pioneered structure-activity re...

journal_title：Psychopharmacology

authors： Vallée M

更新日期：2014-09-01 00:00:00

abstract：:The present study employed an animal model of drug relapse in which previously extinguished heroin self-administration behavior was reinstated following a single reinforced trial. Male albino rats were trained to traverse a straight-alley for a reinforcer consisting of a single IV injection of 0.06 mg/kg diacetylmorph...

journal_title：Psychopharmacology

authors： Ettenberg A,MacConell LA,Geist TD

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND:Soda manufacturers claim that caffeine is added to soda as a flavor enhancer, but many researchers have speculated that caffeine is added to increase the hedonic and reinforcing properties of the soda. Studies in adults have demonstrated that caffeine can condition flavor preferences when added to novel-flav...

journal_title：Psychopharmacology

authors： Temple JL,Ziegler AM,Graczyk A,Bendlin A,O'Leary S,Schnittker YS

更新日期：2012-09-01 00:00:00

abstract：:This study demonstrates that the selective delta receptor antagonists ICI 174864 and naltrindole (NTI) attenuate alcohol intake in a dose-dependent manner, without altering water intake, in rats selectively bred for alcohol preference. ICI 174864 had a very limited duration of action, as evidenced by the fact that sup...

journal_title：Psychopharmacology

authors： Krishnan-Sarin S,Jing SL,Kurtz DL,Zweifel M,Portoghese PS,Li TK,Froehlich JC

更新日期：1995-07-01 00:00:00

abstract：RATIONALE:Whilst the deleterious effects of alcohol on retrospective remembering have been widely documented, no study has yet objectively determined alcohol's effects on prospective memory (PM)--remembering to do something in the future. OBJECTIVES:With this aim, the present study determined the acute effects of alco...

journal_title：Psychopharmacology

authors： Leitz JR,Morgan CJ,Bisby JA,Rendell PG,Curran HV

更新日期：2009-08-01 00:00:00

abstract：:Cholecystokinin (CCK) and dopamine (DA) coexist in both cell body and terminal areas of a mesolimbic pathway that projects from the ventral tegmental area (VTA) to the nucleus accumbens (N ACC). Autoradiography reveals extensive CCK binding sites in the N ACC, but not in the VTA. However, iontophoresis of CCK into the...

journal_title：Psychopharmacology

authors： Pettit HO,Mueller K

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVE:Acute diazepam administration has been shown to decrease plasma cortisol levels consistent with decreased activity of the hypothalamic-pituitary-adrenal axis, especially in individuals experiencing stress. However, the effects of chronic diazepam treatment on cortisol have been less studied, and the relations...

journal_title：Psychopharmacology

authors： Pomara N,Willoughby LM,Sidtis JJ,Cooper TB,Greenblatt DJ

更新日期：2005-02-01 00:00:00

abstract：RATIONALE:Comorbidity with gambling disorder (GD) and alcohol use disorder (AUD) is well documented. OBJECTIVE:The purpose of our study was to examine the influence of genetic alcohol drinking tendency on reward-guided decision making behavior of rats and the impact of dopamine releaser D-amphetamine on this behavior....

journal_title：Psychopharmacology

authors： Oinio V,Sundström M,Bäckström P,Uhari-Väänänen J,Kiianmaa K,Raasmaja A,Piepponen P

更新日期：2018-05-01 00:00:00

abstract：RATIONALE:Nicotine and nicotinic agonists have been shown to improve attentional function. Nicotinic receptors are easily desensitized, and all nicotinic agonists are also desensitizing agents. Although both receptor activation and desensitization are components of the mechanism that mediates the overall effects of nic...

journal_title：Psychopharmacology

authors： Rezvani AH,Cauley M,Xiao Y,Kellar KJ,Levin ED

更新日期：2013-03-01 00:00:00

abstract：RATIONALE:(1S,3aS)-8-(2,3,3,4,5,6-hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one (Ro 64-6198), a non-peptidic agonist for the opioid receptor-like1 (ORL1) receptor, exhibits anxiolytic properties in stressful conditions. OBJECTIVE:The present study was aimed at evaluating whether activation of ...

journal_title：Psychopharmacology

authors： Ciccocioppo R,Biondini M,Antonelli L,Wichmann J,Jenck F,Massi M

更新日期：2002-05-01 00:00:00

abstract：INTRODUCTION:Non-medical use of prescription opioids such as the mu opioid receptor (MOP-r) agonist oxycodone is a growing problem in the USA and elsewhere. There is limited information about oxycodone's impact on diverse gene systems in the brain. OBJECTIVES:The current study was designed to examine how chronic oxyco...

journal_title：Psychopharmacology

authors： Zhang Y,Liang Y,Levran O,Randesi M,Yuferov V,Zhao C,Kreek MJ

更新日期：2017-08-01 00:00:00

abstract：:CSF GABA levels were not significantly different in a group of drug-free psychotic patients compared to a group of psychotic patients at two points during haloperidol treatment or a neurological comparison group. In the untreated group, CSF GABA was significantly negatively correlated with clinical ratings of anxiety ...

journal_title：Psychopharmacology

authors： Bowers MB Jr,Gold BI,Roth RH

更新日期：1980-01-01 00:00:00

abstract：:Suriclone is a new anxiolytic drug belonging to the family of cyclopyrrolones. Although chemically entirely different from the benzodiazepines, it acts as a benzodiazepine agonist with very high affinity for the benzodiazepine receptors. In the present cross-over study, 33 out-patients with a diagnosis of neurotic anx...

journal_title：Psychopharmacology

authors： Gerlach J,Christensen JK,Christensen TL,Elley J,Jensen JP,Larsen SB

更新日期：1987-01-01 00:00:00

abstract：RATIONALE:Nicotine improves cognitive function in a number of animal models including rats, mice, monkeys, and recently, zebrafish. The zebrafish model allows higher throughput and ease in discovering mechanisms of cognitive improvement. MATERIALS AND METHODS:To further characterize the neural bases of nicotine effect...

journal_title：Psychopharmacology

authors： Eddins D,Petro A,Williams P,Cerutti DT,Levin ED

更新日期：2009-01-01 00:00:00

abstract：RATIONALE:Dependence on both alcohol and cocaine is a widespread example of polydrug abuse/dependence. It has been hypothesized that ethanol reward is mediated via increased dopaminergic neurotransmission in mesolimbic striatum, as is the case for cocaine. However, little is known about the neurobiology of ethanol in p...

journal_title：Psychopharmacology

authors： Bradberry CW

更新日期：2002-12-01 00:00:00

abstract：:Plasma fluphenazine levels and plasma total neuroleptic activity (as quantitated by the neuroleptic receptor binding assay) were related to therapeutic response in 15 DSM-III schizophrenic patients who received a predetermined, fixed dose of fluphenazine for 14 days. Mean neuroleptic activity of the plasma was 84% gre...

journal_title：Psychopharmacology

authors： Hitzemann RJ,Garver DL,Mavroidis M,Hirschowitz J,Zemlan FP

更新日期：1986-01-01 00:00:00

abstract：:In a phase II study the antidepressive effect of citalopram, a selective and potent serotonin reuptake inhibitor, was examined in 20 endogenously and three non-endogenously depressed hospitalized patients. Four endogenously depressed patients dropped out due to deterioration early in the treatment period. The remainin...

journal_title：Psychopharmacology

authors： Pedersen OL,Kragh-Sørensen P,Bjerre M,Overø KF,Gram LF

更新日期：1982-01-01 00:00:00

abstract：:7-Hydroxychlorpromazine (7-OHCPZ) has been identified and quantified in CSF from chlorpromazine (CPZ)-treated schizophrenic patients. The level of the metabolite in CSF was similar to that of CPZ. In serum the amount of 7-OHCPZ was about 30% of CPZ. The concentration of 7-OHCPZ in csf was positively and significantly ...

journal_title：Psychopharmacology

authors： Alfredsson G,Lindberg M,Sedvall G

更新日期：1982-01-01 00:00:00

abstract：:Pigeons trained under a two-key drug discrimination procedure eventually learned to discriminate 5 mg/kg phenytoin from saline injections. When 1.25-20 mg/kg doses of phenytoin were substituted for the training dose, the percentage of responses directed to the phenytoin-appropriate key varied directly with dose. Chlor...

journal_title：Psychopharmacology

authors： Krafft K,Cleary J,Poling A

更新日期：1983-01-01 00:00:00

abstract：RATIONALE:In cell culture systems, agonists can promote the phosphorylation and internalization of receptors coupled to G proteins (GPCR), leading to their desensitization. However, in the CNS opioid agonists promote a profound desensitization of their analgesic effects without diminishing the presence of their recepto...

journal_title：Psychopharmacology

authors： Garzón J,Rodríguez-Muñoz M,de la Torre-Madrid E,Sánchez-Blázquez P

更新日期：2005-06-01 00:00:00

abstract：RATIONALE:Previous research has identified a number of factors that appear to moderate the behavioural response to glucose administration. These include physiological state, dose, types of cognitive tasks used and level of cognitive demand. Another potential moderating factor is the length of the fasting interval prior...

journal_title：Psychopharmacology

authors： Owen L,Scholey AB,Finnegan Y,Hu H,Sünram-Lea SI

更新日期：2012-04-01 00:00:00

abstract：RATIONALE:Serotonin (5-HT) and norepinephrine (NE) re-uptake inhibitors (SNRIs) have been proposed to have a higher efficacy and/or faster onset of action than previously available antidepressants. OBJECTIVES:We examined in biochemical, electrophysiological and behavioural assays the antidepressant properties of (S)-(...

journal_title：Psychopharmacology

authors： Artaiz I,Zazpe A,Innerárity A,Del Olmo E,Díaz A,Ruiz-Ortega JA,Castro E,Pena R,Labeaga L,Pazos A,Orjales A

更新日期：2005-11-01 00:00:00

abstract：:We are performing a double-blind trial with inward psychiatric patients. The indication for our psychotropic or psychotherapeutic intervention is mainly severe depression (= major depressive disorders DSM III). For a 3-week trial course trazodone (400 mg daily), amitriptyline (150 mg/die) or placebo capsules were give...

journal_title：Psychopharmacology

authors： Klieser E,Lehmann E

更新日期：1988-01-01 00:00:00

abstract：:Intact male and ovariectomized female rats were trained to lever press under a random ratio (RR) schedule of food reinforcement. Effects of different doses of pentobarbital (1-16 mg/kg) and progesterone (10-80 mg/kg) on response output were studied. Low doses of pentobarbital increased responding, high doses decreased...

journal_title：Psychopharmacology

authors： Heinsbroek RP,van Haaren F,Zantvoord F,van de Poll NE

更新日期：1987-01-01 00:00:00