Abstract:
:Cholecystokinin (CCK) and dopamine (DA) coexist in both cell body and terminal areas of a mesolimbic pathway that projects from the ventral tegmental area (VTA) to the nucleus accumbens (N ACC). Autoradiography reveals extensive CCK binding sites in the N ACC, but not in the VTA. However, iontophoresis of CCK into the VTA results in activation or deactivation of DA neuronal firing rates, and bursting activity (depending on the dose of CCK administered). CCK could have neuromodulatory effects on mesolimbic DA neurons. In two studies, behavioral effects of infusions of CCK into the VTA were examined in the conditioned place preference (CPP) paradigm. The CPP paradigm is a behavioral test used to assess reinforcement induced by drug administration. Drugs with reinforcing properties can condition preferences for novel environments. CCK infusions into VTA (0.0, 0.04, 0.4, and 4.0 ng/cannula) potentiated amphetamine CPPs in a dose-dependent linear manner. CCK infusions by themselves did not have significant effects in the CPP paradigm. Results indicate a neuromodulatory role for CCK on the neuronal mechanisms that mediate the reinforcing effects of amphetamine. Results also implicate sites of action for CCK in the VTA.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Pettit HO,Mueller Kdoi
10.1007/BF00445571subject
Has Abstractpub_date
1989-01-01 00:00:00pages
423-6issue
3eissn
0033-3158issn
1432-2072journal_volume
99pub_type
杂志文章abstract:RATIONALE:It has been suggested that the antipsychotic effect of antipsychotics is mediated by the antagonism of the dopamine D2 receptor in the limbic-cortical regions. Risperidone has an atypical property, but its effect on limbic-cortical regions has not been evaluated. OBJECTIVES:In this study, we examined the rel...
journal_title:Psychopharmacology
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2008-05-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:1995-06-01 00:00:00
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更新日期:2003-03-01 00:00:00
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更新日期:2003-09-01 00:00:00
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更新日期:2015-11-01 00:00:00
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更新日期:2005-07-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1980-01-01 00:00:00