Abstract：
:The residual effects of three hypnotics were investigated by the method of 24-h polygraphy (EEG, EMG, and EOG). The drugs were triazolam 0.25 mg and 0.5 mg, flurazepam 15 mg and 30 mg, nitrazepam 5 mg and 10 mg, and placebo. The subjects were healthy volunteers, eight men and eight women with an average age of 34.3 years. The number of total polygraphic records was 77. Triazolam 0.25 mg and 0.5 mg, flurazepam 30 mg, and nitrazepam 10 mg showed definited sleep inducing and sleep maintenance effects in night recordings. Flurazepam 15 mg and 30 mg and nitrazepam 5 mg and 10 mg were followed by residual effects in morning, afternoon and evening recording periods on the day after the administrations of the hypnotics. However, no effects were seen on the day after the administration of triazolam 0.25 mg and 0.5 mg except for some slight residual effects in the morning. Thus triazolam 0.25 mg and 0.5 mg produces less residual effect than do flurazepam 15 mg and 30 mg, and nitrazepam 5 mg and 10 mg, and 24-h polygraphy is useful for measuring the residual effects of hypnotics.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Ogura C,Nakazawa K,Majima K,Nakamura K,Ueda H,Umezawa Y,Wardell WMdoi
10.1007/BF00426651subject
Has Abstractpub_date
1980-01-01 00:00:00pages
61-5issue
1eissn
0033-3158issn
1432-2072journal_volume
68pub_type
临床试验,杂志文章,随机对照试验abstract：:This study examined and compared withdrawal signs and symptoms from cessation of 0, 2 and 4 mg nicotine gum. In addition, a comparison was made between nicotine gum versus cigarette withdrawal symptoms. Smokers first underwent cigarette deprivation for 4 days and then were randomly assigned to 0 (N = 16), 2 (N = 25), ...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02245656
更新日期：1991-01-01 00:00:00
abstract：OBJECTIVE:The aim of our study was to test whether ketamine produces an antidepressant effect in animal model of olfactory bulbectomy and assess the role of mammalian target of rapamycin (mTOR) pathway in ketamine's antidepressant effect. METHODS:Bulbectomized (OBX) rats and sham controls were assigned to four subgrou...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-016-4256-3
更新日期：2016-06-01 00:00:00
abstract：RATIONALE:Acute alcohol intoxication induces a selective impairment of recognition memory associated with conscious recollection whilst recognition based on familiarity is left intact. OBJECTIVES:We aimed to further elucidate the acute effects of alcohol on recognition memory by assessing three different doses of alco...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-009-1709-y
更新日期：2010-01-01 00:00:00
abstract：:The pharmacokinetic and pharmacodynamic effects of concomitant administration of alprazolam and fluoxetine were studied in this double-blind parallel study in 80 healthy, male volunteers. Subjects were randomly assigned to one of four treatment groups. Drug treatments consisted of 4-day regimens of 1 mg alprazolam fou...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02246031
更新日期：1991-01-01 00:00:00
abstract：RATIONALE:Temporal differentiation of operant behaviour is sensitive to dopaminergic manipulations. Studies using the fixed-interval peak procedure implicated D2 dopamine receptors in these effects. Less is known about the effects of dopaminergic manipulations on temporal differentiation in other timing schedules. OBJ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-006-0339-x
更新日期：2006-04-01 00:00:00
abstract：:Two studies were conducted to replicate and extend previous demonstrations of smoking-induced, dose-related reports of euphoria, and to confirm this relationship using measures of plasma nicotine. In experiment 1, overnight-deprived subjects, in three different sessions, smoked ultralow-, high-nicotine, and usual-bran...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/BF02247422
更新日期：1992-01-01 00:00:00
abstract：RATIONALE:Manipulations of the endocannabinoid system could potentially produce therapeutic effects with minimal risk of adverse cannabis-like side effects. Inhibitors of fatty acid amide hydrolase (FAAH) increase endogenous levels of the cannabinoid-receptor agonist, anandamide, and show promise for treating a wide ra...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-015-4140-6
更新日期：2016-05-01 00:00:00
abstract：:The name of Hayley Treloar Padovano was incorrectly tagged in the original version of this article. Instead of Padovano as family name and Hayley Treloar as given name, it should be Hayley as given name and Treloar Padovano as family name. Correct presentation of author name when online should be Treloar Padovano H. ...
journal_title：Psychopharmacology
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00213-018-4967-8
更新日期：2018-09-01 00:00:00
abstract：RATIONALE:Chronic administration of nicotine in rats results in upregulation of neuronal nicotinic receptors. Upregulation has been proposed to reflect receptor desensitization, which may underlie functional tolerance to nicotine's effects. However, evidence indicates that tolerance and upregulation do not always paral...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130000401
更新日期：2000-05-01 00:00:00
abstract：:The relationship between norepinephrine (NE) content in cortex and spinal cord and acoustic startle amplitude was investigated in two experiments. Administration of diethyldithiocarbamate (DDC) depressed startle amplitude at the same time and dose that it most severely depleted NE content. These results support the co...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00426383
更新日期：1984-01-01 00:00:00
abstract：:The present study employed an animal model of drug relapse in which previously extinguished heroin self-administration behavior was reinstated following a single reinforced trial. Male albino rats were trained to traverse a straight-alley for a reinforcer consisting of a single IV injection of 0.06 mg/kg diacetylmorph...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02246658
更新日期：1996-04-01 00:00:00
abstract：:Twelve healthy male volunteers took part in a double-blind randomised cross-over study composed of three treatment sessions: remoxipride 100 mg; remoxipride 100 mg plus biperiden 4 mg; and biperiden 4 mg. Plasma and urine concentrations of remoxipride and biperiden, plasma prolactin levels, salivary flow and adverse e...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02257403
更新日期：1993-01-01 00:00:00
abstract：RATIONALE:Approximately 20 million adults in the USA have an alcohol use disorder (AUD). There are clinical and preclinical data suggesting that psychedelics may have benefits for AUD. OBJECTIVE:To investigate the effects of the synthetic psychedelic 2,5-dimethoxy-4-iodoamphetamine (DOI) on the behavioral effects of e...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-019-05328-7
更新日期：2019-12-01 00:00:00
abstract：:Rats were treated once with doses of haloperidol or of droperidol below and above the acute ID50 vs the dopamine agonist apomorphine; they were later challenged with an acute dose of apomorphine (0.3 mg/kg, SC) and rated for stereotyped behavioral responses. The two neuroleptics were similar in acute anti-apomorphine ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00431801
更新日期：1985-01-01 00:00:00
abstract：:Rats were presented with noise bursts alone or noise bursts 60 ms after presentation of either a 60 dB or an 80 dB prepulse after injection of the dopamine agonists apomorphine (3 mg/kg) or d-amphetamine (4 mg/kg), the glycine antagonist strychnine (1.5 mg/kg) or the alpha 2 antagonist yohimbine (5 mg/kg). Presentatio...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00174500
更新日期：1988-01-01 00:00:00
abstract：RATIONALE:Kratom is proposed to exhibit therapeutic potential as an opium substitute, but little is known about its dependence-producing profile, particularly of its main psychoactive compound, mitragynine (MG). OBJECTIVES:This study examined the dependence-producing effects of MG using operant-scheduled behaviour in ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-019-05418-6
更新日期：2020-03-01 00:00:00
abstract：RATIONALE:The mechanism involved in AD is complex, which has prompted to develop compounds that could simultaneously interact with several potential targets. Here, we report a new synthesized compound SCR-1693 which is designed to target both AChE and calcium channels that are potential for AD therapy. OBJECTIVES:We i...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-015-4133-5
更新日期：2016-02-01 00:00:00
abstract：:The effects of the enantiomers of 3-PPP on the maintenance of conditioned avoidance responding (CAR) were studied. The weak classical dopamine (DA) agonist (+)-3-PPP failed to interfere with CAR at any dose tested (0.8-13.6 mg/kg). Low doses of the drug produced sedation, while high doses produced behavioural stimulat...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00439266
更新日期：1983-01-01 00:00:00
abstract：RATIONALE:Depressed patients robustly exhibit affective biases in emotional processing which are altered by SSRIs and predict clinical outcome. OBJECTIVES:The objective of this study is to investigate whether psilocybin, recently shown to rapidly improve mood in treatment-resistant depression (TRD), alters patients' e...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-017-4754-y
更新日期：2018-02-01 00:00:00
abstract：RATIONALE:A subset of male rats that self-administer 3,4-methylenedioxypyrovalerone (MDPV) have unusually high levels of drug intake; however, factor(s) that influence this behavior (e.g., reinforcement history and sex) are unknown. OBJECTIVES:Characterize the reinforcing potency and effectiveness of MDPV in female ra...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-020-05726-2
更新日期：2020-11-24 00:00:00
abstract：:This study tested placebo responses in psychomotor performance when caffeine or alcohol was expected. Fifty male university students were assigned to one of four placebo groups or to a no-treatment control group. Two groups received placebo caffeine and two received placebo alcohol. Subjects performed 12 trials on a p...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02245081
更新日期：1994-07-01 00:00:00
abstract：RATIONALE:Robust intravenous (i.v.) nicotine self-administration (SA) in rats has been reported by several laboratories, including our own, using fixed ratio (FR) schedules of reinforcement. Studies on other drugs of abuse, however, suggest that progressive ratio (PR) schedules may provide additional information not ga...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130051153
更新日期：1999-11-01 00:00:00
abstract：RATIONALE:Understanding of the mechanisms of biotransformation of antidepressant drugs, and of their capacity to interact with other medications, is of direct relevance to rational clinical psychopharmacology. OBJECTIVES:To determine the human cytochromes P450 mediating the metabolism of nefazodone, and the inhibitory...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130051039
更新日期：1999-07-01 00:00:00
abstract：RATIONALE:Depressive disorders are conditions that often require continuous treatment, and it is therefore important to evaluate the consequences of prolonged administration. There are few studies assessing cognitive functions of depressed patients after long-term use of antidepressants. OBJECTIVES:This study evaluate...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-005-0274-2
更新日期：2006-03-01 00:00:00
abstract：RATIONALE:Varenicline is believed to work, in part, by reducing craving responses to smoking cues and by reducing general levels of craving; however, these hypotheses have never been evaluated with craving assessed in the natural environments of treatment-seeking smokers. OBJECTIVES:Ecological momentary assessment pro...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-012-2698-9
更新日期：2012-09-01 00:00:00
abstract：:The effects of phencyclidine (PCP) on locomotor activity were compared to those of the stereoisomers of N-allylnormetazocine (NAN) after acute administration to rats. PCP produced swaying and falling movements, increased sniffing behavior, and enhanced horizontal locomotor activity. d-NAN also induced swaying, falling...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00310633
更新日期：1986-01-01 00:00:00
abstract：RATIONALE:Genetically determined differences in susceptibility to drug-induced sensitization could be related to risk for drug consumption. OBJECTIVES:Studies were performed to determine whether selective breeding could be used to create lines of mice with different magnitudes of locomotor sensitization to methampheta...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-010-2086-2
更新日期：2011-04-01 00:00:00
abstract：:The effect of long-term treatment with clozapine in schizophrenia and schizoaffective disorder was evaluated in a retrospective study comprising 96 patients treated with the drug during the period 1974-1986 at the Psychiatric Research Center in Uppsala. All patients had previously been treated with different kinds of ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00442567
更新日期：1989-01-01 00:00:00
abstract：RATIONALE:Decision-making is a complex cognitive process that is mediated, in part, by subregions of the medial prefrontal cortex (PFC). Decision-making is impaired in a number of psychiatric conditions including schizophrenia. Notably, people with schizophrenia exhibit reductions in GABA function in the same PFC areas...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-014-3816-7
更新日期：2015-05-01 00:00:00
abstract：RATIONALE:Direct activation of the cannabinoid CB1 receptor in the dorsolateral periaqueductal gray (dlPAG) inhibits anxiety- and panic-related behaviours in experimental animals. It has remained unclear, however, whether the local endocannabinoid signalling is recruited as a protective mechanism against aversive stimu...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-014-3793-x
更新日期：2015-05-01 00:00:00
