Discriminative stimulus effects of the 5HT1A agonist 8-OH-DPAT: attenuation by mu but not by kappa opioids.

abstract：RATIONALE:Antidepressants are known to modify human sleep patterns. OBJECTIVES:Duloxetine is a new antidepressant with a mechanism of action involving reuptake inhibition of both serotonin (5-HT) and norepinephrine (NE). In this study, the effects of two dosing regimens of duloxetine on sleep electroencephalography (E...

journal_title：Psychopharmacology

authors： Chalon S,Pereira A,Lainey E,Vandenhende F,Watkin JG,Staner L,Granier LA

更新日期：2005-02-01 00:00:00

abstract：:The subjective, psychomotor, and physiological effects of analgesic doses of oral codeine and morphine were examined in 12 healthy volunteers. Subjects ingested placebo, morphine 20 or 40 mg, or codeine 60 or 120 mg in a randomized, double-blind, crossover design. The smaller and larger doses of each drug were putativ...

journal_title：Psychopharmacology

authors： Walker DJ,Zacny JP

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:A history of brief intermittent social defeat stress can escalate cocaine self-administration and induce long-term adaptations in the mesolimbic dopamine system. Extra-hypothalamic corticotrophin releasing factor (CRF) has been shown to be closely associated with stress-induced escalation of drug use. How re...

journal_title：Psychopharmacology

authors： Han X,DeBold JF,Miczek KA

更新日期：2017-09-01 00:00:00

abstract：RATIONALE:The high prevalence of smoking and low cessation rates among individuals with schizophrenia and similar conditions are not well understood. Behavioral economics has been extensively applied to studying addictive behavior and may contribute to understanding smoking in this subpopulation. OBJECTIVES:This study...

journal_title：Psychopharmacology

authors： MacKillop J,Tidey JW

更新日期：2011-07-01 00:00:00

abstract：RATIONALE:Drug-associated environmental stimuli may serve as conditioned reinforcers to enhance drug self-administration behaviors in humans and laboratory animals. However, it can be difficult to distinguish experimentally the conditioned reinforcing effects of a stimulus from other behavioral processes that can chang...

journal_title：Psychopharmacology

authors： Bertz JW,Woods JH

更新日期：2013-09-01 00:00:00

abstract：RATIONALE:A substantial portion of cigarette smokers prefer menthol-flavored cigarettes. To date, however, no studies have examined whether menthol in cigarettes has central pharmacological effects. OBJECTIVE:We investigated psychophysiological and subjective effects of smoking menthol versus non-menthol cigarettes in...

journal_title：Psychopharmacology

authors： Pritchard WS,Houlihan ME,Guy TD,Robinson JH

更新日期：1999-04-01 00:00:00

abstract：RATIONALE:Perospirone is a novel second-generation antipsychotic drug with high affinity to dopamine D(2) receptor and short half-life of plasma concentration. There has been no investigation of dopamine D(2) receptor occupancy in patients with schizophrenia and the time course of occupancy by antipsychotics with peros...

journal_title：Psychopharmacology

authors： Arakawa R,Ito H,Takano A,Okumura M,Takahashi H,Takano H,Okubo Y,Suhara T

更新日期：2010-05-01 00:00:00

abstract：RATIONALE:Stress, a powerful precipitant of drug seeking during abstinence, may also accelerate the return to pathological patterns of intake after initial instances of drug reuse. OBJECTIVE:To explore the effect of stress on a learning process underlying relapse, this study assessed the effect of yohimbine on reacqui...

journal_title：Psychopharmacology

authors： Campbell AT,Kwiatkowski D,Boughner E,Leri F

更新日期：2012-07-01 00:00:00

abstract：RATIONALE:Vasopressin (AVP) plays a role in regulating anxiety, which is thought to be partially mediated through the V1a receptor. Recently, JNJ-17308616 was identified as a V1a antagonist. OBJECTIVES:The purpose of this work was to assess V1a receptor affinity and selectivity of JNJ-17308616 and in vivo efficacy in ...

journal_title：Psychopharmacology

authors： Bleickardt CJ,Mullins DE,Macsweeney CP,Werner BJ,Pond AJ,Guzzi MF,Martin FD,Varty GB,Hodgson RA

更新日期：2009-03-01 00:00:00

abstract：:In the rat, the antimuscarinics atropine and scopolamine failed to block the reduction in pentobarbital-induced sleep time produced by either thyrotropin-releasing hormone (TRH) or MK-771 (a TRH analog). Previous reports have indicated that the marked analeptic effect produced by TRH is antagonized by such agents. It ...

journal_title：Psychopharmacology

authors： Santori EM,Schmidt DE,Kalivas PW,Horita A

更新日期：1981-01-01 00:00:00

abstract：RATIONALE:Rats, like humans, are susceptible to the reinforcing effects of reward-related stimuli presented within a compound stimulus array, putatively analogous to the so-called near-miss effect. We have previously demonstrated using a rodent slot machine task (rSMT) that the reward expectancy these stimuli elicit is...

journal_title：Psychopharmacology

authors： Cocker PJ,Lin MY,Barrus MM,Le Foll B,Winstanley CA

更新日期：2016-09-01 00:00:00

abstract：RATIONALE:Preclinical experimental models of pathological aggressive behavior are a sorely understudied and difficult research area. OBJECTIVES:How valid, reliable, productive, and informative are the most frequently used animal models of excessive aggressive behavior? METHODS:The rationale, key methodological featur...

journal_title：Psychopharmacology

authors： Miczek KA,de Boer SF,Haller J

更新日期：2013-04-01 00:00:00

abstract：:A novel form of experimentally-induced conflict behavior based on the conditioned suppression of drinking (CSD) is described and compared with two conventional animal models of human anxiety--a modified Geller-Seifter and an Estes-Skinner (Conditioned Emotional Response) procedure. The CSD procedure offered significan...

journal_title：Psychopharmacology

authors： Kilts CD,Commissaris RL,Rech RH

更新日期：1981-01-01 00:00:00

abstract：:Established social groups of talapoin monkeys show rank-related differences in aggressive, social and sexual behaviours and visual monitoring, as well as in endocrine and monoamine profiles. Here we describe the effects on these variables of an "anxiogenic drug", beta-carboline carboxylic acid ethyl ester (beta-CCE), ...

journal_title：Psychopharmacology

authors： Vellucci SV,Herbert J,Keverne EB

更新日期：1986-01-01 00:00:00

abstract：RATIONAL:Prefrontal cortex (PFC) and dorsal striatum are part of the neural circuit critical for executive attention. The relationship between 5-HT and aspects of attention and executive control is complex depending on experimental conditions and the level of activation of different 5-HT receptors within the nuclei of ...

journal_title：Psychopharmacology

authors： Agnoli L,Carli M

更新日期：2012-01-01 00:00:00

abstract：:A new benzamide, cis-N-(1-benzyl-2-methylpyrrolidin - 3 - yl) - 5 - chloro - 2 - methoxy - 4 - methylaminobenzamide (YM-09151-2) exhibited more potent and longer-lasting inhibitory effects on apomorphine-induced behaviours (stereotyped behaviour, emesis and hypothermia), and methamphetamine-induced stereotyped behavio...

journal_title：Psychopharmacology

authors： Usuda S,Nishikori K,Noshiro O,Maeno H

更新日期：1981-01-01 00:00:00

abstract：RATIONALE:The development and validation of animal models of the cognitive impairments of schizophrenia have remained challenging subjects. OBJECTIVE:We review evidence from a series of experiments concerning an animal model that dissociates between the disruption of attentional capacities during acute illness periods...

journal_title：Psychopharmacology

authors： Sarter M,Martinez V,Kozak R

更新日期：2009-01-01 00:00:00

abstract：:The effect of aluminum on levels of inorganic phosphorus and acetylcholinesterase in blood and brain and on permeability of the blood-brain barrier (BBB) in different regions of the brain to the neuropeptide delta-sleep-inducing peptide (DSIP) was studied in adult rats. Aluminum (100 mg/kg) significantly increased the...

journal_title：Psychopharmacology

authors： Banks WA,Kastin AJ

更新日期：1985-01-01 00:00:00

abstract：:These experiments examined the neurochemical mechanisms involved in the development and expression of place conditioning produced by heroin. Conditioned place preferences (CPP) lasting up to 8 weeks were obtained with doses of 50-1000 micrograms/kg heroin, using a regimen shown not to produce physical dependence. Nalo...

journal_title：Psychopharmacology

authors： Hand TH,Stinus L,Le Moal M

更新日期：1989-01-01 00:00:00

abstract：:In experiment 1, rats (n = 12) were trained to discriminate the benzodiazepine (BDZ) compound chlordiazepoxide (CDP, 20 mg/kg, IP) from saline in a two-lever food-reinforced procedure, and subsequently were tested for stimulus control with different doses of CDP, Ro 15-1788 (a proposed BDZ receptor antagonist) and Ro ...

journal_title：Psychopharmacology

authors： De Vry J,Slangen JL

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:A growing number of studies suggest that gamma-aminobutyric acid type-B (GABA(B)) receptor agonists reduce alcohol use and craving. OBJECTIVES:This study was designed to further clarify behavioral mechanism(s) by which GABA(B) agonists may decrease alcohol reinforcement. METHODS:Male C57BL/6 J mice were tra...

journal_title：Psychopharmacology

authors： Besheer J,Lepoutre V,Hodge CW

更新日期：2004-07-01 00:00:00

abstract：:Abnormal beta-adrenergic receptor (betaAR) density in the brains of suicide victims has been reported, although results of studies are inconsistent. Ethanol modifies betaAR-mediated signal transduction. Moreover abnormal betaAR function has been implicated in alcoholism. BetaAR antagonists, which were used as ligands ...

journal_title：Psychopharmacology

authors： Gurguis GN,Turkka J,Laruelle M,Kleinman J,Linnoila M

更新日期：1999-07-01 00:00:00

abstract：RATIONALE:The cAMP-dependent protein kinase A (PKA) signaling transduction pathway has been shown to play an important role in the modulation of several ethanol-induced behaviors. Different studies have demonstrated intracellular calcium (Ca(2+))-dependent activation of the PKA cascade after ethanol administration. Thu...

journal_title：Psychopharmacology

authors： Baliño P,Ledesma JC,Aragon CM

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVE:The aim of our study was to test whether ketamine produces an antidepressant effect in animal model of olfactory bulbectomy and assess the role of mammalian target of rapamycin (mTOR) pathway in ketamine's antidepressant effect. METHODS:Bulbectomized (OBX) rats and sham controls were assigned to four subgrou...

journal_title：Psychopharmacology

authors： Holubova K,Kleteckova L,Skurlova M,Ricny J,Stuchlik A,Vales K

更新日期：2016-06-01 00:00:00

abstract：RATIONALE:Modafinil is a well-tolerated psychostimulant drug with low addictive potential that is used to treat patients with narcolepsy or attention deficit disorders and to enhance vigilance in sleep-deprived military personal. So far, understanding of the cognitive enhancing effects of modafinil and the relevant neu...

journal_title：Psychopharmacology

authors： Müller U,Steffenhagen N,Regenthal R,Bublak P

更新日期：2004-12-01 00:00:00

abstract：RATIONALE:Although the effects of D: -cycloserine (DCS) and valproic acid (VPA) on the facilitation of the extinction of fear-conditioned memory have been elucidated in animals, these effects have not been clearly confirmed in humans. OBJECTIVE:This study aimed to determine the effect of DCS (100 mg) and VPA (400 mg) ...

journal_title：Psychopharmacology

authors： Kuriyama K,Honma M,Soshi T,Fujii T,Kim Y

更新日期：2011-12-01 00:00:00

abstract：:The time course of light adaptation after intense light exposure is significantly delayed by alcohol, marijuana, and a combined dose of alcohol and marijuana. These effects were found in a double blind experiment, using 10 subjects. The experimental treatments were placebo, 0.75 ml/kg of 95% ethanol, 8 and 15 mg of de...

journal_title：Psychopharmacology

authors： Adams AJ,Brown B,Haegerstrom-Portnoy G,Flom MC,Jones RT

更新日期：1978-01-31 00:00:00

abstract：RATIONALE:Pre-clinical and clinical studies have suggested that the antidepressant efficacy of escitalopram (ESC) can be augmented by co-administration of aripiprazole (ARI). OBJECTIVE:To establish if the effects of ESC + ARI can be altered by modulating the 5-HT1a receptor. METHODS:Sprague-Dawley male rats received ...

journal_title：Psychopharmacology

authors： Lapointe T,Hudson R,Daniels S,Melanson B,Zhou Y,Leri F

更新日期：2019-07-01 00:00:00

abstract：:The effects of chronic desmethylimipramine (DMI) treatment on measures of incentive motivation for cocaine were assessed in order to investigate the predictive validity of the extinction/reinstatement model of drug craving. Rats were trained to respond for cocaine infusions (0.75 mg/kg per 0.1 ml i.v.) or received yok...

journal_title：Psychopharmacology

authors： Fuchs RA,Tran-Nguyen LT,Specio SE,Groff RS,Neisewander JL

更新日期：1998-01-01 00:00:00

abstract：:The performance of healthy volunteer subjects on an auditory latent inhibition (LI) paradigm was assessed following administration of a single oral dose of d-amphetamine or placebo. It was predicted that a low (5 mg), but not a high (10 mg), dose of d-amphetamine would disrupt LI. The prediction was supported with lef...

journal_title：Psychopharmacology

authors： Gray NS,Pickering AD,Hemsley DR,Dawling S,Gray JA

更新日期：1992-01-01 00:00:00