Little evidence that "denicotinized" menthol cigarettes have pharmacological effects: an EEG/heart-rate/sujective-response study.

abstract：:Amphetamine (AMP) administered in high doses suppresses feeding. However, in low doses AMP has been shown to both suppress and facilitate feeding. Further, there is some indication of individual differences in the feeding response to low doses of AMP. Evidence indicates that AMP's effects on feeding are dopamine-media...

journal_title：Psychopharmacology

authors： Sills TL,Vaccarino FJ

更新日期：1991-01-01 00:00:00

abstract：:CSF GABA levels were not significantly different in a group of drug-free psychotic patients compared to a group of psychotic patients at two points during haloperidol treatment or a neurological comparison group. In the untreated group, CSF GABA was significantly negatively correlated with clinical ratings of anxiety ...

journal_title：Psychopharmacology

authors： Bowers MB Jr,Gold BI,Roth RH

更新日期：1980-01-01 00:00:00

abstract：:The anti-withdrawal effect of clonidine was studied using quasi-morphine abstinence behaviour induced by dipropylacetate (DPA) in naive rats. Clonidine potently suppressed body shakes and locomotor activity (ID50 30 and 40 micrograms/kg IP respectively). Phenoxybenzamine and prazosine did not antagonize the anti-withd...

journal_title：Psychopharmacology

authors： van der Laan JW,Weick G,Hillen FC

更新日期：1983-01-01 00:00:00

abstract：RATIONALE:Atypical antipsychotic drugs are classically associated with lower propensity to extrapyramidal symptoms (EPS) and hyperprolactinemia than typical antipsychotic drugs. It has not been clarified why some atypical antipsychotic drugs, such as amisulpride, induce prolactin plasma concentration (PRL) elevation, b...

journal_title：Psychopharmacology

authors： Bressan RA,Erlandsson K,Spencer EP,Ell PJ,Pilowsky LS

更新日期：2004-09-01 00:00:00

abstract：RATIONALE:Mice are useful tools for dissecting genetic and environmental factors in relation to the study of attention and impulsivity. The five-choice serial reaction time task (5CSRTT) paradigm has been well established in rats, but its transferability to mice is less well documented. OBJECTIVES:This study aims to s...

journal_title：Psychopharmacology

authors： Sanchez-Roige S,Peña-Oliver Y,Stephens DN

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVES:The present study investigates the effects of injections of a specific N-methyl-D-aspartic acid (NMDA) antagonist 3-[(R)-2-carboxypiperazin-4-yl]-propyl-1-phophonic acid (CPP) into the prefrontal cortex (PFC) on the extracellular concentrations of dopamine and acetylcholine in the nucleus accumbens (NAc) and...

journal_title：Psychopharmacology

authors： Del Arco A,Segovia G,Mora F

更新日期：2008-12-01 00:00:00

abstract：:There is a latency period of several weeks before the onset of clinical effect of antidepressant drugs. The detailed mechanisms underlying drug-induced adaptive neuronal changes are not known. To elucidate the involvement of changes in gene expression of candidate transcription factors, we treated rats for 21 days wit...

journal_title：Psychopharmacology

authors： Bjartmar L,Johansson IM,Marcusson J,Ross SB,Seckl JR,Olsson T

更新日期：2000-07-01 00:00:00

abstract：:Intravenous self-administration of d-amphetamine (0.25 mg/kg/injection) decreased in a dose-related fashion after injections of the dopaminergic agonists apomorphine and piribedil. The dopaminergic agonists appear to suppress amphetamine intake in the same way as do 'free' amphetamine injections, by extending drug sat...

journal_title：Psychopharmacology

authors： Yokel RA,Wise RA

更新日期：1978-07-19 00:00:00

abstract：RATIONALE:Brain reward pathways implicated in addiction appear to be less reactive in regular drug users; behavioural manifestations may include decreased sensitivity to natural reinforcers. OBJECTIVES:This study aimed to replicate earlier findings of abstinence-associated incentive motivation deficits in smokers and ...

journal_title：Psychopharmacology

authors： Dawkins L,Powell JH,West R,Powell J,Pickering A

更新日期：2006-12-01 00:00:00

abstract：:It has been proposed that serotonin (5-HT) antagonists counteract neuroleptic-induced extrapyramidal symptoms by disinhibition of dopamine activity. The effects of the 5-HT antagonist mianserin, the anticholinergic drug procyclidine and placebo were evaluated in 16 psychiatric patients with chronic neuroleptic-induced...

journal_title：Psychopharmacology

authors： Korsgaard S,Friis T

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:Contemporary animal models of cocaine addiction focus on increasing the amount of drug consumption to produce addiction-like behavior. However, another critical factor is the temporal pattern of consumption, which in humans is characterized by intermittency, both within and between bouts of use. OBJECTIVE:To...

journal_title：Psychopharmacology

authors： Kawa AB,Bentzley BS,Robinson TE

更新日期：2016-10-01 00:00:00

abstract：:This study demonstrates that the selective delta receptor antagonists ICI 174864 and naltrindole (NTI) attenuate alcohol intake in a dose-dependent manner, without altering water intake, in rats selectively bred for alcohol preference. ICI 174864 had a very limited duration of action, as evidenced by the fact that sup...

journal_title：Psychopharmacology

authors： Krishnan-Sarin S,Jing SL,Kurtz DL,Zweifel M,Portoghese PS,Li TK,Froehlich JC

更新日期：1995-07-01 00:00:00

abstract：RATIONALE:A number of studies have indicated a relationship between the intake of palatable foods or fluids and drug self-administration. OBJECTIVES:Two experiments were conducted to determine whether the intake of sucrose or fat was related to subsequent cocaine self-administration. METHODS:In separate groups of rat...

journal_title：Psychopharmacology

authors： Gosnell BA

更新日期：2000-04-01 00:00:00

abstract：:On the heels of clozapine, we now have a number of newer agents (risperidone, olanzapine, quetiapine, sertindole, and ziprasidone). Are they all the same? What are the differences? How do we best understand them? In this article we review current clinical evidence to compare these issues on four measures of atypicalit...

journal_title：Psychopharmacology

authors： Remington G,Kapur S

更新日期：2000-01-01 00:00:00

abstract：:Ro 15-4513, a partial inverse agonist at the benzodiazepine (BZ) receptor site was labelled with 11C and used for in vitro autoradiography on human post mortem brain sections and for positron emission tomography (PET) on Cynomolgus monkeys. The total radiochemical yield of [11C]Ro 15-4513 was 30-40% with an overall sy...

journal_title：Psychopharmacology

authors： Halldin C,Farde L,Litton JE,Hall H,Sedvall G

更新日期：1992-01-01 00:00:00

abstract：:The serotonergic agent meta-chlorophenylpiperazine (m-CPP) increases temperature and plasma ACTH and other hormones and decreases social interaction, locomotor activity and food intake in rats, most likely via stimulation of 5-HT2C receptors. Repeated daily administration of m-CPP to rats induces rapid tolerance to th...

journal_title：Psychopharmacology

authors： Benjamin J,Greenberg BD,Murphy DL

更新日期：1996-09-01 00:00:00

abstract：:Different groups of rats received combined or separate administration of different doses of piracetam (P1:100, P2:200, and P4:400 mg/kg) and choline (C1:100 and C2:200 mg/kg). Compared to control treatment, C1 significantly improved performance in a delayed alternation (DA) task, while P1, P2, P4 or P1C1 had no effect...

journal_title：Psychopharmacology

authors： Ennaceur A,Delacour J

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Traumatic events are associated with alcohol use problems with increased alcohol craving as a potential mediator. There is still a lack of knowledge regarding the causal nature of this association and its underlying mechanisms. This study investigated the effects of acute trauma exposure on alcohol craving i...

journal_title：Psychopharmacology

authors： Trautmann S,Kräplin A,Dieterich R,Richter J,Muehlhan M

更新日期：2018-10-01 00:00:00

abstract：:There have been a number of claims that high-dose administration of cocaine to rats leads to neurotoxic effects on dopamine neurons. In this study possible neurotoxic effects on monoamine neurons were examined by measuring the effects of cocaine (35 mg/kg daily for 10 days) on the binding of radioligands to uptake sit...

journal_title：Psychopharmacology

authors： Benmansour S,Tejani-Butt SM,Hauptmann M,Brunswick DJ

更新日期：1992-01-01 00:00:00

abstract：:Cigarette smokers have a wide variety of "tar" and nicotine yields to choose from in the current market, ranging from 0.5 mg "tar" and less than 0.05 mg nicotine to 27 mg "tar" and 1.8 mg nicotine by the Federal Trade Commission (FTC) method. To understand better the relationship between FTC nicotine yields and actual...

journal_title：Psychopharmacology

authors： Byrd GD,Robinson JH,Caldwell WS,deBethizy JD

更新日期：1995-11-01 00:00:00

abstract：:The behavioral consequences of prolonged continuous exposure to cocaine were examined in rhesus monkeys. Operant behavior was sampled for 0.5 h every 6 h, and cocaine was continuously infused through an intravenous catheter. Cocaine (4.0-32 mg/kg/day) initially caused reductions in the rate of responding for food and ...

journal_title：Psychopharmacology

authors： Woolverton WL,Kleven MS

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:Recent data suggest that 5-HT7 receptors (5-HT7R) are involved in memory processes and, particularly, those related to novelty-induced arousal, even though this remains so far speculative and controversial. In order to assess the role of 5-HT7R in episodic-like memory, mice were administered 5-carboxamidotryp...

journal_title：Psychopharmacology

authors： Freret T,Paizanis E,Beaudet G,Gusmao-Montaigne A,Nee G,Dauphin F,Bouet V,Boulouard M

更新日期：2014-01-01 00:00:00

abstract：RATIONALE:Methamphetamine (METH) is a powerfully addictive stimulant associated with serious health conditions. Accumulating evidence suggests a role of oxidative stress in METH-induced behavioral abnormalities. Sulforaphane (SFN), found in cruciferous vegetables, is a potent antioxidant. It is of interest to determine...

journal_title：Psychopharmacology

authors： Chen H,Wu J,Zhang J,Fujita Y,Ishima T,Iyo M,Hashimoto K

更新日期：2012-07-01 00:00:00

abstract：RATIONALE:Evidences indicate that methylglyoxal, a highly reactive metabolite of hyperglycemia, can enhance protein glycation, oxidative stress, or inflammation. Mangiferin, a polyphenol compound of C-glucoside, has many beneficial biological activities, including anti-inflammation, anti-oxidation, neuroprotection, cog...

journal_title：Psychopharmacology

authors： Liu YW,Zhu X,Yang QQ,Lu Q,Wang JY,Li HP,Wei YQ,Yin JL,Yin XX

更新日期：2013-08-01 00:00:00

abstract：RATIONALE:We recently demonstrated that blocking specific nicotinic acetylcholine receptors (nAChRs) abolishes the conditioned reinforcing properties of ethanol-associated cues in rat, suggesting nAChRs as promising pharmacological targets for prevention of cue-induced relapse. OBJECTIVES:The present study investigate...

journal_title：Psychopharmacology

authors： Löf E,Olausson P,Stomberg R,Taylor JR,Söderpalm B

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND AND RATIONALE:More than two decades ago, Wise proposed his "anhedonia hypothesis" to explain the role of dopamine in motivated behaviors. The hypothesis posits that dopamine mediates the pleasure experienced by reward obtainment. However, some experimental findings have contested this hypothesis and several ...

journal_title：Psychopharmacology

authors： Barbano MF,Cador M

更新日期：2007-04-01 00:00:00

abstract：:The 2-[14C]deoxyglucose method was used to compare the effects of the acute administration of cocaine by two different routes, intravenous and intraperitoneal, on rates of local cerebral glucose utilization in freely moving rats. Doses were initially chosen on the basis of their ability to elicit equivalent increases ...

journal_title：Psychopharmacology

authors： Porrino LJ

更新日期：1993-01-01 00:00:00

abstract：RATIONALE:Dronabinol (Δ(9)tetrahydrocannabinol) is approved for HIV-related anorexia, yet, little is known about its effects in HIV-positive marijuana smokers. HIV-negative marijuana smokers require higher than recommended dronabinol doses to experience expected effects. OBJECTIVES:Employing a within-subjects, double-...

journal_title：Psychopharmacology

authors： Bedi G,Foltin RW,Gunderson EW,Rabkin J,Hart CL,Comer SD,Vosburg SK,Haney M

更新日期：2010-12-01 00:00:00

abstract：RATIONALE:The involvement of glutamate in fear extinction is perhaps the most promising in terms of facilitating clinical interventions for posttraumatic stress disorder (PTSD). This study was aimed at elucidating the possible role of zif268 on the D-cycloserine (DCS) facilitation effect on extinction. OBJECTIVE:We in...

journal_title：Psychopharmacology

authors： Wu IT,Tang TH,Ko MC,Chiu CY,Lu KT

更新日期：2015-10-01 00:00:00

abstract：RATIONALE:The synthetic progestin medroxyprogesterone acetate (MPA), widely used in hormone therapy (HT) and as the contraceptive Depo Provera, is implicated in detrimental cognitive effects in women. Recent evidence in aged ovariectomized (Ovx) rodents shows that short-term MPA treatment impairs cognition and alters t...

journal_title：Psychopharmacology

authors： Braden BB,Garcia AN,Mennenga SE,Prokai L,Villa SR,Acosta JI,Lefort N,Simard AR,Bimonte-Nelson HA

更新日期：2011-11-01 00:00:00