Abstract:
:The serotonergic agent meta-chlorophenylpiperazine (m-CPP) increases temperature and plasma ACTH and other hormones and decreases social interaction, locomotor activity and food intake in rats, most likely via stimulation of 5-HT2C receptors. Repeated daily administration of m-CPP to rats induces rapid tolerance to these effects of m-CPP. As m-CPP has been used in challenge tests and in preliminary treatment trials in humans, we evaluated the possible development of tolerance to m-CPP in ten healthy human volunteers using a double-blind, random assignment crossover study of placebo versus daily m-CPP infusions. Psychological and physical symptoms of anxiety, temperature, pupil size, diastolic blood pressure, and plasma ACTH, cortisol, and prolactin concentrations were increased by the first administration of m-CPP (0.08 mg/kg) compared to placebo. All of these responses were attenuated on m-CPP days 2 and 3. Plasma m-CPP levels did not differ across the 3 m-CPP days. Repeated m-CPP administration thus appears to induce rapid tolerance to its behavioral and physiological effects in humans. Further investigations of the mechanisms involved in the development of subsensitivity to m-CPP may contribute to increased understanding of the regulation of serotonin-mediated functions and of anxiety disorders.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Benjamin J,Greenberg BD,Murphy DLdoi
10.1007/BF02805987subject
Has Abstractpub_date
1996-09-01 00:00:00pages
140-9issue
2eissn
0033-3158issn
1432-2072journal_volume
127pub_type
临床试验,杂志文章,随机对照试验abstract::The effects of ibogaine (40 and 80 mg/kg, i.p.), an indole alkaloid proposed for the treatment of drug abuse, were determined in three different groups of rats responding under an FR10 schedule of food, cocaine or heroin reinforcement. Ibogaine (80 mg/kg, i.p.) given 60 min before the start of the session resulted in ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246099
更新日期:1995-02-01 00:00:00
abstract::The effects of morphine, ketocyclazocine, cyclazocine, and SKF-10,047 were tested alone and in conjunction with naltrexone or naloxone, in rats responding under a multiple fixed-interval 3-min schedule of food presentation. Under this paradigm, electric shock was delivered on a fixed-ratio schedule for responses occur...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00435274
更新日期:1982-01-01 00:00:00
abstract:RATIONALE:Direct activation of the cannabinoid CB1 receptor in the dorsolateral periaqueductal gray (dlPAG) inhibits anxiety- and panic-related behaviours in experimental animals. It has remained unclear, however, whether the local endocannabinoid signalling is recruited as a protective mechanism against aversive stimu...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3793-x
更新日期:2015-05-01 00:00:00
abstract::When injected IP, the M1 muscarinic receptor antagonist pirenzepine dose-dependently induced a deficit in passive avoidance learning in rats. This activity was optimal at 75 mg/kg injected 1 h before the acquisition session. The deficit induced by pirenzepine was antagonized by oxotremorine (0.03-0.3 mg/kg SC) and phy...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00444707
更新日期:1989-01-01 00:00:00
abstract::The effects of naloxone on diazepam-induced release of behavior in aversive situations were investigated in rats. Naloxone (0.5 and 1 mg/kg-1) suppressed diazepam-induced eating in an unfamiliar situation and reduced (1 mg/kg-1) spontaneous food intake. Naloxone (1 mg/kg-1) canceled the increased lever pressing produc...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426529
更新日期:1980-01-01 00:00:00
abstract:RATIONALE:Buprenorphine is an opioid agonist-antagonist under development in the United States as a sublingual medication for treatment of opioid dependence. Buprenorphine may be abused; therefore, tablets combining buprenorphine with naloxone have been developed with the intent of reducing the abuse risk in people phy...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s002130050066
更新日期:2000-03-01 00:00:00
abstract:RATIONALE:Investigations of the neural consequences of the effects of cocaine on cognition have centered on specific brain circuits including prefrontal cortex, medial temporal lobe and striatum and their roles in controlling drug dependent behavior and addiction. These regions are critical to many aspects of drug abus...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-2017-2
更新日期:2011-01-01 00:00:00
abstract:RATIONALE:Rivastigmine patches are used for patients with Alzheimer's disease (AD), but little is known about the serum concentration of rivastigmine and its metabolite or clinical adherence in relation to skinfold thickness after rivastigmine patch application. OBJECTIVES:The aim of this study was to examine the asso...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-5135-x
更新日期:2019-04-01 00:00:00
abstract:RATIONALE:Lithium is the most widely prescribed mood stabilizer, but the precise mechanism of lithium is unresolved. OBJECTIVE:We examine the effects of the administration of therapeutically relevant concentrations of lithium on the expression of brain-derived neurotrophic factor (BDNF) and its receptor, Trk B, as wel...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100871
更新日期:2001-10-01 00:00:00
abstract:RATIONALE:Perphenazine, a classical antipsychotic drug, has the potential to induce extrapyramidal side effects (EPS). Dopaminergic and serotonergic pathways are involved in the therapeutic and adverse effects of the drug. OBJECTIVES:To evaluate the impact of polymorphisms in the dopamine D(2) and D(3) and serotonin 2...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-006-0622-x
更新日期:2007-03-01 00:00:00
abstract:RATIONALE:Despite the critical role attributed to phosphorylated extracellular signal regulated kinase (pERK1/2) in the nucleus accumbens (Acb) in the actions of addictive drugs, the effects of morphine on ERK1/2 phosphorylation in this area are still controversial. OBJECTIVES:In order to investigate further this issu...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-016-4340-8
更新日期:2016-08-01 00:00:00
abstract:RATIONALE:Beneficial effects of nicotine on cognitive processes including attention have potential therapeutic uses and have been proposed as incentives for tobacco smoking. OBJECTIVES:To establish task conditions under which the effects of nicotine on attention are obtained reliably and to characterise such effects f...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1005-6
更新日期:2002-07-01 00:00:00
abstract::There were marked strain differences in the duration of the protective effects of diazepam against the convulsant actions of penylenetetrazole and picrotoxin in mice. In no case was significant protection found at 12 h or longer, regardless of whether the incidence of or the latencies to myoclonus or tonic-clonic conv...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431698
更新日期:1985-01-01 00:00:00
abstract:RATIONALE:Methamphetamine (METH) is a powerfully addictive stimulant associated with serious health conditions. Accumulating evidence suggests a role of oxidative stress in METH-induced behavioral abnormalities. Sulforaphane (SFN), found in cruciferous vegetables, is a potent antioxidant. It is of interest to determine...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2619-3
更新日期:2012-07-01 00:00:00
abstract::The inferior colliculus is involved in conveying auditory information of an aversive nature to higher cortical structures. Gradual increases in the electrical stimulation of this structure produce progressive aversive responses from vigilance, through freezing, until escape. Recently, we have shown that microinjection...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050900
更新日期:1999-03-01 00:00:00
abstract:RATIONALE:Despite the high prevalence of nicotine use in humans, robust nicotine self-administration has been difficult to demonstrate in laboratory animals. OBJECTIVES:A parametric analysis of nicotine self-administration was conducted to study its reinforcing effects in nonhuman primates. METHODS:Adult rhesus macaq...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-016-4293-y
更新日期:2016-07-01 00:00:00
abstract::Response decrements in an operant task produced by either extinction or by the dopamine receptor blocker pimozide were examined in three experiments which employed intermittent reinforcement schedules. In contrast to the congruency between these treatments previously observed following continuous reinforcement trainin...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432365
更新日期:1980-01-01 00:00:00
abstract::A prospective study of response to treatment with nortriptyline was carried out in a group of 14 inpatients with mixed symptoms of depression and dementia. Platelet membrane fluidity, as reflected by the fluorescence anisotropy of DPH labeled membranes, was determined for all 14 drug-free subjects prior to treatment b...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00174688
更新日期:1988-01-01 00:00:00
abstract::A paradigm for assessing benzodiazepine receptor sensitivity was developed using intravenous midazolam in normal volunteers. After administration of incremental doses of midazolam, alterations in saccadic eye movement parameters and psychological self ratings were assessed. Significant changes included dose-dependent ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244431
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVE:Recent data suggest that 5-HT7 receptors (5-HT7R) are involved in memory processes and, particularly, those related to novelty-induced arousal, even though this remains so far speculative and controversial. In order to assess the role of 5-HT7R in episodic-like memory, mice were administered 5-carboxamidotryp...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-3247-x
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION:A growing number of studies have found evidence that anxiety and depressive disorders are associated with atypical amygdala hyperactivation, which decreases with effective treatment. Interest has emerged in this phenomenon as a possible biological marker for individuals who are likely to benefit from tailo...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-006-0542-9
更新日期:2007-03-01 00:00:00
abstract::The antagonist effects of clocinnamox were evaluated against opioid agonists, acting at mu, kappa and delta-receptors, in rhesus monkeys (n = 3-4) responding under a fixed-ratio 30 (FR 30) schedule for food delivery. Clocinnamox (0.032-0.1 mg/kg) dose-dependently antagonized fentanyl (0.001-0.32 mg/kg) after either a ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246641
更新日期:1996-02-01 00:00:00
abstract:RATIONALE:Studies of ethanol's effects on TSH carried out during the daytime, when its secretion is at its nadir, do not reflect the true action of alcohol on TSH secretion since TSH peak occurs at night. OBJECTIVE:The present study investigated the effects of alcohol on the serum concentrations of TSH in healthy volu...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00213-003-1532-9
更新日期:2003-11-01 00:00:00
abstract::Chronic treatment of rats with choline caused a decrease in the hypothermic response to pilocarpine. The action of choline on the muscarinic receptors is consistent with electrophysiological and binding studies, supporting a direct muscarinic action for choline. Administration of direct muscarinic agonists has been sh...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427955
更新日期:1983-01-01 00:00:00
abstract:RATIONALE:Caffeine is commonly believed to offset the acute effects of alcohol, but some evidence suggests that cognitive processes remain impaired when caffeine and alcohol are coadministered. OBJECTIVES:No previous study has investigated the separate and joint effects of alcohol and caffeine on conflict monitoring a...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-016-4208-y
更新日期:2016-04-01 00:00:00
abstract:RATIONALE:During the course of our investigation of antalarmin, a corticotropin-releasing hormone (CRH) antagonist, in rhesus monkeys, we noticed that large, intravenous doses of antalarmin resulted in behavioral changes that resembled intoxication. OBJECTIVES:Antalarmin was evaluated in rhesus monkeys for its reinfor...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1187-y
更新日期:2002-11-01 00:00:00
abstract::Phencyclidine combined with footshock stress produced a greater increase in the homovanillic acid content of prefrontal cortex than either phencyclidine or footshock alone. Phencyclidine decreased both substance P and substance K in the ventral tegmental area. The results suggest that phencyclidine and footshock activ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02439600
更新日期:1987-01-01 00:00:00
abstract::This study examined the effects of intrahippocampal injections of scopolamine (a muscarinic antagonist drug) on performance of a working-memory task (contingently reinforced T-maze alternation) and a reference-memory task (visual discrimination) by the same rats in the same maze. Rats in the first shipment were traine...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427569
更新日期:1983-01-01 00:00:00
abstract::Recent studies indicate that some aspects of memory can be enhanced by the administration of oxygen or glucose. Considering the dependency of glucose metabolism upon oxygen supply, the present study predicted that administering a combination of 100% oxygen with glucose would have greater memory-enhancing effects than ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s002130050577
更新日期:1998-04-01 00:00:00
abstract::The behavioral profile of corticotropin-releasing factor (CRF) in mediating anxiogenic-like and aversive responses to stressors may be particularly relevant for dependence and withdrawal in drug-experienced organisms. Moreover, stressful aspects of drug exposure in the drug naive organism may also induce CRF system ac...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050563
更新日期:1998-04-01 00:00:00