Abstract:
:A paradigm for assessing benzodiazepine receptor sensitivity was developed using intravenous midazolam in normal volunteers. After administration of incremental doses of midazolam, alterations in saccadic eye movement parameters and psychological self ratings were assessed. Significant changes included dose-dependent slowing of peak velocity, peak acceleration, peak deceleration, reduced saccade acceleration/deceleration ratio and saccade accuracy, and increased sedation self-ratings. Changes in saccade variables and sedation ratings were significantly correlated, and also correlated with plasma midazolam concentrations. No significant changes were seen in saccade latency or anxiety self-ratings. Pharmacological specificity of these changes was demonstrated by their reversal with the benzodiazepine antagonist flumazenil. This challenge paradigm appears to be a sensitive means of assessing benzodiazepine receptor function in man.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Ball DM,Glue P,Wilson S,Nutt DJdoi
10.1007/BF02244431subject
Has Abstractpub_date
1991-01-01 00:00:00pages
361-7issue
3eissn
0033-3158issn
1432-2072journal_volume
105pub_type
杂志文章abstract:RATIONALE:Previous studies have shown that the effect of setting on drug-taking is substance specific in both humans and rats. In particular, we have shown that when the setting of drug self-administration (SA) coincides with the home environment of the rats (resident rats), the rats tend to prefer heroin to cocaine. T...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-015-3877-2
更新日期:2015-07-01 00:00:00
abstract:RATIONALE:Several previous neuroendocrine studies have demonstrated reduced 5-HT1A receptor function in major depressive disorder (MDD). However, hypercortisolaemia or previous drug treatment may have been significant confounds. OBJECTIVES:To replicate previous studies in subjects with MDD who had been drug free for a...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
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更新日期:2003-08-01 00:00:00
abstract:RATIONALE:Several lines of evidence suggest that the pathophysiology of schizophrenia may be associated with altered noradrenergic and glucoregulatory function. OBJECTIVE:The aim of this study was to investigate these alterations during a perturbed homeostatic state. METHODS:Fifteen patients with schizophrenia and 13...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-004-1890-y
更新日期:2004-11-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00464579
更新日期:1982-01-01 00:00:00
abstract:RATIONALE:Higher rates of delay discounting, or impulsive choice, may be related to relapse during abstinence reinforcement interventions for cigarette smoking, and a transdermal nicotine patch may attenuate delay discounting. OBJECTIVE:The objectives of this study are to assess the relation between delay discounting ...
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pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-006-0627-5
更新日期:2007-03-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245234
更新日期:1994-01-01 00:00:00
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journal_title:Psychopharmacology
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doi:10.1007/s00213-013-3284-5
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1995-08-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00427100
更新日期:1981-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1985-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2002-11-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245333
更新日期:1994-11-01 00:00:00
abstract:RATIONALE:The zebrafish dopaminergic system is thought to be evolutionarily conserved and may be amenable to pharmacological manipulation using drugs developed for mammalian receptors. However, only few studies have examined the role of specific receptor subtypes in behaviour of adult zebrafish. OBJECTIVES:The objecti...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3713-0
更新日期:2015-02-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245115
更新日期:1992-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000401
更新日期:2000-05-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246054
更新日期:1995-05-01 00:00:00
abstract:RATIONALE:Endogenous and exogenous cannabinoids acting through the CB1 cannabinoid receptors are implicated in the control of a variety of behavioural and neuroendocrine functions, including emotional responses, and learning and memory processes. Recently, knockout mice deficient in the CB1 cannabinoid receptor have be...
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doi:10.1007/s00213-001-0946-5
更新日期:2002-02-01 00:00:00
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journal_title:Psychopharmacology
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更新日期:2003-11-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1993-01-01 00:00:00
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journal_title:Psychopharmacology
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245135
更新日期:1992-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,评审
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更新日期:2013-03-01 00:00:00
abstract:RATIONALE:Smoking typically begins during adolescence and is largely reinforced by social cues. During adolescence in rats, sensitivity to both social cues and drugs of abuse is enhanced. OBJECTIVES:We have previously demonstrated in adolescent male rats that a low dose of cocaine interacts with social reward to produ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-009-1470-2
更新日期:2009-06-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2011-02-01 00:00:00
abstract:RATIONALE AND OBJECTIVE:Estradiol decline has been associated with depression and anxiety in post-menopausal women. Agomelatine (Ago) is an agonist of the melatonergic MT1/MT2 receptors and an antagonist of the serotonergic 5-HT2c receptors. The present study aimed to evaluate the effects of combining Ago with 17β-estr...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05580-2
更新日期:2020-09-01 00:00:00
abstract:RATIONALE:There is a close relationship between arousal and pupil diameter, decrease in the level of arousal being accompanied by constriction of the pupil (miosis), probably reflecting the attenuation of sympathetic outflow as sedation sets in. Paradoxically, sedation induced by benzodiazepines is not accompanied by m...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
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更新日期:2007-11-01 00:00:00
abstract::The effects of different doses (0.03, 0.06, 0.12, 0.25, 1.0, 2.0, 4.0, and 8.0 mg/kg body weight) of 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) were tested on the acoustic startle reflex in rats. Beginning at 0.12 mg/kg, 5-MeODMT increased startle monotonically up to the highest dose used. 5-MeODMT still increased st...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00435302
更新日期:1980-01-01 00:00:00
abstract::The selective serotonin reuptake inhibitor fluvoxamine interferes with the metabolism of tricyclic antidepressants. The present investigation was set out to characterize these interactions in vitro using rat liver microsomes and in vivo by analysing levels of clomipramine and metabolites in sera of depressed patients ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245180
更新日期:1995-01-01 00:00:00
abstract:RATIONALE:Caffeine and the adenosine A(1) and A(2A) receptor antagonist CGS15943 produce many behavioral effects that are similar to those produced by classic stimulant drugs (e.g. cocaine and amphetamines). OBJECTIVES:The current study evaluated whether CGS15943 would maintain self-administration and reinstate exting...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1410-5
更新日期:2003-07-01 00:00:00