Neurochemical and behavioural investigations of the NMDA receptor-associated glycine site in the rat striatum: functional implications for treatment of parkinsonian symptoms.

Abstract:

:The glutamatergic cortico-striatal and subthalamo-entopeduncular pathways are both overactive in parkinsonism. Previous behavioural investigations have shown that intra-entopeduncular injection of either NMDA-site or glycine-site antagonists results in alleviation of parkinsonian symptoms, although injection of the former is associated with the appearance of anaesthetic-like side effects. These behavioural differences may be mediated by action on different NMDA receptor subtypes. Recent neurochemical and molecular pharmacological studies have indicated the existence of NMDA receptor subtypes which display differential modulation by glycine. In the present study, three potential modes of NMDA antagonism were differentiated in vitro by effects on [3H]-glycine binding to striatal sections. Specific [3H]-glycine binding was totally displaced by the glycine partial agonist (R)-HA-966; the NMDA-site antagonist D-CPP had no effect; and the NMDA-site antagonist D-AP5 displaced [3H]-glycine binding in a subpopulation of glycine sites. The anti-parkinsonian effects of (R)-HA-966, D-CPP and D-AP5 were assessed by intra-striatal injection in reserpine-treated rats and 6-OHDA-lesioned rats. Injection of (R)-HA-966 and D-CPP resulted in alleviation of parkinsonian akinesia, although the latter elicited anaesthetic-like side effects; D-AP5 was ineffective as an anti-parkinsonian agent. (R)-HA-966 was also effective as an anti-parkinsonian agent when administered systemically in the reserpine-treated rat. These data suggest that different classes of NMDA antagonist mediate different behavioural responses within the parkinsonian striatum. The behavioural response produced may depend on the exact nature of the conformational change induced by the antagonist and the location of the subtype most sensitive to that class of compound. Selection of a specific mode of NMDA receptor antagonism or targeting of striatal NMDA receptor subtypes may form the basis of a novel therapeutic approach to Parkinson's disease.

journal_title

Psychopharmacology

authors

Carroll CB,Holloway V,Brotchie JM,Mitchell IJ

doi

10.1007/BF02246054

subject

Has Abstract

pub_date

1995-05-01 00:00:00

pages

55-65

issue

1

eissn

0033-3158

issn

1432-2072

journal_volume

119

pub_type

杂志文章
  • Synergistic efects of opioid and cannabinoid antagonists on food intake.

    abstract:RATIONALE:Central cannabinoid systems have been implicated in appetite regulation through the hyperphagic effects of exogenous and endogenous cannabinoids. These effects may involve activation of reward systems and be mediated in part by opioidergic processes. OBJECTIVE:Cannabinoid-opioid interactions in feeding were ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s002130000596

    authors: Kirkham TC,Williams CM

    更新日期:2001-01-01 00:00:00

  • An IL-6 receptor antagonist attenuates postpartum anhedonia, but has no effect on anhedonia precipitated by subchronic stress in female rats.

    abstract:RATIONALE:Nearly 60-80% of women experience some form of sadness, anxiety, or anhedonia in the weeks following the birth of a child (Patel et al. 23(2):534-42, 2012; Degner 10: 359;j4692, 2017); however, the exact mechanisms that precipitate these changes in mood postpartum are still unknown. It is well-known that the ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-019-05194-3

    authors: Gomez J,Haas NA,Schwarz JM

    更新日期:2019-10-01 00:00:00

  • Failure of muscarinic blockade to antagonize analepsis induced by thyrotropin-releasing hormone and MK-771 in the rat.

    abstract::In the rat, the antimuscarinics atropine and scopolamine failed to block the reduction in pentobarbital-induced sleep time produced by either thyrotropin-releasing hormone (TRH) or MK-771 (a TRH analog). Previous reports have indicated that the marked analeptic effect produced by TRH is antagonized by such agents. It ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00431749

    authors: Santori EM,Schmidt DE,Kalivas PW,Horita A

    更新日期:1981-01-01 00:00:00

  • MK-801-induced behavioural sensitisation alters dopamine release and turnover in rat prefrontal cortex.

    abstract:RATIONALE:Repeated exposure to psychostimulants that either increase dopamine (DA) release or target N-methyl-D-aspartate (NMDA) receptors can induce behavioural sensitisation, a phenomenon that may be important for the processes of addiction and even psychosis. A critical component of behavioural sensitisation is an i...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-014-3689-9

    authors: Cui X,Lefevre E,Turner KM,Coelho CM,Alexander S,Burne TH,Eyles DW

    更新日期:2015-02-01 00:00:00

  • Cholinergic and glutamatergic alterations beginning at the early stages of Alzheimer disease: participation of the phospholipase A2 enzyme.

    abstract:RATIONALE:Alzheimer disease (AD), a progressive neurodegenerative disorder, is the leading cause of dementia in the elderly. A combination of cholinergic and glutamatergic dysfunction appears to underlie the symptomatology of AD, and thus, treatment strategies should address impairments in both systems. Evidence sugges...

    journal_title:Psychopharmacology

    pub_type: 杂志文章,评审

    doi:10.1007/s00213-008-1092-0

    authors: Schaeffer EL,Gattaz WF

    更新日期:2008-05-01 00:00:00

  • Interactions between the reinforcing effects of cocaine and heroin in a drug-vs-food choice procedure in rhesus monkeys: a dose-addition analysis.

    abstract:RATIONALE:Concurrent abuse of cocaine and heroin is a common form of polydrug abuse, but the interactions between the reinforcing effects of cocaine and heroin are poorly understood. Dose-addition analysis is a tool for the quantitative assessment of drug interactions, but this analysis has not been applied to evaluati...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-004-2133-y

    authors: Negus SS

    更新日期:2005-06-01 00:00:00

  • Increased sensitivity to amphetamine and facilitation of amphetamine self-administration after 6-hydroxydopamine lesions of the amygdala.

    abstract::The effects of 6-OHDA lesions of dopamine terminals within the amygdala were investigated on i) (+) amphetamine-induced locomotor hyperactivity and ii) the acquisition of intravenous self-administration of (+) amphetamine. The lesioned rats exhibited increased locomotor activity in response to (+) amphetamine (0.75 an...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00176851

    authors: Deminière JM,Taghzouti K,Tassin JP,Le Moal M,Simon H

    更新日期:1988-01-01 00:00:00

  • Differential reversal of various dopamine antagonists by anticholinergics in Sidman avoidance: possible relationship to adrenergic blockade.

    abstract::Various dopamine receptor antagonists have divergent clinical and neurochemical properties. The relative ability of anticholinergics (benztropine and scopolamine) to reverse these drugs was assessed in squirrel monkeys and rats performing a Sidman avoidance task. In monkeys, benztropine markedly attenuated the effects...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00432433

    authors: Liebman JM,Neale R,Noreika L,Braunwalder A

    更新日期:1981-01-01 00:00:00

  • Direct effects of diazepam on emotional processing in healthy volunteers.

    abstract:RATIONALE:Pharmacological agents used in the treatment of anxiety have been reported to decrease threat relevant processing in patients and healthy controls, suggesting a potentially relevant mechanism of action. However, the effects of the anxiolytic diazepam have typically been examined at sedative doses, which do no...

    journal_title:Psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00213-008-1082-2

    authors: Murphy SE,Downham C,Cowen PJ,Harmer CJ

    更新日期:2008-09-01 00:00:00

  • Comparative effects of pulmonary and parenteral Δ⁹-tetrahydrocannabinol exposure on extinction of opiate-induced conditioned aversion in rats.

    abstract:RATIONALE:Evidence suggesting that the endogenous cannabinoid (eCB) system can be manipulated to facilitate or impair extinction of learned behaviours has important consequences for opiate withdrawal and abstinence. We demonstrated that the fatty acid amide hydrolase (FAAH) inhibitor URB597, which increases eCB levels,...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-014-3798-5

    authors: Manwell LA,Mallet PE

    更新日期:2015-05-01 00:00:00

  • Prepulse inhibition during withdrawal from an escalating dosage schedule of amphetamine.

    abstract:RATIONALE:Psychomotor stimulants can induce psychotic states in humans that closely resemble those observed in patients with idiopathic schizophrenia. Attentional and sensorimotor gating impairments are observed in schizophrenic patients using the latent inhibition (LI) and prepulse inhibition (PPI) behavioral assays, ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-002-1254-4

    authors: Russig H,Murphy CA,Feldon J

    更新日期:2003-09-01 00:00:00

  • Prefrontal cortical hypometabolism during low-dose interferon alpha treatment.

    abstract:OBJECTIVE:To evaluate prospectively interferon alpha (IFN-alpha) associated effects on cerebral glucose metabolism and its correlation to neuropsychiatric symptoms during low-dose IFN-alpha-treatment. METHODS:Eleven patients treated with low-dose IFN-alpha for chronic hepatitis C were prospectively evaluated by neurop...

    journal_title:Psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s002130000549

    authors: Juengling FD,Ebert D,Gut O,Engelbrecht MA,Rasenack J,Nitzsche EU,Bauer J,Lieb K

    更新日期:2000-11-01 00:00:00

  • Repeated exposures intensify rather than diminish the rewarding effects of amphetamine, morphine, and cocaine.

    abstract::It is commonly believed that repeated exposures diminish the pleasurable effects of drugs and hence that pleasure must have only a minor role in addiction. In six experiments with rats, repeated exposures to amphetamine, morphine, or cocaine were found to enhance the drug-induced rewarding effect as measured by condit...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00451687

    authors: Lett BT

    更新日期:1989-01-01 00:00:00

  • Early postnatal clonidine treatment results in altered regional catecholamine utilisation in adult rat brain.

    abstract::Clonidine is a clinically used antihypertensive which has been suggested to produce physiological changes in children after exposure in utero. The aim of our study was to test the hypothesis that chronic exposure of the developing brain to an alpha 2-adrenergic agonist like clonidine would influence the adult neuroche...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF02253583

    authors: Feenstra MG,van Galen H,Boer GJ

    更新日期:1992-01-01 00:00:00

  • Dipropylacetate-induced quasi-morphine abstinence behaviour in the rat: suppression by alpha 2-adrenoceptor stimulation.

    abstract::The anti-withdrawal effect of clonidine was studied using quasi-morphine abstinence behaviour induced by dipropylacetate (DPA) in naive rats. Clonidine potently suppressed body shakes and locomotor activity (ID50 30 and 40 micrograms/kg IP respectively). Phenoxybenzamine and prazosine did not antagonize the anti-withd...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00427276

    authors: van der Laan JW,Weick G,Hillen FC

    更新日期:1983-01-01 00:00:00

  • NMDA receptor antagonism: escalation of aggressive behavior in alcohol-drinking mice.

    abstract:RATIONALE:Memantine is a potential treatment for alcoholic patients, yet few studies investigate the effect of concurrent treatment with memantine and ethanol on aggression. We evaluated aggressive behavior following ethanol consumption and treatment with glutamatergic drugs to characterize interactions between these c...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-012-2734-9

    authors: Newman EL,Chu A,Bahamón B,Takahashi A,Debold JF,Miczek KA

    更新日期:2012-11-01 00:00:00

  • Yawning induced by apomorphine, physostigmine or pilocarpine is potentiated by dihydropyridine calcium channel blockers.

    abstract::Previous studies have shown that dihydropyridine (DHP) calcium channel blockers can potentiate yawning induced by apomorphine in rats. The present study was undertaken to examine whether or not this interaction was seen with other compounds that induce yawning or if it represented a specific interaction with dopaminer...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF02244401

    authors: Bourson A,Moser PC

    更新日期:1990-01-01 00:00:00

  • Behavioral effects of benzylideneoxymorphone (BOM), a low efficacy µ opioid receptor agonist and a δ opioid receptor antagonist.

    abstract:RATIONALE:Opioids remain the drugs of choice for treating moderate to severe pain, although adverse effects often limit use. Drugs acting concomitantly as agonists at μ opioid receptors and antagonists at δ opioid receptors produce antinociceptive effects with a reduced profile of adverse effects; one such drug, benzyl...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-020-05638-1

    authors: Mada S,Gerak LR,Soyer A,Maguire DR,Hu Z,Minervini V,Cunningham CW,France CP

    更新日期:2020-12-01 00:00:00

  • Twelve-hour brain lithium concentration in lithium maintenance treatment of manic-depressive disorder: daily versus alternate-day dosing schedule.

    abstract::The 12-h brain lithium concentration was measured by lithium-7 magnetic resonance spectroscopy in ten manic-depressive patients receiving daily or alternate-day lithium carbonate treatment. The median dose of lithium carbonate was 800 mg in the daily treatment group and 1200 mg in the alternate-day group. Median 12-h ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF02246668

    authors: Jensen HV,Plenge P,Stensgaard A,Mellerup ET,Thomsen C,Aggernaes H,Henriksen O

    更新日期:1996-04-01 00:00:00

  • Separate mechanisms for behavioral, cardiovascular, and hormonal responses to dextroamphetamine in man.

    abstract::The neurochemical specificity of physiological, biochemical, and psychological responses to dextroamphetamine was tested by pretreating volunteers with haloperidol (0.014 mg/kg IM), propranolol (0.1 mg/kg IV), thymoxamine (0.1 mg/kg IV), or placebo prior to 0.3 mg/kg IV amphetamine. Healthy volunteers (N = 12) partici...

    journal_title:Psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF00427446

    authors: Nurnberger JI Jr,Simmons-Alling S,Kessler L,Jimerson S,Schreiber J,Hollander E,Tamminga CA,Nadi NS,Goldstein DS,Gershon ES

    更新日期:1984-01-01 00:00:00

  • Habituation of acoustic startle is disrupted by psychotomimetic drugs: differential dependence on dopaminergic and nitric oxide modulatory mechanisms.

    abstract:RATIONALE:A deficit in attention and information processing has been considered a central feature in schizophrenia, which might lead to stimulus overload and cognitive fragmentation. It has been shown that patients with schizophrenia display a relative inability to gate incoming stimuli. Thus, patients repeatedly subje...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-004-1901-z

    authors: Klamer D,Pålsson E,Revesz A,Engel JA,Svensson L

    更新日期:2004-11-01 00:00:00

  • Differences in the effects of d-fenfluramine and morphine on various responses of rats to painful stimuli.

    abstract::The effects of d-fenfluramine and morphine on various nociceptive responses of rats were investigated. Unlike morphine, which inhibited all the responses examined, d-fenfluramine inhibited jumping and paw licking of rats on a hot plate, but did not increase the latency of tail withdrawal from hot water. The effects of...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00435276

    authors: Rochat C,Cervo L,Romandini S,Samanin R

    更新日期:1982-01-01 00:00:00

  • Inhibition of shaking movements in rats by central administration of cholinergic and adrenergic agents.

    abstract::Shaking movements of the body, similar to that made by a dog when wet ('wet-dog shakes'), occur in rats in response to pharmacological stimuli and in response to stimuli associated with cold and skin irritation. In this study, shaking movements, elicited by a variety of stimuli, were inhibited by central administratio...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00429002

    authors: Wei ET

    更新日期:1983-01-01 00:00:00

  • The dopamine D2 receptor antagonist sulpiride modulates striatal BOLD signal during the manipulation of information in working memory.

    abstract:RATIONALE:Dopamine (DA) plays an important role in working memory. However, the precise functions supported by different DA receptor subtypes in different neural regions remain unclear. OBJECTIVE:The present study used pharmacological, event-related fMRI to test the hypothesis that striatal dopamine is important for t...

    journal_title:Psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00213-009-1634-0

    authors: Dodds CM,Clark L,Dove A,Regenthal R,Baumann F,Bullmore E,Robbins TW,Müller U

    更新日期:2009-11-01 00:00:00

  • Voraciousness induced in cats by benzodiazepines.

    abstract::Different benzodiazepines, when administered to fasting cats, increased both the total amount of food eaten and also the rate at which food was ingested. Moreover, when injected to foodsatiated cats, these compounds made them resume eating voraciously. Pentobarbital also stimulated food intake, but was much less poten...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00428710

    authors: Mereu GP,Fratta W,Chessa P,Gessa GL

    更新日期:1976-05-05 00:00:00

  • An organoselenium compound improves behavioral, endocrinal and neurochemical changes induced by corticosterone in mice.

    abstract:RATIONALE:3-(4-Fluorophenylselenyl)-2,5-diphenylselenophene (F-DPS) is a promising organoselenium compound that shows antidepressant-like properties related to interaction with the serotonergic system. OBJECTIVES:In this study, a mouse model of anxiety/depressant-like behavior induced by long-term corticosterone treat...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-013-3361-9

    authors: Gai BM,Bortolatto CF,Heck SO,Stein AL,Duarte MM,Zeni G,Nogueira CW

    更新日期:2014-05-01 00:00:00

  • Methamphetamine addiction: involvement of CREB and neuroinflammatory signaling pathways.

    abstract:RATIONALE AND OBJECTIVES:Addiction to psychostimulant methamphetamine (METH) remains a major public health problem in the world. Animal models that use METH self-administration incorporate many features of human drug-taking behavior and are very helpful in elucidating mechanisms underlying METH addiction. These models ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章,评审

    doi:10.1007/s00213-016-4235-8

    authors: Krasnova IN,Justinova Z,Cadet JL

    更新日期:2016-05-01 00:00:00

  • The behavioral and biochemical effects of lithium on dopaminergic agonist-induced supersensitivity.

    abstract::Dopaminergic behavioral supersensitivity may be induced by chronic treatment with either dopaminergic agonists or antagonists. We demonstrate that the development of agonist-induced supersensitivity is resistant to chronic lithium exposure. Furthermore, chronic lithium alone enhances the stereotypic response to acute ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00427448

    authors: Rubin EH,Wooten GF

    更新日期:1984-01-01 00:00:00

  • Pharmacology of saccadic eye movements in man. 1. Effects of the benzodiazepine receptor ligands midazolam and flumazenil.

    abstract::A paradigm for assessing benzodiazepine receptor sensitivity was developed using intravenous midazolam in normal volunteers. After administration of incremental doses of midazolam, alterations in saccadic eye movement parameters and psychological self ratings were assessed. Significant changes included dose-dependent ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF02244431

    authors: Ball DM,Glue P,Wilson S,Nutt DJ

    更新日期:1991-01-01 00:00:00

  • Decreased sensitivity in adolescent versus adult rats to the antidepressant-like effects of cannabidiol.

    abstract:RATIONALE:Cannabidiol is a non-psychoactive phytocannabinoid with great therapeutic potential in diverse psychiatric disorders; however, its antidepressant potential has been mainly ascertained in adult rats. OBJECTIVES:To compare the antidepressant-like response induced by cannabidiol in adolescent and adult rats and...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-020-05481-4

    authors: Bis-Humbert C,García-Cabrerizo R,García-Fuster MJ

    更新日期:2020-06-01 00:00:00