Phencyclidine-induced potentiation of brain stimulation reward: acute effects are not altered by repeated administration.

Abstract:

:Phencyclidine (PCP; 2.5 or 5.0 mg/kg) potentiated the effects of rewarding hypothalamic brain stimulation, causing parallel leftward shifts of the functions that relate rate of responding to stimulation frequency. Thus, like a number of other drugs of abuse, PCP lowered the "dose" of stimulation required to maintain responding at a given criterion. No progressive changes in the reward-potentiating effects of PCP were evident when the rats were tested once per week for 8 weeks; there was neither tolerance nor sensitization to the initial rewarding properties of PCP. However, in subsequent locomotor tests rats appeared to be already sensitized to PCP; this raises the possibility that the electrical stimulation of the lateral hypothalamus itself maximally sensitized the animals to the stimulant effects of the drug.

journal_title

Psychopharmacology

authors

Carlezon WA Jr,Wise RA

doi

10.1007/BF02253528

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

402-8

issue

4

eissn

0033-3158

issn

1432-2072

journal_volume

111

pub_type

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