Elevated prolactin responses to L-tryptophan infusion in medication-free depressed patients.

abstract：:In order to assess the possible effects of central GABA activation on the consolidation of shock avoidance, the GABA-T inhibitor amino-oxyacetic acid (AOAA) was administered posttrial to adult male rats. Learning was assessed over nine widely spaced sessions of 20 trials each. AOAA-treated animals showed learning with...

journal_title：Psychopharmacology

authors： Katz RJ,Liebler L

更新日期：1978-03-01 00:00:00

abstract：:Male Sprague-Dawley rats weighing 116--241 g were injected i.p. with ketamine hydrochloride, 80 mg per kilo of body weight. Immediately after loss of righting reflex, scopolamine, physostigmine, and mecamylamine were administered i.p. to different groups of rats. Control animals received sterile saline by the same rou...

journal_title：Psychopharmacology

authors： Figallo EM,Wingard LB Jr

更新日期：1979-03-14 00:00:00

abstract：RATIONALE:Smokers show heightened activation toward smoking-related stimuli and experience increased cravings which can precipitate smoking cessation relapse. Exercise can be effective for modulating cigarette cravings and attenuating reactivity to smoking cues, but the mechanism by which these effects occur remains un...

journal_title：Psychopharmacology

authors： Janse Van Rensburg K,Taylor A,Benattayallah A,Hodgson T

更新日期：2012-06-01 00:00:00

abstract：RATIONALE:Executive function impairment, as classically assessed using the Wisconsin Card Sort Test or intradimensional/extradimensional tests, is a key feature of schizophrenia but remains inadequately treated by existing therapies. Recently, however, erythropoietin has been shown to improve attentional set-shifting p...

journal_title：Psychopharmacology

authors： Goetghebeur PJ,Lerdrup L,Sylvest A,Dias R

更新日期：2010-12-01 00:00:00

abstract：RATIONALE:The party drug ecstasy is frequently used in combination with other drugs like marihuana and alcohol. In addition, a substantial proportion of the MDMA users has claimed to drive a car when under the influence of MDMA and/or other drugs. OBJECTIVE:To assess the effects of MDMA and alcohol, combined and alone...

journal_title：Psychopharmacology

authors： Kuypers KP,Samyn N,Ramaekers JG

更新日期：2006-09-01 00:00:00

abstract：RATIONALE:A growing number of studies suggest that gamma-aminobutyric acid type-B (GABA(B)) receptor agonists reduce alcohol use and craving. OBJECTIVES:This study was designed to further clarify behavioral mechanism(s) by which GABA(B) agonists may decrease alcohol reinforcement. METHODS:Male C57BL/6 J mice were tra...

journal_title：Psychopharmacology

authors： Besheer J,Lepoutre V,Hodge CW

更新日期：2004-07-01 00:00:00

abstract：RATIONALE:Rats, like humans, are susceptible to the reinforcing effects of reward-related stimuli presented within a compound stimulus array, putatively analogous to the so-called near-miss effect. We have previously demonstrated using a rodent slot machine task (rSMT) that the reward expectancy these stimuli elicit is...

journal_title：Psychopharmacology

authors： Cocker PJ,Lin MY,Barrus MM,Le Foll B,Winstanley CA

更新日期：2016-09-01 00:00:00

abstract：RATIONALE:Several studies have suggested that modulation of the glutamatergic system via metabotropic glutamate receptors (mGlu) could be a new and efficient way to achieve antipsychotic-like activity. OBJECTIVES:Here, we decided to investigate the possible role of the group III mGlu receptor ligands, LSP1-2111, the g...

journal_title：Psychopharmacology

authors： Wierońska JM,Stachowicz K,Acher F,Lech T,Pilc A

更新日期：2012-04-01 00:00:00

abstract：RATIONALE:Both methylphenidate (MPH), a catecholamine reuptake blocker, and guanfacine, an alpha2A agonist, are used to treat attention-deficit hyperactivity disorder (ADHD). Childhood impulsivity, including delay discounting, is associated with increased substance use during adolescence. These effects can be mitigated...

journal_title：Psychopharmacology

authors： Freund N,Jordan CJ,Lukkes JL,Norman KJ,Andersen SL

更新日期：2019-02-01 00:00:00

abstract：RATIONALE:In cell culture systems, agonists can promote the phosphorylation and internalization of receptors coupled to G proteins (GPCR), leading to their desensitization. However, in the CNS opioid agonists promote a profound desensitization of their analgesic effects without diminishing the presence of their recepto...

journal_title：Psychopharmacology

authors： Garzón J,Rodríguez-Muñoz M,de la Torre-Madrid E,Sánchez-Blázquez P

更新日期：2005-06-01 00:00:00

abstract：:Effects of chlordiazepoxide (CDP) and ethanolamine-O-sulphate (EOS) alone and in combination were tested on the acquisition and performance of continuous reinforcement - time out (CR-TO) and variable interval reinforcement - time out (VI-TO) operant discriminations in rats. CDP disrupted acquisition of CR-TO discrimin...

journal_title：Psychopharmacology

authors： Hodges H,Baum S,Taylor P,Green S

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Ketamine, a non-competitive N-methyl-D: -aspartic acid antagonist, has been widely used for anaesthetic purposes. At sub-anaesthetic dosage, it induces a dissociative state similar to schizophrenia. The discovery of this effect on dissociative state has led to its use as a pharmacological model of schizophre...

journal_title：Psychopharmacology

authors： Pouget P,Wattiez N,Rivaud-Péchoux S,Gaymard B

更新日期：2010-05-01 00:00:00

abstract：:Sixty-two DSM III chronic schizophrenic inpatients were selected for a double-blind, placebo controlled, multi-centre, relapse prevention study of remoxipride, a selective dopamine (D2)-receptor antagonist. After a 1 month placebo washout, 23 patients had relapsed and were withdrawn. Of the remaining patients 19 were ...

journal_title：Psychopharmacology

authors： King DJ,Blomqvist M,Cooper SJ,Doherty MM,Mitchell MJ,Montgomery RC

更新日期：1992-01-01 00:00:00

abstract：RATIONALE:Morphine and buprenorphine have analgesic and anxiolytic-like properties. While their analgesic effects have been well characterized, their anxiolytic-like properties have not. OBJECTIVES:Effects of acute morphine and buprenorphine on the expression of acoustic fear-potentiated startle (FPS) and naloxone pre...

journal_title：Psychopharmacology

authors： Glover EM,Davis M

更新日期：2008-06-01 00:00:00

abstract：:Administration of the serotonin (5-HT)1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) facilitates the expression of masculine sexual behavior in male and female rats as well as in male rhesus monkeys and inhibits lordosis behavior in female rats. In the present study the effects of 8-OH-DPAT on ...

journal_title：Psychopharmacology

authors： Paredes RG,Kica E,Baum MJ

更新日期：1994-05-01 00:00:00

abstract：RATIONALE:Convulsions associated with cocaine toxicity are a serious aspect of cocaine-related emergency room incidents. Seizures can result from a single high dose of cocaine, and evidence is accumulating that correlates repetitive administration of sub-convulsive doses of cocaine with a decreased seizure threshold, a...

journal_title：Psychopharmacology

authors： Miller KA,Witkin JM,Ungard JT,Gasior M

更新日期：2000-01-01 00:00:00

abstract：RATIONALE:Concurrent abuse of cocaine and heroin is a common form of polydrug abuse, but the interactions between the reinforcing effects of cocaine and heroin are poorly understood. Dose-addition analysis is a tool for the quantitative assessment of drug interactions, but this analysis has not been applied to evaluati...

journal_title：Psychopharmacology

authors： Negus SS

更新日期：2005-06-01 00:00:00

abstract：:The effect of long-term treatment with clozapine in schizophrenia and schizoaffective disorder was evaluated in a retrospective study comprising 96 patients treated with the drug during the period 1974-1986 at the Psychiatric Research Center in Uppsala. All patients had previously been treated with different kinds of ...

journal_title：Psychopharmacology

authors： Lindström LH

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVE:Recent data suggest that 5-HT7 receptors (5-HT7R) are involved in memory processes and, particularly, those related to novelty-induced arousal, even though this remains so far speculative and controversial. In order to assess the role of 5-HT7R in episodic-like memory, mice were administered 5-carboxamidotryp...

journal_title：Psychopharmacology

authors： Freret T,Paizanis E,Beaudet G,Gusmao-Montaigne A,Nee G,Dauphin F,Bouet V,Boulouard M

更新日期：2014-01-01 00:00:00

abstract：:After publication of this paper, the authors determined an error in Fig. 2C. ...

journal_title：Psychopharmacology

authors： Zhang B,Xiong F,Ma Y,Li B,Mao Y,Zhou Z,Yu H,Li J,Li C,Fu J,Wang J,Zhao X

更新日期：2019-07-01 00:00:00

abstract：:The effects of drugs on one aspect of impulsive behaviour were evaluated using a schedule in which rats were trained to complete a fixed consecutive number of responses on one of two levers before pressing the second to obtain a reinforcer (FCN). Terminating the chain before completing the FCN resulted in the omission...

journal_title：Psychopharmacology

authors： Evenden JL

更新日期：1998-08-01 00:00:00

abstract：RATIONALE:Higher rates of delay discounting, or impulsive choice, may be related to relapse during abstinence reinforcement interventions for cigarette smoking, and a transdermal nicotine patch may attenuate delay discounting. OBJECTIVE:The objectives of this study are to assess the relation between delay discounting ...

journal_title：Psychopharmacology

authors： Dallery J,Raiff BR

更新日期：2007-03-01 00:00:00

abstract：:The release of serotonin (5-HT) at serotonergic nerve terminals is regulated by 5-HT(1B) autoreceptors. Several studies have reported that the effects of selective 5-HT reuptake inhibitors (SSRIs) on extracellular 5-HT are augmented by 5-HT(1B) receptor antagonists, whereas administration of these antagonists alone do...

journal_title：Psychopharmacology

authors： de Groote L,Klompmakers AA,Olivier B,Westenberg HG

更新日期：2003-05-01 00:00:00

abstract：:The forced swimming test is reviewed. This test appears to be suitable for detecting antidepressant activity in rats but not in mice. Difference in experimental procedure may account for the different sensitivity to drugs of the two animal species. ...

journal_title：Psychopharmacology

authors： Borsini F,Meli A

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:The drug discrimination procedure has proven to be a valuable tool for studying the mechanism of action of psychoactive drugs. Recently, mice with targeted gene mutations have been developed that may also prove useful in evaluating the role of specific receptors in mediating the actions of drugs. We were inte...

journal_title：Psychopharmacology

authors： Smith RL,Barrett RJ,Sanders-Bush E

更新日期：2003-02-01 00:00:00

abstract：:Twenty-nine subjects performed a reaction time task with four levels of choice-task complexity under non-smoking, sham smoking, and low, medium and high nicotine cigarette conditions. Nicotine reduced decision time, while sham smoking increased decision time. This effect was independent of subjects' habitual levels of...

journal_title：Psychopharmacology

authors： Bates T,Pellett O,Stough C,Mangan G

更新日期：1994-03-01 00:00:00

abstract：:Both muscarinic antagonists, such as scopolamine, and benzodiazepine receptor (BZR) agonists, such as diazepam, produce a reliable impairment in the performance of one trial passive avoidance. Such deficits are frequently interpreted as drug-induced amnesia. However, these deficits could also result from a learning im...

journal_title：Psychopharmacology

authors： Cole BJ,Jones GH

更新日期：1995-03-01 00:00:00

abstract：:Experiments were carried out using rats to investigate whether 5-HT1A neural mechanisms are involved in lithium-induced conditioned taste aversion (CTA). We found that the 5-HT1A antagonists p-MPPI and pindolol caused CTA similar to that produced by LiCl. The 5-HT1A agonist 8-OH-DPAT counteracted lithium-induced CTA. ...

journal_title：Psychopharmacology

authors： Wegener G,Smith DF,Rosenberg R

更新日期：1997-09-01 00:00:00

abstract：:Dopamine (DA), injected unilaterally into rat forebrain after pretreatment with a monoamine oxidase inhibitor, equipotently induced locomotor arousal when placed in the nucleus accumbens septi (a limbic site) and contralateral deviation of the head when placed in the corpus striatum (an extrapyramidal target); testing...

journal_title：Psychopharmacology

authors： Campbell A,Yeghiayan S,Baldessarini RJ,Neumeyer JL

更新日期：1991-01-01 00:00:00

abstract：:The effects of ethanol on locomotor activity and rotarod performance were measured in the rat. Apomorphine (4 mg/kg s.c.) antagonized and pimozide (0.75 - 1.50 mg/kg s.c.) enhanced the effects of a 2 g/kg dose of ethanol on rotarod performance. No such interaction was seen with pentobarbital, 25 mg/kg, a dose sufficie...

journal_title：Psychopharmacology

authors： Bacopoulos NG,Bize I,Levine J,Van Orden LS 3rd

更新日期：1979-01-31 00:00:00