Differential effects of the serotonin1A agonist, 8-OH-DPAT, on masculine and feminine sexual behavior of the ferret.

abstract：:Various dopamine receptor antagonists have divergent clinical and neurochemical properties. The relative ability of anticholinergics (benztropine and scopolamine) to reverse these drugs was assessed in squirrel monkeys and rats performing a Sidman avoidance task. In monkeys, benztropine markedly attenuated the effects...

journal_title：Psychopharmacology

authors： Liebman JM,Neale R,Noreika L,Braunwalder A

更新日期：1981-01-01 00:00:00

abstract：RATIONALE:In animal studies, the common club drug 3,4-methylendioxymethamphetamine (MDMA, "Ecstasy") consistently caused a prolonged loss of presynaptic serotonergic neurons, and evidence suggests that MDMA consumption may also affect the human serotonergic system. Serotonin (5-HT) has been implicated in the regulation...

journal_title：Psychopharmacology

authors： Quednow BB,Kühn KU,Hoppe C,Westheide J,Maier W,Daum I,Wagner M

更新日期：2007-01-01 00:00:00

abstract：:The effects of naloxone on diazepam-induced release of behavior in aversive situations were investigated in rats. Naloxone (0.5 and 1 mg/kg-1) suppressed diazepam-induced eating in an unfamiliar situation and reduced (1 mg/kg-1) spontaneous food intake. Naloxone (1 mg/kg-1) canceled the increased lever pressing produc...

journal_title：Psychopharmacology

authors： Soubrié P,Jobert A,Thiebot MH

更新日期：1980-01-01 00:00:00

abstract：RATIONALE:The ability of tobacco harm reduction strategies to produce significant reductions in toxin exposure is limited by compensatory increases in smoking behavior. Characterizing factors contributing to the marked individual variability in compensation may be useful for understanding this phenomenon and assessing ...

journal_title：Psychopharmacology

authors： Harris AC,Pentel PR,LeSage MG

更新日期：2009-09-01 00:00:00

abstract：:Acute alcohol intoxication disrupts memory acquisition in humans and laboratory animals. This review summarizes recent behavioral and immediate early gene expression studies addressing the mechanisms of this phenomenon. Most behavioral investigations agree that the amnestic effect of alcohol is due to its preferential...

journal_title：Psychopharmacology

authors： Ryabinin AE

更新日期：1998-09-01 00:00:00

abstract：:To test the Pavlovian conditioning model of alcohol tolerance, two groups of eight male social drinkers each received five administrations of alcohol and five administrations of an equal volume of tonic each, on an alternating basis, during the initial 10-session tolerance development phase of the study. Group 1 recei...

journal_title：Psychopharmacology

authors： Shapiro AP,Nathan PE

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:Aminoadamantanes represent a class of NMDA glutamate receptor antagonists that reduce alcohol consumption and may prevent alcohol-induced neuronal adaptations and side effects. OBJECTIVE:Behavioral specificity of memantine and amantadine on alcohol drinking in a schedule-induced polydipsia (SIP) task was inv...

journal_title：Psychopharmacology

authors： Escher T,Call SB,Blaha CD,Mittleman G

更新日期：2006-09-01 00:00:00

abstract：:The effect of the intracerebroventricular (ICV) administration of taurine on amnesia, convulsions and death caused by hypoxia was investigated in mice. Taurine in doses of 80-100 micrograms/mouse impaired acquisition of a single trial in passive avoidance performance, but protected mice from the learning impairment in...

journal_title：Psychopharmacology

authors： Malcangio M,Bartolini A,Ghelardini C,Bennardini F,Malmberg-Aiello P,Franconi F,Giotti A

更新日期：1989-01-01 00:00:00

abstract：:Doses of eight phenylethylamines were substituted for cocaine on a drug-maintained behavior baseline in baboons. Intravenous infusions of drug were contingent upon completion of 160 lever presses (a 160-response fixed-ratio schedule; FR 160). A 3-h time-out period followed each infusion, permitting a maximum of 8 infu...

journal_title：Psychopharmacology

authors： Griffiths RR,Winger G,Brady JV,Snell JD

更新日期：1976-11-24 00:00:00

abstract：:Serotonergic mechanisms have been implicated in the pathophysiology of depression and in the neuropharmacology of antidepressant treatment. One measure of central serotonergic function is the prolactin (PRL) response to IV L-tryptophan (L-TRP). We used the L-TRP test to assess the role of serotonin in the mechanism of...

journal_title：Psychopharmacology

authors： McCance-Katz E,Price LH,Charney DS,Heninger GR

更新日期：1992-01-01 00:00:00

abstract：:In a double-blind comparison of haloperidol decanoate and fluphenazine decanoate given 4-weekly for 60 weeks as maintenance therapy in 38 chronic schizophrenic in-patients, plasma haloperidol, fluphenazine and prolactin levels were measured at regular intervals by radioimmunoassay. After the first injection, the mean ...

journal_title：Psychopharmacology

authors： Wiles DH,McCreadie RG,Whitehead A

更新日期：1990-01-01 00:00:00

abstract：RATIONALE:Initial sensitivity to drugs of abuse often predicts subsequent use and abuse, but this relationship is not always observed in human studies. Moreover, studies examining the relationship between initial locomotor sensitivity and the rewarding and reinforcing effects of drugs in animal models have also been eq...

journal_title：Psychopharmacology

authors： Roberts AJ,Casal L,Huitron-Resendiz S,Thompson T,Tarantino LM

更新日期：2018-04-01 00:00:00

abstract：RATIONALE:Electrophysiological studies have identified a scalp potential, the late positive potential (LPP), which is modulated by the emotional intensity of observed stimuli. Previous work has shown that the LPP reflects the modulation of activity in extrastriate visual cortical structures, but little is known about t...

journal_title：Psychopharmacology

authors： de Rover M,Brown SB,Boot N,Hajcak G,van Noorden MS,van der Wee NJ,Nieuwenhuis S

更新日期：2012-02-01 00:00:00

abstract：RATIONALE:Schizophrenia is a severe, persistent, and fairly common mental illness. Haloperidol is widely used and is effective against the symptoms of psychosis seen in schizophrenia. Chronic oral haloperidol administration decreased the number of astrocytes in the parietal cortex of macaque monkeys (Konopaske et al., ...

journal_title：Psychopharmacology

authors： Konopaske GT,Bolo NR,Basu AC,Renshaw PF,Coyle JT

更新日期：2013-11-01 00:00:00

abstract：INTRODUCTION:Dopamine D2 receptor occupancy levels needed for the maintenance treatment of schizophrenia remain to be elucidated. We examined 3-year clinical outcomes of patients with schizophrenia who received long-acting injectable risperidone (LAI risperidone) at baseline and investigated their dopamine D2 receptor ...

journal_title：Psychopharmacology

authors： Ikai S,Suzuki T,Mimura M,Uchida H

更新日期：2016-12-01 00:00:00

abstract：RATIONALE:Direct activation of the cannabinoid CB1 receptor in the dorsolateral periaqueductal gray (dlPAG) inhibits anxiety- and panic-related behaviours in experimental animals. It has remained unclear, however, whether the local endocannabinoid signalling is recruited as a protective mechanism against aversive stimu...

journal_title：Psychopharmacology

authors： Viana TG,Hott SC,Resstel LB,Aguiar DC,Moreira FA

更新日期：2015-05-01 00:00:00

abstract：RATIONALE:Inattentional blindness (IB) is the inability to detect a salient yet unexpected task irrelevant stimulus in one's visual field when attention is engaged in an ongoing primary task. The present study is the first to examine the impact of both task difficulty and alcohol consumption on IB and primary task perf...

journal_title：Psychopharmacology

authors： Harvey AJ,Bayless SJ,Hyams G

更新日期：2018-01-01 00:00:00

abstract：RATIONALE:Over the last decade, many new psychostimulant analogues have appeared on the recreational drug market and most are derivatives of amphetamine or cathinone. Another class of designer drugs is derived from the 2-aminoindan structural template. Several members of this class, including the parent compound 2-amin...

journal_title：Psychopharmacology

authors： Halberstadt AL,Brandt SD,Walther D,Baumann MH

更新日期：2019-03-01 00:00:00

abstract：:To assess the effects of chlordiazepoxide (CDP) on a stable discrimination performance, eight rats were trained on a simple brightness discrimination and injected with three dosages (0, 5, and 10 mg/kg) once performance was stable. Signal detection analysis of the results was used to differentiate sensory from motor/r...

journal_title：Psychopharmacology

authors： Francis RL,Cooper SJ

更新日期：1979-06-21 00:00:00

abstract：RATIONALE:Several halogenated analogs of benztropine (BZT) have previously been characterized as potent DA uptake inhibitors with behavioral profiles that indicate diminished psychomotor stimulant effects relative to cocaine. In a previous study using a fixed-ratio 10 schedule, two chloro-analogs (3'-Cl-BZT and 4'-Cl-B...

journal_title：Psychopharmacology

authors： Woolverton WL,Hecht GS,Agoston GE,Katz JL,Newman AH

更新日期：2001-04-01 00:00:00

abstract：RATIONALE:3,4-Methylenedioxymethamphetamine (MDMA or "ecstasy") causes serotonin neuron damage in laboratory animals. The serotonin system is known to be important in the regulation of mood. Previous research has shown that MDMA users score higher on self-report ratings of depression than controls. However, MDMA users ...

journal_title：Psychopharmacology

authors： Roiser JP,Sahakian BJ

更新日期：2004-05-01 00:00:00

abstract：RATIONALE:Cocaine dependence is a major health concern and there are no effective pharmacotherapies currently available. Although cocaine is an indirect DA agonist that binds to all three monoamine transporters, there is much evidence implicating a greater role for the dopamine (DAT) than norepinephrine (NET) and serot...

journal_title：Psychopharmacology

authors： Cook CD,Carroll IF,Beardsley PM

更新日期：2001-12-01 00:00:00

abstract：:The present study was undertaken to investigate thoroughly the preclinical psychopharmacological profile of venlafaxine, testing a wide range of doses in animal models indicative of antidepressant-like effects. Venlafaxine was found to be active in mouse forced swimming test (at 8, 16, 32 and 64 mg/kg) and to increase...

journal_title：Psychopharmacology

authors： Redrobe JP,Bourin M,Colombel MC,Baker GB

更新日期：1998-07-01 00:00:00

abstract：:The effect of the dopamine receptor antagonist haloperidol on the development of sensitization to ethanol-induced increases in locomotor activity was examined in DBA/2J mice. In Experiment 1, different groups of mice were given saline or ethanol (2 g/kg) immediately before each of four locomotor activity sessions (48-...

journal_title：Psychopharmacology

authors： Broadbent J,Grahame NJ,Cunningham CL

更新日期：1995-08-01 00:00:00

abstract：:Recent studies indicate that morphine dependence, assessed as the severity of naloxone-precipitated opiate withdrawal in rats, is attenuated by dizocipline, a non-competitive, excitatory amino acid antagonist. Because ethanol is a putative excitatory amino acid antagonist, the present study compared the effects of co-...

journal_title：Psychopharmacology

authors： Shoemaker WJ,Kosten TA,Muly SM

更新日期：1997-11-01 00:00:00

abstract：RATIONALE:The α7 nicotinic acetylcholine receptor (nAChR) has been implicated as a target in modulating nicotine reward. However, the effect of pharmacological agents that have been shown to alter the channel properties of the α7 nAChR is not well understood in nicotine reward. OBJECTIVES:This study aimed to investiga...

journal_title：Psychopharmacology

authors： Jackson A,Alkhlaif Y,Papke RL,Brunzell DH,Damaj MI

更新日期：2019-12-01 00:00:00

abstract：:Abnormal beta-adrenergic receptor (betaAR) density in the brains of suicide victims has been reported, although results of studies are inconsistent. Ethanol modifies betaAR-mediated signal transduction. Moreover abnormal betaAR function has been implicated in alcoholism. BetaAR antagonists, which were used as ligands ...

journal_title：Psychopharmacology

authors： Gurguis GN,Turkka J,Laruelle M,Kleinman J,Linnoila M

更新日期：1999-07-01 00:00:00

abstract：:The effects of pindolol on the prolactin (PRL) and growth hormone (GH) responses to intravenous tryptophan (LTP) were studied in eight healthy male volunteers. Pindolol pretreatment (40 mg over 48 h) markedly attenuated the GH response to LTP and modestly, but significantly, reduced the LTP-induced increase in plasma ...

journal_title：Psychopharmacology

authors： Smith CE,Ware CJ,Cowen PJ

更新日期：1991-01-01 00:00:00

abstract：RATIONALE:Previous behavioral and biochemical studies suggest that allosteric coupling processes initiated by benzodiazepines, barbiturates and neuroactive steroids can be sub-categorized on the basis of their sensitivities to antagonism by increased atmospheric pressure. However, biochemical evidence supporting this h...

journal_title：Psychopharmacology

authors： Davies DL,McCauley LD,Bolger MB,Alkana RL

更新日期：2001-10-01 00:00:00

abstract：INTRODUCTION:Model psychosis is characterised by experimentally induced symptoms of withdrawal from reality, frequently accompanied by perceptual disturbances, thought disorders, delusional ideas and sometimes by hallucinations. These "altered states of consciousness" provide a long-standing and valid approach to enhan...

journal_title：Psychopharmacology

authors： Koethe D,Hoyer C,Leweke FM

更新日期：2009-11-01 00:00:00