Differential effects on naloxone against the diazepam-induced release of behavior in rats in three aversive situations.

abstract：:In order to assess the contribution of cerebellar effects of ethanol to the production of ataxia, "nervous" (nr/nr) and control (nr/+ or +/+) C3H mice were tested for locomotor ability 2 min after being given intraperitoneal ethanol injections. The nr/nr mice suffer from loss of most of their cerebellar Purkinje cells...

journal_title：Psychopharmacology

authors： Northup LR

更新日期：1976-07-28 00:00:00

abstract：:The phase of highly focused, repetitive behavior (stereotypy) induced by amphetamine in rats emerges after an initial period of locomotor activation. To assess the neuronal correlates of this behavioral transition, single-unit activity was recorded from the dorsal striatum of awake, unrestrained rats. Units were first...

journal_title：Psychopharmacology

authors： Rebec GV,White IM,Puotz JK

更新日期：1997-04-01 00:00:00

abstract：:On the heels of clozapine, we now have a number of newer agents (risperidone, olanzapine, quetiapine, sertindole, and ziprasidone). Are they all the same? What are the differences? How do we best understand them? In this article we review current clinical evidence to compare these issues on four measures of atypicalit...

journal_title：Psychopharmacology

authors： Remington G,Kapur S

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVES:Previous studies have investigated the occupancy of the serotonin reuptake transporter (SERT) after clinical doses of citalopram and other selective serotonin reuptake inhibitors. In the present study, the occupancies of SERT after multiple doses of escitalopram and citalopram were compared using the radioli...

journal_title：Psychopharmacology

authors： Klein N,Sacher J,Geiss-Granadia T,Mossaheb N,Attarbaschi T,Lanzenberger R,Spindelegger C,Holik A,Asenbaum S,Dudczak R,Tauscher J,Kasper S

更新日期：2007-04-01 00:00:00

abstract：RATIONALE:Alcohol intoxication can dampen negative affective reactions to stressors. Recently, it has been proposed that these acute anxiolytic effects of alcohol may extend to dampening of negative affective reactions to error commission during cognitive control tasks. Nonetheless, empirical verification of this claim...

journal_title：Psychopharmacology

authors： Cofresí RU,Bartholow BD

更新日期：2020-11-01 00:00:00

abstract：:Cocaine and amphetamine produce several behavioral effects, most notably locomotor stimulation. Biochemically, evidence suggests specific involvement of dopaminergic systems, although not necessarily identical sites, in mediating cocaine- and amphetamine-induced locomotor stimulation. This study examined the effects o...

journal_title：Psychopharmacology

authors： George FR,Porrino LJ,Ritz MC,Goldberg SR

更新日期：1991-01-01 00:00:00

abstract：RATIONALE:Coping styles are fundamental characteristics of behavior that affect susceptibility to, and resilience during, mental and physical illness. Shifts from passive to active coping are considered therapeutic goals in many stress-related disorders, but the neural control of coping is poorly understood. Based on e...

journal_title：Psychopharmacology

authors： Haller J,Goldberg SR,Pelczer KG,Aliczki M,Panlilio LV

更新日期：2013-12-01 00:00:00

abstract：:Rat open field behavior is often used as a tool to study the behavioral effects of drugs. In this report, drug-induced patterns of locomotion in an open field were studied with the aid of a simple new statistic. Briefly, the animal's path through the open field is converted into a series of trips. Gamma (gamma) estima...

journal_title：Psychopharmacology

authors： Mueller K,Hollingsworth EM,Cross DR

更新日期：1989-01-01 00:00:00

abstract：:Seven neuroleptic-free schizophrenic patients received bromocriptine and eight schizophrenic patients received CF 25-397, both ergot derivatives with dopamine agonist activity. Psychosis failed to improve in response to either drug at the relatively low doses administered. Unlike the antipsychotic property of apomorph...

journal_title：Psychopharmacology

authors： Tamminga CA,Schaffer MH

更新日期：1979-01-01 00:00:00

abstract：RATIONALE:Previous observations revealed that defeated and subsequently individually housed rats do not display behavioral anticipatory responses to the conditioned presentation of a bell/light stimulus associated with free access to a 5% sucrose solution reward. The absence of the appetitive responses suggests a decre...

journal_title：Psychopharmacology

authors： Von Frijtag JC,Van den Bos R,Spruijt BM

更新日期：2002-07-01 00:00:00

abstract：RATIONALE:Results from clinical studies have shown that topiramate effectively reduces alcohol consumption in a population of heavy-drinking alcohol-dependent humans. OBJECTIVES:We undertook this preclinical study in order to establish topiramate's efficacy in a rodent model and to determine whether topiramate's effic...

journal_title：Psychopharmacology

authors： Breslin FJ,Johnson BA,Lynch WJ

更新日期：2010-01-01 00:00:00

abstract：:Serotonin(5-HT)-stimulated intracellular calcium(Ca) mobilization was measured in the platelets of depressed patients to assess 5-HT2 receptor function. The 5-HT-induced Ca response was significantly higher in unmedicated patients with bipolar depression and melancholic major depression than in those with non-melancho...

journal_title：Psychopharmacology

authors： Kusumi I,Koyama T,Yamashita I

更新日期：1994-01-01 00:00:00

abstract：RATIONALE:Recent studies have shown that pharmacological inhibition of the 12-lipoxygenase pathway selectively blocks opioid inhibition of GABAergic synaptic currents. A similar mechanism has been shown for the regulation of glutamate release in the ventral tegmental area (VTA) during acute withdrawal from morphine, al...

journal_title：Psychopharmacology

authors： Walters CL,Wang BC,Godfrey M,Sun D,Funk CD,Blendy JA

更新日期：2003-11-01 00:00:00

abstract：:The effects of acute marijuana intoxication on remote memory and new learning were assessed. To test for the effects of marijuana on remote memory, titles of one-season television shows, aired up to 14 years previously, were used in three tests measuring recognition, temporal judgement and detailed recall of facts fro...

journal_title：Psychopharmacology

authors： Wetzel CD,Janowsky DS,Clopton PL

更新日期：1982-01-01 00:00:00

abstract：RATIONALE:Individual differences in the rate of nicotine metabolism (RNM) could be related to dependence and success in stopping smoking. A range of studies have examined RNM measured by the ratio of trans-3'-hydroxycotinine and cotinine in body fluids (the ratio). A systematic review of this literature is needed to dr...

journal_title：Psychopharmacology

authors： West O,Hajek P,McRobbie H

更新日期：2011-11-01 00:00:00

abstract：RATIONALE:2-Bromoterguride, a dopamine D2 receptor partial agonist with antagonist properties at serotonin 5-HT2A receptors and α2C-adrenoceptors, meets the prerequisites of a putative atypical antipsychotic drug (APD). We recently showed that 2-bromoterguride is effective in tests of positive symptoms of schizophrenia...

journal_title：Psychopharmacology

authors： Tarland E,Franke RT,Fink H,Pertz HH,Brosda J

更新日期：2018-01-01 00:00:00

abstract：RATIONALE:Certain disorders, such as depression and anxiety, to which serotonin dysfunction is historically associated, are also associated with lower assessments of other people's trustworthiness. Serotonergic changes are known to alter cognitive responses to threatening stimuli. This effect may manifest socially as r...

journal_title：Psychopharmacology

authors： Simonsen A,Scheel-Krüger J,Jensen M,Roepstorff A,Møller A,Frith CD,Campbell-Meiklejohn D

更新日期：2014-07-01 00:00:00

abstract：RATIONALE:Evidence that alcohol leads to increased aggressive behaviour is equivocal and confounded by evidence that such effects may operate indirectly via expectancy. One mechanism by which alcohol consumption may increase aggressive behaviour is via alterations in the processing of emotional facial cues. OBJECTIVES...

journal_title：Psychopharmacology

authors： Attwood AS,Ataya AF,Benton CP,Penton-Voak IS,Munafò MR

更新日期：2009-06-01 00:00:00

abstract：:The present study was conducted to determine whether methadone maintenance alters the pharmacodynamic effects of single doses of cocaine. Twenty-two current users of IV cocaine who were not seeking treatment for their illicit cocaine use participated while living on a research unit. Eleven were maintained on methadone...

journal_title：Psychopharmacology

authors： Preston KL,Sullivan JT,Strain EC,Bigelow GE

更新日期：1996-01-01 00:00:00

abstract：RATIONALE:Oleoyl glycine (OlGly), a recently discovered fatty acid amide that is structurally similar to N- acylethanolamines, which include the endocannabinoid, anandamide (AEA), as well as endogenous peroxisome proliferator-activated receptor alpha (PPARα) agonists oleoylethanolamide (OEA) and palmitoylethanolamide (...

journal_title：Psychopharmacology

authors： Petrie GN,Wills KL,Piscitelli F,Smoum R,Limebeer CL,Rock EM,Humphrey AE,Sheppard-Perkins M,Lichtman AH,Mechoulam R,Di Marzo V,Parker LA

更新日期：2019-09-01 00:00:00

abstract：:Phencyclidine (PCP) and sigma ligands produce a typical excitatory behaviour in rats, characterized by circling and head- and body-weaving. Excitatory amino acid antagonists such as 2-amino 5-phosphonovaleric acid (AP5) or 3-(+/-)-2-carboxypiperazin-4-yl)propyl-l-phosphonic acid (CPP) also produce a PCP-like excitator...

journal_title：Psychopharmacology

authors： Sagratella S,Scotti de Carolis A,Pèzzola A,Popoli P

更新日期：1991-01-01 00:00:00

abstract：RATIONALE:Considerable evidence suggests that genetic factors combine with environmental influences to impact on the development of aggressive behavior. A genetic variant that has repeatedly been reported to render individuals more sensitive to the presence of adverse experiences, including stress exposure during fetal...

journal_title：Psychopharmacology

authors： Buchmann AF,Zohsel K,Blomeyer D,Hohm E,Hohmann S,Jennen-Steinmetz C,Treutlein J,Becker K,Banaschewski T,Schmidt MH,Esser G,Brandeis D,Poustka L,Zimmermann US,Laucht M

更新日期：2014-08-01 00:00:00

abstract：RATIONALE:Brain reward pathways implicated in addiction appear to be less reactive in regular drug users; behavioural manifestations may include decreased sensitivity to natural reinforcers. OBJECTIVES:This study aimed to replicate earlier findings of abstinence-associated incentive motivation deficits in smokers and ...

journal_title：Psychopharmacology

authors： Dawkins L,Powell JH,West R,Powell J,Pickering A

更新日期：2006-12-01 00:00:00

abstract：:The effect of long-term lithium carbonate treatment on parameters of immediate, short-, and long-term memory was examined in a group of bipolar affectively ill patients. The lithium treatment group recalled significantly fewer words across trials on a verbal learning task than a group of bipolar affectively ill patien...

journal_title：Psychopharmacology

authors： Reus VI,Targum SD,Weingartner H,Post RM

更新日期：1979-05-08 00:00:00

abstract：RATIONALE:It has recently been reported that chronic nicotine administration at subconvulsive doses causes seizures, a phenomenon referred to as kindling. Evidence points to the involvement of oxidative stress in pharmacological and electrical kindling, sex is known to influence the brain's response to nicotine. OBJEC...

journal_title：Psychopharmacology

authors： Gomes PX,de Oliveira GV,de Araújo FY,de Barros Viana GS,de Sousa FC,Hyphantis TN,Grunberg NE,Carvalho AF,Macêdo DS

更新日期：2013-01-01 00:00:00

abstract：:Two 2-(di-n-propylamino)tetralin (DPAT) compounds, 8-OH-DPAT and 5-OH-DPAT, with reported effects on central 5-HT and DA receptors respectively, were tested for their effects on the acoustic startle response in rats. 8-OH-DPAT was given in doses of 0.25-2.0 mg/kg IP and 5-OH-DPAT in doses of 1.0-8.0 mg/kg IP. Both com...

journal_title：Psychopharmacology

authors： Svensson L,Ahlenius S

更新日期：1983-01-01 00:00:00

abstract：:Male rats of the Long-Evans strain were divided into two equal groups of nine each and given either 7.0 mg/kg trimethyltin (TMT) or 0.9% saline by intragastric gavage. The pattern of self-selection of alcohol in concentrations of 3%--30% was examined in both groups at 21 and 150 days following the gavage. The TMT-trea...

journal_title：Psychopharmacology

authors： Myers RD,Swartzwelder HS,Dyer RS

更新日期：1982-01-01 00:00:00

abstract：RATIONALE:A recent report described sex differences in the effects of nicotine use and withdrawal on prepulse inhibition of acoustic startle (PPI), but no sex differences in PPI in non-smokers. OBJECTIVE:To determine whether previously reported male>female acoustic PPI reflect sex differences in smoking effects on PPI...

journal_title：Psychopharmacology

authors： Swerdlow NR,Geyer MA,Hartman PL,Sprock J,Auerbach PP,Cadenhead K,Perry W,Braff DL

更新日期：1999-09-01 00:00:00

abstract：RATIONALE:Gonadal steroid hormones altered opioid antinociception under some conditions in rodents, and we reported previously that chronic estradiol enhanced kappa but not mu opioid antinociception in ovariectomized rhesus monkeys. Sex differences have also been observed in the antinociceptive effects of opioid agonis...

journal_title：Psychopharmacology

authors： Negus SS,Mello NK

更新日期：2002-01-01 00:00:00

abstract：:The effects of the CCKB-receptor agonist pentagastrin, a synthetic analogue of the cholecystokinin tetrapeptide (CCK-4), were studied in seven patients suffering from obsessive compulsive disorder (OCD) and seven healthy controls. All subjects were challenged with an IV dose of 0.6 micrograms/kg pentagastrin or placeb...

journal_title：Psychopharmacology

authors： de Leeuw AS,Den Boer JA,Slaap BR,Westenberg HG

更新日期：1996-08-01 00:00:00