Abstract：
:Male rats of the Long-Evans strain were divided into two equal groups of nine each and given either 7.0 mg/kg trimethyltin (TMT) or 0.9% saline by intragastric gavage. The pattern of self-selection of alcohol in concentrations of 3%--30% was examined in both groups at 21 and 150 days following the gavage. The TMT-treated rat consistently drank less alcohol than did the controls at every concentration of alcohol. This difference in alcohol intake was equally significant when the rats were tested in a food-contingent, schedule-induced polydipsia situation. Further, although the TMT-lesioned animal consumed fewer calories per day in the form of alcohol, their overall daily caloric intakes were slightly higher than those of the controls. These results are interpreted as a consequence of damage to structures of the forebrain and as part of a syndrome of behavioral and neurological pathology.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Myers RD,Swartzwelder HS,Dyer RSdoi
10.1007/BF00470580subject
Has Abstractpub_date
1982-01-01 00:00:00pages
19-22issue
1eissn
0033-3158issn
1432-2072journal_volume
78pub_type
杂志文章abstract：RATIONALE:Clinically, nicotine improves attention, but this has proven difficult to demonstrate preclinically. We tested nicotine in Sprague-Dawley (SD) and Lister hooded (LH) rats in the five-choice serial reaction time task. Since SD rats demonstrate lower asymptotic performance than LH rats, we surmised that nicotin...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130000605
更新日期：2001-02-01 00:00:00
abstract：RATIONALE:Understanding the mechanisms responsible for stress-induced relapse is important for guiding treatment strategies aimed at minimizing the contribution of stress to addiction. Evidence suggests that these mechanisms involve interactions between noradrenergic systems and the neuropeptide corticotropin-releasing...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-014-3535-0
更新日期：2014-10-01 00:00:00
abstract：:Four-day-old chicks respond to isolation with distress calling. A decrease in distress calling during isolation seems to reflect some general aspect of depressive syndrome and appears to be sensitive to pharmacological manipulation. Diverse clinically active antidepressants are able to counteract this decrease with hi...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00442235
更新日期：1989-01-01 00:00:00
abstract：:The authors review the literature regarding the pharmacokinetics of long-acting injectable neuroleptic drugs (LINS). There are important differences between LINS and oral neuroleptics that affect their pharmacokinetics. By avoiding first pass metabolism in gut and liver, LINS result in lower circulating concentrations...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/BF00441937
更新日期：1989-01-01 00:00:00
abstract：:A review and meta-analysis by Hamer et al. (2006) showed that a single session of exercise can attenuate post-exercise blood pressure (BP) responses to stress, but no studies examined the effects among smokers or with brisk walking. Healthy volunteers (n=60), averaging 28 years of age and smoking 15 cigarettes daily, ...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-005-0275-1
更新日期：2006-01-01 00:00:00
abstract：RATIONALE:Schizophrenia is a complex psychiatric disorder comprised of three main classes of symptoms: positive, negative and cognitive symptoms. Currently, no approved treatment exists for the cognitive symptoms. There is thus a great need for research aiming at identifying novel targets for treatment of this indicati...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-010-2039-9
更新日期：2011-03-01 00:00:00
abstract：:The acute effect of ethanol upon the NSD (normalized slope descriptors) or Hjorth parameters of EEG were analyzed in 11 students. The maximal blood-alcohol concentration ranged from 1.0--1.7 mg/l. The activity (mean amplitude) increased and the complexity (frequency spread) decreased significantly as a function of tim...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00429184
更新日期：1978-12-15 00:00:00
abstract：:The results confirm that NMDA receptor blockade can result in improved retention performance of mice in step-down passive avoidance. A series of behavioural variations and analyses revealed that memory in the task depended mainly on the appearance of the grid that had been associated with shock, rather than on the exe...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244300
更新日期：1991-01-01 00:00:00
abstract：RATIONALE:Decision-making is a complex cognitive process that is mediated, in part, by subregions of the medial prefrontal cortex (PFC). Decision-making is impaired in a number of psychiatric conditions including schizophrenia. Notably, people with schizophrenia exhibit reductions in GABA function in the same PFC areas...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-014-3816-7
更新日期：2015-05-01 00:00:00
abstract：:The capacity of the specific narcotic antagonists naltrexone and naloxone to block the discriminative effects produced by morphine in the rat were evaluated using a two-choice, discrete-trial avoidance task. The antagonists produced a dose-dependent and time-dependent blockade of morphine's effects as measured by resp...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00430479
更新日期：1976-11-10 00:00:00
abstract：INTRODUCTION:Genetic causes, or predisposition, are increasingly accepted to be part of the ethiopathogenesis of many neuropsychiatric diseases. While genes can be studied in any type of cells, their physiological function in human brain cells is difficult to evaluate, particularly in living subjects. METHODS:As a fir...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-013-3384-2
更新日期：2014-03-01 00:00:00
abstract：RATIONALE:Stress, a powerful precipitant of drug seeking during abstinence, may also accelerate the return to pathological patterns of intake after initial instances of drug reuse. OBJECTIVE:To explore the effect of stress on a learning process underlying relapse, this study assessed the effect of yohimbine on reacqui...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-012-2640-1
更新日期：2012-07-01 00:00:00
abstract：:Nefiracetam is undergoing preclinical and clinical tests as a cognition-enhancing drug in Alzheimer's disease (AD). Nicotinic cholinergic receptors are lost in AD, and nicotinic as well as muscarinic cholinergic receptors are involved in the modulation of eyeblink conditioning. Experiments were carried out using young...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050275
更新日期：1997-05-01 00:00:00
abstract：:Rats were trained in a Y-maze on a two-choice simultaneous black-white discrimination with either black or white as S+. Animals were then transferred to one of three discrimination tasks. In task 1 (New S-), a new stimulus, either vertical or horizontal stripes, was substituted for the original S-. In task 2 (New S+),...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00179945
更新日期：1987-01-01 00:00:00
abstract：:In order to study trends in smoking withdrawal symptoms, 35 participants in a smoking cessation clinic completed four questionnaires daily for 2 weeks. The questionnaire dealt with a variety of symptoms which a factor analysis showed could be grouped into four factors: stimulation, desire to smoke, and physical and ps...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00634151
更新日期：1976-10-20 00:00:00
abstract：:Low doses of 8-OH-DPAT (62.5-250 micrograms/kg) were reinforcing in the place preference conditioning procedure, while a higher dose (1 mg/kg) supported a conditioned place aversion. The 5-HT synthesis inhibitor PCPA, and the DA antagonists pimozide and sulpiride, had no effect when administered alone, but abolished t...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244082
更新日期：1991-01-01 00:00:00
abstract：:Progabide inhibited male rat sexual behavior at a dose of 200 mg/kg. This dose had only modest effects on ambulatory activity and no effect at all on motor coordination as evaluated by a rotarod test. The GABAA antagonist bicuculline, at a dose of 1 mg/kg, blocked the effects of progabide on sex behavior. In contrast,...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050158
更新日期：1997-01-01 00:00:00
abstract：:A paradigm for assessing benzodiazepine receptor sensitivity was developed using intravenous midazolam in normal volunteers. After administration of incremental doses of midazolam, alterations in saccadic eye movement parameters and psychological self ratings were assessed. Significant changes included dose-dependent ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244431
更新日期：1991-01-01 00:00:00
abstract：RATIONALE:Cocaine-seeking behavior can be investigated in rodents using the conditioned place preference (CPP) paradigm, in which the drug-paired environment serves as a conditioned stimulus. Such approach allowed to previously demonstrate the importance of the neuromodulatory sigma1 (sigma1) receptor in acquisition of...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-004-1814-x
更新日期：2004-09-01 00:00:00
abstract：BACKGROUND:Caffeine has a well-established effect on reaction times (RTs) but the neurocognitive mechanisms underlying this are unclear. METHODS:In the present study, 15 female participants performed an oddball task after ingesting caffeine or a placebo, and electroencephalographic data were obtained. Single-trial P3b...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-017-4790-7
更新日期：2018-03-01 00:00:00
abstract：RATIONALE:Dysfunction of executive neuropsychological performance, mediated by the prefrontal cortex, has been the central focus of recent attention deficit/ hyperkinetic disorder (AD-HKD) research. The role of other potential neuropsychological "risk factors", such as recognition memory, remains understudied. Further,...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00213-004-1833-7
更新日期：2004-09-01 00:00:00
abstract：:The tricyclic anticonvulsant carbamazepine (CBZ) is effective in pain and affective disorder, but the mechanism of action for this drug has not been defined. Recently it was reported that CBZ had interaction with adenosine receptor, which is related to the inhibition of release of neurotransmitter. In the present stud...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00179186
更新日期：1986-01-01 00:00:00
abstract：:Continuous low-level (0.825 mg/kg/h for 20 h) administration of AP through SC in-dwelling silicone reservoirs in the rat induced behavioral and biochemical changes that were similar to those induced by low levels (0.1 mg/kg) of acutely administered AP (decreased behavioral activity and decreased dopamine metabolism in...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427314
更新日期：1985-01-01 00:00:00
abstract：:Administration of various doses of 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) to rats produced dose-related decreases in 1-h food intake in the food-deprived paradigm. Pretreatment with spiperone (5-HT1A/5-HT2/D2 antagonist), propranolol or CGP361A (beta-adrenoceptor antagonists that also have binding affinit...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02247721
更新日期：1992-01-01 00:00:00
abstract：:Fifty-nine depressed female inpatients were treated with 100 mg amitriptyline (AMT) IM for 4 weeks. Depression ratings and determinations of the parent drug and nortriptyline (NT) were performed weekly. No direct relationship between plasma AMT + NT concentrations and therapeutic response was apparent, but beneficial ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244602
更新日期：1990-01-01 00:00:00
abstract：RATIONALE:Repeated administrations of ethanol induce a progressive and enduring increase in its locomotor stimulant effects, a phenomenon termed behavioral sensitization that has not been systematically characterized. OBJECTIVE:The aim of the present studies was to characterize the development and expression of ethano...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-008-1266-9
更新日期：2008-12-01 00:00:00
abstract：:Abnormal beta-adrenergic receptor (betaAR) density in the brains of suicide victims has been reported, although results of studies are inconsistent. Ethanol modifies betaAR-mediated signal transduction. Moreover abnormal betaAR function has been implicated in alcoholism. BetaAR antagonists, which were used as ligands ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130051029
更新日期：1999-07-01 00:00:00
abstract：RATIONALE:Buprenorphine is a low-efficacy mu opioid agonist that can reduce drug taking in opioid abusers; however, the mechanism by which buprenorphine modifies the actions of other drug taking and the consequences of repeated treatment with buprenorphine are not fully understood. OBJECTIVE:The purposes of this study...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-001-0943-8
更新日期：2002-03-01 00:00:00
abstract：:The effects of single and long-term haloperidol administration on rat open field behavior was studied. Withdrawal from long-term haloperidol treatment induced a significant increase in all parameters of activity recorded, except rearing. There was a direct relationship between the impairment of motor function induced ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00429212
更新日期：1981-01-01 00:00:00
abstract：RATIONALE:Although the behavioral effects of systemic injection of lipopolysaccharide (LPS) have been extensively investigated, the modulation of these effects by natural environmental factors has received little attention. OBJECTIVES:The present study investigated whether or not locomotor activity reductions and the ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-003-1554-3
更新日期：2003-12-01 00:00:00
