Abstract：
:To test the Pavlovian conditioning model of alcohol tolerance, two groups of eight male social drinkers each received five administrations of alcohol and five administrations of an equal volume of tonic each, on an alternating basis, during the initial 10-session tolerance development phase of the study. Group 1 received alcohol in a "distinct" environment and received tonic in a "home" environment. For group 2, the relationship between environmental cues and substances consumed was reversed. In a subsequent tolerance test session, both groups received alcohol in the distinct environment. When group 2 subjects were tested in this session under cues never before associated with alcohol, they were significantly more impaired on a complex cognitive task than group 1 subjects who expected alcohol; this result was in accord with the classical conditioning model of tolerance. In a final session, both groups received tonic in the distinct environment. As predicted, group 1 exhibited a compensatory enhancement in cognitive performance relative to group 2.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Shapiro AP,Nathan PEdoi
10.1007/BF00310519subject
Has Abstractpub_date
1986-01-01 00:00:00pages
90-5issue
1eissn
0033-3158issn
1432-2072journal_volume
88pub_type
杂志文章abstract：RATIONALE:Acute physical dependence refers to the withdrawal syndrome precipitated by an opioid antagonist administered several hours after either a single dose or a short-term infusion of an opioid agonist. OBJECTIVES:We examined the mechanism of nicotine-induced attenuation of naloxone-precipitated withdrawal syndro...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-003-1595-7
更新日期：2004-02-01 00:00:00
abstract：RATIONALE:3,4-Methylenedioxymethamphetamine (MDMA) produces a long-term depletion of serotonin (5-HT) in the rat brain; this depletion may have some functional consequences. OBJECTIVE:The aim of the present study was to evaluate the acute effects of MDMA on the extracellular concentrations of dopamine and 5-HT, body t...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130051143
更新日期：1999-11-01 00:00:00
abstract：:The title of this article is "Effect of a dual orexin receptor antagonist (DORA-12) on sleep and event-related oscillations in rats exposed to ethanol vapor during adolescence". ...
journal_title：Psychopharmacology
pub_type： 已发布勘误
doi：10.1007/s00213-020-05673-y
更新日期：2020-11-01 00:00:00
abstract：:Lu 25-109 [5-(2-ethyl-2H-tetrazol-5-yl)-1,2,3,6-tetrahydro-1-methylpyridine] , has M agonistic and M2/M3 antagonistic effects at muscarinic receptors in vitro; a pharmacological profile that may be beneficial in treatment of Alzheimer's disease. In the present study, we compare functional in vivo effects of Lu 25-109 ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050615
更新日期：1998-06-01 00:00:00
abstract：:Neither acquisition learning nor 24-h retention was significantly altered by 6-hydroxydopamine intracerebral injections which depleted forebrain noradrenaline (NA) to less than 5% of control values. The absence of passive avoidance impairment cannot be ascribed to functional recovery following the lesion (indicated by...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427627
更新日期：1979-11-01 00:00:00
abstract：:The relationship between norepinephrine (NE) content in cortex and spinal cord and acoustic startle amplitude was investigated in two experiments. Administration of diethyldithiocarbamate (DDC) depressed startle amplitude at the same time and dose that it most severely depleted NE content. These results support the co...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00426383
更新日期：1984-01-01 00:00:00
abstract：:The inferior colliculus is involved in conveying auditory information of an aversive nature to higher cortical structures. Gradual increases in the electrical stimulation of this structure produce progressive aversive responses from vigilance, through freezing, until escape. Recently, we have shown that microinjection...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050900
更新日期：1999-03-01 00:00:00
abstract：RATIONALE:Previous experiments have shown that d-amphetamine disrupts timing behaviour in rats. It has been proposed that d-amphetamine's effects reflect a reduction in the period of the pacemaker of the hypothetical internal clock. However, some studies have obtained conflicting results. OBJECTIVE:To examine the effe...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130000422
更新日期：2000-06-01 00:00:00
abstract：RATIONALE:Schizophrenia is a complex neuropsychiatric disorder characterized, in part, by impaired dopamine signaling. TAK-063 is a selective inhibitor of phosphodiesterase 10A, a key regulator of intracellular signaling pathways that is highly expressed in the striatum. OBJECTIVE:Safety, tolerability, and pharmacokin...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-016-4412-9
更新日期：2016-10-01 00:00:00
abstract：:Rats selectively bred for high alcohol sleep times (HAS) and those that are less affected (LAS) by hypnotic doses (3.0-3.6 g/kg) of ethanol were tested for differential responses to the aversive effects of 1.0 g/kg ethanol in a conditioned place preference task. Likewise, the effects of 0.3-1.0 g/kg ethanol on spontan...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245271
更新日期：1992-01-01 00:00:00
abstract：RATIONALE:Alcohol use disorders are associated with deficits in adaptive behavior. While some behavioral impairments that are associated with alcohol use disorders may predate exposure to drugs of abuse, others may result directly from exposure to drugs of abuse, including alcohol. Identifying a causal role for how alc...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-015-4101-0
更新日期：2016-01-01 00:00:00
abstract：RATIONALE:Kratom is proposed to exhibit therapeutic potential as an opium substitute, but little is known about its dependence-producing profile, particularly of its main psychoactive compound, mitragynine (MG). OBJECTIVES:This study examined the dependence-producing effects of MG using operant-scheduled behaviour in ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-019-05418-6
更新日期：2020-03-01 00:00:00
abstract：RATIONALE:N-methyl-D-aspartate (NMDA) receptors play crucial roles in learning and memory, but the role of each NMDA receptor subtype in a specific cognitive process is unclear. Non-selective blockers of NMDA receptor are used to model the cognitive impairment in schizophrenia and Alzheimer's disease. Counter-intuitive...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-015-4008-9
更新日期：2015-11-01 00:00:00
abstract：:Fourteen rats were trained to discriminate the effects of gamma-hydroxybutyrate (GHB) (sodium salt, 200 mg/kg) and saline in a two-lever choice task using a fixed ratio 10 schedule of water reinforcement. Intermediate responding, i.e., responding not fully appropriate for either training condition was observed in test...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00426468
更新日期：1981-01-01 00:00:00
abstract：:CSF GABA levels were not significantly different in a group of drug-free psychotic patients compared to a group of psychotic patients at two points during haloperidol treatment or a neurological comparison group. In the untreated group, CSF GABA was significantly negatively correlated with clinical ratings of anxiety ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427885
更新日期：1980-01-01 00:00:00
abstract：RATIONALE:Neuromedin-U (NmU) is an agonist at NMU1R and NMU2R. The brain distribution of NmU and its receptors, in particular NMU2R, suggests widespread central roles for NmU. In agreement, centrally administered NmU affects feeding behaviour, energy expenditure and pituitary output. Further central nervous system (CNS...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-004-1918-3
更新日期：2004-12-01 00:00:00
abstract：RATIONALE:The effects of caffeine, especially caffeinated coffee, on human performance have been extensively studied. However, few studies have been naturalistic representations of how tea/coffee is normally consumed in terms of dose and time of consumption. OBJECTIVES:This study investigated the effects of day-long c...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002130000383
更新日期：2000-04-01 00:00:00
abstract：:Four macaques with lesions of dorsolateral frontal cortex and 4 normal monkeys were injected with 1 mg/kg d-amphetamine. Observations of social behaviors and motor activity were conducted over a 1-month period. The results of this experiment show a partial dissociation of effects of amphetamines on behavior of normal ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00428704
更新日期：1976-05-05 00:00:00
abstract：:Normal unoperated rats were tested for rotation (i.e., circling behavior) in a spherical "rotometer" and dose-response relationships were generated using d-amphetamine, apomorphine, L-Dopa, haloperidol, and scopolamine. The rotation induced by amphetamine was significantly antagonized by alpha-methyl-p-tyrosine and ha...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427609
更新日期：1976-06-23 00:00:00
abstract：RATIONALE:Convulsions associated with cocaine toxicity are a serious aspect of cocaine-related emergency room incidents. Seizures can result from a single high dose of cocaine, and evidence is accumulating that correlates repetitive administration of sub-convulsive doses of cocaine with a decreased seizure threshold, a...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050027
更新日期：2000-01-01 00:00:00
abstract：RATIONALE:Ecstasy is a commonly used psychoactive drug with 3,4-methylenedioxymethamphetamine (MDMA) as the main content. Importantly, it has been suggested that use of MDMA may be neurotoxic particularly for serotonergic (5-hydroxytryptamine (5-HT)) neurons. In the past decades, several molecular imaging studies exami...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-016-4396-5
更新日期：2016-10-01 00:00:00
abstract：:N-Methyl-D-aspartate (NMDA) antagonists induce psychotomimetic effects in humans that closely resemble negative and cognitive symptoms of schizophrenia. NMDA agonists, in contrast, may significantly ameliorate such symptoms. In rodents, phencyclidine (PCP) and other NMDA antagonists induce a hyperlocomotory syndrome t...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050168
更新日期：1997-01-01 00:00:00
abstract：:The effects of ibogaine (40 and 80 mg/kg, i.p.), an indole alkaloid proposed for the treatment of drug abuse, were determined in three different groups of rats responding under an FR10 schedule of food, cocaine or heroin reinforcement. Ibogaine (80 mg/kg, i.p.) given 60 min before the start of the session resulted in ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02246099
更新日期：1995-02-01 00:00:00
abstract：:The effects of pindolol on the prolactin (PRL) and growth hormone (GH) responses to intravenous tryptophan (LTP) were studied in eight healthy male volunteers. Pindolol pretreatment (40 mg over 48 h) markedly attenuated the GH response to LTP and modestly, but significantly, reduced the LTP-induced increase in plasma ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244090
更新日期：1991-01-01 00:00:00
abstract：RATIONALE:Stressful life events are suggested to contribute to the development of various pathologies, such as cardiovascular disorders, whose etiopathogenesis is highly associated with elevated levels of serum amyloid A (SAA) proteins. SAA synthesis in the liver is regulated by a complex network of cytokines acting in...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-018-5149-4
更新日期：2019-06-01 00:00:00
abstract：:The alcohol-preferring AA rats have previously been shown to drink more solution containing the opioid etonitazene than the alcohol-avoiding ANA rats. The present experiments were initiated to see whether the line difference in opioid and alcohol intake would persist if an intravenous (i.v.) route of self-administrati...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02247335
更新日期：1996-06-01 00:00:00
abstract：RATIONALE:We recently demonstrated that blocking specific nicotinic acetylcholine receptors (nAChRs) abolishes the conditioned reinforcing properties of ethanol-associated cues in rat, suggesting nAChRs as promising pharmacological targets for prevention of cue-induced relapse. OBJECTIVES:The present study investigate...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-010-1957-x
更新日期：2010-10-01 00:00:00
abstract：RATIONALE:Alzheimer's disease (AD) is characterized by memory loss and synaptic damage. Previous studies suggested that xanthoceraside decreases glutamate-induced PC12 cell death, ameliorates memory deficits, and increases the number of dendritic spines in AD mice. These results indicated that xanthoceraside might have...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-017-4775-6
更新日期：2018-01-01 00:00:00
abstract：:The place-preference paradigm was evaluated as a measure of morphine's positive reinforcing properties. Previous place-preference studies obtained a morphine place preference of 26%-63%. In order to examine whether differences in procedure may account for this scatter, the present experiment investigated whether there...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00432040
更新日期：1984-01-01 00:00:00
abstract：RATIONALE:A sensitized dopamine system may be linked to the genesis of psychotic symptoms in schizophrenia. Following withdrawal from amphetamine exposures, psychotic-like traits have been robustly demonstrated, but the presence of cognitive/mnemonic deficits remains uncertain. METHODS:Adult male Lewis and Fischer rat...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-009-1514-7
更新日期：2009-11-01 00:00:00
