Abstract:
RATIONALE:Acute physical dependence refers to the withdrawal syndrome precipitated by an opioid antagonist administered several hours after either a single dose or a short-term infusion of an opioid agonist. OBJECTIVES:We examined the mechanism of nicotine-induced attenuation of naloxone-precipitated withdrawal syndrome when used to produce an aversive motivational state in a place-conditioning paradigm. METHODS:The effect of nicotine was investigated through place aversion induced by naloxone in morphine-pretreated rats. Additionally, the mechanism of nicotine action in this model was explored specifically in relation to the dopaminergic system through the use of dopamine receptor antagonist and agonist. RESULTS:Place avoidance behavior was potently elicited by naloxone (0.5 mg/kg s.c.) 24 h after a single exposure to morphine (10 mg/kg s.c.). Avoidance behavior was attenuated by pretreatment with a 0.2-mg/kg dose of nicotine 15 min prior to naloxone administration. The effect of nicotine was completely blocked by mecamylamine, but not hexamethonium. The dopamine receptor antagonists haloperidol (0.05, 0.1 mg/kg, s.c.), SCH23390 (0.1 mg/kg, s.c.), raclopride (1.0 mg/kg, s.c.) and eticlopride (0.1 mg/kg, s.c.) showed effects similar to mecamylamine. Additionally, the dopamine receptor agonist apomorphine (0.03, 0.1, 0.3 mg/kg, s.c.) inhibited naloxone-induced place aversion in morphine-treated rats. CONCLUSION:The inhibitory effect of nicotine on place aversion induced by naloxone-precipitated morphine withdrawal may involve a dopaminergic portion of the central nervous system.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Araki H,Kawakami KY,Jin C,Suemaru K,Kitamura Y,Nagata M,Futagami K,Shibata K,Kawasaki H,Gomita Ydoi
10.1007/s00213-003-1595-7subject
Has Abstractpub_date
2004-02-01 00:00:00pages
398-404issue
4eissn
0033-3158issn
1432-2072journal_volume
171pub_type
杂志文章abstract::The present studies were undertaken to investigate the neuroactive steroidal modulation of feeding behavior and possible involvement of gamma-aminobutyric acid type-A (GABA-A) and mitochondrial diazepam binding inhibitor (DBI) receptors (MDR) in food-deprived male mice. Allopregnanolone (0.5-2 mg/kg), a neurosteroid, ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050635
更新日期:1998-06-01 00:00:00
abstract::Different venlafaxine doses (1, 5, and 10 mg/kg) and saline solution were administered to ten male Wistar rats (Latin-Square design). Compared with saline, venlafaxine produced a dose-related suppression of REM sleep and an increase in wake time while slow wave sleep was reduced. This effect is similar to the one that...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050194
更新日期:1997-02-01 00:00:00
abstract:RATIONALE:Results from clinical studies have shown that topiramate effectively reduces alcohol consumption in a population of heavy-drinking alcohol-dependent humans. OBJECTIVES:We undertook this preclinical study in order to establish topiramate's efficacy in a rodent model and to determine whether topiramate's effic...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-009-1683-4
更新日期:2010-01-01 00:00:00
abstract:RATIONALE:Quitting smoking is often very challenging, leading to frequent relapse. Exposure to acute and chronic stress during abstinence increases the likelihood of relapse to smoking. In rodents, stress acutely reinstates nicotine seeking after extinction of nicotine self-administration (SA). However, whether reacqui...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3501-x
更新日期:2014-08-01 00:00:00
abstract:RATIONALE:Indirect-acting serotonin (5-HT) receptor agonists can enhance the antinociceptive effects of morphine; however, the specific 5-HT receptor subtype(s) mediating this enhancement is not established. OBJECTIVE:This study examined interactions between morphine and both 5-HT(1A) and 5-HT(2A) receptor agonists in...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-012-2870-2
更新日期:2013-02-01 00:00:00
abstract:RATIONALE:Pindolol has been reported to shorten the onset of antidepressant action of selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitors (SSRIs) as well as to increase their efficacy. It has been postulated that pindolol enhances the antidepressant effect of SSRIs by blocking somatodendritic 5-HT1A aut...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000470
更新日期:2000-07-01 00:00:00
abstract::The effects of scopolamine, an anticholinergic drug, of trimipramine, a tricyclic antidepressant with both anticholinergic and sedative properties, of diazepam and a placebo, on explicit memory and repetition priming were assessed using a free-recall task and a word-stem completion task. Forty-eight healthy volunteers...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02244116
更新日期:1990-01-01 00:00:00
abstract:RATIONALE:Accumulating evidence for the presence of GABA(A) ρ receptors within the amygdala which differ from other members of the GABA(A) receptor family in both subunit composition and functional properties has been recently obtained. OBJECTIVES:This work was conducted to study whether GABA(A) ρ receptors may have a...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1973-x
更新日期:2010-12-01 00:00:00
abstract:RATIONALE:Decision-making is a complex cognitive process that is mediated, in part, by subregions of the medial prefrontal cortex (PFC). Decision-making is impaired in a number of psychiatric conditions including schizophrenia. Notably, people with schizophrenia exhibit reductions in GABA function in the same PFC areas...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3816-7
更新日期:2015-05-01 00:00:00
abstract:RATIONALE:It has been suggested that the antipsychotic effect of antipsychotics is mediated by the antagonism of the dopamine D2 receptor in the limbic-cortical regions. Risperidone has an atypical property, but its effect on limbic-cortical regions has not been evaluated. OBJECTIVES:In this study, we examined the rel...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s002130000643
更新日期:2001-02-01 00:00:00
abstract:RATIONALE:Treatment of the most widely abused drugs, nicotine and alcohol, is hampered by high rates of relapse. Varenicline tartrate, an α4β2 nicotinic receptor partial agonist, is currently prescribed as a smoking cessation aid. However, there is emerging evidence that it may also modulate alcohol seeking and cogniti...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2213-8
更新日期:2011-07-01 00:00:00
abstract:RATIONALE:Ecstasy is a commonly used psychoactive drug with 3,4-methylenedioxymethamphetamine (MDMA) as the main content. Importantly, it has been suggested that use of MDMA may be neurotoxic particularly for serotonergic (5-hydroxytryptamine (5-HT)) neurons. In the past decades, several molecular imaging studies exami...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-016-4396-5
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVE:This study aims to conduct an evidence review of the effectiveness, harms, and cost-effectiveness of pharmacogenomics-guided antidepressant treatment for major depressive disorder. METHODS:We searched MEDLINE®, the Cochrane Central Registry of Controlled Trials, and PsycINFO through February 2017. We used pr...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-017-4622-9
更新日期:2017-06-01 00:00:00
abstract:RATIONAL:In recent years, evidence suggests that modafinil may be useful for certain symptom domains of schizophrenia, especially for the negative and cognitive symptoms. However, the results are not consistent. OBJECTIVE:This study was designed to investigate the effect of modafinil added to risperidone in patients w...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-011-2513-z
更新日期:2012-04-01 00:00:00
abstract:RATIONALE:Available neurochemical probes that lower brain dopamine (DA) levels in man are limited by their tolerability and efficacy. For instance, the acute lowering of brain tyrosine is well tolerated, but only modestly lowers brain DA levels. Modification of tyrosine depletion to robustly lower DA levels would provi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-2977-0
更新日期:2013-05-01 00:00:00
abstract:RATIONALE:Selective attention deficit, characterised by the inability to differentiate relevant from irrelevant information, is considered to underlie many cognitive deficits of schizophrenia, and appears to be only marginally responsive to treatment with current antipsychotics. OBJECTIVES:We compared the activity of ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-005-2268-5
更新日期:2005-08-01 00:00:00
abstract::A continuing challenge for preclinical research on anxiolytic drugs is to capture the affective dimension that characterizes anxiety and aggression, either in their adaptive forms or when they become of clinical concern. Experimental protocols for the preclinical study of anxiolytic drugs typically involve the suppres...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/BF02245590
更新日期:1995-09-01 00:00:00
abstract:RATIONALE:Dronabinol (Δ(9)tetrahydrocannabinol) is approved for HIV-related anorexia, yet, little is known about its effects in HIV-positive marijuana smokers. HIV-negative marijuana smokers require higher than recommended dronabinol doses to experience expected effects. OBJECTIVES:Employing a within-subjects, double-...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1995-4
更新日期:2010-12-01 00:00:00
abstract::5-Hydroxytryptamine1A (5-HT1A) receptors have been shown to be suppressed by corticosteroid hormones in a variety of animal experimental paradigms. It has been suggested that this effect may be central to the pathophysiology of severe clinical depressive illness, a condition in which 5-HT1A receptor function is reduce...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002130050711
更新日期:1998-10-01 00:00:00
abstract::The exploratory behavior of pigs was studied in two successive daily 20-mn sessions in a two-compartment box by counting the number of crossings from one compartment to the other and observing the activity patterns. Injection of 1 mg/kg diazepam before the first session increased the number of crossings without affect...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431643
更新日期:1977-03-16 00:00:00
abstract::Cigarette smokers have a wide variety of "tar" and nicotine yields to choose from in the current market, ranging from 0.5 mg "tar" and less than 0.05 mg nicotine to 27 mg "tar" and 1.8 mg nicotine by the Federal Trade Commission (FTC) method. To understand better the relationship between FTC nicotine yields and actual...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02246082
更新日期:1995-11-01 00:00:00
abstract:RATIONALE:Spontaneous fluctuations in the size of the pupil in darkness are a recognized index of sleepiness, and these fluctuations can be quantitatively measured using the pupillographic sleepiness test (PST). The central noradrenergic system is believed to play a role in the maintenance of alertness, and there is ev...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s002130000398
更新日期:2000-05-01 00:00:00
abstract::The purpose of this study was to assess the effects of acute nicotine administration, following a 12-h cigarette deprivation period, using a computerized performance assessment battery (PAB). The PAB was comprised of five tasks which were selected to reflect a variety of complex acquired behaviors, sometimes referred ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00443406
更新日期:1989-01-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Functional (pharmacodynamic) ethanol tolerance can be evidenced within a single session of exposure to ethanol (acute or within-session tolerance), or after repeated ethanol exposures (chronic or between-session tolerance). To investigate whether acute and chronic tolerance to ethanol are inter...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100722
更新日期:2001-06-01 00:00:00
abstract::Experiments assessed the development of tolerance to morphine stimulus control during treatment with selected maintenance doses of morphine. Separate groups of rats were trained to discriminate saline and either 3.2 mg/kg or 5.6 mg/kg morphine under fixed-ratio schedules of food delivery. Dose-response functions for g...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245745
更新日期:1990-01-01 00:00:00
abstract:RATIONALE/OBJECTIVES:Previous research has shown that ecstasy users are impaired in thinking and reasoning. The present study sought to explore the possibility that syllogistic reasoning errors in ecstasy users were due to an inability to construct a model of the premises due to working memory limitations. METHODS:Twe...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-005-0006-7
更新日期:2005-09-01 00:00:00
abstract:RATIONALE:Cocaine (COC), ethanol (EtOH), and methamphetamine (MA) are widely abused substances and share the ability to induce behavioral stimulation in mice and humans. Understanding the biological basis of behavioral stimulation to COC, EtOH, and MA may provide a greater understanding of drug and alcohol abuse. OBJE...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-007-0969-7
更新日期:2008-02-01 00:00:00
abstract::This paper reports the reduction of the concentration of the neuropeptide somatostatin in the CSF of patients with affective illness during treatment with the anticonvulsant carbamazepine. None of the other psychotropic agents used in this study similarly affected CSF somatostatin, although zimelidine appeared to incr...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00428416
更新日期:1985-01-01 00:00:00
abstract::The effects of intra-amygdala injections of corticotropin-releasing factor (CRF) on memory and exploratory behavior in rats were examined in the present study. Rats with chronically implanted cannulae received intra-amygdala injections of vehicle or CRF at a dose of 0.01, 0.1 or 1.0 micrograms, either immediately afte...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00177566
更新日期:1988-01-01 00:00:00
abstract:RATIONALE:Abstinence from drug occurs in human addicts for several reasons, including the avoidance of adverse consequences. OBJECTIVES:To explore a model of drug use in the face of adverse consequences in rats through intermittent punishment of drug seeking and to investigate whether the ability to withhold seeking r...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-007-0805-0
更新日期:2007-09-01 00:00:00