Abstract:
:Neither acquisition learning nor 24-h retention was significantly altered by 6-hydroxydopamine intracerebral injections which depleted forebrain noradrenaline (NA) to less than 5% of control values. The absence of passive avoidance impairment cannot be ascribed to functional recovery following the lesion (indicated by testing 24 h post-operation) and by using the F-344 strain of rat which does not show denervation supersensitivity as measured by NA-sensitive adenylate cyclase. Nonassociative freezing to electric footshock, changed by the injections, resulted in slower acquisition at a footshock level 4 mA, but not at 1 mA.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Mason ST,Fibiger HCdoi
10.1007/BF00427627subject
Has Abstractpub_date
1979-11-01 00:00:00pages
179-82issue
2eissn
0033-3158issn
1432-2072journal_volume
66pub_type
杂志文章abstract::Administration of 10 mg/kg TRH to mice was found to reduce the sleep and hypothermia induced by 4.7 g/kg ethanol. However, TRH did not reduce the sleep of mice that were given gamma-hydroxybutyric acid (GHBA), baclophen, or aminooxyacetic acid (AOAA) in combination with 3 g/kg/ ethanol. TRH also failed to reverse the ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00439101
更新日期:1977-04-29 00:00:00
abstract::Selectively bred FAST mice are highly susceptible, while SLOW mice are less susceptible, to the locomotor stimulant effects of ethanol. Heritability estimates indicate that approximately 15% of the variance in the FAST lines is of additive genetic origin, while low susceptibility is ostensibly nonheritable. Inbreeding...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244259
更新日期:1991-01-01 00:00:00
abstract::The effects of benzodiazepine (triazolam 0.25 and 0.50 mg) on different aspects of cognitive function were assessed. Triazolam impaired free recall and recognition of information presented after drug administration. In contrast to these impairments in explicit memory, a memory function that did not require conscious a...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02245415
更新日期:1992-01-01 00:00:00
abstract::The alcohol-preferring AA rats have previously been shown to drink more solution containing the opioid etonitazene than the alcohol-avoiding ANA rats. The present experiments were initiated to see whether the line difference in opioid and alcohol intake would persist if an intravenous (i.v.) route of self-administrati...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02247335
更新日期:1996-06-01 00:00:00
abstract::Patients who develop persistent parkinsonism while on chronic neuroleptic therapy may be predisposed towards the development of tardive dyskinesia (TD). We investigated this issue in an animal model of TD by examining the association between catalepsy and the syndrome of neuroleptic-induced vacuous chewing movements (...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245832
更新日期:1995-03-01 00:00:00
abstract::EEG measures have been shown to differ in human subjects who are at genetically increased risk for the development of alcoholism. In the present study, EEG was recorded in rats that were selectively bred for alcohol-preferring (P) and nonpreferring (NP) behaviors during an ethanol self-administration paradigm. In this...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244335
更新日期:1993-01-01 00:00:00
abstract::The concentration of kynurenine in plasma from depressed patients and control subjects has been measured using a sensitive and specific method. The levels of kynurenine in the plasma of depressed patients and controls are not significantly different and are not influenced by age or sex. The severity of affective distu...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00426632
更新日期:1978-12-08 00:00:00
abstract::The intensity of the head-twitch response and the 5-hydroxytryptamine (5-HT) syndrome (tremor, fore-paw treading, head-weaving and hind-limb abduction) was measured in male CFLP mice following IP injection of 5 mg/kg 5-methoxy-N,N-dimethyltryptamine (5-MeODMT). The results of separate experiments carried out at 1.5-h ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431714
更新日期:1985-01-01 00:00:00
abstract::Diazepam-sensitive (DS) and -resistant (DR) mice were selectively bred for increased and reduced sensitivity to the ataxic effects of diazepam (40 mg/kg). Other response differences between DS and DR mice may reflect pleiotropic effects of the genes fixed during their selection. These mice were tested for their sensit...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244976
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVE:People with schizophrenia exhibit a high obesity rate. However, little is known about the prevalence of obesity and its relationship with clinical symptoms and metabolic indicators in first-episode drug-naïve (FEDN) schizophrenia. METHODS:Demographic and lipid parameters were gathered from 297 FEDN schizophr...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05727-1
更新日期:2020-11-25 00:00:00
abstract::Serotonin is a neurotransmitter that is widely distributed throughout the central nervous system. The role of serotonin in schizophrenia is still unclear. Postmortem studies of serotonin receptor subtypes in schizophrenia have been inconclusive for the most part. The most promising findings involve a reduction in 5-HT...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/BF02245003
更新日期:1993-01-01 00:00:00
abstract:RATIONALE:The Scheduled High Alcohol Consumption (SHAC) binge drinking model is a simple, partial murine model with which to investigate some of the neurobiological underpinnings of alcoholism. OBJECTIVES:The SHAC model was used to characterize monoamine and amino acid adaptations produced in the nucleus accumbens (NA...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0641-7
更新日期:2007-03-01 00:00:00
abstract::Peripheral administration of the unsulphated cholecystokinin octapeptide (CCK-8us) led to an anxiogenic-like action in the elevated plus-maze model of anxiety in rats. Devazepide and L-365,260 showed potent anxiolytic-like effects at similar doses. The fact that devazepide is 1000 times more potent as a CCK-A receptor...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244646
更新日期:1993-01-01 00:00:00
abstract::Dopaminergic behavioral supersensitivity may be induced by chronic treatment with either dopaminergic agonists or antagonists. We demonstrate that the development of agonist-induced supersensitivity is resistant to chronic lithium exposure. Furthermore, chronic lithium alone enhances the stereotypic response to acute ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427448
更新日期:1984-01-01 00:00:00
abstract:RATIONALE:Animal studies indicate that dopamine pathways in the ventral striatum code for the motivational salience of both rewarding and aversive stimuli, but evidence for this mechanism in humans is less established. We have developed a functional magnetic resonance imaging (fMRI) model which permits examination of t...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-011-2278-4
更新日期:2011-09-01 00:00:00
abstract::There is increasing interest in the potential functional role of the octapeptide angiotensin II (AII) in psychiatric and cognitive disorders. The novel angiotensin II (AII) receptor antagonists, losartan and PD123177, selective for the AT1 and AT2 receptor subtypes respectively, constitute important pharmacological to...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246450
更新日期:1996-08-01 00:00:00
abstract::We investigated the possibility that repeated electrical stimulation of the basolateral amygdala (kindling) would increase punished behavior, a pre-clinical indicator of anti-anxiety activity. Male Sprague-Dawley rats, prepared with electrodes in the left basolateral nucleus and frontal cortex, were trained to bar-pre...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00216053
更新日期:1988-01-01 00:00:00
abstract::Rats were trained to bar-press for intravenous infusions of morphine sulfate during 1-h daily test sessions. Rates of morphine self-administration were enhanced by lesions of the frontal cortex and hippocampus and transiently reduced by lesions of the medial forebrain bundle and medial thalamus. Dose-response studies ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426752
更新日期:1978-05-31 00:00:00
abstract::In the present study we have investigated the effects of diazepam (DZP) (10 mg/kg) treatment of rat dams during different periods of gestation or during lactation on the development and behavior of their offspring. The results show that DZP exposure during different phases of early development has differing effects on...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427422
更新日期:1984-01-01 00:00:00
abstract::Chronic administration of the benzodiazepine (BZ) receptor agonist chlordiazepoxide (CDP) produced tolerance to its motor-impairing effects but little or no tolerance to its hypothermic effects or to its amnesic effects in the radial arm maze. Male Sprague-Dawley rats were pretreated for 14 days with CDP (25 mg/kg, b....
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244749
更新日期:1994-06-01 00:00:00
abstract::In a shuttle-box self-stimulation paradigm, analgesic doses of morphine increase the amount of time a rat leaves rewarding brain stimulation on, without altering average OFF times. This paradigm may serve as a model for the euphoria induced by narcotic drugs and as a useful tool for evaluating the reinforcing effects ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426581
更新日期:1977-11-15 00:00:00
abstract::Acute alcohol administration to rats has in preliminary studies been reported to drastically increase the binding of the benzodiazepine (BZ) receptor antagonist [3H]flumazenil (Ro 15-1788) to central BZ receptors. In the present study the effect of acute alcohol ingestion on the disposition of [11C]flumazenil in the h...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245135
更新日期:1992-01-01 00:00:00
abstract:RATIONALE AND OBJECTIVE:Because of the important role of dopamine in neurotransmission, it would be useful to be able to image brain dopamine receptor-mediated signal transduction in animals and humans. Administering the D1-D2 receptor agonist apomorphine may allow us to do this, as the D2-like receptor is reported to ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1073-3
更新日期:2008-05-01 00:00:00
abstract::An experiment was carried out in the pigeon to assess the effects of sodium amylobarbitone (SAB) on memory, using a delayed pair comparison task. Performance was disrupted at all delays by doses of 10 and 20 mg/kg SAB and it was concluded that this effect was not due to perceptual impairment or stereotyped responding,...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426038
更新日期:1979-03-29 00:00:00
abstract:RATIONALE:Evidences indicate that methylglyoxal, a highly reactive metabolite of hyperglycemia, can enhance protein glycation, oxidative stress, or inflammation. Mangiferin, a polyphenol compound of C-glucoside, has many beneficial biological activities, including anti-inflammation, anti-oxidation, neuroprotection, cog...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-3061-5
更新日期:2013-08-01 00:00:00
abstract::Elderly normal volunteers (N = 12, mean age 70.4 years) were administered placebo or diazepam 2.5, 5, 10 mg in four consecutive sessions separated by at least a 1-week interval. Memory and psychomotor performance and plasma diazepam concentrations were assessed at baseline and at 1 and 3 h following drug administratio...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00555210
更新日期:1984-01-01 00:00:00
abstract:RATIONALE:Like other monoamine releasers such as D-amphetamine, chronic treatment with phenmetrazine can attenuate cocaine self-administration in monkeys. OBJECTIVES:The present studies extended this finding to rodents and to cocaine-primed reinstatement, a putative laboratory animal model of relapse. METHODS:In expe...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-015-3875-4
更新日期:2015-07-01 00:00:00
abstract:INTRODUCTION:The majority of individuals who suffer an episode of depression go on to experience recurrences. We have proposed, based upon the observation that reducing serotonin via acute tryptophan depletion (ATD) is more likely to induce negative mood in recovered depressed individuals than never depressed individua...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-009-1533-4
更新日期:2009-08-01 00:00:00
abstract::The effects of morphine, ketocyclazocine, cyclazocine, and SKF-10,047 were tested alone and in conjunction with naltrexone or naloxone, in rats responding under a multiple fixed-interval 3-min schedule of food presentation. Under this paradigm, electric shock was delivered on a fixed-ratio schedule for responses occur...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00435274
更新日期:1982-01-01 00:00:00
abstract:RATIONALE:Therapeutic efficacy of antidepressant drugs appears to be related to their ability in producing neuroadaptive changes that restore normal brain function. Activity-regulated cytoskeletal associated protein (Arc) is an effector immediate early gene that plays a fundamental role in activity-dependent neural pla...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1276-7
更新日期:2008-12-01 00:00:00