Differential regulation of the behavioral effects of chlordiazepoxide.

abstract：RATIONALE:Acute tryptophan depletion (ATD) transiently lowers central serotonin levels and can induce depressive mood states and cognitive defects. Previous studies have shown that ATD impairs object recognition in rats. OBJECTIVES:As individual differences exist in central serotonin neurotransmission, the impact of A...

journal_title：Psychopharmacology

authors： Olivier JD,Jans LA,Korte-Bouws GA,Korte SM,Deen PM,Cools AR,Ellenbroek BA,Blokland A

更新日期：2008-10-01 00:00:00

abstract：:Chronic treatment (2 weeks) with piracetam (500 mg/kg, once daily PO) elevated m-cholinoceptor density in the frontal cortex of aged (18 months) female mice by about 30-40%, but had no effect on m-cholinoceptor density in the frontal cortex of young (4 weeks) mice. The effect of piracetam on m-cholinoceptor density as...

journal_title：Psychopharmacology

authors： Pilch H,Müller WE

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:The involvement of dopamine neurotransmission in opiate reward remains controversial. OBJECTIVE:To investigate the dopaminergic basis of opiate reward by comparing the effect of systemic injection of the D2/D3 antagonist sulpiride on morphine self-administration (ICSA) into the ventral tegmental area (VTA) o...

journal_title：Psychopharmacology

authors： David V,Durkin TP,Cazala P

更新日期：2002-03-01 00:00:00

abstract：:Corticotropin releasing factor (CRF), a neuropeptide secreted by hypothalamic and extrahypothalamic neurons, is thought to mediate stress-related behaviors. The tension reduction hypothesis suggests that ethanol drinking reduces stress; that drinking is reinforced by this reduced stress; and that the probability of dr...

journal_title：Psychopharmacology

authors： Bell SM,Reynolds JG,Thiele TE,Gan J,Figlewicz DP,Woods SC

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:Emerging data indicate the neuromodulator adenosine may play a role in the therapeutics of schizophrenia. Adenosine A(2A) receptor stimulation exerts a functional antagonism at postsynaptic D(2) receptors. Data from animal models relevant to schizophrenia support a therapeutic effect of modulating adenosiner...

journal_title：Psychopharmacology

authors： Wonodi I,Gopinath HV,Liu J,Adami H,Hong LE,Allen-Emerson R,McMahon RP,Thaker GK

更新日期：2011-11-01 00:00:00

abstract：RATIONALE:Nicotine replacement is commonly used to treat tobacco use in heavy-drinking smokers. However, few studies have examined the effect of nicotine replacement on subjective and physiological responses to alcohol and alcohol drinking behavior. OBJECTIVE:The primary aim of this within-subject, double-blind study ...

journal_title：Psychopharmacology

authors： McKee SA,O'Malley SS,Shi J,Mase T,Krishnan-Sarin S

更新日期：2008-02-01 00:00:00

abstract：:Three recently arrived drug naive Cebus apella monkeys with "spontaneous" stereotyped oral movements were treated with apomorphine and haloperidol using a wide dose range. Low doses of apomorphine (0.05-0.1 mg/kg) suppressed the oral stereotypies without affecting normal behaviour such as grooming and scratching. High...

journal_title：Psychopharmacology

authors： Korsgaard S,Povlsen UJ,Randrup A

更新日期：1985-01-01 00:00:00

abstract：RATIONALE:Central CB1 cannabinoid receptors regulate anxiety-like and appetitive consummatory behaviors. Pharmacological antagonism/inverse-agonism of CB1 receptors increases anxiety and decreases appetitive behaviors; however, neither well-defined dose nor context dependence of these effects has been simultaneously as...

journal_title：Psychopharmacology

authors： Gamble-George JC,Conger JR,Hartley ND,Gupta P,Sumislawski JJ,Patel S

更新日期：2013-08-01 00:00:00

abstract：RATIONALE:Individuals with schizophrenia have high smoking-related morbidity and mortality rates and need powerful and innovative smoking cessation interventions. OBJECTIVES:This proof-of-concept study investigated the feasibility and initial efficacy of combining a contingency management intervention with bupropion t...

journal_title：Psychopharmacology

authors： Tidey JW,Rohsenow DJ,Kaplan GB,Swift RM,Reid N

更新日期：2011-09-01 00:00:00

abstract：:The effect of the intravenous administration of ergot alkaloids on epileptic responses to intermittent photic stimulation )IPS) has been studied in adolescent baboons, Papio papio, from Senegal. Ergocornine, 1--2 mg/kg, produced marked autonomic and behavioural effects, slowed the EEG, and abolished myoclonic response...

journal_title：Psychopharmacology

authors： Anlezark G,Meldrum B

更新日期：1978-04-14 00:00:00

abstract：:The place-preference paradigm was evaluated as a measure of morphine's positive reinforcing properties. Previous place-preference studies obtained a morphine place preference of 26%-63%. In order to examine whether differences in procedure may account for this scatter, the present experiment investigated whether there...

journal_title：Psychopharmacology

authors： Blander A,Hunt T,Blair R,Amit Z

更新日期：1984-01-01 00:00:00

abstract：OBJECTIVE:Recent data suggest that 5-HT7 receptors (5-HT7R) are involved in memory processes and, particularly, those related to novelty-induced arousal, even though this remains so far speculative and controversial. In order to assess the role of 5-HT7R in episodic-like memory, mice were administered 5-carboxamidotryp...

journal_title：Psychopharmacology

authors： Freret T,Paizanis E,Beaudet G,Gusmao-Montaigne A,Nee G,Dauphin F,Bouet V,Boulouard M

更新日期：2014-01-01 00:00:00

abstract：:Diazepam-sensitive (DS) and -resistant (DR) mice were selectively bred for increased and reduced sensitivity to the ataxic effects of diazepam (40 mg/kg). Other response differences between DS and DR mice may reflect pleiotropic effects of the genes fixed during their selection. These mice were tested for their sensit...

journal_title：Psychopharmacology

authors： Phillips TJ,Gallaher EJ

更新日期：1992-01-01 00:00:00

abstract：:Murine neuroblastoma cells (clone N1E-115) possess both high- and low-affinity muscarinic receptors. The low-affinity muscarinic receptor, when stimulated, initiates the formation of cyclic GMP by activating the enzyme guanylate cyclase; whereas stimulation of the high-affinity receptor inhibits prostaglanding E1-medi...

journal_title：Psychopharmacology

authors： Kanba S,Pfenning M,Richelson E

更新日期：1985-01-01 00:00:00

abstract：RATIONALE:Longitudinal, population-based studies can better assess the relationship of ecstasy use with depression. OBJECTIVES:We examined whether change in ecstasy use was associated with change in depressive symptoms/probable depression over a 4-year period, among a large Australian sample. METHODS:The Personality ...

journal_title：Psychopharmacology

authors： George AM,Olesen S,Tait RJ

更新日期：2013-10-01 00:00:00

abstract：RATIONALE:Only a small percentage of individuals seeking treatment for their marijuana use achieves sustained abstinence, suggesting more treatment options are needed. OBJECTIVES:We investigated the effects of baclofen (study 1) and mirtazapine (study 2) in a human laboratory model of marijuana intoxication, withdrawa...

journal_title：Psychopharmacology

authors： Haney M,Hart CL,Vosburg SK,Comer SD,Reed SC,Cooper ZD,Foltin RW

更新日期：2010-08-01 00:00:00

abstract：RATIONALE:Oleoyl glycine (OlGly), a recently discovered fatty acid amide that is structurally similar to N- acylethanolamines, which include the endocannabinoid, anandamide (AEA), as well as endogenous peroxisome proliferator-activated receptor alpha (PPARα) agonists oleoylethanolamide (OEA) and palmitoylethanolamide (...

journal_title：Psychopharmacology

authors： Petrie GN,Wills KL,Piscitelli F,Smoum R,Limebeer CL,Rock EM,Humphrey AE,Sheppard-Perkins M,Lichtman AH,Mechoulam R,Di Marzo V,Parker LA

更新日期：2019-09-01 00:00:00

abstract：RATIONALE:Hypofunction of striatal dopamine neurotransmission, or hypodopaminergia, is a consequence of excessive ethanol use and is hypothesized to be a critical component of alcoholism, driving alcohol intake in an attempt to restore dopamine levels; however, the neurochemical mechanisms involved in these dopaminergi...

journal_title：Psychopharmacology

authors： Siciliano CA,Calipari ES,Yorgason JT,Lovinger DM,Mateo Y,Jimenez VA,Helms CM,Grant KA,Jones SR

更新日期：2016-04-01 00:00:00

abstract：RATIONALE:Clinical data with 3,4-methylenedioxymethamphetamine (MDMA) in post-traumatic stress disorder (PTSD) patients recently stimulated interest on the potential therapeutic use of psychedelics in disorders characterized by maladaptive memories, including substance use disorders (SUD). The rationale for the use of ...

journal_title：Psychopharmacology

authors： Fattore L,Piva A,Zanda MT,Fumagalli G,Chiamulera C

更新日期：2018-02-01 00:00:00

abstract：RATIONALE:Delta-opioid agonists produce a number of behavioral effects, including convulsions, antinociception, locomotor stimulation, and antidepressant-like effects. The development of these compounds as treatments for depression is limited by their convulsive effects. Therefore, determining how to separate the convu...

journal_title：Psychopharmacology

authors： Jutkiewicz EM,Rice KC,Traynor JR,Woods JH

更新日期：2005-11-01 00:00:00

abstract：:The i.v. pentylenetetrazol seizure threshold was increased by 2.5 mg/kg and decreased by 15 mg/kg of a single (+)-amphetamine dose. After 7 consecutive days of amphetamine administration, tolerance developed to the decrease but not to the increase in seizure threshold. At 12--48 h after the last dose of 2.5 mg/kg seiz...

journal_title：Psychopharmacology

authors： Riffee WH,Gerald MC

更新日期：1977-01-31 00:00:00

abstract：:Established social groups of talapoin monkeys show rank-related differences in aggressive, social and sexual behaviours and visual monitoring, as well as in endocrine and monoamine profiles. Here we describe the effects on these variables of an "anxiogenic drug", beta-carboline carboxylic acid ethyl ester (beta-CCE), ...

journal_title：Psychopharmacology

authors： Vellucci SV,Herbert J,Keverne EB

更新日期：1986-01-01 00:00:00

abstract：:Maternal pup searching behaviour of lactating house mice treated with apomorphine, haloperidol or saline was examined on a running board with a central depression as a nest. Pup searching was elicited by artificial ultrasonic stimuli: a female moved out from the nest either towards a 50 kHz tone (key stimulus) which i...

journal_title：Psychopharmacology

authors： Wegener S,Schmidt WJ,Ehret G

更新日期：1988-01-01 00:00:00

abstract：:Food intake of four adult male baboons (Papio c. anubis) was monitored during daily experimental sessions lasting 22 h. Food was available under a two-component operant schedule. Following completion of the first "procurement component" response requirement, access to food, i.e., a meal, became available under the sec...

journal_title：Psychopharmacology

authors： Foltin RW,Fischman MW,Byrne MF

更新日期：1989-01-01 00:00:00

abstract：RATIONALE:A number of studies have indicated a relationship between the intake of palatable foods or fluids and drug self-administration. OBJECTIVES:Two experiments were conducted to determine whether the intake of sucrose or fat was related to subsequent cocaine self-administration. METHODS:In separate groups of rat...

journal_title：Psychopharmacology

authors： Gosnell BA

更新日期：2000-04-01 00:00:00

abstract：RATIONALE:The metabotropic glutamate (mGlu5) receptor subtype 5 antagonist MPEP attenuates self-administration of numerous drugs of abuse. OBJECTIVES:The purpose of the present study was to explore whether MPEP-induced decreases in nicotine and cocaine self-administration reflect attenuation of the reinforcing and inc...

journal_title：Psychopharmacology

authors： Paterson NE,Markou A

更新日期：2005-04-01 00:00:00

abstract：:The problem of the advantage of using nortriptyline (NT) plasma level during treatment for endogenous depression has been approached. In an ordinary psychiatric department, 34 patients had their NT level checked the second week of treatment and their dosage subsequently adjusted, if it was outside the recommended ther...

journal_title：Psychopharmacology

authors： Sørensen B,Kragh-Sørensen P,Larsen NE,Hvidberg EF

更新日期：1978-09-15 00:00:00

abstract：:In the studies reported here, we investigated the effects of nicotine on memory for unrelated word lists. Nicotine was delivered through cigarette smoking, and memory performance was assessed using both intentional and incidental recall tasks, and employing an additional, indirect measure of memory. We report the resu...

journal_title：Psychopharmacology

authors： Rusted J,Graupner L,Warburton D

更新日期：1995-06-01 00:00:00

abstract：:5,7-Dihydroxytryptamine (5,7-DHT) or the vehicle was administered once into both lateral ventricles of the rat. Desmethylimipramine (DMI) was administered IP prior to the intraventricular injection of 5,7-DHT to prevent the destruction of norepinephrine (NE) terminals. Following recovery from surgery, ethanol (5 g/kg,...

journal_title：Psychopharmacology

authors： Lê AD,Khanna JM,Kalant H,LeBlanc AE

更新日期：1980-02-01 00:00:00

abstract：:Two groups of schizophrenic outpatients were treated with perphenazine decanoate (N = 20) and cis(z)-flupentixol decanoate (N = 24) respectively. Every 3 months the dose was gradually reduced until symptoms appeared that were suggestive of a prodromal phase of a psychotic episode. A slightly higher dose was then promp...

journal_title：Psychopharmacology

authors： Kistrup K,Gerlach J,Aaes-Jørgensen T,Larsen NE

更新日期：1991-01-01 00:00:00