Abstract:
RATIONALE:Delta-opioid agonists produce a number of behavioral effects, including convulsions, antinociception, locomotor stimulation, and antidepressant-like effects. The development of these compounds as treatments for depression is limited by their convulsive effects. Therefore, determining how to separate the convulsive and antidepressant-like characteristics of these compounds is essential for their potential clinical use. OBJECTIVE:The present study tests the hypothesis that the rate of delta-opioid agonist administration greatly contributes to the convulsive properties, but not the antidepressant-like effects, of delta-opioid agonists. MATERIALS AND METHODS:The delta-opioid agonist SNC80 (1, 3.2, and 10 mg kg-1 or vehicle) was administered to Sprague-Dawley rats by intravenous infusion over different durations of time (20 s, 20, or 60 min). Convulsions were measured by observation prior to determining antidepressant-like effects in the forced swim test. RESULTS:Slowing the rate of SNC80 administration minimized delta agonist-induced convulsions without altering the effects of SNC80 in the forced swim test. CONCLUSIONS:These data suggest that delta agonist-induced antidepressant properties are independent of convulsive effects, and that it may be possible to eliminate the convulsions produced by delta agonists, further promoting their potential clinical utility.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Jutkiewicz EM,Rice KC,Traynor JR,Woods JHdoi
10.1007/s00213-005-0138-9subject
Has Abstractpub_date
2005-11-01 00:00:00pages
588-96issue
4eissn
0033-3158issn
1432-2072journal_volume
182pub_type
杂志文章abstract::In previous research, sensitization of stereotypy induced by injections of 2.5 mg/kg amphetamine did not interfere with subsequent tolerance development to the hypophagic effect of 2 mg/kg. This study examined the effect of a higher sensitizing dose. Rats given intermittent injections of 5 mg/kg amphetamine and then c...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050788
更新日期:1998-12-01 00:00:00
abstract::The i.v. pentylenetetrazol seizure threshold was increased by 2.5 mg/kg and decreased by 15 mg/kg of a single (+)-amphetamine dose. After 7 consecutive days of amphetamine administration, tolerance developed to the decrease but not to the increase in seizure threshold. At 12--48 h after the last dose of 2.5 mg/kg seiz...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431736
更新日期:1977-01-31 00:00:00
abstract:RATIONALE:Asenapine, a psychopharmacologic agent developed for schizophrenia and bipolar disorder, has higher affinity for 5-HT(2A/C,6,7) and alpha(2) adrenergic receptors than for D(2) receptors. Asenapine exhibits potent antipsychotic-like effects without inducing catalepsy, increases cortical and subcortical dopamin...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1456-5
更新日期:2009-06-01 00:00:00
abstract::Augmentation with low-dose fluvoxamine (50-100 mg/day) to antipsychotic treatment may improve the negative symptoms in schizophrenic patients, but involves a risk of drug-drug interaction. We studied the effects of fluvoxamine on plasma concentrations of haloperidol and reduced haloperidol, and their clinical symptoms...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-003-1567-y
更新日期:2004-01-01 00:00:00
abstract::The development of tolerance to the behavioral and biochemical effects of ethanol was studied. Rats were made tolerant to ethanol by the administration of daily ethanol injections (3 g/kg, IP) for 7 and 28 days. Tolerance developed both to the behavioral (hypothermic, sedative) and biochemical (accumulation of dopamin...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244097
更新日期:1990-01-01 00:00:00
abstract::The administration of trycyclic antidepressants followed by reserpine-like drugs elicits a pattern of stereotyped locomotor activity. Using desmethylimipramine (DMI) followed by tetrabenazine (TBZ), activity could be reliably elicited only in young rats, and only by using very high doses of TBZ. The latency of onset o...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426790
更新日期:1978-06-15 00:00:00
abstract::The ventral tegmental area (VTA) evaluates salience of environmental stimuli and provides dopaminergic innervation to many brain areas affected by acute and chronic ethanol exposure. While primarily associated with rewarding and reinforcing stimuli, recent evidence indicates a role for the VTA in aversion as well. Eth...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-018-4875-y
更新日期:2018-06-01 00:00:00
abstract::NCQ 298 ((S)-3-iodo-N-[(l-ethyl-2-pyrrolidinyl)methyl]-5,6- dimethoxysalicylamide) has an iodine substituent. We have labelled NCQ 298 with 123I and 125I, and used the radioligands as tracers in receptor studies in vitro, in vivo in autoradiography and in SPECT studies on Cynomolgus monkeys. [125I]NCQ 298 bound in vit...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244067
更新日期:1991-01-01 00:00:00
abstract::Red blood cell (RBC) glycine levels were examined in 27 bipolar patients, treated with lithium carbonate for a minimum of 8 months, who were either hypomanic, depressed, or euthymic in their mood. We found no difference in the RBC glycine or in the RBC: plasma glycine ratio between the hypomanic, depressed, or euthymi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00433732
更新日期:1982-01-01 00:00:00
abstract:RATIONALE:The development and validation of animal models of the cognitive impairments of schizophrenia have remained challenging subjects. OBJECTIVE:We review evidence from a series of experiments concerning an animal model that dissociates between the disruption of attentional capacities during acute illness periods...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
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更新日期:2009-01-01 00:00:00
abstract::To confirm the conclusions from a previous study supporting the usefullness of electropupillogram (E.P.G.) in predicting clinical response, data from three separate studies with hyperkinetic and learning disabled (L.D.) children treated with stimulants were surveyed. Change in extent of pupillary contraction (E.C.) af...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00426885
更新日期:1978-04-28 00:00:00
abstract:RATIONALE:Certain disorders, such as depression and anxiety, to which serotonin dysfunction is historically associated, are also associated with lower assessments of other people's trustworthiness. Serotonergic changes are known to alter cognitive responses to threatening stimuli. This effect may manifest socially as r...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-014-3444-2
更新日期:2014-07-01 00:00:00
abstract:RATIONALE:The purpose of the present investigation was to evaluate the effects of the D3 agonist (+/-)-7-hydroxy-dipropylaminotetralin (7-OH-DPAT), various dopamine (DA) agonists and DA antagonists on the antinociceptive effects of mu opioids. METHODS:Antinociception was assessed using a warm-water tail-withdrawal pro...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050999
更新日期:1999-06-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1047-9
更新日期:2002-06-01 00:00:00
abstract:RATIONALE:2-Bromoterguride, a dopamine D2 receptor partial agonist with antagonist properties at serotonin 5-HT2A receptors and α2C-adrenoceptors, meets the prerequisites of a putative atypical antipsychotic drug (APD). We recently showed that 2-bromoterguride is effective in tests of positive symptoms of schizophrenia...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4747-x
更新日期:2018-01-01 00:00:00
abstract::The sensitivity of the dopaminergic hypothalamic pituitary system, as indicated by growth hormone (GH) release after apomorphine (0.5 mg SC), was studied in 11 chronic schizophrenic in-patients under long-term neuroleptic (NL) therapy and after 12 and 30 days' drug withdrawal. GH peak levels after a 12-day drug-free p...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00555228
更新日期:1984-01-01 00:00:00
abstract::The present study was conducted to determine whether methadone maintenance alters the pharmacodynamic effects of single doses of cocaine. Twenty-two current users of IV cocaine who were not seeking treatment for their illicit cocaine use participated while living on a research unit. Eleven were maintained on methadone...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02246276
更新日期:1996-01-01 00:00:00
abstract::Rats that are placed in a novel environment containing a probe will explore the environment and the probe. Exploration of the probe is reduced when the probe is electrified. We here report that chlordiazepoxide blocks this inhibition, and have determined some of the pharmacological features of this new experimental pr...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00178505
更新日期:1986-01-01 00:00:00
abstract:RATIONALE:We previously demonstrated that the addition of the selective norepinephrine reuptake inhibitor reboxetine attenuates olanzapine-induced weight gain. Using the same study sample, we also sought to determine whether reboxetine's weight-attenuating effect was accompanied by a beneficial effect on metabolic and ...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-013-3199-1
更新日期:2013-11-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-5000-y
更新日期:2019-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002130000637
更新日期:2001-03-01 00:00:00
abstract::The purpose of this study was to determine if multiple aspects of drug and food-reinforced behavior could be measured in a single study. Drug or food seeking can be observed under four conditions: 1) internal drug or food cues and external stimulus cues present; self-administration, 2) only internal cues present; prim...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050338
更新日期:1997-08-01 00:00:00
abstract::Bromocriptine (0.5-6.0 mg/day) was administered to seven unmedicated chronic schizophrenic and two schizoaffective patients. Transient slight improvement was noted in four patients and marked improvement in one other. Clinical improvement was associated with nausea and drowsiness. These doses of bromocriptine stimulat...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00439271
更新日期:1983-01-01 00:00:00
abstract::After initial exposure to 80 mg/kg, pigeons trained on a two-key drug discrimination procedure rapidly learned to discriminate 120 mg/kg ethosuximide from saline. When 40-160 mg/kg doses of ethosuximide were administered during generalization tests, the percentage of responses directed to the ethosuximide-appropriate ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00207236
更新日期:1987-01-01 00:00:00
abstract:RATIONALE:Indirect-acting serotonin (5-HT) receptor agonists can enhance the antinociceptive effects of morphine; however, the specific 5-HT receptor subtype(s) mediating this enhancement is not established. OBJECTIVE:This study examined interactions between morphine and both 5-HT(1A) and 5-HT(2A) receptor agonists in...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-012-2870-2
更新日期:2013-02-01 00:00:00
abstract::Two 2-(di-n-propylamino)tetralin (DPAT) compounds, 8-OH-DPAT and 5-OH-DPAT, with reported effects on central 5-HT and DA receptors respectively, were tested for their effects on the acoustic startle response in rats. 8-OH-DPAT was given in doses of 0.25-2.0 mg/kg IP and 5-OH-DPAT in doses of 1.0-8.0 mg/kg IP. Both com...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427793
更新日期:1983-01-01 00:00:00
abstract:RATIONALE:Repeated social stress experiences engender "behavioral sensitization" and may also increase the potential for abuse of psychomotor stimulants, particularly cocaine use during "binges." OBJECTIVE:Experimental protocols were designed to induce behavioral sensitization through exposures to social-defeat stress...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100858
更新日期:2001-12-01 00:00:00
abstract:RATIONALE:Vasopressin (AVP) plays a role in regulating anxiety, which is thought to be partially mediated through the V1a receptor. Recently, JNJ-17308616 was identified as a V1a antagonist. OBJECTIVES:The purpose of this work was to assess V1a receptor affinity and selectivity of JNJ-17308616 and in vivo efficacy in ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1354-x
更新日期:2009-03-01 00:00:00
abstract::Neuroimaging has been identified as a potentially powerful probe for the in vivo study of drug effects on the brain with utility across several phases of drug development spanning preclinical and clinical investigations. Specifically, neuroimaging can provide insight into drug penetration and distribution, target enga...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-015-3968-0
更新日期:2015-11-01 00:00:00
abstract:RATIONALE:An important goal of addiction research is to discover neurobiological markers that could predict the severity of addiction and help to determine appropriate treatment. Brain-derived neurotrophic factor (BDNF) and thiobarbituric acid reactive substances (TBARS) are being related to cerebral plasticity and imp...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3542-1
更新日期:2014-10-01 00:00:00