A reappraisal of the interaction between tricyclic antidepressants and reserpine-like drugs.

abstract：RATIONALE:Combining neuroleptics with 5-HT1A ligands is thought to improve the preclinical profile of neuroleptics and may be of interest in the development of new compounds that have greater therapeutic potential and/or are better tolerated. OBJECTIVE:To examine 1) the ability of 5-HT1A ligands to alter the effects o...

journal_title：Psychopharmacology

authors： Prinssen EP,Kleven MS,Koek W

更新日期：1999-05-01 00:00:00

abstract：RATIONALE:The endocannabinoid system has been implicated in the pathogenesis of major depression (MD) as well as in the mediation of antidepressant drug effects. OBJECTIVES:To analyze CNR1 gene variants in MD and clinical response to citalopram (selective serotonin re-uptake inhibitors [SSRI]). METHODS:The role of CN...

journal_title：Psychopharmacology

authors： Mitjans M,Serretti A,Fabbri C,Gastó C,Catalán R,Fañanás L,Arias B

更新日期：2013-06-01 00:00:00

abstract：RATIONALE:Elevated whole-blood serotonin (5-HT) is a robust biomarker in ~ 30% of patients with autism spectrum disorders, in which repetitive behavior is a core symptom. Furthermore, elevated whole-blood 5-HT has also been described in patients with pediatric obsessive-compulsive disorder. The 5-HT1B receptor is assoc...

journal_title：Psychopharmacology

authors： O'Reilly KC,Connor M,Pierson J,Shuffrey LC,Blakely RD,Ahmari SE,Veenstra-VanderWeele J

更新日期：2021-01-29 00:00:00

abstract：:Doses of eight phenylethylamines were substituted for cocaine on a drug-maintained behavior baseline in baboons. Intravenous infusions of drug were contingent upon completion of 160 lever presses (a 160-response fixed-ratio schedule; FR 160). A 3-h time-out period followed each infusion, permitting a maximum of 8 infu...

journal_title：Psychopharmacology

authors： Griffiths RR,Winger G,Brady JV,Snell JD

更新日期：1976-11-24 00:00:00

abstract：:This study investigated behavioural effects of very potent 5-HT reuptake inhibitors after acute treatment (cianopramine and citalopram), as well as after chronic treatment (cianopramine), in two behavioural models of anxiety: 1) the light/dark choice procedure in mice and 2) the elevated plus-maze test in rats. In add...

journal_title：Psychopharmacology

authors： Griebel G,Moreau JL,Jenck F,Misslin R,Martin JR

更新日期：1994-01-01 00:00:00

abstract：:An experiment was conducted to test whether centrally acting drugs could act as conditioned stimuli (CS) in a classical conditioning paradigm in which electric shock acted as the unconditioned stimulus (US) and suppression of drinking was used as an indicator of a conditioned response (CR). Thirsty rats were allowed t...

journal_title：Psychopharmacology

authors： Overton DA,Shen CF,Tatham TA

更新日期：1993-01-01 00:00:00

abstract：RATIONALE:Neuroanatomical evidence suggests that GABAergic deficits and progressive cortical atrophy occur with schizophrenia. OBJECTIVE:To evaluate the hypothesis that neurodevelopmental deficits affect neurodegeneration occurring with schizophrenia, this study examined a novel animal model for schizophrenia-related ...

journal_title：Psychopharmacology

authors： Abekawa T,Ito K,Nakato Y,Koyama T

更新日期：2011-06-01 00:00:00

abstract：:The intensity of the head-twitch response and the 5-hydroxytryptamine (5-HT) syndrome (tremor, fore-paw treading, head-weaving and hind-limb abduction) was measured in male CFLP mice following IP injection of 5 mg/kg 5-methoxy-N,N-dimethyltryptamine (5-MeODMT). The results of separate experiments carried out at 1.5-h ...

journal_title：Psychopharmacology

authors： Moser PC,Redfern PH

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Several different animal models are currently used to research the neurodegenerative movement disorder Parkinson's disease (PD). RESULTS:Models based on the genetic deficits associated with a small percentage of sufferers demonstrate the pathological accumulation of alpha-synuclein characteristic of the dis...

journal_title：Psychopharmacology

authors： Lane E,Dunnett S

更新日期：2008-08-01 00:00:00

abstract：RATIONALE:The integrity of cortical cholinergic transmission is vital to attentional processing. A growing literature suggests that alterations in attentional processing accompany addictive drug use. This study examined the effects of acute and repeated administration of nicotine on cortical acetylcholine release. OBJ...

journal_title：Psychopharmacology

authors： Arnold HM,Nelson CL,Sarter M,Bruno JP

更新日期：2003-02-01 00:00:00

abstract：:The effects of d-fenfluramine and morphine on various nociceptive responses of rats were investigated. Unlike morphine, which inhibited all the responses examined, d-fenfluramine inhibited jumping and paw licking of rats on a hot plate, but did not increase the latency of tail withdrawal from hot water. The effects of...

journal_title：Psychopharmacology

authors： Rochat C,Cervo L,Romandini S,Samanin R

更新日期：1982-01-01 00:00:00

abstract：:BALB/cJ, DBA/2J, and C57BL/6J mice were injected with caffeine and tested, in the five choice Yerkes-Thompson Bryant-Bovt Nitti apparatus for patterns discrimination, in two sets of experiments. In the first the patterns were opposite oriented oblique bars, in the second U-shaped figures, one opened toward the right, ...

journal_title：Psychopharmacology

authors： Castellano C

更新日期：1977-03-16 00:00:00

abstract：RATIONALE:Repeated high doses of morphine in the rat cause stereotypic gnawing behavior that can be re-expressed by a low dose of morphine weeks and even months after the initial treatment. The determination of the role of serotonin in this sensitized morphine-induced behavior has both empirical and theoretical relevan...

journal_title：Psychopharmacology

authors： Wennemer HK,Kornetsky C

更新日期：1999-09-01 00:00:00

abstract：RATIONALE:The nicotine delivery rate is a key feature of tobacco product design, yet there have been limited human studies examining the effects of nicotine as a function of delivery rate. OBJECTIVE:We developed an intravenous nicotine infusion protocol to evaluate differential effects of nicotine delivery rate on sub...

journal_title：Psychopharmacology

authors： Jensen KP,Valentine G,Gueorguieva R,Sofuoglu M

更新日期：2020-05-01 00:00:00

abstract：RATIONALE:The gut microbiota is increasingly recognized as a potential mediator of psychiatric diseases. Depressed patients have been shown to have a different microbiota composition compared with healthy controls, and several lines of research now aim to restore this dysbiosis. To develop novel treatments, preclinical...

journal_title：Psychopharmacology

authors： Tillmann S,Abildgaard A,Winther G,Wegener G

更新日期：2019-05-01 00:00:00

abstract：:Two groups of socially housed rhesus monkeys were raised under conditions differing in the degree of control or mastery over appetitive stimuli (food, water, and treats) in the 1st year of life. At age 18-24 months, a benzodiazepine receptor inverse agonist, beta-carboline-3-carboxylic acid ethyl ester (beta-CCE), was...

journal_title：Psychopharmacology

authors： Insel TR,Scanlan J,Champoux M,Suomi SJ

更新日期：1988-01-01 00:00:00

abstract：:A two flavour, unbiased, taste preference conditioning procedure was used to test for possible motivating effects of gamma 2-MSH. Three training trials failed to produce any significant effect with doses ranging from 2.4 to 40 micrograms/ICV infusion in drug-naive, non-operated or placebo-implanted rats. However, in r...

journal_title：Psychopharmacology

authors： Mucha RF,van Ree JM

更新日期：1989-01-01 00:00:00

abstract：:Administration of the serotonin (5-HT)1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) facilitates the expression of masculine sexual behavior in male and female rats as well as in male rhesus monkeys and inhibits lordosis behavior in female rats. In the present study the effects of 8-OH-DPAT on ...

journal_title：Psychopharmacology

authors： Paredes RG,Kica E,Baum MJ

更新日期：1994-05-01 00:00:00

abstract：RATIONALE:We test methods to advance (shift earlier) circadian rhythms without producing misalignment between rhythms and sleep. We previously tested (1) a gradually advancing sleep/dark schedule plus morning bright light and afternoon/evening melatonin and (2) the same sleep schedule with only morning bright light. No...

journal_title：Psychopharmacology

authors： Crowley SJ,Eastman CI

更新日期：2013-02-01 00:00:00

abstract：:A group of 14 schizophrenics who remained symptomatic after neuroleptic treatment received either 0.02 mcg/kg CCK-8 or saline placebo intravenously. Thereafter, 13 received the alternative infusion as a crossover treatment. A second group of 16 such patients received 0.04 mcg/kg CCK-8 or saline intravenously and, ther...

journal_title：Psychopharmacology

authors： Peselow E,Angrist B,Sudilovsky A,Corwin J,Siekierski J,Trent F,Rotrosen J

更新日期：1987-01-01 00:00:00

abstract：INTRODUCTION:Model psychosis is characterised by experimentally induced symptoms of withdrawal from reality, frequently accompanied by perceptual disturbances, thought disorders, delusional ideas and sometimes by hallucinations. These "altered states of consciousness" provide a long-standing and valid approach to enhan...

journal_title：Psychopharmacology

authors： Koethe D,Hoyer C,Leweke FM

更新日期：2009-11-01 00:00:00

abstract：:Two experiments were carried out on pigeons to assess the effects of acute ethanol (ETOH) administration on a delayed pair comparison procedure. ETOH disrupted performance at the two higher doses (1.0 and 2.0 g/kg, given orally). When the initial (zero delay) performance levels of treated and untreated birds were equa...

journal_title：Psychopharmacology

authors： Sahgal A,Ekberg SC,Howell SJ,Iversen SD

更新日期：1980-01-01 00:00:00

abstract：:Chronic administration of the pre-synaptic alpha-adrenoreceptor agonist clonidine decreases the concentration of the extra-neuronal metabolite of noradrenaline normetanephrine in the amygdaloid cortex and increases it in the mid-brain. Conversely, blockade of these pre-synaptic receptors by yohimbine increases the nor...

journal_title：Psychopharmacology

authors： Fludder JM,Leonard BE

更新日期：1979-09-01 00:00:00

abstract：:A combined analysis of data from 11 controlled studies of loxapine versus either chlorpromazine or trifluoperazine in acute schizophrenia (5 studies) and chronic schizophrenia (6 studies) showed statistically significant superiority of loxapine on several items and factors of standardized psychiatric rating scales. Up...

journal_title：Psychopharmacology

authors： Bishop MP,Simpson GM,Dunnett CW,Kiltie H

更新日期：1977-01-31 00:00:00

abstract：RATIONALE:Convergent evidence shows that alcohol exerts its effects on social behavior via modulation of amygdala reactivity to affective stimuli. Given that affective processing involves dynamic interactions between the amygdala and the prefrontal cortex (PFC), alcohol's effects are likely to extend beyond regional ch...

journal_title：Psychopharmacology

authors： Gorka SM,Fitzgerald DA,King AC,Phan KL

更新日期：2013-09-01 00:00:00

abstract：:The effect of the intracerebroventricular (ICV) administration of taurine on amnesia, convulsions and death caused by hypoxia was investigated in mice. Taurine in doses of 80-100 micrograms/mouse impaired acquisition of a single trial in passive avoidance performance, but protected mice from the learning impairment in...

journal_title：Psychopharmacology

authors： Malcangio M,Bartolini A,Ghelardini C,Bennardini F,Malmberg-Aiello P,Franconi F,Giotti A

更新日期：1989-01-01 00:00:00

abstract：RATIONALE:There is evidence that events early in post-weaning life influence brain development and subsequent adult behaviour and therefore play an important role in the causation of certain psychiatric disorders in later life. Exposing rodents to stressors during the juvenile period has been suggested as a model of in...

journal_title：Psychopharmacology

authors： Peleg-Raibstein D,Feldon J

更新日期：2011-03-01 00:00:00

abstract：:The present study assessed the discriminative stimulus effects of the delta-opioid agonist [D-Pen2-D-Pen5]enkephalin (DPDPE) in pigeons. Food-restricted pigeons were trained to discriminate between i.c.v injections of 100 micrograms [D-Pen2-D-Pen5]enkephalin (DPDPE) and saline in a two-key operant procedure; acquisiti...

journal_title：Psychopharmacology

authors： Jewett DC,Mosberg HI,Woods JH

更新日期：1996-10-01 00:00:00

abstract：:In rats with unilateral 6-hydroxydopamine (6-OHDA) lesions of the medial forebrain bundle, pretreatment with the D1 DA antagonists, SCH 23390 (7-chloro-8-hydroxy-2,3,4,5-tetrahydro-3-methyl-1-phenyl-1H-3-benzazepin e) and A66359 (1- 2-bromo-4,5-dimethoxybenzyl]-7-hydroxy-6-methoxy-2-methyl- 1,2,3,4 tetrahydroisoquinol...

journal_title：Psychopharmacology

authors： Gnanalingham KK,Hunter AJ,Jenner P,Marsden CD

更新日期：1995-02-01 00:00:00

abstract：RATIONALE:The ability of tobacco harm reduction strategies to produce significant reductions in toxin exposure is limited by compensatory increases in smoking behavior. Characterizing factors contributing to the marked individual variability in compensation may be useful for understanding this phenomenon and assessing ...

journal_title：Psychopharmacology

authors： Harris AC,Pentel PR,LeSage MG

更新日期：2009-09-01 00:00:00