Differences in the effects of d-fenfluramine and morphine on various responses of rats to painful stimuli.

abstract：RATIONALE:It has recently been reported that chronic nicotine administration at subconvulsive doses causes seizures, a phenomenon referred to as kindling. Evidence points to the involvement of oxidative stress in pharmacological and electrical kindling, sex is known to influence the brain's response to nicotine. OBJEC...

journal_title：Psychopharmacology

authors： Gomes PX,de Oliveira GV,de Araújo FY,de Barros Viana GS,de Sousa FC,Hyphantis TN,Grunberg NE,Carvalho AF,Macêdo DS

更新日期：2013-01-01 00:00:00

abstract：:Much of the research implicating learning in the development of tolerance to ethanol-induced impairment has used an experimental design in which different groups receive drug either before or after an opportunity to perform an instrumental or operant task. The stronger tolerance observed in subjects who perform while ...

journal_title：Psychopharmacology

authors： Cunningham CL,Losli SM,Risinger FO

更新日期：1992-01-01 00:00:00

abstract：:Patients taking lithium often report difficulties in concentration, memory, learning, and attention and many of these complaints are verified on psychometric testing. Laboratory tests of cognitive functions in healthy volunteers on chronic lithium demonstrate that disruptions in memory-learning processes are apparent ...

journal_title：Psychopharmacology

authors： Weingartner H,Rudorfer MV,Linnoila M

更新日期：1985-01-01 00:00:00

abstract：:Animals responding for biphasic square wave stimulation to the VTA were treated for 26 days with a low dose (0.07 mg/kg) of the neuroleptic haloperidol and tested at 1 h post-injection. Initially the drug induced a pronounced lateral displacement of the baseline rate-intensity function, concomitant with a depression i...

journal_title：Psychopharmacology

authors： Lynch MR,Carey RJ

更新日期：1990-01-01 00:00:00

abstract：:The cholinergic hypothesis of Alzheimer's disease (AD) has strongly influenced research on learning and memory over the last decade. However, there has been limited success treating AD dementia with cholinomimetics. Furthermore, there are indications that other neurotransmitter systems affected by this disease may be ...

journal_title：Psychopharmacology

authors： Camacho F,Smith CP,Vargas HM,Winslow JT

更新日期：1996-04-01 00:00:00

abstract：RATIONALE:Cocaine dependence is a major health concern and there are no effective pharmacotherapies currently available. Although cocaine is an indirect DA agonist that binds to all three monoamine transporters, there is much evidence implicating a greater role for the dopamine (DAT) than norepinephrine (NET) and serot...

journal_title：Psychopharmacology

authors： Cook CD,Carroll IF,Beardsley PM

更新日期：2001-12-01 00:00:00

abstract：:A theory of acute tolerance to alcohol is proposed that includes two assumptions: 1) acute tolerance is a linear process with time, and 2) the slope of the line is a measure of the magnitude of the acute tolerance effect. Evidence that supports the validity of the theory is presented both from studies in which blood a...

journal_title：Psychopharmacology

authors： Radlow R

更新日期：1994-02-01 00:00:00

abstract：:Parenteral administration of the adenosine deaminase (ADA) inhibitor erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) results in a profound decrease in spontaneous motor activity in mice and rats. The inhibition of cortical ADA activity measured ex vivo parallels the decrease in spontaneous motor activity in a time-depend...

journal_title：Psychopharmacology

authors： Mendelson WB,Kuruvilla A,Watlington T,Goehl K,Paul SM,Skolnick P

更新日期：1983-01-01 00:00:00

abstract：RATIONALE:Typical neuroleptic medications are still administered to as many as 40% of patients receiving antipsychotic treatment in the US. Intermittent administration or interruption of long-term neuroleptic medication for schizophrenia may increase the incidence of human tardive dyskinesias, and similarly may produce...

journal_title：Psychopharmacology

authors： Linn GS,Lifshitz K,O'Keeffe RT,Lee K,Camp-Lifshitz J

更新日期：2001-01-01 00:00:00

abstract：RATIONALE:Successive negative contrast (SNC) describes a change in the behaviour of an animal following a downshift in the quantitative or qualitative value of an expected reward. This behavioural response has been hypothesised to be linked to affective state, with negative states associated with larger and/or prolonge...

journal_title：Psychopharmacology

authors： Phelps CE,Mitchell EN,Nutt DJ,Marston HM,Robinson ES

更新日期：2015-08-01 00:00:00

abstract：:The capacity of the specific narcotic antagonists naltrexone and naloxone to block the discriminative effects produced by morphine in the rat were evaluated using a two-choice, discrete-trial avoidance task. The antagonists produced a dose-dependent and time-dependent blockade of morphine's effects as measured by resp...

journal_title：Psychopharmacology

authors： Shannon HE,Holtzman SG

更新日期：1976-11-10 00:00:00

abstract：RATIONALE:Recent studies have shown that metabotropic glutamate receptor 5 (mGluR5) can modulate N-methyl-D-aspartate (NMDA) receptor function in vivo. For example, the mGluR5 antagonist, 2-methyl-6-(phenylethynyl)-pyridine (MPEP) can potentiate PCP (phencyclidine)-evoked hyperactivity and PCP-induced disruptions in pr...

journal_title：Psychopharmacology

authors： Campbell UC,Lalwani K,Hernandez L,Kinney GG,Conn PJ,Bristow LJ

更新日期：2004-09-01 00:00:00

abstract：RATIONALE:The ultra-short-acting mu opioid agonist analgesic/anesthetic remifentanil (RMF) is extremely rapidly eliminated from blood (half-life in rats, 0.3-0.7 min). This extremely fast elimination is thought to be the main reason why RMF maintains such high rates of responding in animal operant-conditioning models o...

journal_title：Psychopharmacology

authors： Crespo JA,Sturm K,Saria A,Zernig G

更新日期：2005-12-01 00:00:00

abstract：RATIONALE:Indirect-acting serotonin (5-HT) receptor agonists can enhance the antinociceptive effects of morphine; however, the specific 5-HT receptor subtype(s) mediating this enhancement is not established. OBJECTIVE:This study examined interactions between morphine and both 5-HT(1A) and 5-HT(2A) receptor agonists in...

journal_title：Psychopharmacology

authors： Li JX,Shah AP,Patel SK,Rice KC,France CP

更新日期：2013-02-01 00:00:00

abstract：RATIONALE:Morphine and buprenorphine have analgesic and anxiolytic-like properties. While their analgesic effects have been well characterized, their anxiolytic-like properties have not. OBJECTIVES:Effects of acute morphine and buprenorphine on the expression of acoustic fear-potentiated startle (FPS) and naloxone pre...

journal_title：Psychopharmacology

authors： Glover EM,Davis M

更新日期：2008-06-01 00:00:00

abstract：RATIONALE:Amphetamine administration has been found to affect the degree of cerebral dominance for motor control in animals. In humans, cerebral dopamine neurotransmission is also correlated to motor dominance. Since language dominance is related to motor dominance, amphetamine might also affect cerebral dominance for ...

journal_title：Psychopharmacology

authors： Sommer IE,Oranje B,Ramsey NF,Klerk FA,Mandl RC,Westenberg HG,Kahn RS

更新日期：2006-01-01 00:00:00

abstract：:Several behaviors associated with the serotonin syndrome have been reported in rats following administration of the 5-HT1A receptor agonist 8-OH-DPAT. The present investigation approached this phenomenon from an ethopharmacological perspective, and provided a detailed temporal analysis of the behavioral effects of thi...

journal_title：Psychopharmacology

authors： Blanchard RJ,Shepherd JK,Armstrong J,Tsuda SF,Blanchard DC

更新日期：1993-01-01 00:00:00

abstract：:The results confirm that NMDA receptor blockade can result in improved retention performance of mice in step-down passive avoidance. A series of behavioural variations and analyses revealed that memory in the task depended mainly on the appearance of the grid that had been associated with shock, rather than on the exe...

journal_title：Psychopharmacology

authors： Weiskrantz L,Mondadori C

更新日期：1991-01-01 00:00:00

abstract：:After learning a light-cued, go-no go successive discrimination to criterion, male Sprague-Dawley rats received 0, 5, or 10 mg/kg chlordiazepoxide on six performance sessions, followed by two drug-recovery (saline) sessions. Chlordiazepoxide impaired discrimination performance in a dose-dependent manner, with animals ...

journal_title：Psychopharmacology

authors： Cole SO,Michaleski A

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:The exact behavioral nature of drug-induced reinstatement of drug seeking is still debated. As an incentive, the drug can have general facilitatory influences on appetitive behaviors. As an interoceptive stimulus, the drug can acquire discriminative properties and control behavior. OBJECTIVE:This study asses...

journal_title：Psychopharmacology

authors： Keiflin R,Isingrini E,Cador M

更新日期：2008-05-01 00:00:00

abstract：RATIONALE:Previous behavioral and biochemical studies suggest that allosteric coupling processes initiated by benzodiazepines, barbiturates and neuroactive steroids can be sub-categorized on the basis of their sensitivities to antagonism by increased atmospheric pressure. However, biochemical evidence supporting this h...

journal_title：Psychopharmacology

authors： Davies DL,McCauley LD,Bolger MB,Alkana RL

更新日期：2001-10-01 00:00:00

abstract：:The effect of the dopamine receptor antagonist haloperidol on the development of sensitization to ethanol-induced increases in locomotor activity was examined in DBA/2J mice. In Experiment 1, different groups of mice were given saline or ethanol (2 g/kg) immediately before each of four locomotor activity sessions (48-...

journal_title：Psychopharmacology

authors： Broadbent J,Grahame NJ,Cunningham CL

更新日期：1995-08-01 00:00:00

abstract：:The present study was undertaken to investigate thoroughly the preclinical psychopharmacological profile of venlafaxine, testing a wide range of doses in animal models indicative of antidepressant-like effects. Venlafaxine was found to be active in mouse forced swimming test (at 8, 16, 32 and 64 mg/kg) and to increase...

journal_title：Psychopharmacology

authors： Redrobe JP,Bourin M,Colombel MC,Baker GB

更新日期：1998-07-01 00:00:00

abstract：:The effects of benzodiazepine (BZ) antagonists on operant behavior were examined in rats chronically administered a low dose of diazepam (DZ). The low maintenance dose of DZ (5 mg/kg twice daily) was selected as more closely associated with its anxiolytic effects than the higher treatment doses previously used to stud...

journal_title：Psychopharmacology

authors： Lucki I,Kucharik RF

更新日期：1990-01-01 00:00:00

abstract：RATIONALE:H(3)-receptor inverse agonists raise a great interest as innovative therapeutics in several central disorders. Whereas their procognitive properties are well established, their antipsychotic-like properties are still debated. OBJECTIVES:We further explored the effect of maximal doses (3-10 mg/kg) of ciproxif...

journal_title：Psychopharmacology

authors： Burban A,Sadakhom C,Dumoulin D,Rose C,Le Pen G,Frances H,Arrang JM

更新日期：2010-07-01 00:00:00

abstract：RATIONALE:Although most opioid self-administration research has been conducted with laboratory animals, such research with humans is necessary to answer questions unique to human drug-taking behavior. OBJECTIVE:We investigated the influence of morphine dose and an alternative non-drug reinforcer on choice between morp...

journal_title：Psychopharmacology

authors： Heishman SJ,Schuh KJ,Schuster CR,Henningfield JE,Goldberg SR

更新日期：2000-02-01 00:00:00

abstract：RATIONALE:Depression is a frequent non-motor symptom in Parkinson's disease (PD) with increasing rates with the progression of the disease. Molecular imaging studies have shown a reduction of dopamine transporter (DAT) density in depressed PD patients (dPD); however, DAT role in the pathophysiology of PD depression is ...

journal_title：Psychopharmacology

authors： Felicio AC,Moriyama TS,Godeiro-Junior C,Shih MC,Hoexter MQ,Borges V,Silva SM,Amaro-Junior E,Andrade LA,Ferraz HB,Bressan RA

更新日期：2010-07-01 00:00:00

abstract：:While chronic intermittent administration of stimulants often induces behavioral sensitization in adulthood, stimulant sensitization has rarely been reported prior to weaning [around postnatal day (P) 21]. Consistent pairing of drug administration with the test context often facilitates sensitization in adults, yet yo...

journal_title：Psychopharmacology

authors： Wood RD,Tirelli E,Snyder KJ,Heyser CJ,LaRocca TM,Spear LP

更新日期：1998-07-01 00:00:00

abstract：:The serotonergic agent meta-chlorophenylpiperazine (m-CPP) increases temperature and plasma ACTH and other hormones and decreases social interaction, locomotor activity and food intake in rats, most likely via stimulation of 5-HT2C receptors. Repeated daily administration of m-CPP to rats induces rapid tolerance to th...

journal_title：Psychopharmacology

authors： Benjamin J,Greenberg BD,Murphy DL

更新日期：1996-09-01 00:00:00

abstract：RATIONALE:Synergistic or supra-additive interactions between the anorectics (dex)fenfluramine and phentermine have been reported previously in the rat and in the clinic. Studies with 5-HT2C antagonists and 5-HT2C knockouts have demonstrated dexfenfluramine hypophagia in the rodent to be mediated by actions at the 5-HT2...

journal_title：Psychopharmacology

authors： Grottick AJ,Whelan K,Sanabria EK,Behan DP,Morgan M,Sage C

更新日期：2015-06-01 00:00:00