Differential effects of post-weaning juvenile stress on the behaviour of C57BL/6 mice in adolescence and adulthood.

abstract：RATIONALE:Nicotine and nicotinic agonists have been shown to improve attentional function. Nicotinic receptors are easily desensitized, and all nicotinic agonists are also desensitizing agents. Although both receptor activation and desensitization are components of the mechanism that mediates the overall effects of nic...

journal_title：Psychopharmacology

authors： Rezvani AH,Cauley M,Xiao Y,Kellar KJ,Levin ED

更新日期：2013-03-01 00:00:00

abstract：:In mice, quipazine has shown several behavioral effects: It antagonizes hypothermia induced by a high dose of apomorphine without altering climbing or stereotyped behavior; it antagonizes oxotremorine-induced hypothermia without altering tremors or peripheral signs; and it increases the toxicity of yohimbine. These th...

journal_title：Psychopharmacology

authors： Francès H,Lecrubier Y,Puech AJ,Simon P

更新日期：1980-01-01 00:00:00

abstract：RATIONALE:Drugs that rapidly increase dopamine levels have an increased risk of abuse. Dasotraline (DAS) is a dopamine and norepinephrine reuptake inhibitor characterized by slow oral absorption with low potential for abuse. However, it remains unclear whether intravenous (i.v.) administration would facilitate the rapi...

journal_title：Psychopharmacology

authors： Lew R,Constantinescu CC,Holden D,Carson RE,Carroll V,Galluppi G,Koblan KS,Hopkins SC

更新日期：2020-11-01 00:00:00

abstract：RATIONALE:Indirect-acting serotonin (5-HT) receptor agonists can enhance the antinociceptive effects of morphine; however, the specific 5-HT receptor subtype(s) mediating this enhancement is not established. OBJECTIVE:This study examined interactions between morphine and both 5-HT(1A) and 5-HT(2A) receptor agonists in...

journal_title：Psychopharmacology

authors： Li JX,Shah AP,Patel SK,Rice KC,France CP

更新日期：2013-02-01 00:00:00

abstract：RATIONALE:Amphetamine administration has been found to affect the degree of cerebral dominance for motor control in animals. In humans, cerebral dopamine neurotransmission is also correlated to motor dominance. Since language dominance is related to motor dominance, amphetamine might also affect cerebral dominance for ...

journal_title：Psychopharmacology

authors： Sommer IE,Oranje B,Ramsey NF,Klerk FA,Mandl RC,Westenberg HG,Kahn RS

更新日期：2006-01-01 00:00:00

abstract：:Phenelzine (PLZ) is a non-selective monoamine oxidase (MAO) inhibitor commonly used to treat depression and panic disorder. In addition to increasing levels of biogenic amines in the brain, PLZ elevates brain levels of the amino acid gamma-aminobutyric acid (GABA; Baker et al. 1991; present study). Given the extensive...

journal_title：Psychopharmacology

authors： Parent MB,Habib MK,Baker GB

更新日期：1999-03-01 00:00:00

abstract：RATIONALE:Individuals with schizophrenia have high smoking-related morbidity and mortality rates and need powerful and innovative smoking cessation interventions. OBJECTIVES:This proof-of-concept study investigated the feasibility and initial efficacy of combining a contingency management intervention with bupropion t...

journal_title：Psychopharmacology

authors： Tidey JW,Rohsenow DJ,Kaplan GB,Swift RM,Reid N

更新日期：2011-09-01 00:00:00

abstract：:In a placebo-controlled study, we investigated the influence of nicotine on late-day aviation performance in 15 non-smoking subjects. In a within-subjects design, subjects were tested on 2 days, each lasting 8 h and consisting of three 75-min simulator flights (late-afternoon practice, evening test, night test). Prior...

journal_title：Psychopharmacology

authors： Mumenthaler MS,Taylor JL,O'Hara R,Yesavage JA

更新日期：1998-11-01 00:00:00

abstract：:Pigeons trained to discriminate between the presence and absence of delta 9-THC (0.56 mg/kg, IM, intramuscularly) were tested with diazepam (5.6-30 mg/kg), administered IG (intragastrically), and were found to generalize the response associated with the THC training to the diazepam treatment only to a limited extent. ...

journal_title：Psychopharmacology

authors： Järbe TU,Hiltunen AJ

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Interrelationships between the discriminative stimulus and reinforcing properties of psychoactive drugs and the way in which they may interact to control drug intake are unclear. Studies have shown that drug history can influence the expression of drug-produced behavioral effects. OBJECTIVE:The present study...

journal_title：Psychopharmacology

authors： Childs E,Shoaib M,Stolerman IP

更新日期：2006-06-01 00:00:00

abstract：RATIONALE:Human behavioral pharmacology studies can examine how medications that target different neurotransmitter systems influence different aspects of smoking. Naltrexone and bupropion have been shown to alter ad lib smoking behavior; however, medication effects on nicotine reward in a cigarette choice paradigm have...

journal_title：Psychopharmacology

authors： Rukstalis M,Jepson C,Strasser A,Lynch KG,Perkins K,Patterson F,Lerman C

更新日期：2005-06-01 00:00:00

abstract：:The effects of the benzomorphan antagonist Mr 2266 and the selective delta-antagonist ICI 154,129 on the body weight gain of 6-day-old suckling rat pups was observed. Mr 2266 significantly reduced body weight gain in these animals, though ICI 154,129 had no affect on this variable. These findings suggest that mu- and ...

journal_title：Psychopharmacology

authors： Jackson HC,Sewell RD

更新日期：1984-01-01 00:00:00

abstract：OBJECTIVE:The primary aim of this project was to examine the role of alcohol use in smoking lapse behavior, as alcohol consumption is a known risk factor for poor smoking cessation outcomes. MATERIALS AND METHODS:We have developed a novel human laboratory model to examine two primary aspects of alcohol-mediated tobacc...

journal_title：Psychopharmacology

authors： McKee SA,Krishnan-Sarin S,Shi J,Mase T,O'Malley SS

更新日期：2006-12-01 00:00:00

abstract：:A theory of acute tolerance to alcohol is proposed that includes two assumptions: 1) acute tolerance is a linear process with time, and 2) the slope of the line is a measure of the magnitude of the acute tolerance effect. Evidence that supports the validity of the theory is presented both from studies in which blood a...

journal_title：Psychopharmacology

authors： Radlow R

更新日期：1994-02-01 00:00:00

abstract：:Although previous studies have shown that pharmacological agents, such as buprenorphine, and alternative nondrug reinforcers, such as money or sweetened solutions, reduce cocaine self-administration, few studies have examined the combined effects of these two approaches. The purpose of the present study was to evaluat...

journal_title：Psychopharmacology

authors： Comer SD,Lac ST,Wyvell CL,Carroll ME

更新日期：1996-06-01 00:00:00

abstract：:Parenteral administration of the adenosine deaminase (ADA) inhibitor erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) results in a profound decrease in spontaneous motor activity in mice and rats. The inhibition of cortical ADA activity measured ex vivo parallels the decrease in spontaneous motor activity in a time-depend...

journal_title：Psychopharmacology

authors： Mendelson WB,Kuruvilla A,Watlington T,Goehl K,Paul SM,Skolnick P

更新日期：1983-01-01 00:00:00

abstract：:Clonidine is a clinically used antihypertensive which has been suggested to produce physiological changes in children after exposure in utero. The aim of our study was to test the hypothesis that chronic exposure of the developing brain to an alpha 2-adrenergic agonist like clonidine would influence the adult neuroche...

journal_title：Psychopharmacology

authors： Feenstra MG,van Galen H,Boer GJ

更新日期：1992-01-01 00:00:00

abstract：:Phencyclidine combined with footshock stress produced a greater increase in the homovanillic acid content of prefrontal cortex than either phencyclidine or footshock alone. Phencyclidine decreased both substance P and substance K in the ventral tegmental area. The results suggest that phencyclidine and footshock activ...

journal_title：Psychopharmacology

authors： Bowers MB Jr,Bannon MJ,Hoffman FJ Jr

更新日期：1987-01-01 00:00:00

abstract：RATIONALE:Diazepam, a benzodiazepine with a relatively rapid onset of clinical effects, has been associated with suicide and other self-aggressive acts. The evidence for this association, however, comes exclusively from retrospective non-experimental studies. Although suggestive, the results of these studies do not sup...

journal_title：Psychopharmacology

authors： Berman ME,Jones GD,McCloskey MS

更新日期：2005-02-01 00:00:00

abstract：RATIONALE:Greater incidence of anxiety and depressive disorders of women compared to men may be due in part to progesterone (P) and its neuroactive metabolite, 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP), acting in limbic regions, such as the amygdala. OBJECTIVE:If P's metabolism via 5alpha-reduction to 3alpha...

journal_title：Psychopharmacology

authors： Walf AA,Sumida K,Frye CA

更新日期：2006-06-01 00:00:00

abstract：:The residual effects of three hypnotics were investigated by the method of 24-h polygraphy (EEG, EMG, and EOG). The drugs were triazolam 0.25 mg and 0.5 mg, flurazepam 15 mg and 30 mg, nitrazepam 5 mg and 10 mg, and placebo. The subjects were healthy volunteers, eight men and eight women with an average age of 34.3 ye...

journal_title：Psychopharmacology

authors： Ogura C,Nakazawa K,Majima K,Nakamura K,Ueda H,Umezawa Y,Wardell WM

更新日期：1980-01-01 00:00:00

abstract：RATIONALE:Recent studies suggest that orexin/hypocretin is involved in drug reward and drug-seeking behaviors, including ethanol self-administration. However, orexin's role in ethanol-induced seeking behaviors remains unclear. OBJECTIVE:These studies examined the role of orexin in the acquisition and expression of eth...

journal_title：Psychopharmacology

authors： Voorhees CM,Cunningham CL

更新日期：2011-04-01 00:00:00

abstract：:Roxindole is a potent autoreceptor-selective dopamine agonist with additional properties as a serotonin reuptake inhibitor and 5-HT1A agonist. In order to get more insight into its mode of action in various psychiatric populations, we evaluated the effects of subchronic roxindole treatment on pituitary and adrenal hor...

journal_title：Psychopharmacology

authors： Gründer G,Wetzel H,Hillert A,Jochum E,Hiemke C,Benkert O

更新日期：1995-02-01 00:00:00

abstract：:Chronic administration of the benzodiazepine (BZ) receptor agonist chlordiazepoxide (CDP) produced tolerance to its motor-impairing effects but little or no tolerance to its hypothermic effects or to its amnesic effects in the radial arm maze. Male Sprague-Dawley rats were pretreated for 14 days with CDP (25 mg/kg, b....

journal_title：Psychopharmacology

authors： Shumsky JS,Lucki I

更新日期：1994-06-01 00:00:00

abstract：:This study examined and compared withdrawal signs and symptoms from cessation of 0, 2 and 4 mg nicotine gum. In addition, a comparison was made between nicotine gum versus cigarette withdrawal symptoms. Smokers first underwent cigarette deprivation for 4 days and then were randomly assigned to 0 (N = 16), 2 (N = 25), ...

journal_title：Psychopharmacology

authors： Hatsukami DK,Skoog K,Huber M,Hughes J

更新日期：1991-01-01 00:00:00

abstract：RATIONALE:Decision-making is a complex cognitive process that is mediated, in part, by subregions of the medial prefrontal cortex (PFC). Decision-making is impaired in a number of psychiatric conditions including schizophrenia. Notably, people with schizophrenia exhibit reductions in GABA function in the same PFC areas...

journal_title：Psychopharmacology

authors： Paine TA,O'Hara A,Plaut B,Lowes DC

更新日期：2015-05-01 00:00:00

abstract：:The objective of the present study was to determine whether the development of behavioral sensitization to apomorphine could be blocked by either D1 or D2 selective dopamine antagonists. In three experiments, male rats received 10-21 daily injections of a selective D1 (SCH 23390; 0 or 0.5 mg/kg IP) or D2 (sulpiride; 0...

journal_title：Psychopharmacology

authors： Mattingly BA,Rowlett JK,Graff JT,Hatton BJ

更新日期：1991-01-01 00:00:00

abstract：:The present studies were undertaken to investigate the neuroactive steroidal modulation of feeding behavior and possible involvement of gamma-aminobutyric acid type-A (GABA-A) and mitochondrial diazepam binding inhibitor (DBI) receptors (MDR) in food-deprived male mice. Allopregnanolone (0.5-2 mg/kg), a neurosteroid, ...

journal_title：Psychopharmacology

authors： Reddy DS,Kulkarni SK

更新日期：1998-06-01 00:00:00

abstract：:NNC 756 is a new benzazepine with high affinity and selectivity for D1-dopamine receptors. In a double-blind, placebo controlled, cross-over study, positron emission tomography and the radioligand [11C]SCH 23390 were used to determine central D1-dopamine receptor occupancy after a single oral dose of 80 mg NNC 756 in ...

journal_title：Psychopharmacology

authors： Karlsson P,Farde L,Halldin C,Sedvall G,Ynddal L,Sloth-Nielsen M

更新日期：1995-05-01 00:00:00

abstract：:In the majority of Parkinson's disease (PD) patients, long-term dopamine (DA) replacement therapy leads to dyskinesia characterized by abnormal involuntary movements (AIMs). There are various mechanisms of dyskinesia, such as the sensitization of striatal DA D1 receptors (D1R) and upregulation of DA D3 receptors (D3R)...

journal_title：Psychopharmacology

authors： Lanza K,Chemakin K,Lefkowitz S,Saito C,Chambers N,Bishop C

更新日期：2020-01-01 00:00:00