Signs and symptoms from nicotine gum abstinence.

abstract：:This was a 4-week, three-center, double-blind, randomized, parallel, placebo-controlled evaluation of the efficacy and safety of bupropion in hospitalized depressed patients. Results from 27 placebo and 48 bupropion-treated patients were analyzed for efficacy and safety. Assessments of efficacy and safety were made at...

journal_title：Psychopharmacology

authors： Zung WW,Brodie HK,Fabre L,McLendon D,Garver D

更新日期：1983-01-01 00:00:00

abstract：RATIONALE:Fluoxetine (Prozac®) is the most frequently prescribed drug to battle depression in pregnant women, but its safety in the unborn child has not yet been established. Fluoxetine, a selective serotonin reuptake inhibitor, crosses the placenta, leading to increased extracellular serotonin levels and potentially n...

journal_title：Psychopharmacology

authors： Olivier JD,Vallès A,van Heesch F,Afrasiab-Middelman A,Roelofs JJ,Jonkers M,Peeters EJ,Korte-Bouws GA,Dederen JP,Kiliaan AJ,Martens GJ,Schubert D,Homberg JR

更新日期：2011-10-01 00:00:00

abstract：RATIONALE:A growing number of studies suggest that gamma-aminobutyric acid type-B (GABA(B)) receptor agonists reduce alcohol use and craving. OBJECTIVES:This study was designed to further clarify behavioral mechanism(s) by which GABA(B) agonists may decrease alcohol reinforcement. METHODS:Male C57BL/6 J mice were tra...

journal_title：Psychopharmacology

authors： Besheer J,Lepoutre V,Hodge CW

更新日期：2004-07-01 00:00:00

abstract：:In an operant learning lever-pressing procedure on an FR10 schedule of milk reinforcement, male Wistar rats were trained to discriminate between saline and 3 mg/kg IP DN-2327, a new anxiolytic which acts on benzodiazepine receptors, 3 mg/kg IP diazepam or 15 mg/kg IP pentylenetetrazol (PTZ). More than 80% appropriate ...

journal_title：Psychopharmacology

authors： Wada T,Fukuda N

更新日期：1993-01-01 00:00:00

abstract：RATIONALE:Working memory performance may be improved or decreased by amphetamine, depending on baseline working memory capacity and amphetamine dosage. This variable effect suggests an optimal range of monaminergic activity for working memory, either below or above which it is compromised. We directly tested this possi...

journal_title：Psychopharmacology

authors： Tipper CM,Cairo TA,Woodward TS,Phillips AG,Liddle PF,Ngan ET

更新日期：2005-08-01 00:00:00

abstract：:The peripheral BDZ receptor ligand Ro 5-4864 was administered to rabbits in doses ranging from 0.2 to 7 mg/kg IV. Changes in electrocortical activity appeared within 1 min after administration, characterized by trains of slow waves in the posterior sensorimotor and optic cortices (0.6-2 mg/kg) and by grand mal seizure...

journal_title：Psychopharmacology

authors： Massotti M,Lucantoni D

更新日期：1986-01-01 00:00:00

abstract：:Primiparous rats received 0.05, 0.25, 0.50, or 1.50 mg d-amphetamine/kg body weight, injected IP, when offspring reached 3-4 and 10-11 days of age. A multidimensional analysis of their maternal behavior revealed that at doses as low as 0.25 mg/kg, amphetamine had a disruptive effect on mother-pup intercontact interval...

journal_title：Psychopharmacology

authors： Piccirillo M,Alpert JE,Cohen DJ,Shaywitz BA

更新日期：1980-01-01 00:00:00

abstract：:Both muscarinic antagonists, such as scopolamine, and benzodiazepine receptor (BZR) agonists, such as diazepam, produce a reliable impairment in the performance of one trial passive avoidance. Such deficits are frequently interpreted as drug-induced amnesia. However, these deficits could also result from a learning im...

journal_title：Psychopharmacology

authors： Cole BJ,Jones GH

更新日期：1995-03-01 00:00:00

abstract：RATIONALE:Information is sparse on neurotransmitter deficiencies in frontotemporal dementia (FTD), in particular with reference to distinct histological subgroups and Alzheimer's disease (AD). OBJECTIVES:To evaluate in FTD with the major histologies, and compare with AD and controls, neurotransmission indices, as thes...

journal_title：Psychopharmacology

authors： Bowen DM,Procter AW,Mann DM,Snowden JS,Esiri MM,Neary D,Francis PT

更新日期：2008-03-01 00:00:00

abstract：:The behavioral effects of intraventricularly (IVT) administered (-)-nicotine on food-maintained behavior were studied. Rats responded by pressing a lever under various fixed ratio (FR) schedules. Infusion of 5 microgram of (-)-nicotine suppressed responding under an FR 16 schedule for 11-13 min. The effect was inverse...

journal_title：Psychopharmacology

authors： DeNoble VJ,Dragan VP,Carron L

更新日期：1982-01-01 00:00:00

abstract：RATIONALE:Recent studies have implicated an important role for the dorsal striatum during craving for cocaine and in cocaine-seeking after abstinence in rats. OBJECTIVES:We compared the effects of pharmacological inactivation of mesencephalic dopamine (DA) cell body regions and dorsal vs ventral striatal terminal fiel...

journal_title：Psychopharmacology

authors： See RE,Elliott JC,Feltenstein MW

更新日期：2007-10-01 00:00:00

abstract：RATIONALE:It has been reported that in panic disorder (PD), tryptophan depletion enhances the vulnerability to experimentally induced panic, while the administration of serotonin precursors blunts the response to challenges. OBJECTIVES:Using a high-dose carbon dioxide (CO(2)) challenge, we aimed to investigate the eff...

journal_title：Psychopharmacology

authors： Colasanti A,Esquivel G,den Boer E,Horlings A,Dandachi A,Oostwegel JL,van Donkelaar EL,Griez EJ,Schruers K

更新日期：2011-06-01 00:00:00

abstract：:In the rat, lysergic acid diethylamide (LSD) 0.5 mg/kg and 2-bromo lysergic acid diethylamide (BOL) 0.5 mg/kg increased the rate of the striatal in vivo tyrosine hydroxylation as measured by the DOPA accumulation after decarboxylase inhibition. Neither LSD nor BOL significantly changed the DOPA accumulation in the olf...

journal_title：Psychopharmacology

authors： Persson SA

更新日期：1978-10-31 00:00:00

abstract：RATIONALE:Central cannabinoid systems have been implicated in appetite regulation through the hyperphagic effects of exogenous and endogenous cannabinoids. These effects may involve activation of reward systems and be mediated in part by opioidergic processes. OBJECTIVE:Cannabinoid-opioid interactions in feeding were ...

journal_title：Psychopharmacology

authors： Kirkham TC,Williams CM

更新日期：2001-01-01 00:00:00

abstract：:The central effects of acetylsalicylic acid (ASA) are discussed controversially. In animal models, it has been shown that ASA can interact with the central serotonergic and catecholaminergic neuronal system. However, the relevance of this interaction for humans is still unknown. We performed a study on the influence o...

journal_title：Psychopharmacology

authors： Austermann M,Grotemeyer KH,Evers S,Rödding D,Husstedt IW

更新日期：1998-08-01 00:00:00

abstract：:The effects of 4 weeks of treatment with the selective monoamine oxidase (MAO) inhibiting antidepressant clorgyline and pargyline on the sleep of affectively disordered patients were studied. Both inhibitors resulted in near total suppression of REM sleep, a decrease in total sleep time, and an increase in the percent...

journal_title：Psychopharmacology

authors： Cohen RM,Pickar D,Garnett D,Lipper S,Gillin JC,Murphy DL

更新日期：1982-01-01 00:00:00

abstract：RATIONALE:It has been suggested that the antipsychotic effect of antipsychotics is mediated by the antagonism of the dopamine D2 receptor in the limbic-cortical regions. Risperidone has an atypical property, but its effect on limbic-cortical regions has not been evaluated. OBJECTIVES:In this study, we examined the rel...

journal_title：Psychopharmacology

authors： Yasuno F,Suhara T,Okubo Y,Sudo Y,Inoue M,Ichimiya T,Tanada S

更新日期：2001-02-01 00:00:00

abstract：RATIONALE:The mechanism involved in AD is complex, which has prompted to develop compounds that could simultaneously interact with several potential targets. Here, we report a new synthesized compound SCR-1693 which is designed to target both AChE and calcium channels that are potential for AD therapy. OBJECTIVES:We i...

journal_title：Psychopharmacology

authors： Zhang Z,Chen R,An W,Wang C,Liao G,Dong X,Bi A,Yin Z,Luo L

更新日期：2016-02-01 00:00:00

abstract：:Rats were chronically administered either haloperidol (HAL) or fluphenazine (FLU) via depot injections for 8 months, given these same drugs in their drinking water for the next 2 months, and then withdrawn from the drugs. Throughout the experiment the animals were tested repeatedly in an enclosed tube using a computer...

journal_title：Psychopharmacology

authors： See RE,Levin ED,Ellison GD

更新日期：1988-01-01 00:00:00

abstract：:Oral movements (OMs) in rats administered chronic haloperidol (HAL) were quantified simultaneously by a human observer and via a computerized video analysis system which monitored the distance between the upper and low lips using TV images. The human observer data indicated that during HAL administration the total dur...

journal_title：Psychopharmacology

authors： Ellison G,See R,Levin E,Kinney J

更新日期：1987-01-01 00:00:00

abstract：INTRODUCTION:Gelsemine is a natural alkaloid extracted from Gelsemium elegans Benth., a traditional Chinese medicinal herb. Gelsemine has been shown to penetrate the brain, and could produce neurological activities, such as anxiolytic and neuralgia-alleviating effects, suggesting that this natural compound might be use...

journal_title：Psychopharmacology

authors： Chen L,Pan H,Bai Y,Li H,Yang W,Lin ZX,Cui W,Xian YF

更新日期：2020-07-01 00:00:00

abstract：:Physostigmine (1.0mg) or placebo were administered intravenously over 1-h period to seven male normal volunteers beginning 35 min after sleep onset. The results indicate that physostigmine induced the onset of REM sleep but did not significantly alter the duration of individual REM sleep periods. Physostigmine signifi...

journal_title：Psychopharmacology

authors： Gillin JC,Sitaram N,Mendelson WB,Wyatt RJ

更新日期：1978-06-15 00:00:00

abstract：RATIONALE:The cAMP-dependent protein kinase A (PKA) signaling transduction pathway has been shown to play an important role in the modulation of several ethanol-induced behaviors. Different studies have demonstrated intracellular calcium (Ca(2+))-dependent activation of the PKA cascade after ethanol administration. Thu...

journal_title：Psychopharmacology

authors： Baliño P,Ledesma JC,Aragon CM

更新日期：2014-12-01 00:00:00

abstract：:Various dopamine receptor antagonists have divergent clinical and neurochemical properties. The relative ability of anticholinergics (benztropine and scopolamine) to reverse these drugs was assessed in squirrel monkeys and rats performing a Sidman avoidance task. In monkeys, benztropine markedly attenuated the effects...

journal_title：Psychopharmacology

authors： Liebman JM,Neale R,Noreika L,Braunwalder A

更新日期：1981-01-01 00:00:00

abstract：:The effects of ibogaine (40 and 80 mg/kg, i.p.), an indole alkaloid proposed for the treatment of drug abuse, were determined in three different groups of rats responding under an FR10 schedule of food, cocaine or heroin reinforcement. Ibogaine (80 mg/kg, i.p.) given 60 min before the start of the session resulted in ...

journal_title：Psychopharmacology

authors： Dworkin SI,Gleeson S,Meloni D,Koves TR,Martin TJ

更新日期：1995-02-01 00:00:00

abstract：RATIONALE:Dysfunction of executive neuropsychological performance, mediated by the prefrontal cortex, has been the central focus of recent attention deficit/ hyperkinetic disorder (AD-HKD) research. The role of other potential neuropsychological "risk factors", such as recognition memory, remains understudied. Further,...

journal_title：Psychopharmacology

authors： Rhodes SM,Coghill DR,Matthews K

更新日期：2004-09-01 00:00:00

abstract：:The purpose of this study was to compare the subchronic, low-dose effects of clozapine with those of olanzapine in a learned behavioral task previously shown to distinguish between clozapine and haloperidol with acute and subchronic treatment regimes. Rats were trained to use a single forelimb to press a force-recordi...

journal_title：Psychopharmacology

authors： Stanford JA,Fowler SC

更新日期：1997-08-01 00:00:00

abstract：RATIONALE:There is evidence that events early in post-weaning life influence brain development and subsequent adult behaviour and therefore play an important role in the causation of certain psychiatric disorders in later life. Exposing rodents to stressors during the juvenile period has been suggested as a model of in...

journal_title：Psychopharmacology

authors： Peleg-Raibstein D,Feldon J

更新日期：2011-03-01 00:00:00

abstract：RATIONALE:(+/-) 3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") is an amphetamine analog and drug of abuse. In animals, MDMA damages brain serotonin (5-HT) neurons at doses that overlap with those used recreationally by some humans. To date, few functional sequelae of MDMA-induced 5-HT damage have been identified. ...

journal_title：Psychopharmacology

authors： McCann UD,Mertl M,Eligulashvili V,Ricaurte GA

更新日期：1999-04-01 00:00:00

abstract：RATIONALE:Alzheimer disease (AD), a progressive neurodegenerative disorder, is the leading cause of dementia in the elderly. A combination of cholinergic and glutamatergic dysfunction appears to underlie the symptomatology of AD, and thus, treatment strategies should address impairments in both systems. Evidence sugges...

journal_title：Psychopharmacology

authors： Schaeffer EL,Gattaz WF

更新日期：2008-05-01 00:00:00