Synergistic efects of opioid and cannabinoid antagonists on food intake.

abstract：:The name of Hayley Treloar Padovano was incorrectly tagged in the original version of this article. Instead of Padovano as family name and Hayley Treloar as given name, it should be Hayley as given name and Treloar Padovano as family name. Correct presentation of author name when online should be Treloar Padovano H. ...

journal_title：Psychopharmacology

authors： Mereish EH,Treloar Padovano H,Wemm S,Miranda R Jr

更新日期：2018-09-01 00:00:00

abstract：:Cholecystokinin (CCK) and dopamine (DA) coexist in both cell body and terminal areas of a mesolimbic pathway that projects from the ventral tegmental area (VTA) to the nucleus accumbens (N ACC). Autoradiography reveals extensive CCK binding sites in the N ACC, but not in the VTA. However, iontophoresis of CCK into the...

journal_title：Psychopharmacology

authors： Pettit HO,Mueller K

更新日期：1989-01-01 00:00:00

abstract：:the immediate posttrial injection of oxotremorine (0.250 mu Mol/kg, IP) can facilitate the retention of a passive-avoidance response in mice. After the administration of alfa-methyl-p-tyrosine methylester (alpha-MPT) by intracerebroventricular injection at doses that had no effect on retention (100 microgram, 10 micro...

journal_title：Psychopharmacology

authors： Huygens P,Baratti CM,Gardella JL,Filinger E

更新日期：1980-01-01 00:00:00

abstract：RATIONALE:Gabolysat PC60 is a fish protein hydrolysate with anxiolytic properties commonly used as a nutritional supplement. OBJECTIVE:The diazepam-like effects of PC60 on stress responsiveness of the rat pituitary-adrenal system and on sympathoadrenal activity were studied. METHODS:The activity of the pituitary-adre...

journal_title：Psychopharmacology

authors： Bernet F,Montel V,Noël B,Dupouy JP

更新日期：2000-03-01 00:00:00

abstract：:Sixty-two DSM III chronic schizophrenic inpatients were selected for a double-blind, placebo controlled, multi-centre, relapse prevention study of remoxipride, a selective dopamine (D2)-receptor antagonist. After a 1 month placebo washout, 23 patients had relapsed and were withdrawn. Of the remaining patients 19 were ...

journal_title：Psychopharmacology

authors： King DJ,Blomqvist M,Cooper SJ,Doherty MM,Mitchell MJ,Montgomery RC

更新日期：1992-01-01 00:00:00

abstract：:The behavioural effects of selective mu-, kappa- and delta-opioid agonists in 5-, 10- and 20-day-old rats were investigated by observational analysis. The predominant response to mu-agonists was behavioural depression. High doses (10 mg/kg IP) of morphine and DAGO (D-Ala2, NMe-Phe4, Glyol5-enkephalin) produced overt s...

journal_title：Psychopharmacology

authors： Jackson HC,Kitchen I

更新日期：1989-01-01 00:00:00

abstract：RATIONALE:The occurrence of methamphetamine (METH) use by the smoking route is increasing. A nonhuman primate model for examining the reinforcing effects of smoked METH would be valuable for testing potential interventions for treating METH abuse disorders. OBJECTIVE:The purpose of the present study was to examine the...

journal_title：Psychopharmacology

authors： Newman JL,Carroll ME

更新日期：2006-10-01 00:00:00

abstract：RATIONALE:The post-extinction exposure of rats to a sub-conditioning procedure (SCP; i.e., retraining with a shock intensity that is too weak to induce by itself significant fear conditioning) has been reported to provoke the reemergence of extinguished fear. This phenomenon can be prevented by chronic fluoxetine treat...

journal_title：Psychopharmacology

authors： Deschaux O,Zheng X,Lavigne J,Nachon O,Cleren C,Moreau JL,Garcia R

更新日期：2013-01-01 00:00:00

abstract：RATIONALE:Delta-opioid agonists produce a number of behavioral effects, including convulsions, antinociception, locomotor stimulation, and antidepressant-like effects. The development of these compounds as treatments for depression is limited by their convulsive effects. Therefore, determining how to separate the convu...

journal_title：Psychopharmacology

authors： Jutkiewicz EM,Rice KC,Traynor JR,Woods JH

更新日期：2005-11-01 00:00:00

abstract：RATIONALE:Premature discontinuation of antidepressant drugs is a frequent clinical problem. Adverse effects are common, occur early on in treatment and are reported to be one of the main reasons for discontinuation of antidepressant treatment. OBJECTIVES:To investigate the association between adverse effects occurring...

journal_title：Psychopharmacology

authors： Crawford AA,Lewis S,Nutt D,Peters TJ,Cowen P,O'Donovan MC,Wiles N,Lewis G

更新日期：2014-08-01 00:00:00

abstract：RATIONALE:Alcohol use disorders are associated with deficits in adaptive behavior. While some behavioral impairments that are associated with alcohol use disorders may predate exposure to drugs of abuse, others may result directly from exposure to drugs of abuse, including alcohol. Identifying a causal role for how alc...

journal_title：Psychopharmacology

authors： Barker JM,Lench DH,Chandler LJ

更新日期：2016-01-01 00:00:00

abstract：:The problem of the advantage of using nortriptyline (NT) plasma level during treatment for endogenous depression has been approached. In an ordinary psychiatric department, 34 patients had their NT level checked the second week of treatment and their dosage subsequently adjusted, if it was outside the recommended ther...

journal_title：Psychopharmacology

authors： Sørensen B,Kragh-Sørensen P,Larsen NE,Hvidberg EF

更新日期：1978-09-15 00:00:00

abstract：:The behavioral effects of repeated methylphenidate (MPH) treatment were assessed in the adult rat. Protein kinase A (PKA) and adenylyl cyclase (basal and DA-stimulated) activity in the dorsal striatum (i.e., caudate-putamen) were measured to determine whether MPH-induced alterations in these enzymes correlate with the...

journal_title：Psychopharmacology

authors： Crawford CA,McDougall SA,Meier TL,Collins RL,Watson JB

更新日期：1998-03-01 00:00:00

abstract：:An operant task for the measurement of sustained attention or vigilance in rats was characterized. The task requires the animals to respond to the presentation of visual signals (presented for 25, 50, or 500 ms) by operating one lever ("hits") and to the absence of a signal by operating the opposite lever ("correct re...

journal_title：Psychopharmacology

authors： McGaughy J,Sarter M

更新日期：1995-02-01 00:00:00

abstract：RATIONALE:Preclinical studies suggest that medications enhancing the brain gamma amino butyric acid (GABA) system attenuate the rewarding effects of stimulants including nicotine. These preclinical studies have not been followed up in systematic human studies. OBJECTIVES:This study was conducted to examine the effects...

journal_title：Psychopharmacology

authors： Sofuoglu M,Mouratidis M,Yoo S,Culligan K,Kosten T

更新日期：2005-09-01 00:00:00

abstract：:To assess the effects of chlordiazepoxide (CDP) on a stable discrimination performance, eight rats were trained on a simple brightness discrimination and injected with three dosages (0, 5, and 10 mg/kg) once performance was stable. Signal detection analysis of the results was used to differentiate sensory from motor/r...

journal_title：Psychopharmacology

authors： Francis RL,Cooper SJ

更新日期：1979-06-21 00:00:00

abstract：:In the conditioned reinforcement paradigm, animals learn a new instrumental response reinforced solely by conditioned reward (a stimulus that has previously been associated with primary reward). It has been shown that psychostimulants potentiate responding for conditioned reward and there is evidence that the nucleus ...

journal_title：Psychopharmacology

authors： Kelley AE,Delfs JM

更新日期：1991-01-01 00:00:00

abstract：RATIONALE:Psychopharmacology needs novel quantitative measures and theoretical approaches based on computational modelling that can be used to help translate behavioural findings from experimental animals to humans, including patients with neuropsychiatric disorders. OBJECTIVES:This brief review exemplifies this appro...

journal_title：Psychopharmacology

authors： Robbins TW,Cardinal RN

更新日期：2019-08-01 00:00:00

abstract：RATIONALE:Hypericum perforatum L., known as St. John's wort (SJW), is used as a phytotherapeutic agent for the treatment of mild to moderate forms of depression. OBJECTIVES:The aim of the present study was to evaluate the effect of SJW extract (STW 3-VI; 250 and 500 mg/kg; p.o.) and fluoxetine (10 mg/kg, p.o.) on gene...

journal_title：Psychopharmacology

authors： Jungke P,Ostrow G,Li JL,Norton S,Nieber K,Kelber O,Butterweck V

更新日期：2011-02-01 00:00:00

abstract：:A variety of behaviors were studied in an open-field setting after i.v. amphetamine (0.5, 2.0, 8.0 mg/kg), phenmetrazine (1.0, 4.0, 16.0 mg/kg), or fenfluramine (1.0, 4.0, 16.0 mg/kg). Amphetamine and phenmetrazine increased ambulation initially and rearing during the whole experiment, and decreased grooming. At 30 an...

journal_title：Psychopharmacology

authors： Lindquist MP,Götestam KG

更新日期：1977-12-19 00:00:00

abstract：:Peak saccadic eye movement velocity (SEV) and average smooth pursuit gain (SP) are reduced in a dose-dependent manner by diazepam and provide reliable, quantitative measures of benzodiazepine agonist effects. To evaluate the specificity of these eye movement effects for agents acting at the central GABA-benzodiazepine...

journal_title：Psychopharmacology

authors： Hopfenbeck JR,Cowley DS,Radant A,Greenblatt DJ,Roy-Byrne PP

更新日期：1995-04-01 00:00:00

abstract：:Monoamine neurotransmitter systems, along with cholinergic systems, are known to play important roles in cognition, and are disrupted in at least some patients with dementia of the Alzheimer type (DAT). This suggests that monoamine-enhancing drugs might ameliorate cognitive symptoms in certain patients with DAT. L-Dep...

journal_title：Psychopharmacology

authors： Tariot PN,Sunderland T,Weingartner H,Murphy DL,Welkowitz JA,Thompson K,Cohen RM

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Postmortem and positron emission tomography (PET) studies have reported several alterations in serotonin 1A receptor (5-HT(1A)) binding parameters in patients with schizophrenia. This study examines 5-HT(1A) availability in vivo in individuals with schizophrenia and schizo-affective disorder. MATERIALS AND ...

journal_title：Psychopharmacology

authors： Frankle WG,Lombardo I,Kegeles LS,Slifstein M,Martin JH,Huang Y,Hwang DR,Reich E,Cangiano C,Gil R,Laruelle M,Abi-Dargham A

更新日期：2006-12-01 00:00:00

abstract：:The uptake of 3H-5-HT in synaptosomes from rat brains was investigated. Addition of DA or NA had only a slight or no effect on the uptake. When the uptake into NA and DA neurons was inhibited by the addition of high concentrations of NA and DA, the uptake of 3H-5-HT was unchanged. This was also found after destruction...

journal_title：Psychopharmacology

authors： Hyttel J

更新日期：1978-12-15 00:00:00

abstract：RATIONALE:Pharmacological agents used in the treatment of anxiety have been reported to decrease threat relevant processing in patients and healthy controls, suggesting a potentially relevant mechanism of action. However, the effects of the anxiolytic diazepam have typically been examined at sedative doses, which do no...

journal_title：Psychopharmacology

authors： Murphy SE,Downham C,Cowen PJ,Harmer CJ

更新日期：2008-09-01 00:00:00

abstract：RATIONALE:Opioid receptor antagonists reliably alter the expression or extinction of ethanol's conditioned motivational effects as indexed by the place conditioning procedure, suggesting endogenous opioids are normally involved. These studies examined how exogenous stimulation of opioid receptors alters ethanol's condi...

journal_title：Psychopharmacology

authors： Cunningham CL,Bakner L,Schuette LM,Young EA

更新日期：2021-01-01 00:00:00

abstract：RATIONALE:Genetically determined differences in susceptibility to drug-induced sensitization could be related to risk for drug consumption. OBJECTIVES:Studies were performed to determine whether selective breeding could be used to create lines of mice with different magnitudes of locomotor sensitization to methampheta...

journal_title：Psychopharmacology

authors： Scibelli AC,McKinnon CS,Reed C,Burkhart-Kasch S,Li N,Baba H,Wheeler JM,Phillips TJ

更新日期：2011-04-01 00:00:00

abstract：:Most post-mortem autoradiographic studies have described striatal dopamine D(2) receptor up-regulation due to chronic neuroleptic exposure. The aim of our study was to compare in-vivo striatal D(2) receptor density in neuroleptic-naive and neuroleptic-free schizophrenic patients. We included 28 young (mean age: 28+/-8...

journal_title：Psychopharmacology

authors： Lomeña F,Catafau AM,Parellada E,Bernardo M,Font M,Gutiérrez F,Pavía J

更新日期：2004-03-01 00:00:00

abstract：:Four benzodiazepine tranquilizers have been tested, alone or in combination with scopolamine, on the spontaneous locomotor activity of BALB/c mice. Scopolamine-induced locomotor stimulation was enhanced by chlordiazepoxide, diazepam, and medazepam, but not by bromazepam. These effects are similar to those exerted by t...

journal_title：Psychopharmacology

authors： Sansone M

更新日期：1980-01-01 00:00:00

abstract：RATIONALE:Several previous neuroendocrine studies have demonstrated reduced 5-HT1A receptor function in major depressive disorder (MDD). However, hypercortisolaemia or previous drug treatment may have been significant confounds. OBJECTIVES:To replicate previous studies in subjects with MDD who had been drug free for a...

journal_title：Psychopharmacology

authors： Porter RJ,Gallagher P,Watson S,Smith MS,Young AH

更新日期：2003-08-01 00:00:00