Effect of a specific 5-HT uptake inhibitor, citalopram (Lu 10-171), on 3H-5-HT uptake in rat brain synaptosomes in vitro.

Abstract:

:The uptake of 3H-5-HT in synaptosomes from rat brains was investigated. Addition of DA or NA had only a slight or no effect on the uptake. When the uptake into NA and DA neurons was inhibited by the addition of high concentrations of NA and DA, the uptake of 3H-5-HT was unchanged. This was also found after destruction of NA and DA neurons by 6-hydroxydopamine treatment. Furthermore, the uptake of 3H-5-HT was almost equal in different brain parts containing NA and DA in very different amounts. These observations show that the uptake measured with 3H-5-HT is specific for 5-HT neurons. The present study revealed that citalopram and chlorimipramine inhibited uptake competitively, and in this respect the two drugs were equipotent. Compared with a series of tricyclic thymoleptics, the two drugs were the most potent inhibitors of 5-HT uptake, about 20 to 35 times more active than imipramine and amitriptyline. The metabolites of citalopram were also rather potent. The results obtained in the present study correlate closely with those obtained using inhibition of 14C-5-HT uptake in blood platelets, or using the inhibition of H 75/12-induced 5-HT depletion in rat brain. When rats were treated orally with citalopram or chlorimipramine, the inhibition of 3H-5-HT uptake in synaptosomes derived from these rats was two times greater after citalopram than after chlorimipramine.

journal_title

Psychopharmacology

authors

Hyttel J

doi

10.1007/BF00429172

subject

Has Abstract

pub_date

1978-12-15 00:00:00

pages

13-8

issue

1

eissn

0033-3158

issn

1432-2072

journal_volume

60

pub_type

杂志文章
  • Pharmacological and behavioral characterization of cocaine-kindled seizures in mice.

    abstract:RATIONALE:Convulsions associated with cocaine toxicity are a serious aspect of cocaine-related emergency room incidents. Seizures can result from a single high dose of cocaine, and evidence is accumulating that correlates repetitive administration of sub-convulsive doses of cocaine with a decreased seizure threshold, a...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s002130050027

    authors: Miller KA,Witkin JM,Ungard JT,Gasior M

    更新日期:2000-01-01 00:00:00

  • Comparison of anti-conflict drug effects in three experimental animal models of anxiety.

    abstract::A novel form of experimentally-induced conflict behavior based on the conditioned suppression of drinking (CSD) is described and compared with two conventional animal models of human anxiety--a modified Geller-Seifter and an Estes-Skinner (Conditioned Emotional Response) procedure. The CSD procedure offered significan...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00427112

    authors: Kilts CD,Commissaris RL,Rech RH

    更新日期:1981-01-01 00:00:00

  • Tranylcypromine vs nortriptyline vs placebo in depressed outpatients: a controlled trial.

    abstract::This study was designed to compare the therapeutic and adverse effects of tranylcypromine (a monoamine oxidase inhibitor), nortriptyline (a tricyclic antidepressant), and placebo. A total of 122 depressed outpatients randomly assigned to double-blind treatment with one of these agents completed the 4-week protocol. Tr...

    journal_title:Psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF00427786

    authors: White K,Razani J,Cadow B,Gelfand R,Palmer R,Simpson G,Sloane RB

    更新日期:1984-01-01 00:00:00

  • The behavioral and biochemical effects of lithium on dopaminergic agonist-induced supersensitivity.

    abstract::Dopaminergic behavioral supersensitivity may be induced by chronic treatment with either dopaminergic agonists or antagonists. We demonstrate that the development of agonist-induced supersensitivity is resistant to chronic lithium exposure. Furthermore, chronic lithium alone enhances the stereotypic response to acute ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00427448

    authors: Rubin EH,Wooten GF

    更新日期:1984-01-01 00:00:00

  • Acamprosate suppresses the expression of morphine-induced sensitization in rats but does not affect heroin self-administration or relapse induced by heroin or stress.

    abstract::Acamprosate (calcium-acetyl homotaurinate) is a new compound used in the treatment of alcohol abuse. Because of the putative link between alcoholism and the endogenous opioid systems in both humans and laboratory animals, we tested in rats the effects of acamprosate on behavioral and neurochemical effects of opioid dr...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s002130050730

    authors: Spanagel R,Sillaber I,Zieglgänsberger W,Corrigall WA,Stewart J,Shaham Y

    更新日期:1998-10-01 00:00:00

  • Regulation of intravenous cocaine self-administration in rats selectively bred for high (HiS) and low (LoS) saccharin intake.

    abstract:RATIONALE:Rats selectively bred for high saccharin (HiS) intake consume more alcohol and acquire intravenous (i.v.) cocaine self-administration more rapidly than their low saccharin (LoS)-consuming counterparts. The present experiment was designed to determine whether HiS and LoS rats differed in other aspects of drug ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-006-0600-3

    authors: Carroll ME,Anderson MM,Morgan AD

    更新日期:2007-02-01 00:00:00

  • Naltrexone decreases craving and alcohol self-administration in alcohol-dependent subjects and activates the hypothalamo-pituitary-adrenocortical axis.

    abstract:BACKGROUND:This laboratory study investigated the mechanisms by which the opioid antagonist, naltrexone, reduces the risk of relapse to heavy drinking in individuals with alcohol dependence. METHODS:Eighteen alcohol-dependent, non-treatment-seeking volunteers were randomized to 50 mg naltrexone or placebo for 6 days a...

    journal_title:Psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s002130100919

    authors: O'Malley SS,Krishnan-Sarin S,Farren C,Sinha R,Kreek MJ

    更新日期:2002-02-01 00:00:00

  • Stimuli produced by observing responses make rats' ethanol self-administration more resistant to price increases.

    abstract:RATIONALE:Observing responses bring sensory receptors into contact with environmental stimuli. In the observing-response procedure, periods in which an operant response (e.g. pressing a lever) is reinforced by drug deliveries alternate with periods in which this response is never reinforced (i.e. extinction). These alt...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-003-1390-5

    authors: Shahan TA

    更新日期:2003-05-01 00:00:00

  • GABA involvement in memory consolidation: evidence from posttrial amino-oxyacetic acid.

    abstract::In order to assess the possible effects of central GABA activation on the consolidation of shock avoidance, the GABA-T inhibitor amino-oxyacetic acid (AOAA) was administered posttrial to adult male rats. Learning was assessed over nine widely spaced sessions of 20 trials each. AOAA-treated animals showed learning with...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00431848

    authors: Katz RJ,Liebler L

    更新日期:1978-03-01 00:00:00

  • Chronic treatment with fluoxetine prevents the return of extinguished auditory-cued conditioned fear.

    abstract:RATIONALE:We have recently shown that post-extinction exposure of rats to a sub-threshold reminder shock can reactivate extinguished context-related freezing and found that chronic treatment with fluoxetine before fear extinction prevents this phenomenon. OBJECTIVES:In the present study, we examined whether these find...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-010-2134-y

    authors: Deschaux O,Spennato G,Moreau JL,Garcia R

    更新日期:2011-05-01 00:00:00

  • BIMT 17: a putative antidepressant with a fast onset of action?

    abstract::BIMT 17, the only compound reported to be a full 5-HT1A agonist and a 5-HT2A antagonist at the frontal cortex, was assessed in three animal paradigms sensitive to antidepressants in rats: olfactory bulbectomy (OB), differential-reinforcement-of-low rate 72-s (DRL 72-s) and learned helplessness (LH). In the OB rats, BI...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s002130050474

    authors: Borsini F,Cesana R,Kelly J,Leonard BE,McNamara M,Richards J,Seiden L

    更新日期:1997-12-01 00:00:00

  • Antinociceptive effect of chronic nicotine and nociceptive effect of its withdrawal measured by hot-plate and tail-flick in rats.

    abstract::Nicotine (6 mg/kg/day) was administered subcutaneously via Alzet osmotic pumps to rats for 28 days. Nociception was measured by the hot-plate and tail-flick methods. A significant antinociceptive effect was demonstrated during the first week of the treatment; after that tolerance developed, lasting for the remaining p...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF02245428

    authors: Yang CY,Wu WH,Zbuzek VK

    更新日期:1992-01-01 00:00:00

  • Further studies of the reinforcing effects of benztropine analogs in rhesus monkeys.

    abstract:RATIONALE:Several halogenated analogs of benztropine (BZT) have previously been characterized as potent DA uptake inhibitors with behavioral profiles that indicate diminished psychomotor stimulant effects relative to cocaine. In a previous study using a fixed-ratio 10 schedule, two chloro-analogs (3'-Cl-BZT and 4'-Cl-B...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s002130000616

    authors: Woolverton WL,Hecht GS,Agoston GE,Katz JL,Newman AH

    更新日期:2001-04-01 00:00:00

  • Differences in the effects of d-fenfluramine and morphine on various responses of rats to painful stimuli.

    abstract::The effects of d-fenfluramine and morphine on various nociceptive responses of rats were investigated. Unlike morphine, which inhibited all the responses examined, d-fenfluramine inhibited jumping and paw licking of rats on a hot plate, but did not increase the latency of tail withdrawal from hot water. The effects of...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00435276

    authors: Rochat C,Cervo L,Romandini S,Samanin R

    更新日期:1982-01-01 00:00:00

  • Higher serotonin transporter occupancy after multiple dose administration of escitalopram compared to citalopram: an [123I]ADAM SPECT study.

    abstract:OBJECTIVES:Previous studies have investigated the occupancy of the serotonin reuptake transporter (SERT) after clinical doses of citalopram and other selective serotonin reuptake inhibitors. In the present study, the occupancies of SERT after multiple doses of escitalopram and citalopram were compared using the radioli...

    journal_title:Psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00213-006-0666-y

    authors: Klein N,Sacher J,Geiss-Granadia T,Mossaheb N,Attarbaschi T,Lanzenberger R,Spindelegger C,Holik A,Asenbaum S,Dudczak R,Tauscher J,Kasper S

    更新日期:2007-04-01 00:00:00

  • IBZM SPECT imaging of striatal dopamine-2 receptors in psychotic patients treated with the novel antipsychotic substance quetiapine in comparison to clozapine and haloperidol.

    abstract::We investigated the striatal dopamine-2 (D2) receptor occupancy caused by different antipsychotic substances in 18 psychotic patients (16 with schizophrenic and two with schizoaffective disorder according to DSM-IV) with single photon emission computed tomography (SPECT) using 123I-iodobenzamide (IBZM) as tracer subst...

    journal_title:Psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s002130050409

    authors: Küfferle B,Tauscher J,Asenbaum S,Vesely C,Podreka I,Brücke T,Kasper S

    更新日期:1997-10-01 00:00:00

  • Serotonin and dopamine receptor gene polymorphisms and the risk of extrapyramidal side effects in perphenazine-treated schizophrenic patients.

    abstract:RATIONALE:Perphenazine, a classical antipsychotic drug, has the potential to induce extrapyramidal side effects (EPS). Dopaminergic and serotonergic pathways are involved in the therapeutic and adverse effects of the drug. OBJECTIVES:To evaluate the impact of polymorphisms in the dopamine D(2) and D(3) and serotonin 2...

    journal_title:Psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00213-006-0622-x

    authors: Gunes A,Scordo MG,Jaanson P,Dahl ML

    更新日期:2007-03-01 00:00:00

  • Increased sensitivity to benzodiazepine antagonists in rats following chronic treatment with a low dose of diazepam.

    abstract::The effects of benzodiazepine (BZ) antagonists on operant behavior were examined in rats chronically administered a low dose of diazepam (DZ). The low maintenance dose of DZ (5 mg/kg twice daily) was selected as more closely associated with its anxiolytic effects than the higher treatment doses previously used to stud...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF02244103

    authors: Lucki I,Kucharik RF

    更新日期:1990-01-01 00:00:00

  • Hypnotic susceptibility to various depressants in rats selected for differential ethanol sensitivity.

    abstract::MA rats, bred for greater motor impairment following subhypnotic doses of ethanol, were found to be more sensitive to the hypnotic effects of phenobarbital and chloral hydrate than were LA rats. In addition, the previously reported finding of a difference between the two lines of rats in duration of loss of righting r...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00426674

    authors: Riley EP,Shapiro NR,Lochry EA

    更新日期:1979-02-28 00:00:00

  • Environment-dependent effects of ethanol on DOPAC and HVA in various brain regions of ethanol-tolerant rats.

    abstract::The development of tolerance to the behavioral and biochemical effects of ethanol was studied. Rats were made tolerant to ethanol by the administration of daily ethanol injections (3 g/kg, IP) for 7 and 28 days. Tolerance developed both to the behavioral (hypothermic, sedative) and biochemical (accumulation of dopamin...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF02244097

    authors: Liljequist S,Ekman A,Snape B,Söderpalm B,Engel JA

    更新日期:1990-01-01 00:00:00

  • Synergistic interaction between nicotine and social rewards in adolescent male rats.

    abstract:RATIONALE:Smoking typically begins during adolescence and is largely reinforced by social cues. During adolescence in rats, sensitivity to both social cues and drugs of abuse is enhanced. OBJECTIVES:We have previously demonstrated in adolescent male rats that a low dose of cocaine interacts with social reward to produ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-009-1470-2

    authors: Thiel KJ,Sanabria F,Neisewander JL

    更新日期:2009-06-01 00:00:00

  • Plasma and brain pharmacokinetic profile of cannabidiol (CBD), cannabidivarine (CBDV), Δ⁹-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats and mice following oral and intraperitoneal administration and CBD action on obsessive-compulsive behavi

    abstract:RATIONALE:Phytocannabinoids are useful therapeutics for multiple applications including treatments of constipation, malaria, rheumatism, alleviation of intraocular pressure, emesis, anxiety and some neurological and neurodegenerative disorders. Consistent with these medicinal properties, extracted cannabinoids have rec...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-011-2415-0

    authors: Deiana S,Watanabe A,Yamasaki Y,Amada N,Arthur M,Fleming S,Woodcock H,Dorward P,Pigliacampo B,Close S,Platt B,Riedel G

    更新日期:2012-02-01 00:00:00

  • GABA(B) receptor agonists reduce operant ethanol self-administration and enhance ethanol sedation in C57BL/6J mice.

    abstract:RATIONALE:A growing number of studies suggest that gamma-aminobutyric acid type-B (GABA(B)) receptor agonists reduce alcohol use and craving. OBJECTIVES:This study was designed to further clarify behavioral mechanism(s) by which GABA(B) agonists may decrease alcohol reinforcement. METHODS:Male C57BL/6 J mice were tra...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-003-1769-3

    authors: Besheer J,Lepoutre V,Hodge CW

    更新日期:2004-07-01 00:00:00

  • Purine nucleoside--mediated immobility in mice: reversal by antidepressants.

    abstract::In the forced swimming-induced immobility (despair) test model, adenosine, and 2-chloroadenosine treatment prolonged the immobilization period in mice. Dipyridamole, which is known to inhibit adenosine uptake, potentiated the adenosine effect. The purinoceptor antagonists caffeine and theophylline blocked purine nucle...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00429665

    authors: Kulkarni SK,Mehta AK

    更新日期:1985-01-01 00:00:00

  • Early postnatal clonidine treatment results in altered regional catecholamine utilisation in adult rat brain.

    abstract::Clonidine is a clinically used antihypertensive which has been suggested to produce physiological changes in children after exposure in utero. The aim of our study was to test the hypothesis that chronic exposure of the developing brain to an alpha 2-adrenergic agonist like clonidine would influence the adult neuroche...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF02253583

    authors: Feenstra MG,van Galen H,Boer GJ

    更新日期:1992-01-01 00:00:00

  • Intermediate affinity and potency of clozapine and low affinity of other neuroleptics and of antidepressants at H3 receptors.

    abstract::It was the aim of the present study to determine the affinities of four neuroleptics and five antidepressants for histamine H3 receptors. In rat brain cortex membranes, the specifically bound [3H]-N alpha-methylhistamine was monophasically displaced by clozapine (pKi 6.15). The other drugs did not completely displace ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF02247479

    authors: Kathmann M,Schlicker E,Göthert M

    更新日期:1994-12-01 00:00:00

  • Effect of subcutaneous nicotine injections of EEG alpha frequency in non-smokers: a placebo-controlled pilot study.

    abstract::The effect of two subcutaneous injections of 0.6 mg nicotine, administered 40 min apart, was compared with placebo in four non-smoking subjects in a counter-balanced double-blind crossover design. The nicotine injections produced mean peak plasma nicotine concentrations of 5.3 ng/ml 10 min after the first injection an...

    journal_title:Psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF02244767

    authors: Foulds J,McSorley K,Sneddon J,Feyerabend C,Jarvis MJ,Russell MA

    更新日期:1994-06-01 00:00:00

  • Repeated exposures intensify rather than diminish the rewarding effects of amphetamine, morphine, and cocaine.

    abstract::It is commonly believed that repeated exposures diminish the pleasurable effects of drugs and hence that pleasure must have only a minor role in addiction. In six experiments with rats, repeated exposures to amphetamine, morphine, or cocaine were found to enhance the drug-induced rewarding effect as measured by condit...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00451687

    authors: Lett BT

    更新日期:1989-01-01 00:00:00

  • Residual effects of hypnotics: triazolam, flurazepam, and nitrazepam.

    abstract::The residual effects of three hypnotics were investigated by the method of 24-h polygraphy (EEG, EMG, and EOG). The drugs were triazolam 0.25 mg and 0.5 mg, flurazepam 15 mg and 30 mg, nitrazepam 5 mg and 10 mg, and placebo. The subjects were healthy volunteers, eight men and eight women with an average age of 34.3 ye...

    journal_title:Psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF00426651

    authors: Ogura C,Nakazawa K,Majima K,Nakamura K,Ueda H,Umezawa Y,Wardell WM

    更新日期:1980-01-01 00:00:00

  • Lack of reinforcement enhancing effects of nicotine in non-dependent smokers.

    abstract:RATIONALE:Recent animal research has shown that, aside from its primary and secondary reinforcing effects, nicotine may enhance reinforcement from stimuli unrelated to nicotine intake. Little human research has directly examined this potentially important influence of nicotine. OBJECTIVES:We report two virtually ident...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-009-1574-8

    authors: Perkins KA,Grottenthaler A,Wilson AS

    更新日期:2009-09-01 00:00:00