Brain catecholamines modifications. The effects on memory facilitation induced by oxotremorine in mice.

abstract：RATIONALE:Relapse to drug-seeking in abstinent heroin addicts and reinstatement in experimental animals are observed when exposed to drug-associated stimuli or cues, the drug itself, and stressful events. It has been shown that footshock-induced stress increases the rewarding effects of opiates, delays extinction, and ...

journal_title：Psychopharmacology

authors： Ribeiro Do Couto B,Aguilar MA,Manzanedo C,Rodríguez-Arias M,Armario A,Miñarro J

更新日期：2006-05-01 00:00:00

abstract：RATIONALE:Carrageenan-induced hyperalgesia is a widely used pain model in rodents. However, characteristics of carrageenan-induced hyperalgesia and effects of analgesic drugs under these conditions are unknown in nonhuman primates. OBJECTIVE:The aims of this study were to develop carrageenan-induced hyperalgesia in rh...

journal_title：Psychopharmacology

authors： Sukhtankar DD,Lee H,Rice KC,Ko MC

更新日期：2014-04-01 00:00:00

abstract：:The effects of chronic desmethylimipramine (DMI) treatment on measures of incentive motivation for cocaine were assessed in order to investigate the predictive validity of the extinction/reinstatement model of drug craving. Rats were trained to respond for cocaine infusions (0.75 mg/kg per 0.1 ml i.v.) or received yok...

journal_title：Psychopharmacology

authors： Fuchs RA,Tran-Nguyen LT,Specio SE,Groff RS,Neisewander JL

更新日期：1998-01-01 00:00:00

abstract：RATIONALE:Robust intravenous (i.v.) nicotine self-administration (SA) in rats has been reported by several laboratories, including our own, using fixed ratio (FR) schedules of reinforcement. Studies on other drugs of abuse, however, suggest that progressive ratio (PR) schedules may provide additional information not ga...

journal_title：Psychopharmacology

authors： Donny EC,Caggiula AR,Mielke MM,Booth S,Gharib MA,Hoffman A,Maldovan V,Shupenko C,McCallum SE

更新日期：1999-11-01 00:00:00

abstract：:Carbachol, muscarine, eserine and neostigmine injected into the cerebral ventricles of conscious cats evoked emotional behaviour with aggression, autonomic and motor phenomena as well as clonic-tonic convulsions. The main and the most impressive feature of the gross behavioural effects of intraventricular carbachol, m...

journal_title：Psychopharmacology

authors： Beleslin DB,Samardzić R

更新日期：1979-04-11 00:00:00

abstract：:The in vivo potency of mazindol for binding to striatal dopamine transporters (DAT) was assessed by [123I]beta-CIT ([123I]2beta-carbomethoxy-3beta-(4-iodophenyl)tropane) single photon emission computed tomography (SPECT). Cocaine-dependent subjects (n = 12) underwent three SPECT scans; one before, between, and after s...

journal_title：Psychopharmacology

authors： Malison RT,McCance E,Carpenter LL,Baldwin RM,Seibyl JP,Price LH,Kosten TR,Innis RB

更新日期：1998-06-01 00:00:00

abstract：RATIONALE:Repeated exposure to psychostimulants that either increase dopamine (DA) release or target N-methyl-D-aspartate (NMDA) receptors can induce behavioural sensitisation, a phenomenon that may be important for the processes of addiction and even psychosis. A critical component of behavioural sensitisation is an i...

journal_title：Psychopharmacology

authors： Cui X,Lefevre E,Turner KM,Coelho CM,Alexander S,Burne TH,Eyles DW

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:The rise in heroin addiction has heightened the need for novel and effective treatments. Physical exercise has been shown as an effective treatment for stimulant abuse in clinical and pre-clinical research. However, this treatment has not yet been tested on opioid addiction. This study examined the effects o...

journal_title：Psychopharmacology

authors： Smethells JR,Greer A,Dougen B,Carroll ME

更新日期：2020-02-01 00:00:00

abstract：RATIONALE:Rats selectively bred for high saccharin (HiS) intake consume more alcohol and acquire intravenous (i.v.) cocaine self-administration more rapidly than their low saccharin (LoS)-consuming counterparts. The present experiment was designed to determine whether HiS and LoS rats differed in other aspects of drug ...

journal_title：Psychopharmacology

authors： Carroll ME,Anderson MM,Morgan AD

更新日期：2007-02-01 00:00:00

abstract：RATIONALE:Schizophrenia is characterized by a large variety of cognitive symptoms, among which information processing deficits have been extensively studied. So far, these aspects have been found to be remarkably stable and effective treatment is still lacking. Traditionally, information processing is subdivided into p...

journal_title：Psychopharmacology

authors： Ellenbroek BA

更新日期：2004-06-01 00:00:00

abstract：RATIONALE:Preclinical experimental models of pathological aggressive behavior are a sorely understudied and difficult research area. OBJECTIVES:How valid, reliable, productive, and informative are the most frequently used animal models of excessive aggressive behavior? METHODS:The rationale, key methodological featur...

journal_title：Psychopharmacology

authors： Miczek KA,de Boer SF,Haller J

更新日期：2013-04-01 00:00:00

abstract：:Two enantiomers (1S and 1R) of delta-3-tetrahydrocannabinol were assayed in man for psychoactivity. The 1S enantiomer had definite psychic actions, qualitatively similar to those of delta-1-tetrahydrocannabinol, but quantitatively less potent (1:3 to 1:6). Adding the two enantiomers together did not increase the effec...

journal_title：Psychopharmacology

authors： Hollister LE,Gillespie HK,Mechoulam R,Srebnik M

更新日期：1987-01-01 00:00:00

abstract：RATIONALE:Pharmacokinetics of melatonin in children might differ from that in adults. OBJECTIVES:This study aims to establish a dose-response relationship for melatonin in advancing dim light melatonin onset (DLMO), sleep onset (SO), and reducing sleep onset latency (SOL) in children between 6 and 12 years with chroni...

journal_title：Psychopharmacology

authors： van Geijlswijk IM,van der Heijden KB,Egberts AC,Korzilius HP,Smits MG

更新日期：2010-10-01 00:00:00

abstract：:In the studies reported here, we investigated the effects of nicotine on memory for unrelated word lists. Nicotine was delivered through cigarette smoking, and memory performance was assessed using both intentional and incidental recall tasks, and employing an additional, indirect measure of memory. We report the resu...

journal_title：Psychopharmacology

authors： Rusted J,Graupner L,Warburton D

更新日期：1995-06-01 00:00:00

abstract：:Two methods were used to assess nicotine-induced antinociception: tail withdrawal from a hot water bath and hind paw withdrawal from a hotplate. Nicotine doses which produced 75-80% maximum response were 0.75 mg/kg (free base) for tail withdrawal and 0.35 mg/kg for paw withdrawal. The peripheral blocker chlorisondamin...

journal_title：Psychopharmacology

authors： Caggiula AR,Epstein LH,Perkins KA,Saylor S

更新日期：1995-12-01 00:00:00

abstract：:The effects of various psychomotor stimulant drugs and drugs outside this class were examined on the efficacy of stimuli previously paired with reinforcement or reward (conditioned reinforcers, CR) in controlling responding. Pipradrol (5-45 mumol/kg), d-amphetamine (1.25-15.0 mumol/kg), and the cocaine analogues WIN 3...

journal_title：Psychopharmacology

authors： Robbins TW,Watson BA,Gaskin M,Ennis C

更新日期：1983-01-01 00:00:00

abstract：:The relationship between changes in IV tyramine pressor sensitivity accompanying selective monoamine oxidase (MAO) inhibitor treatment and estimates of MAO-A and MAO-B inhibition in vivo were studied. Reductions in platelet MAO activity provided an index of MAO-B inhibition, while changes in plasma 3-methoxy-4-hydroxy...

journal_title：Psychopharmacology

authors： Pickar D,Cohen RM,Jimerson DC,Lake CR,Murphy DL

更新日期：1981-01-01 00:00:00

abstract：:ApolipoproteinE (ApoE) genotype has recently been identified as a major risk factor for Alzheimer's disease (AD) but the mechanism(s) by which ApoE isoforms influence this disease remain unclear. Recent studies suggest that mice deficient in ApoE may exhibit impaired central cholinergic function. Since this neurotrans...

journal_title：Psychopharmacology

authors： Anderson R,Higgins GA

更新日期：1997-07-01 00:00:00

abstract：:It has been shown that pretreatment with dopamine (DA) receptor blockers disrupts the effect of intravenously (IV) and intracerebrally (ICV), but not intraperitoneally (IP) administered cocaine on place preference conditioning (PPC). The present study was undertaken to further evaluate possible differences between IV ...

journal_title：Psychopharmacology

authors： Nomikos GG,Spyraki C

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Cocaine dependence is a major health concern and there are no effective pharmacotherapies currently available. Although cocaine is an indirect DA agonist that binds to all three monoamine transporters, there is much evidence implicating a greater role for the dopamine (DAT) than norepinephrine (NET) and serot...

journal_title：Psychopharmacology

authors： Cook CD,Carroll IF,Beardsley PM

更新日期：2001-12-01 00:00:00

abstract：:A theory of acute tolerance to alcohol is proposed that includes two assumptions: 1) acute tolerance is a linear process with time, and 2) the slope of the line is a measure of the magnitude of the acute tolerance effect. Evidence that supports the validity of the theory is presented both from studies in which blood a...

journal_title：Psychopharmacology

authors： Radlow R

更新日期：1994-02-01 00:00:00

abstract：RATIONALE:Dysfunction of glutamatergic neurotransmission has been implicated in the pathophysiology of obsessive-compulsive disorder (OCD) and recent clinical reports suggest that some glutamate modulating agents are efficacious in the treatment of this disorder. N-acetylcysteine (NAC) is a readily available amino acid...

journal_title：Psychopharmacology

authors： Lafleur DL,Pittenger C,Kelmendi B,Gardner T,Wasylink S,Malison RT,Sanacora G,Krystal JH,Coric V

更新日期：2006-01-01 00:00:00

abstract：RATIONALE:Cannabinoid antagonists purportedly have greater effects in reducing the intake of highly palatable food compared to less palatable food. However, this assertion is based on free-feeding studies in which the amount of palatable food eaten under baseline conditions is often confounded with other variables, suc...

journal_title：Psychopharmacology

authors： Buckley JL,Rasmussen EB

更新日期：2014-05-01 00:00:00

abstract：RATIONALE:Though interoceptive properties of antidepressants have been described, discriminative stimulus (DS) properties of mirtazapine, which does not affect monoamine reuptake, remain uncharacterized. OBJECTIVES:The objectives of the study are to train rats to recognize a mirtazapine DS, then perform substitution s...

journal_title：Psychopharmacology

authors： Dekeyne A,Millan MJ

更新日期：2009-04-01 00:00:00

abstract：RATIONALE:Mice are useful tools for dissecting genetic and environmental factors in relation to the study of attention and impulsivity. The five-choice serial reaction time task (5CSRTT) paradigm has been well established in rats, but its transferability to mice is less well documented. OBJECTIVES:This study aims to s...

journal_title：Psychopharmacology

authors： Sanchez-Roige S,Peña-Oliver Y,Stephens DN

更新日期：2012-01-01 00:00:00

abstract：RATIONALE:Cortisol levels rise sharply immediately after electroconvulsive therapy (ECT); the resultant stimulation of steroid receptors in the hippocampus may be beneficial or harmful to cognition, depending on the magnitude of the stimulation. Steroid mechanisms may therefore modulate ECT-induced amnesia. OBJECTIVES...

journal_title：Psychopharmacology

authors： Nagaraja N,Andrade C,Sudha S,Madan Singh N,Chandra JS,Venkataraman BV

更新日期：2007-01-01 00:00:00

abstract：:Different groups of rats received combined or separate administration of different doses of piracetam (P1:100, P2:200, and P4:400 mg/kg) and choline (C1:100 and C2:200 mg/kg). Compared to control treatment, C1 significantly improved performance in a delayed alternation (DA) task, while P1, P2, P4 or P1C1 had no effect...

journal_title：Psychopharmacology

authors： Ennaceur A,Delacour J

更新日期：1987-01-01 00:00:00

abstract：RATIONALE:Somatostatin and its receptors have been localized in brain nuclei implicated in motor control, such as the striatum, nucleus accumbens, ventral pallidum, and globus pallidus (GP). OBJECTIVES:The objective of this study was to investigate the role of somatostatin receptors (sst(1,2,4)) in the GP on dopamine ...

journal_title：Psychopharmacology

authors： Marazioti A,Pitychoutis PM,Papadopoulou-Daifoti Z,Spyraki C,Thermos K

更新日期：2008-12-01 00:00:00

abstract：RATIONALE:Pindolol has been reported to shorten the onset of antidepressant action of selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitors (SSRIs) as well as to increase their efficacy. It has been postulated that pindolol enhances the antidepressant effect of SSRIs by blocking somatodendritic 5-HT1A aut...

journal_title：Psychopharmacology

authors： Arborelius L,Linnér L,Wallsten C,Ahlenius S,Svensson TH

更新日期：2000-07-01 00:00:00

abstract：:Animal experimental studies suggest that the therapeutic effect of selective serotonin re-uptake inhibitors (SSRIs) may involve neuroadaptive changes in pre- and post-synaptic serotonin1A (5-HT1A) receptors. We used the endocrine and hypothermic responses to the 5-HT1A receptor agonist, gepirone (20 mg orally), to ass...

journal_title：Psychopharmacology

authors： Sargent P,Williamson DJ,Pearson G,Odontiadis J,Cowen PJ

更新日期：1997-08-01 00:00:00