Abstract:
BACKGROUND:The rise in heroin addiction has heightened the need for novel and effective treatments. Physical exercise has been shown as an effective treatment for stimulant abuse in clinical and pre-clinical research. However, this treatment has not yet been tested on opioid addiction. This study examined the effects of physical activity (wheel running) on heroin-seeking in rats within a reinstatement paradigm (i.e., heroin relapse model). METHODS:Female and male rats were trained to self-administer intravenous heroin (0.015 mg/kg). Once trained, rats were placed into extinction (i.e., heroin abstinence) for 21 days with continuous access to a locked or unlocked running wheel. After extinction, rats were tested for drug- (heroin, caffeine, and yohimbine) and cue-primed reinstatement of heroin-seeking. RESULTS:Females completed more wheel revolutions than males across all study phases. Access to an unlocked running wheel reduced extinction and reinstatement of heroin-seeking, with greater reductions in females than males across several reinstatement conditions. In the locked wheel group, female rats showed greater reinstatement of heroin-seeking than males across several priming conditions. CONCLUSIONS:Wheel running reduced heroin-seeking in male and female rats, with females showing a more robust effect during reinstatement. The locked wheel group allowed an examination of sex differences in heroin reinstatement, which revealed that females showed greater vulnerability to heroin reinstatement than males, but with no other sex differences observed in maintenance or extinction. Overall, the results indicate that voluntary physical exercise may be an effective treatment for heroin dependence in humans.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Smethells JR,Greer A,Dougen B,Carroll MEdoi
10.1007/s00213-019-05381-2subject
Has Abstractpub_date
2020-02-01 00:00:00pages
453-463issue
2eissn
0033-3158issn
1432-2072pii
10.1007/s00213-019-05381-2journal_volume
237pub_type
杂志文章abstract:RATIONALE:The mechanism involved in AD is complex, which has prompted to develop compounds that could simultaneously interact with several potential targets. Here, we report a new synthesized compound SCR-1693 which is designed to target both AChE and calcium channels that are potential for AD therapy. OBJECTIVES:We i...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-015-4133-5
更新日期:2016-02-01 00:00:00
abstract:RATIONALE:Evidence that alcohol leads to increased aggressive behaviour is equivocal and confounded by evidence that such effects may operate indirectly via expectancy. One mechanism by which alcohol consumption may increase aggressive behaviour is via alterations in the processing of emotional facial cues. OBJECTIVES...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-009-1463-1
更新日期:2009-06-01 00:00:00
abstract::We examined the possibility that anoxia at birth can alter behavioral sensitization to amphetamine during adulthood. Male rats born either vaginally or by Cesarean section with or without an additional 15-min period of anoxia received five once-daily injections of either d-amphetamine (2.0 mg/kg, i.p.) or vehicle or n...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050419
更新日期:1997-10-01 00:00:00
abstract:RATIONALE:Alcohol and nicotine addiction are prevalent conditions that co-occur. Despite the prevalence of co-use, factors that influence the suppression and enhancement of concurrent alcohol and nicotine intake are largely unknown. OBJECTIVES:Our goals were to assess how nicotine abstinence and availability influence...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-019-05426-6
更新日期:2020-04-01 00:00:00
abstract:RATIONALE:Previous studies have shown that buspirone, a partial 5-HT(1A) receptor agonist, produces antinociceptive effects in rats and mice; Ca(2+) plays a critical role as a second messenger in mediating nociceptive transmission. 5-HT(1A) receptors have been proven to be coupled functionally with various types of Ca(...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1327-4
更新日期:2003-03-01 00:00:00
abstract::The effect of pretreatment with ritanserin, a potent and selective serotonin-S2 (5-HT2) receptor antagonist, on the prolactin (PRL) response to electroconvulsive therapy (ECT) was studied in seven female patients suffering from major depressive disorder. They were given either ECT alone, or ECT after 10 or 20 mg ritan...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244407
更新日期:1990-01-01 00:00:00
abstract::Behavioral performances of normotensive and hypertensive adult male baboons were tested before, during, and following chronic oral dosing with nifedipine. Performances during a five-color simultaneous match-to-sample task were measured during three dosing schedules (0.20, 0.68, and 1.14 mg/kg/day) and vehicle. Each do...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245802
更新日期:1990-01-01 00:00:00
abstract:RATIONALE:Contemporary animal models of cocaine addiction focus on increasing the amount of drug consumption to produce addiction-like behavior. However, another critical factor is the temporal pattern of consumption, which in humans is characterized by intermittency, both within and between bouts of use. OBJECTIVE:To...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-016-4393-8
更新日期:2016-10-01 00:00:00
abstract:RATIONALE:Heavy ecstasy use in humans has been associated with cognitive impairments and changes in cognitive brain function supposedly due to damage to the serotonin system. There is concern that even a single dose of 3,4-methylenedioxymethamphetamine may be neurotoxic, but very little is known about the consequences ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-007-0792-1
更新日期:2007-08-01 00:00:00
abstract:RATIONALE:Nicotine can enhance attentional performance in humans, a property that may be of therapeutic utility. OBJECTIVES:To identify brain sites mediating nicotine-induced attentional enhancement. METHODS:Nicotine (0, 1, 2, 4 and 8 microg) was injected bilaterally into the dorsal hippocampus and the prelimbic area...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1438-6
更新日期:2003-07-01 00:00:00
abstract::The effects of monoamine oxidase inhibitors (MAOIs) that selectively inhibit the MAO-A or MAO-B forms of MAO were studied in rats performing under a differential-reinforcement-of-low-rate 72-s (DRL 72-s) schedule of reinforcement. Clorgyline and CGP11'305A, irreversible and reversible MAO-A inhibitors, respectively, i...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00177554
更新日期:1988-01-01 00:00:00
abstract:RATIONALE:Previous studies indicate that the rewarding effect of D-1 dopamine receptor stimulation in nucleus accumbens (NAc) shell is greater in food-restricted (FR) than in ad libitum fed (AL) rats. The D-1 receptor is positively coupled to adenylyl cyclase and activates protein kinase A (PKA). OBJECTIVES:The purpos...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2602-z
更新日期:2012-06-01 00:00:00
abstract:RATIONALE:Premature discontinuation of antidepressant drugs is a frequent clinical problem. Adverse effects are common, occur early on in treatment and are reported to be one of the main reasons for discontinuation of antidepressant treatment. OBJECTIVES:To investigate the association between adverse effects occurring...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-014-3467-8
更新日期:2014-08-01 00:00:00
abstract:RATIONALE:Most adult smokers start smoking during their adolescence. This adolescent initiation may be due to multiple factors, but little evidence is available regarding whether their brains are differentially sensitive to the addictive effects of nicotine during adolescence. OBJECTIVE:To test the hypothesis that ado...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1758-6
更新日期:2004-07-01 00:00:00
abstract::Prepulse inhibition (PPI) of an acoustic startle response is impaired in schizophrenics. PPI can also be studied in the rat, and is impaired by dopamine (DA) D2/3 receptor agonists such as apomorphine. This disruption is reversed by DA antagonists, leading to proposals that this approach may be a useful means to ident...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246437
更新日期:1995-11-01 00:00:00
abstract:RATIONALE:Vasopressin (AVP) plays a role in regulating anxiety, which is thought to be partially mediated through the V1a receptor. Recently, JNJ-17308616 was identified as a V1a antagonist. OBJECTIVES:The purpose of this work was to assess V1a receptor affinity and selectivity of JNJ-17308616 and in vivo efficacy in ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1354-x
更新日期:2009-03-01 00:00:00
abstract:RATIONALE:The occurrence of methamphetamine (METH) use by the smoking route is increasing. A nonhuman primate model for examining the reinforcing effects of smoked METH would be valuable for testing potential interventions for treating METH abuse disorders. OBJECTIVE:The purpose of the present study was to examine the...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0479-z
更新日期:2006-10-01 00:00:00
abstract::The 12-h brain lithium concentration was measured by lithium-7 magnetic resonance spectroscopy in ten manic-depressive patients receiving daily or alternate-day lithium carbonate treatment. The median dose of lithium carbonate was 800 mg in the daily treatment group and 1200 mg in the alternate-day group. Median 12-h ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246668
更新日期:1996-04-01 00:00:00
abstract::Roxindole is a potent autoreceptor-selective dopamine agonist with additional properties as a serotonin reuptake inhibitor and 5-HT1A agonist. In order to get more insight into its mode of action in various psychiatric populations, we evaluated the effects of subchronic roxindole treatment on pituitary and adrenal hor...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246221
更新日期:1995-02-01 00:00:00
abstract:RATIONALE:The effects of acute bouts of physical activity (PA) on Strength of Desire (SoD) and Desire to Smoke (DtS) using individual participant data (IPD) from 19 acute randomised controlled studies were quantified. However, there is a need to identify factors influencing this relationship. OBJECTIVES:To understand ...
journal_title:Psychopharmacology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00213-014-3450-4
更新日期:2014-04-01 00:00:00
abstract::A double-blind, placebo-controlled, cross-over study in ten normal volunteers assessed the effects of the subcutaneous administration of adrenaline on platelet MAO activity, in an attempt to replicate previous findings of increased MAO activity following adrenaline. Platelet counts, cortisol plasma concentrations, and...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00430491
更新日期:1976-11-10 00:00:00
abstract:RATIONALE:Schizophrenia is a severe, persistent, and fairly common mental illness. Haloperidol is widely used and is effective against the symptoms of psychosis seen in schizophrenia. Chronic oral haloperidol administration decreased the number of astrocytes in the parietal cortex of macaque monkeys (Konopaske et al., ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-3136-3
更新日期:2013-11-01 00:00:00
abstract::It was shown previously that behavioural effects of apomorphine (locomotor activation and stereotyped behaviour) can be conditioned when they are associated with well-defined environmental stimuli. In the present study, the hypothesis was tested that glutamatergic mechanisms play an important role either in formation ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244064
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:This laboratory study investigated the mechanisms by which the opioid antagonist, naltrexone, reduces the risk of relapse to heavy drinking in individuals with alcohol dependence. METHODS:Eighteen alcohol-dependent, non-treatment-seeking volunteers were randomized to 50 mg naltrexone or placebo for 6 days a...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002130100919
更新日期:2002-02-01 00:00:00
abstract:RATIONALE:Stressful life events are suggested to contribute to the development of various pathologies, such as cardiovascular disorders, whose etiopathogenesis is highly associated with elevated levels of serum amyloid A (SAA) proteins. SAA synthesis in the liver is regulated by a complex network of cytokines acting in...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-5149-4
更新日期:2019-06-01 00:00:00
abstract::Neither acquisition learning nor 24-h retention was significantly altered by 6-hydroxydopamine intracerebral injections which depleted forebrain noradrenaline (NA) to less than 5% of control values. The absence of passive avoidance impairment cannot be ascribed to functional recovery following the lesion (indicated by...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427627
更新日期:1979-11-01 00:00:00
abstract:RATIONALE:Ecstasy is a commonly used psychoactive drug with 3,4-methylenedioxymethamphetamine (MDMA) as the main content. Importantly, it has been suggested that use of MDMA may be neurotoxic particularly for serotonergic (5-hydroxytryptamine (5-HT)) neurons. In the past decades, several molecular imaging studies exami...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-016-4396-5
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Rats reared in social isolation exhibit various cognitive and behavioural abnormalities in adulthood. However, impulsivity following this treatment still remains unclear, especially in response to medications used in attention deficit hyperactivity disorder, such as amphetamine. METHODS:Using an isolation-r...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4579-8
更新日期:2017-05-01 00:00:00
abstract:RATIONALE:Subthreshold smokers (who smoke < or =5 cigarettes/day) experience withdrawal symptoms, yet they smoke less than is required to maintain serum nicotine levels. OBJECTIVES:For study 1, our aim was to determine (1) if adult subthreshold smokers report withdrawal symptoms; (2) how they rate symptom severity; (3...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0497-x
更新日期:2006-10-01 00:00:00
abstract::A placebo-controlled study with six normal volunteers was carried out using 1 mg haloperidol IM. In some EEG frequency bands, the power density due to haloperidol appeared to increase or decrease depending on the subject. Nevertheless, if the results of the six subjects are taken together, the effects of haloperidol a...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00431753
更新日期:1981-01-01 00:00:00