Abstract：
RATIONALE:Pharmacokinetics of melatonin in children might differ from that in adults. OBJECTIVES:This study aims to establish a dose-response relationship for melatonin in advancing dim light melatonin onset (DLMO), sleep onset (SO), and reducing sleep onset latency (SOL) in children between 6 and 12 years with chronic sleep onset insomnia (CSOI). METHODS:The method used for this study is the randomized, placebo-controlled double-blind trial. Children with CSOI (n = 72) received either melatonin 0.05, 0.1, and 0.15 mg/kg or placebo during 1 week. Sleep was assessed with log and actigraphy during this week and the week before. Outcomes were the shifts in DLMO, SO, and SOL. RESULTS:Treatment with melatonin significantly advanced SO and DLMO by approximately 1 h and decreased SOL by 35 min. Within the three melatonin groups, effect size was not different, but the circadian time of administration (TOA) correlated significantly with treatment effect on DLMO (r (s) = -0.33, p = 0.022) and SO (r (s) = -0.38, p = 0.004), whereas clock TOA was correlated with SO shift (r = -0.35, p = 0.006) and not with DLMO shift. CONCLUSIONS:No dose-response relationship of melatonin with SO, SOL, and DLMO is found within a dosage range of 0.05-0.15 mg/kg. The effect of exogenous melatonin on SO, SOL, and DLMO increases with an earlier circadian TOA. The soporific effects of melatonin enhance the SO shift. This study demonstrates that melatonin for treatment of CSOI in children is effective in a dosage of 0.05 mg/kg given at least 1 to 2 h before DLMO and before desired bedtime.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
van Geijlswijk IM,van der Heijden KB,Egberts AC,Korzilius HP,Smits MGdoi
10.1007/s00213-010-1962-0subject
Has Abstractpub_date
2010-10-01 00:00:00pages
379-91issue
3eissn
0033-3158issn
1432-2072journal_volume
212pub_type
杂志文章,随机对照试验abstract：:Recent studies indicate that morphine dependence, assessed as the severity of naloxone-precipitated opiate withdrawal in rats, is attenuated by dizocipline, a non-competitive, excitatory amino acid antagonist. Because ethanol is a putative excitatory amino acid antagonist, the present study compared the effects of co-...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050428
更新日期：1997-11-01 00:00:00
abstract：:Administration of 10 mg/kg TRH to mice was found to reduce the sleep and hypothermia induced by 4.7 g/kg ethanol. However, TRH did not reduce the sleep of mice that were given gamma-hydroxybutyric acid (GHBA), baclophen, or aminooxyacetic acid (AOAA) in combination with 3 g/kg/ ethanol. TRH also failed to reverse the ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00439101
更新日期：1977-04-29 00:00:00
abstract：:the immediate posttrial injection of oxotremorine (0.250 mu Mol/kg, IP) can facilitate the retention of a passive-avoidance response in mice. After the administration of alfa-methyl-p-tyrosine methylester (alpha-MPT) by intracerebroventricular injection at doses that had no effect on retention (100 microgram, 10 micro...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00433098
更新日期：1980-01-01 00:00:00
abstract：:Lu 25-109 [5-(2-ethyl-2H-tetrazol-5-yl)-1,2,3,6-tetrahydro-1-methylpyridine] , has M agonistic and M2/M3 antagonistic effects at muscarinic receptors in vitro; a pharmacological profile that may be beneficial in treatment of Alzheimer's disease. In the present study, we compare functional in vivo effects of Lu 25-109 ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050615
更新日期：1998-06-01 00:00:00
abstract：:Ibogaine is currently being investigated for its potential use as an anti-addictive agent. In the present study we sought to determine whether prior morphine exposure influences the ability of ibogaine to inhibit morphine-induced locomotor stimulation. Female Sprague-Dawley rats were pretreated once a day for 1-4 days...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02246495
更新日期：1995-10-01 00:00:00
abstract：:Biotransformation of phenacetin via O-deethylation to acetaminophen, an index reaction reflecting activity of Cytochrome P450-1A2, was studied in microsomal preparations from a series of human livers. Acetaminophen formation was consistent with a double Michaelis-Menten system, with low-Km (mean Km1 = 68 microM) and h...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050149
更新日期：1996-12-01 00:00:00
abstract：RATIONALE:Both central serotonergic and nicotinic systems play important roles in a variety of neurobehavioral functions; however, the interactions of these two systems have not been fully characterized. The current study served to determine the impact of a relatively selective 5-HT2A receptor antagonist, ketanserin, o...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-004-2060-y
更新日期：2005-05-01 00:00:00
abstract：RATIONALE:3,4-Methylenedioxymethamphetamine (MDMA or "ecstasy") causes serotonin neuron damage in laboratory animals. The serotonin system is known to be important in the regulation of mood. Previous research has shown that MDMA users score higher on self-report ratings of depression than controls. However, MDMA users ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-003-1705-6
更新日期：2004-05-01 00:00:00
abstract：RATIONALE:Piper methysticum extract (kava kava) possesses numerous therapeutic properties, but it is unknown which of its principle constituents (kavalactones) subserve such effects. OBJECTIVES:This experiment sought to characterize the putative anxiolytic properties of P. methysticum extract and its six principle kav...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130100686
更新日期：2001-04-01 00:00:00
abstract：:Three sets of experiments were carried out in a Y water maze in which mice had to swim toward the light or the dark, in two different procedures. The first procedure involved, orientation toward a light source (L procedure), corresponding to natural preference, the latter involved orientation toward the dark (D proced...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00496858
更新日期：1976-08-17 00:00:00
abstract：RATIONALE:Cortisol levels rise sharply immediately after electroconvulsive therapy (ECT); the resultant stimulation of steroid receptors in the hippocampus may be beneficial or harmful to cognition, depending on the magnitude of the stimulation. Steroid mechanisms may therefore modulate ECT-induced amnesia. OBJECTIVES...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-006-0593-y
更新日期：2007-01-01 00:00:00
abstract：:The low rate of success for identifying effective treatments for cognitive dysfunction has prompted recent efforts to improve pharmaceutical discovery and development. In particular, investigators have emphasized improving translation from pre-clinical to clinical research. A specific area of focus has been touchscree...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-015-4012-0
更新日期：2015-11-01 00:00:00
abstract：RATIONALE:Early life exposure to stress and to GABAA receptor modulators have well-defined and persistent behavioral effects. A single neonatal injection of the GABAergic neurosteroid allopregnanolone (3alpha-hydroxy,5alpha-pregnane-20-one, 10 mg/kg, i.p.) alters the localization of prefrontal cortex (PFC) interneurons...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-006-0360-0
更新日期：2006-06-01 00:00:00
abstract：RATIONALE:The party drug ecstasy is frequently used in combination with other drugs like marihuana and alcohol. In addition, a substantial proportion of the MDMA users has claimed to drive a car when under the influence of MDMA and/or other drugs. OBJECTIVE:To assess the effects of MDMA and alcohol, combined and alone...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-006-0434-z
更新日期：2006-09-01 00:00:00
abstract：RATIONALE:The involvement of dopamine neurotransmission in opiate reward remains controversial. OBJECTIVE:To investigate the dopaminergic basis of opiate reward by comparing the effect of systemic injection of the D2/D3 antagonist sulpiride on morphine self-administration (ICSA) into the ventral tegmental area (VTA) o...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-001-0981-2
更新日期：2002-03-01 00:00:00
abstract：:In two experiments, phenobarbitone sodium (30 mg/kg) reliably enhanced water consumption and extended the duration of drinking in 24h water-deprived male rats. The opiate receptor antagonists naloxone (0.1-10 mg/kg) and naltrexone (0.1-10 mg/kg) both decreased water intake and reduced the duration of drinking. When th...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00433011
更新日期：1983-01-01 00:00:00
abstract：:The peripheral BDZ receptor ligand Ro 5-4864 was administered to rabbits in doses ranging from 0.2 to 7 mg/kg IV. Changes in electrocortical activity appeared within 1 min after administration, characterized by trains of slow waves in the posterior sensorimotor and optic cortices (0.6-2 mg/kg) and by grand mal seizure...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00180835
更新日期：1986-01-01 00:00:00
abstract：:The relationship between nicotine yield as determined by the FTC method and nicotine absorption was examined in 72 smokers in a more rigorous repetition of a previous study of 33 smokers. For this study, 113 smokers evenly distributed across four FTC "tar" yield ranges were recruited, only 72 demonstrated reasonable c...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/s002130050720
更新日期：1998-10-01 00:00:00
abstract：:Withdrawal was precipitated by naloxone at different intervals, up to 22.5 h, following a last maintenance injection in morphine-dependent rats. Different symptoms of withdrawal were found to be preeminent following different morphine-naloxone intervals. Locomotor activity, jumping, and writhing were precipitated most...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00426773
更新日期：1977-10-20 00:00:00
abstract：:CSF GABA levels were not significantly different in a group of drug-free psychotic patients compared to a group of psychotic patients at two points during haloperidol treatment or a neurological comparison group. In the untreated group, CSF GABA was significantly negatively correlated with clinical ratings of anxiety ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427885
更新日期：1980-01-01 00:00:00
abstract：BACKGROUND:Marijuana intoxication appears to impair response inhibition, but it is unclear if impaired inhibition and associated brain abnormalities persist after prolonged abstinence among adolescent users. We hypothesized that brain activation during a go/no-go task would show persistent abnormalities in adolescent m...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/s00213-007-0823-y
更新日期：2007-10-01 00:00:00
abstract：:The effect of long-term lithium carbonate treatment on parameters of immediate, short-, and long-term memory was examined in a group of bipolar affectively ill patients. The lithium treatment group recalled significantly fewer words across trials on a verbal learning task than a group of bipolar affectively ill patien...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00426919
更新日期：1979-05-08 00:00:00
abstract：:The title of this article is "Effect of a dual orexin receptor antagonist (DORA-12) on sleep and event-related oscillations in rats exposed to ethanol vapor during adolescence". ...
journal_title：Psychopharmacology
pub_type： 已发布勘误
doi：10.1007/s00213-020-05673-y
更新日期：2020-11-01 00:00:00
abstract：:Passive avoidance learning was significantly impaired by atropine (5 mg/kg, IP) or scopolamine (0.5 mg/kg), but not by methyl-atropine (5 mg/kg) or methyl-scopolamine (0.5 mg/kg), from postnatal day 15 on. In contrast, an improvement was observed, not significant at 11 days and significant at 13 days, probably due to ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00449124
更新日期：1982-01-01 00:00:00
abstract：RATIONALE:Alcohol use disorders are associated with deficits in adaptive behavior. While some behavioral impairments that are associated with alcohol use disorders may predate exposure to drugs of abuse, others may result directly from exposure to drugs of abuse, including alcohol. Identifying a causal role for how alc...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-015-4101-0
更新日期：2016-01-01 00:00:00
abstract：RATIONALE:Available neurochemical probes that lower brain dopamine (DA) levels in man are limited by their tolerability and efficacy. For instance, the acute lowering of brain tyrosine is well tolerated, but only modestly lowers brain DA levels. Modification of tyrosine depletion to robustly lower DA levels would provi...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-013-2977-0
更新日期：2013-05-01 00:00:00
abstract：RATIONALE:Previously, we have shown that d-amphetamine (AMPH) was more potent than d-methamphetamine (METH) at increasing extracellular levels of dopamine (DA) in the prefrontal cortex (PFC) at doses that had similar effects in the nucleus accumbens. Since working memory depends on PFC DA, it was postulated that AMPH w...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-003-1522-y
更新日期：2003-11-01 00:00:00
abstract：:2Beta-propanoyl-3beta-(4-tolyl)-tropane (PTT) is a cocaine analog which has been shown in rhesus monkeys to have cocaine-like discriminative stimulus effects and a long duration of action (>8 h), yet does not function as a reinforcer when substituted for cocaine in monkeys responding under a fixed-interval 5-min sched...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050549
更新日期：1998-03-01 00:00:00
abstract：RATIONALE:Corticostriatal circuits are widely implicated in the top-down control of attention including inhibitory control and behavioural flexibility. However, recent neurophysiological evidence also suggests a role for thalamic inputs to striatum in behaviours related to salient, reward-paired cues. OBJECTIVES:Here,...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-017-4627-4
更新日期：2017-08-01 00:00:00
abstract：:Rats were made hyperphagic by 6-hydroxydopamine (6-OHDA) injected bilaterally into the ventral midbrain; then they were restricted to a 6 h/day feeding schedule and tested for appetite suppression with amphetamine and fenfluramine in randomized order. Amphetamine anorexia was diminished while fenfluramine anorexia was...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00426393
更新日期：1984-01-01 00:00:00
