Measuring impulsivity in mice: the five-choice serial reaction time task.

abstract：RATIONALE:The emergence of the consumption of highly potent synthetic cannabinoid receptor agonists (spice drugs) that produce important neurological symptoms has prompted the research on the consequences of acute and chronic use of these new psychoactive substances. Most studies on cannabinoid dependence have been per...

journal_title：Psychopharmacology

authors： Serrano A,Vadas E,Ferrer B,Bilbao A,Granado N,Suárez J,Pavon FJ,Moratalla R,Rodríguez de Fonseca F

更新日期：2021-02-01 00:00:00

abstract：RATIONALE:Behavioral disturbances (BD) are prevalent in patients with substance use disorders (SUD). OBJECTIVES:To test the hypothesis that chronic exposure to cocaine could favor the acquisition of BD that were not present in childhood. METHODS:We used child and adult ADHD self-report screening scales (WURS-25 and A...

journal_title：Psychopharmacology

authors： Vorspan F,de Witt P,Zerdazi EH,Karsinti E,Ksouda K,Icick R,Bellivier F,Marie N,Brousse G,Bloch V

更新日期：2020-11-01 00:00:00

abstract：:The effects of four indirect dopamine agonists, d-amphetamine (0.25-4.0 mg/kg), cocaine (2.5-40.0 mg/kg), GBR 12909 (10.0-30.0 mg/kg), and nomifensine (5.0-20.0 mg/kg), on the behavioral organization of movements in an unconditioned motor paradigm were investigated in rats. The extended scaling hypothesis using the fl...

journal_title：Psychopharmacology

authors： Paulus MP,Callaway CW,Geyer MA

更新日期：1993-01-01 00:00:00

abstract：:Chlordiazepoxide (5 and 10 mg/kg) and diazepam (2.5 mg/kg) reduced the latency to eat and enhanced feeding response to familiar food in a food-preference test. The increased feeding response resulted from an increased frequency of individual eating episodes (bouts) without significant change in the episode duration. E...

journal_title：Psychopharmacology

authors： Cooper SJ

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:The main psychoactive component of cannabis, delta-9-tetrahydrocannabinol (THC), can impair driving performance. Cannabidiol (CBD), a non-intoxicating cannabis component, is thought to mitigate certain adverse effects of THC. It is possible then that cannabis containing equivalent CBD and THC will differenti...

journal_title：Psychopharmacology

authors： Arkell TR,Lintzeris N,Kevin RC,Ramaekers JG,Vandrey R,Irwin C,Haber PS,McGregor IS

更新日期：2019-09-01 00:00:00

abstract：RATIONALE:Considerable research indicates that "ecstasy" users perceive their memory for future intentions (prospective memory) to be impaired. However, only one empirical study to date has directly tested how this capacity is affected by ecstasy use, and this study provided relatively limited information regarding the...

journal_title：Psychopharmacology

authors： Rendell PG,Gray TJ,Henry JD,Tolan A

更新日期：2007-11-01 00:00:00

abstract：RATIONALE:Cognitive rehabilitation is now recognized as an important tool in the treatment of schizophrenia, and findings in this area are emerging rapidly. There is a need for a systematic review of the effects of the different training programs. OBJECTIVES:To review quantitatively the controlled studies on cognitive...

journal_title：Psychopharmacology

authors： Krabbendam L,Aleman A

更新日期：2003-09-01 00:00:00

abstract：:2Beta-propanoyl-3beta-(4-tolyl)-tropane (PTT) is a cocaine analog which has been shown in rhesus monkeys to have cocaine-like discriminative stimulus effects and a long duration of action (>8 h), yet does not function as a reinforcer when substituted for cocaine in monkeys responding under a fixed-interval 5-min sched...

journal_title：Psychopharmacology

authors： Birmingham AM,Nader SH,Grant KA,Davies HM,Nader MA

更新日期：1998-03-01 00:00:00

abstract：RATIONALE:Partial dopamine receptor agonists have been proposed as candidate pharmacotherapies for cocaine dependence. OBJECTIVE:This 42-day, within-subject, human laboratory study assessed how maintenance on aripiprazole, a partial D(2) receptor agonist, influenced smoked cocaine self-administration, cardiovascular m...

journal_title：Psychopharmacology

authors： Haney M,Rubin E,Foltin RW

更新日期：2011-08-01 00:00:00

abstract：RATIONALE:Pharmacokinetics of melatonin in children might differ from that in adults. OBJECTIVES:This study aims to establish a dose-response relationship for melatonin in advancing dim light melatonin onset (DLMO), sleep onset (SO), and reducing sleep onset latency (SOL) in children between 6 and 12 years with chroni...

journal_title：Psychopharmacology

authors： van Geijlswijk IM,van der Heijden KB,Egberts AC,Korzilius HP,Smits MG

更新日期：2010-10-01 00:00:00

abstract：:The behavioral effects of intraventricularly (IVT) administered (-)-nicotine on food-maintained behavior were studied. Rats responded by pressing a lever under various fixed ratio (FR) schedules. Infusion of 5 microgram of (-)-nicotine suppressed responding under an FR 16 schedule for 11-13 min. The effect was inverse...

journal_title：Psychopharmacology

authors： DeNoble VJ,Dragan VP,Carron L

更新日期：1982-01-01 00:00:00

abstract：:The effects of d-fenfluramine and morphine on various nociceptive responses of rats were investigated. Unlike morphine, which inhibited all the responses examined, d-fenfluramine inhibited jumping and paw licking of rats on a hot plate, but did not increase the latency of tail withdrawal from hot water. The effects of...

journal_title：Psychopharmacology

authors： Rochat C,Cervo L,Romandini S,Samanin R

更新日期：1982-01-01 00:00:00

abstract：:The modulation of spontaneous (social and individual) behaviour as a function of the age of the rat (1, 3, 6, 12, 18 and 24 months) and of scopolamine dose (0.1, 0.2, 0.3 and 0.5 mg/kg) was studied. Observations were conducted during the dark phase of the reverse light/dark schedule using a reintroduction procedure. R...

journal_title：Psychopharmacology

authors： Soffié M,Bronchart M

更新日期：1988-01-01 00:00:00

abstract：:To investigate the role of D1 dopamine receptors in the discriminative stimulus effects of cocaine, two rhesus monkeys were trained in a two-lever, food-reinforced, drug discrimination paradigm to discriminate cocaine (0.2 mg/kg, IM) from saline. Administration of various doses of cocaine resulted in a dose-related in...

journal_title：Psychopharmacology

authors： Kleven MS,Anthony EW,Goldberg LI,Woolverton WL

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Chronic administration of nicotine in rats results in upregulation of neuronal nicotinic receptors. Upregulation has been proposed to reflect receptor desensitization, which may underlie functional tolerance to nicotine's effects. However, evidence indicates that tolerance and upregulation do not always paral...

journal_title：Psychopharmacology

authors： McCallum SE,Caggiula AR,Booth S,Breese CR,Lee MJ,Donny EC,Leonard S,Sved AF

更新日期：2000-05-01 00:00:00

abstract：:The present experiment examined effects of nicotine on body weight of male and female rats when Oreo cookies, potato chips, laboratory chow, and water were available. Body weight and eating behavior were measured for 17-day periods before, during, and after nicotine or saline administration. There was an inverse relat...

journal_title：Psychopharmacology

authors： Grunberg NE,Popp KA,Winders SE

更新日期：1988-01-01 00:00:00

abstract：:Lithium elicits opposite effects on two behavioural syndromes in rats: enhancement of the 5-HT1A-linked serotonin syndrome and attenuation of the 5-HT2-linked wet dog shakes. The ability of intracerebroventricular (ICV) myo-inositol or forskolin to reverse the enhancement of the serotonin syndrome by lithium was teste...

journal_title：Psychopharmacology

authors： Kofman O,Levin U

更新日期：1995-03-01 00:00:00

abstract：RATIONALE:Observing responses bring sensory receptors into contact with environmental stimuli. In the observing-response procedure, periods in which an operant response (e.g. pressing a lever) is reinforced by drug deliveries alternate with periods in which this response is never reinforced (i.e. extinction). These alt...

journal_title：Psychopharmacology

authors： Shahan TA

更新日期：2003-05-01 00:00:00

abstract：:Acamprosate (calcium-acetyl homotaurinate) is a new compound used in the treatment of alcohol abuse. Because of the putative link between alcoholism and the endogenous opioid systems in both humans and laboratory animals, we tested in rats the effects of acamprosate on behavioral and neurochemical effects of opioid dr...

journal_title：Psychopharmacology

authors： Spanagel R,Sillaber I,Zieglgänsberger W,Corrigall WA,Stewart J,Shaham Y

更新日期：1998-10-01 00:00:00

abstract：:Acute and chronic effects of ethosuximide (40, 80, and 120 mg/kg), phenytoin (2.5, 5, and 7.5 mg/kg), clonazepam (0.25, 0.5, and 0.75 mg/kg), and valproic acid (40, 80, and 120 mg/kg) were examined in pigeons performing under a delayed-matching-to-sample procedure. Acute administration of clonazepam or valproic acid p...

journal_title：Psychopharmacology

authors： Poling A,Picker M,Vande Polder D,Clark R

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:Pindolol has been reported to shorten the onset of antidepressant action of selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitors (SSRIs) as well as to increase their efficacy. It has been postulated that pindolol enhances the antidepressant effect of SSRIs by blocking somatodendritic 5-HT1A aut...

journal_title：Psychopharmacology

authors： Arborelius L,Linnér L,Wallsten C,Ahlenius S,Svensson TH

更新日期：2000-07-01 00:00:00

abstract：:The discriminative stimulus effect of midazolam, a short-acting benzodiazepine, was used for testing the effects of drugs thought to act as antagonists at different sites in the proposed benzodiazepine receptor complex. Rats were trained in a standard two-bar operant conditioning procedure with food reinforcers delive...

journal_title：Psychopharmacology

authors： Stolerman IP,Garcha HS,Rose IC

更新日期：1986-01-01 00:00:00

abstract：:Administration of various doses of 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) to rats produced dose-related decreases in 1-h food intake in the food-deprived paradigm. Pretreatment with spiperone (5-HT1A/5-HT2/D2 antagonist), propranolol or CGP361A (beta-adrenoceptor antagonists that also have binding affinit...

journal_title：Psychopharmacology

authors： Aulakh CS,Hill JL,Yoney HT,Murphy DL

更新日期：1992-01-01 00:00:00

abstract：:The present study compared cocaine-induced hyperlocomotion and cocaine i.v. self-administration in DBA/2J and C57BL/6J mice. In the locomotor activity experiment, these strains were tested for hyperlocomotion after i.p. cocaine injection (0-60.0 mg/kg), using a Digiscan Animal Activity Monitoring System. In the cocain...

journal_title：Psychopharmacology

authors： Rocha BA,Odom LA,Barron BA,Ator R,Wild SA,Forster MJ

更新日期：1998-07-01 00:00:00

abstract：:Pigeons were trained to peck each of two response keys. Periods during which pecks on one key (the food key) produced access to grain according to a random-ratio 80 schedule alternated irregularly with periods during which food-key responses had no scheduled consequences (extinction). Both keys remained amber unless a...

journal_title：Psychopharmacology

authors： Dearing ME,Branch MN

更新日期：1981-01-01 00:00:00

abstract：RATIONALE:Contemporary animal models of cocaine addiction focus on increasing the amount of drug consumption to produce addiction-like behavior. However, another critical factor is the temporal pattern of consumption, which in humans is characterized by intermittency, both within and between bouts of use. OBJECTIVE:To...

journal_title：Psychopharmacology

authors： Kawa AB,Bentzley BS,Robinson TE

更新日期：2016-10-01 00:00:00

abstract：:The effect of the intravenous administration of ergot alkaloids on epileptic responses to intermittent photic stimulation )IPS) has been studied in adolescent baboons, Papio papio, from Senegal. Ergocornine, 1--2 mg/kg, produced marked autonomic and behavioural effects, slowed the EEG, and abolished myoclonic response...

journal_title：Psychopharmacology

authors： Anlezark G,Meldrum B

更新日期：1978-04-14 00:00:00

abstract：RATIONALE:The ultra-short-acting mu opioid agonist analgesic/anesthetic remifentanil (RMF) is extremely rapidly eliminated from blood (half-life in rats, 0.3-0.7 min). This extremely fast elimination is thought to be the main reason why RMF maintains such high rates of responding in animal operant-conditioning models o...

journal_title：Psychopharmacology

authors： Crespo JA,Sturm K,Saria A,Zernig G

更新日期：2005-12-01 00:00:00

abstract：RATIONALE:The non-selective nicotinic acetylcholine receptor (nAChR) agonist nicotine has been argued to improve attention via enhanced filtering of irrelevant stimuli. Here, we tested this hypothesis in the context of smooth pursuit eye movements (SPEMs), an oculomotor function previously shown to improve with nicotin...

journal_title：Psychopharmacology

authors： Meyhöfer I,Kasparbauer AM,Steffens M,Ettinger U

更新日期：2019-07-01 00:00:00

abstract：:The relationship between changes in IV tyramine pressor sensitivity accompanying selective monoamine oxidase (MAO) inhibitor treatment and estimates of MAO-A and MAO-B inhibition in vivo were studied. Reductions in platelet MAO activity provided an index of MAO-B inhibition, while changes in plasma 3-methoxy-4-hydroxy...

journal_title：Psychopharmacology

authors： Pickar D,Cohen RM,Jimerson DC,Lake CR,Murphy DL

更新日期：1981-01-01 00:00:00