Abstract:
:Administration of various doses of 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) to rats produced dose-related decreases in 1-h food intake in the food-deprived paradigm. Pretreatment with spiperone (5-HT1A/5-HT2/D2 antagonist), propranolol or CGP361A (beta-adrenoceptor antagonists that also have binding affinities for 5-HT1A and 5-HT1B sites) and MDL-72222 (5-HT3 antagonist) did not attenuate DOI-induced suppression of food intake. In contrast, pretreatment with metergoline (5-HT1/5-HT2 antagonist) completely blocked whereas mesulergine, mianserin and ritanserin (5-HT1C/5-HT2 antagonists) partially blocked DOI's effect on food intake. On the other hand, pretreatment with MDL-72222 but not with m-chlorophenylpiperazine (m-CPP) significantly potentiated DOI-induced suppression of food intake. Furthermore, the food intake suppressant effects of various doses of DOI were found to be similar in the Fawn-Hooded (FH) rat strain as compared to the Wistar rat strain. These findings suggest that DOI-induced suppression of food intake is mediated by stimulation of both 5-HT1C and 5-HT2 receptors.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Aulakh CS,Hill JL,Yoney HT,Murphy DLdoi
10.1007/BF02247721subject
Has Abstractpub_date
1992-01-01 00:00:00pages
444-8issue
4eissn
0033-3158issn
1432-2072journal_volume
109pub_type
杂志文章abstract:RATIONALE:Although the behavioral effects of systemic injection of lipopolysaccharide (LPS) have been extensively investigated, the modulation of these effects by natural environmental factors has received little attention. OBJECTIVES:The present study investigated whether or not locomotor activity reductions and the ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1554-3
更新日期:2003-12-01 00:00:00
abstract:RATIONALE:H(3)-receptor inverse agonists raise a great interest as innovative therapeutics in several central disorders. Whereas their procognitive properties are well established, their antipsychotic-like properties are still debated. OBJECTIVES:We further explored the effect of maximal doses (3-10 mg/kg) of ciproxif...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1863-2
更新日期:2010-07-01 00:00:00
abstract:RATIONALE:Hypericum perforatum L., known as St. John's wort (SJW), is used as a phytotherapeutic agent for the treatment of mild to moderate forms of depression. OBJECTIVES:The aim of the present study was to evaluate the effect of SJW extract (STW 3-VI; 250 and 500 mg/kg; p.o.) and fluoxetine (10 mg/kg, p.o.) on gene...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-2032-3
更新日期:2011-02-01 00:00:00
abstract::Psychopharmacological studies using caffeinated beverages or caffeine have rarely considered temporal effects on psychological and physiological function or the specific contribution of caffeine, hot water, or beverage type to the observed effects. The effect of 400 ml hot tea, coffee, and water consumption on systoli...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s002130050438
更新日期:1997-11-01 00:00:00
abstract::Human eyeblink conditioning, a relatively simple form of learning and memory, has previously been shown to be impaired by the central and peripheral anticholinergic scopolamine. The present study compared the behavioral effects of scopolamine with the benzodiazepine lorazepam and a peripherally active anticholinergic,...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02246273
更新日期:1995-12-01 00:00:00
abstract:RATIONALE:Varenicline is believed to work, in part, by reducing craving responses to smoking cues and by reducing general levels of craving; however, these hypotheses have never been evaluated with craving assessed in the natural environments of treatment-seeking smokers. OBJECTIVES:Ecological momentary assessment pro...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-012-2698-9
更新日期:2012-09-01 00:00:00
abstract::Intravenous self-administration of d-amphetamine (0.25 mg/kg/injection) decreased in a dose-related fashion after injections of the dopaminergic agonists apomorphine and piribedil. The dopaminergic agonists appear to suppress amphetamine intake in the same way as do 'free' amphetamine injections, by extending drug sat...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427393
更新日期:1978-07-19 00:00:00
abstract::Rats injected with doses of d-amphetamine 0--5.0 mg/kg were observed continuously in either an enclosed Y-maze or on an elevated Y-shaped platform. Patterns of increased walking and stereotypy were unaffected by the type of apparatus, but rearing remained totally suppressed at all dose levels on the elevated platform....
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431954
更新日期:1979-04-25 00:00:00
abstract:RATIONALE:Combining neuroleptics with 5-HT1A ligands is thought to improve the preclinical profile of neuroleptics and may be of interest in the development of new compounds that have greater therapeutic potential and/or are better tolerated. OBJECTIVE:To examine 1) the ability of 5-HT1A ligands to alter the effects o...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050972
更新日期:1999-05-01 00:00:00
abstract:RATIONALE:Treatment of attention-deficit/hyperactivity disorder (ADHD) has for many years relied on psychostimulants, particularly various formulations of amphetamines and methylphenidate. These are central nervous system stimulants and are scheduled because of their abuse potential. Atomoxetine (atomoxetine hydrochlor...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-013-2986-z
更新日期:2013-03-01 00:00:00
abstract::Cortical and hippocampal EEGs in animal models of schizophrenia were compared to those obtained with psychotomimetics or antipsychotic agents by utilizing power spectral analysis. Models of positive schizophrenic symptoms were created with methamphetamine (MAP) and cocaine, and a model of both negative and positive sy...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050306
更新日期:1997-06-01 00:00:00
abstract::The behavioral performance of inbred mouse strains was examined in animal models of anxiety to evaluate the potential contribution of genetic factors to fear-motivated behaviors. The preference that randomly bred mice and rats exhibit for the enclosed as opposed to the open arms of an elevated maze has been considered...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244948
更新日期:1993-01-01 00:00:00
abstract:RATIONALE:Although psilocybin has been used for centuries for religious purposes, little is known scientifically about its acute and persisting effects. OBJECTIVES:This double-blind study evaluated the acute and longer-term psychological effects of a high dose of psilocybin relative to a comparison compound administer...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-006-0457-5
更新日期:2006-08-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Blood oxygen level dependent (BOLD) contrast pharmacological magnetic resonance imaging (phMRI) is an increasingly popular technique that allows the non-invasive investigation of spatial and temporal changes in rat brain function in response to pharmacological stimulation in vivo. Rat brain BOL...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-005-2213-7
更新日期:2005-08-01 00:00:00
abstract::Acamprosate (calcium-acetyl homotaurinate) is a new compound used in the treatment of alcohol abuse. Because of the putative link between alcoholism and the endogenous opioid systems in both humans and laboratory animals, we tested in rats the effects of acamprosate on behavioral and neurochemical effects of opioid dr...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050730
更新日期:1998-10-01 00:00:00
abstract:RATIONALE:The majority of pharmacotherapies proposed for cocaine dependence have been marginally effective and frequently have undesirable side effects. We recently demonstrated that short-term treatment with citicoline decreased self-reported desire to use cocaine in crack cocaine users. OBJECTIVE:The present study w...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002130100824
更新日期:2001-09-01 00:00:00
abstract::The effects of ibogaine (40 and 80 mg/kg, i.p.), an indole alkaloid proposed for the treatment of drug abuse, were determined in three different groups of rats responding under an FR10 schedule of food, cocaine or heroin reinforcement. Ibogaine (80 mg/kg, i.p.) given 60 min before the start of the session resulted in ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246099
更新日期:1995-02-01 00:00:00
abstract::In an attempt to define the nature of the involvement of delta 9-tetrahydrocannabinol (THC) with central cholinergic neurotransmission, the effects of THC on direct cholinergic stimulation of the rat brain were investigated. THC, in doses of 3 mg/kg and 6 mg/kg, administered intraperitoneally (i.p.), potentiated the e...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426661
更新日期:1979-02-28 00:00:00
abstract:BACKGROUND:Although ethanol is frequently used in combination with other psychoactive drugs, the behavioral and pharmacological reasons for this form of polydrug abuse have not been well described. MATERIALS AND METHODS:Rhesus monkeys with indwelling intravenous catheters produced intravenous injections of ethanol (50...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-007-0809-9
更新日期:2007-09-01 00:00:00
abstract:RATIONALE:Considerable research indicates that "ecstasy" users perceive their memory for future intentions (prospective memory) to be impaired. However, only one empirical study to date has directly tested how this capacity is affected by ecstasy use, and this study provided relatively limited information regarding the...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-007-0859-z
更新日期:2007-11-01 00:00:00
abstract:RATIONALE:We have shown that differences in the level of neural activation to stimuli associated with smoking vs. natural rewards, a biomarker related to reward sensitivity, predict treatment outcome. OBJECTIVES:This paper examined whether this biomarker moderates the impact of bupropion or varenicline on smoking cess...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-017-4580-2
更新日期:2017-06-01 00:00:00
abstract:RATIONALE:While reserpine-induced oral movements (OM), an animal model of tardive dyskinesia, are more persistent in old than in adult rats, old animals present spontaneous OM, which are phenomenologically similar to those presented by reserpine-treated adult rats. We postulate that these OM may be the result of oxidat...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1081-7
更新日期:2002-06-01 00:00:00
abstract:RATIONALE:The phenomenon of sensitization has been theoretically implicated in mediating various aspects of drug addiction. Recent dose-response studies demonstrated that pretreatment with the putative antiaddictive agent, ibogaine (IBO), and a synthetic iboga alkaloid congener, 18-methoxycoronaridine (18-MC), increase...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000478
更新日期:2000-08-01 00:00:00
abstract:RATIONALE:Environmental stimuli associated with drugs of abuse are believed to play a major role in the motivation to take drugs, drug dependence, and relapse. Previous work from this laboratory demonstrated that the response-contingent presentation of drug-related, visual cues was at least as important as nicotine in ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1156-5
更新日期:2002-09-01 00:00:00
abstract:RATIONALE:Previous studies indicate that the rewarding effect of D-1 dopamine receptor stimulation in nucleus accumbens (NAc) shell is greater in food-restricted (FR) than in ad libitum fed (AL) rats. The D-1 receptor is positively coupled to adenylyl cyclase and activates protein kinase A (PKA). OBJECTIVES:The purpos...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2602-z
更新日期:2012-06-01 00:00:00
abstract::The discriminative stimulus (DS) effect of apomorphine was investigated in rats trained in a two-lever, food-reinforcement procedure. Rats were given subcutaneous injections of saline or 0.1 mg/kg apomorphine HCl, 15 min before training sessions. The training dose of apomorphine was chosen to activate dopamine autorec...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00690928
更新日期:1987-01-01 00:00:00
abstract:RATIONALE:The beneficial effects of nicotinic acetylcholine receptor (nAChR) agonists on cognitive performance have been widely shown. Paradoxically, recent preclinical studies employing extremely low doses of nAChR antagonists have also found cognitive enhancement, perhaps pointing to a novel treatment mechanism for c...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-016-4443-2
更新日期:2017-01-01 00:00:00
abstract::The purpose of this review was to establish in vivo apparent pA2 and pKB values for antagonism of the discriminative stimulus effects of benzodiazepine ligands, and to compare these values to those obtained from other behavioral procedures. Articles were chosen from the Medline data base from January 1976 to August 19...
journal_title:Psychopharmacology
pub_type: 杂志文章,meta分析
doi:10.1007/s002130050103
更新日期:1996-11-01 00:00:00
abstract::This study examined the effects of intrahippocampal injections of scopolamine (a muscarinic antagonist drug) on performance of a working-memory task (contingently reinforced T-maze alternation) and a reference-memory task (visual discrimination) by the same rats in the same maze. Rats in the first shipment were traine...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427569
更新日期:1983-01-01 00:00:00
abstract::The effects of 4 weeks of treatment with the selective monoamine oxidase (MAO) inhibiting antidepressant clorgyline and pargyline on the sleep of affectively disordered patients were studied. Both inhibitors resulted in near total suppression of REM sleep, a decrease in total sleep time, and an increase in the percent...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00432251
更新日期:1982-01-01 00:00:00