Abstract:
:The discriminative stimulus (DS) effect of apomorphine was investigated in rats trained in a two-lever, food-reinforcement procedure. Rats were given subcutaneous injections of saline or 0.1 mg/kg apomorphine HCl, 15 min before training sessions. The training dose of apomorphine was chosen to activate dopamine autoreceptors selectively. Stimulus generalization studies demonstrated that the DS effects generalized completely to other direct-acting dopaminergic agonists such as N-n-propylnorapomorphine (NPNA), pergolide, lergotrile, and bromocriptine. The indirect-acting dopamine agonists, (+)amphetamine, cocaine, and methylphenidate produced predominantly saline-appropriate lever responses. The DS effect of apomorphine at the training dose was incompletely antagonized by haloperidol or metoclopramide. The dopaminergic antagonists tested, however, also partially generalized to apomorphine. Both enantiomers of 3-(3-hydroxyphenyl)-N-n-propylpiperidine (3-PPP) produced apomorphine-appropriate lever choice with the (-) enantiomer being slightly more potent. The discriminative property of this (0.1 mg/kg) dose of apomorphine has characteristics consistent with selective dopamine autoreceptor activation.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Tang AH,Franklin SRdoi
10.1007/BF00690928subject
Has Abstractpub_date
1987-01-01 00:00:00pages
61-6issue
1eissn
0033-3158issn
1432-2072journal_volume
91pub_type
杂志文章abstract:RATIONALE:It has been demonstrated that major differences between mice of the C57BL/6J and DBA/2J inbred strains for amphetamine-induced place conditioning (preference and avoidance, respectively) are evident in standard housing conditions but abolished by temporary restricted feeding. This gene-experience model may be...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1647-z
更新日期:2004-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF00429665
更新日期:1985-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2014-08-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2014-11-01 00:00:00
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更新日期:2000-07-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02247469
更新日期:1994-12-01 00:00:00
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doi:10.1007/s00213-020-05515-x
更新日期:2020-07-01 00:00:00
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doi:10.1007/s00213-009-1544-1
更新日期:2009-08-01 00:00:00
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更新日期:2004-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00213-015-4183-8
更新日期:2016-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF02244259
更新日期:1991-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1994-06-01 00:00:00
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更新日期:2005-08-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1978-12-15 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1993-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00470580
更新日期:1982-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02253726
更新日期:1990-01-01 00:00:00
abstract:RATIONALE:3,4-Methylenedioxypyrovalerone (MDPV) is a synthetic cathinone abused for its cocaine-like psychostimulant effects in "bath salts" products. While there are currently no pharmacotherapies for MDPV abuse, rodent studies suggest immunotherapy may offer a feasible treatment option. OBJECTIVES:These studies test...
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pub_type: 杂志文章
doi:10.1007/s00213-020-05558-0
更新日期:2020-09-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00430491
更新日期:1976-11-10 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-019-05331-y
更新日期:2019-12-01 00:00:00
abstract::Self-injection of phencyclidine HCI (PCP) and four of its analogues was examined in baboons. IV injections of drug were dependent upon completion of 160 lever presses (a 160-response fixed-ratio schedule). A 3-h time-out period followed each injection, permitting a maximum of eight injections per day. Self-injection p...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00428537
更新日期:1984-01-01 00:00:00
abstract::Chronic treatment of rats with the antipsychotic drug molindone (2.5 mg/kg) did not elicit behavioral supersensitivity to apomorphine (AP) (0.25 mg/kg) or increased striatal 3H-spiroperidol binding, whereas treatment with haloperidol (0.5-1.0 mg/kg) produced manifestations of dopaminergic supersensitivity in both para...
journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1982-01-01 00:00:00