Genetic deletion of dopamine D1 receptors increases the sensitivity to cannabinoid CB1 receptor antagonist-precipitated withdrawal when compared with wild-type littermates: studies in female mice repeatedly exposed to the Spice cannabinoid HU-210.


RATIONALE:The emergence of the consumption of highly potent synthetic cannabinoid receptor agonists (spice drugs) that produce important neurological symptoms has prompted the research on the consequences of acute and chronic use of these new psychoactive substances. Most studies on cannabinoid dependence have been performed in male animals, and there is a need of studies using female subjects. OBJECTIVES:In the present study, we evaluated only in female animals the role of dopamine D1 receptors in the behavioral responses induced by acute and repeated stimulation of cannabinoid CB1 receptors, including the development of physical dependence, since cannabinoid CB1 receptors are co-localized with dopamine D1 receptors on GABAergic neurons projecting to the substantia nigra. METHODS:To this end, female dopamine D1 receptor-deficient mice and wild-type littermates were treated with HU-210, a potent synthetic cannabinoid agonist. RESULTS:Mutant mice displayed an enhanced response to acute motor and hypothermic effects to HU-210 when compared with wild-type females. The administration of SR141716A precipitated behavioral signs of withdrawal in mice treated subchronically with HU-210. Severity of cannabinoid withdrawal syndrome was potentiated in dopamine D1-deficient female mice. Indeed, 4 of 6 abstinence signs were increased in mutant mice. CONCLUSIONS:These results support for a role of dopamine D1 receptors in the acute, chronic, and withdrawal actions of spice drugs.




Serrano A,Vadas E,Ferrer B,Bilbao A,Granado N,Suárez J,Pavon FJ,Moratalla R,Rodríguez de Fonseca F




Has Abstract


2021-02-01 00:00:00














  • Behavioral assessment of atypical antipsychotics in rats: studies of the effects of olanzapine (Zyprexa).

    abstract:RATIONALE:Previous work has shown that clozapine suppressed tacrine-induced jaw movements at lower doses than those required for suppression of lever pressing. OBJECTIVE:The novel atypical antipsychotic olanzapine was assessed in these behavioral tests. METHODS:The effect of acute olanzapine on the suppression of tac...


    pub_type: 杂志文章


    authors: Trevitt JT,Carlson BB,Salamone JD

    更新日期:1999-08-01 00:00:00

  • Effect of clozapine upon schedule-induced polydipsia (SIP) resembles neither the actions of dopamine D1 nor D2 blockade.

    abstract::The effects of clozapine (CLOZ) upon acquired schedule-induced polydipsia in rats were compared to the effects of the dopamine (DA) D1 antagonist SCH 23390 (SCH) and the DA D2 antagonist raclopride (RAC). All three compounds suppressed water consumption, but only SCH and RAC decreased drinking efficiency. SCH was the ...


    pub_type: 杂志文章


    authors: Didriksen M,Olsen GM,Christensen AV

    更新日期:1993-01-01 00:00:00

  • Comparison of measured and FTC-predicted nicotine uptake in smokers.

    abstract::Cigarette smokers have a wide variety of "tar" and nicotine yields to choose from in the current market, ranging from 0.5 mg "tar" and less than 0.05 mg nicotine to 27 mg "tar" and 1.8 mg nicotine by the Federal Trade Commission (FTC) method. To understand better the relationship between FTC nicotine yields and actual...


    pub_type: 临床试验,杂志文章


    authors: Byrd GD,Robinson JH,Caldwell WS,deBethizy JD

    更新日期:1995-11-01 00:00:00

  • Atypical antipsychotics: are some more atypical than others?

    abstract::On the heels of clozapine, we now have a number of newer agents (risperidone, olanzapine, quetiapine, sertindole, and ziprasidone). Are they all the same? What are the differences? How do we best understand them? In this article we review current clinical evidence to compare these issues on four measures of atypicalit...


    pub_type: 杂志文章,评审


    authors: Remington G,Kapur S

    更新日期:2000-01-01 00:00:00

  • The shock probe conflict procedure. A new assay responsive to benzodiazepines, barbiturates and related compounds.

    abstract::Rats that are placed in a novel environment containing a probe will explore the environment and the probe. Exploration of the probe is reduced when the probe is electrified. We here report that chlordiazepoxide blocks this inhibition, and have determined some of the pharmacological features of this new experimental pr...


    pub_type: 杂志文章


    authors: Meert TF,Colpaert FC

    更新日期:1986-01-01 00:00:00

  • Cues predicting drug or food reward restore morphine-induced place conditioning in mice lacking delta opioid receptors.

    abstract:RATIONALE:The exact role of delta opioid receptors in drug-induced conditioned place preference (CPP) remains debated. Under classical experimental conditions, morphine-induced CPP is decreased in mice lacking delta opioid receptors (Oprd1 (-/-)). Morphine self-administration, however, is maintained, suggesting that dr...


    pub_type: 杂志文章


    authors: Le Merrer J,Faget L,Matifas A,Kieffer BL

    更新日期:2012-09-01 00:00:00

  • Cocaine facilitation of prefrontal cortex self-stimulation: a microstructural and pharmacological analysis.

    abstract::A novel self-stimulation methodology involving a fixed-interval (FI-5 s) schedule of reinforcement, microanalysis and threshold evaluation was used to investigate the effects of cocaine on rats lever pressing for electrical stimulation of the prefrontal cortex. Cocaine (15 mg/kg) increased medial prefrontal cortex (MP...


    pub_type: 杂志文章


    authors: McGregor IS,Atrens DM,Jackson DM

    更新日期:1992-01-01 00:00:00

  • A multistep general theory of transition to addiction.

    abstract:BACKGROUND:Several theories propose alternative explanations for drug addiction. OBJECTIVES:We propose a general theory of transition to addiction that synthesizes knowledge generated in the field of addiction into a unitary explanatory frame. MAJOR PRINCIPLES OF THE THEORY:Transition to addiction results from a sequ...


    pub_type: 杂志文章


    authors: Piazza PV,Deroche-Gamonet V

    更新日期:2013-10-01 00:00:00

  • Antinociceptive effects of central and systemic administrations of nicotine in the rat.

    abstract::Nicotine (0.16--0.50 mg/kg, SC) was found to exert a potent antinociceptive action on thermal stimuli as measured by the tail-flick test. This antinociceptive action of nicotine could be blocked by centrally active nicotinic or muscarinic blockers implicating both classes of cholinergic receptors in this effect. Quate...


    pub_type: 杂志文章


    authors: Sahley TL,Berntson GG

    更新日期:1979-11-01 00:00:00

  • Association between major depression and cardiovascular risk: the role of antidepressant medication.

    abstract:RATIONALE AND OBJECTIVES:Major depressive disorder (MDD) is associated with an increased risk for cardiovascular disease (CVD). Apart from biological and life style factors, the use of antidepressants and their potentially adverse effects might contribute to the increased CVD risk. Therefore, we compared cardiovascular...


    pub_type: 杂志文章


    authors: Kuehl LK,Muhtz C,Hinkelmann K,Dettenborn L,Wingenfeld K,Spitzer C,Otte C

    更新日期:2016-09-01 00:00:00

  • Residual effects of hypnotics: triazolam, flurazepam, and nitrazepam.

    abstract::The residual effects of three hypnotics were investigated by the method of 24-h polygraphy (EEG, EMG, and EOG). The drugs were triazolam 0.25 mg and 0.5 mg, flurazepam 15 mg and 30 mg, nitrazepam 5 mg and 10 mg, and placebo. The subjects were healthy volunteers, eight men and eight women with an average age of 34.3 ye...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ogura C,Nakazawa K,Majima K,Nakamura K,Ueda H,Umezawa Y,Wardell WM

    更新日期:1980-01-01 00:00:00

  • Electrophysiological indices of acute effects of ethanol on involuntary attention shifting.

    abstract::Dose-related effects of ethanol (placebo, 0.30, and 0.60 g/kg) on behavioral and event-related brain potential (ERP) indices of involuntary attention shifting of audition were investigated. ERPs were recorded from 11 healthy social drinkers during a forced-choice reaction-time (RT) task. Subjects were presented with 1...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Jääskeläinen IP,Schröger E,Näätänen R

    更新日期:1999-01-01 00:00:00

  • Cocaine-like discriminative stimulus effects of novel cocaine and 3-phenyltropane analogs in the rat.

    abstract:RATIONALE:Cocaine dependence is a major health concern and there are no effective pharmacotherapies currently available. Although cocaine is an indirect DA agonist that binds to all three monoamine transporters, there is much evidence implicating a greater role for the dopamine (DAT) than norepinephrine (NET) and serot...


    pub_type: 杂志文章


    authors: Cook CD,Carroll IF,Beardsley PM

    更新日期:2001-12-01 00:00:00

  • Response to alcohol in females with a paternal history of alcoholism.

    abstract:RATIONALE:Several studies have demonstrated that males with a family history of alcoholism (FHP) show less of a response to alcohol (e.g. lower ratings of intoxication) than males without a family history of alcoholism (FHN). The purpose of this pilot study was to determine if FHP females also showed a reduced sensitiv...


    pub_type: 临床试验,杂志文章


    authors: Evans SM,Levin FR

    更新日期:2003-08-01 00:00:00

  • Assessment of working memory in rats using spatial alternation behavior with variable retention intervals: effects of fixed-ratio size and scopolamine.

    abstract::The effects of fixed-ratio (FR) size, scopolamine, and the interactions between FR size and scopolamine were investigated in male F344 rats on working memory as assessed by spatial alternation behavior maintained under FR schedules of food presentation where the interval between trials was varied among values of 2, 4,...


    pub_type: 杂志文章


    authors: Shannon HE,Bemis KG,Hart JC

    更新日期:1990-01-01 00:00:00

  • Facilitation of brain stimulation reward by MK-801 (dizocilpine) may be independent of D2-like dopamine receptor stimulation in rats.

    abstract:RATIONALE:Dopamine (DA) and glutamate (Glu) interactions in the mesocorticolimbic pathway may regulate motivation and reward and contribute to schizophrenia and drug abuse. We have recently demonstrated synergistic effects of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptor blockade and ...


    pub_type: 杂志文章


    authors: Clements RL,Greenshaw AJ

    更新日期:2005-10-01 00:00:00

  • N-acetylcysteine augmentation in serotonin reuptake inhibitor refractory obsessive-compulsive disorder.

    abstract:RATIONALE:Dysfunction of glutamatergic neurotransmission has been implicated in the pathophysiology of obsessive-compulsive disorder (OCD) and recent clinical reports suggest that some glutamate modulating agents are efficacious in the treatment of this disorder. N-acetylcysteine (NAC) is a readily available amino acid...


    pub_type: 信件


    authors: Lafleur DL,Pittenger C,Kelmendi B,Gardner T,Wasylink S,Malison RT,Sanacora G,Krystal JH,Coric V

    更新日期:2006-01-01 00:00:00

  • Subjective well-being and quality of life under atypical antipsychotic treatment.

    abstract::The increasing interest in subjective well-being and quality of life of schizophrenic patients represents a conceptual shift in therapeutic outcome criteria. Symptom reduction alone was the most essential outcome parameter for a long time; with the development of atypical antipsychotics more ambitious success criteria...


    pub_type: 杂志文章,评审


    authors: Karow A,Naber D

    更新日期:2002-06-01 00:00:00

  • Effect of transdermal nicotine replacement on alcohol responses and alcohol self-administration.

    abstract:RATIONALE:Nicotine replacement is commonly used to treat tobacco use in heavy-drinking smokers. However, few studies have examined the effect of nicotine replacement on subjective and physiological responses to alcohol and alcohol drinking behavior. OBJECTIVE:The primary aim of this within-subject, double-blind study ...


    pub_type: 临床试验,杂志文章


    authors: McKee SA,O'Malley SS,Shi J,Mase T,Krishnan-Sarin S

    更新日期:2008-02-01 00:00:00

  • Localisation of NMU1R and NMU2R in human and rat central nervous system and effects of neuromedin-U following central administration in rats.

    abstract:RATIONALE:Neuromedin-U (NmU) is an agonist at NMU1R and NMU2R. The brain distribution of NmU and its receptors, in particular NMU2R, suggests widespread central roles for NmU. In agreement, centrally administered NmU affects feeding behaviour, energy expenditure and pituitary output. Further central nervous system (CNS...


    pub_type: 杂志文章


    authors: Gartlon J,Szekeres P,Pullen M,Sarau HM,Aiyar N,Shabon U,Michalovich D,Steplewski K,Ellis C,Elshourbagy N,Duxon M,Ashmeade TE,Harrison DC,Murdock P,Wilson S,Ennaceur A,Atkins A,Heidbreder C,Hagan JJ,Hunter AJ,Jones

    更新日期:2004-12-01 00:00:00

  • Evaluation of the levels of free and total amitriptyline and metabolites in the plasma and brain of the rat after long-term administration of doses used in receptor studies.

    abstract::This study was conducted in order to investigate the level of amitriptyline (AT) and its metabolites. Three separate experiments were carried out. In two of these experiments, rats were treated over 7 days with IP doses of AT (10 mg/kg in experiment A and 2 X 20 mg/kg in experiment C). The rats were sacrificed either ...


    pub_type: 杂志文章


    authors: Baumann P,Gaillard JM,Jonzier-Perey M,Gerber C,Bouras C

    更新日期:1984-01-01 00:00:00

  • The relationships between clinical response, psychophysiological variables and plasma levels of amitriptyline and diazepam in neurotic outpatients.

    abstract::In a 4 week study of the response of neurotic outpatients to treatment with amitriptyline, diazepam, amitriptyline and diazepam, or placebo clinical and psychophysiological variables and plasma levels of the drug were assessed. Clinical improvements were substantial in all treatment groups but clear relationships betw...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Johnstone EC,Bourne RC,Crow TJ,Frith CD,Gamble S,Lofthouse R,Owen F,Owens DG,Robinson J,Stevens M

    更新日期:1981-01-01 00:00:00

  • Dose-dependent effect of ethanol on extracellular dopamine in mesolimbic striatum of awake rhesus monkeys: comparison with cocaine across individuals.

    abstract:RATIONALE:Dependence on both alcohol and cocaine is a widespread example of polydrug abuse/dependence. It has been hypothesized that ethanol reward is mediated via increased dopaminergic neurotransmission in mesolimbic striatum, as is the case for cocaine. However, little is known about the neurobiology of ethanol in p...


    pub_type: 杂志文章


    authors: Bradberry CW

    更新日期:2002-12-01 00:00:00

  • Double dissociation of serotonergic and dopaminergic mechanisms on attentional performance using a rodent five-choice reaction time task.

    abstract:RATIONALE:Converging evidence suggests that dopaminergic and serotonergic mechanisms affect distinct aspects of cognitive performance. Experiments using the rodent five-choice reaction time task have established a critical role for dopaminergic mechanisms in the rat medial prefrontal cortex (mPFC), but have yielded onl...


    pub_type: 杂志文章


    authors: Passetti F,Dalley JW,Robbins TW

    更新日期:2003-01-01 00:00:00

  • Amplified reacquisition of nicotine self-administration in rats by repeated stress during abstinence.

    abstract:RATIONALE:Quitting smoking is often very challenging, leading to frequent relapse. Exposure to acute and chronic stress during abstinence increases the likelihood of relapse to smoking. In rodents, stress acutely reinstates nicotine seeking after extinction of nicotine self-administration (SA). However, whether reacqui...


    pub_type: 杂志文章


    authors: Yu G,Chen H,Sharp BM

    更新日期:2014-08-01 00:00:00

  • Evaluation of SCH 39166 as PET ligand for central D1 dopamine receptor binding and occupancy in man.

    abstract::SCH 39166 is the first selective D1-dopamine receptor antagonist developed for clinical trials in schizophrenia. SCH 39166 was evaluated as a radioligand for PET, labeled with 11C, and as a D1-dopamine receptor antagonist after single oral doses in healthy men. After intravenous injection of [11C]SCH 39166 distributio...


    pub_type: 临床试验,杂志文章


    authors: Karlsson P,Sedvall G,Halldin C,Swahn CG,Farde L

    更新日期:1995-10-01 00:00:00

  • Selective attenuation of the antinociceptive effects of mu opioids by the putative dopamine D3 agonist 7-OH-DPAT.

    abstract:RATIONALE:The purpose of the present investigation was to evaluate the effects of the D3 agonist (+/-)-7-hydroxy-dipropylaminotetralin (7-OH-DPAT), various dopamine (DA) agonists and DA antagonists on the antinociceptive effects of mu opioids. METHODS:Antinociception was assessed using a warm-water tail-withdrawal pro...


    pub_type: 杂志文章


    authors: Cook CD,Rodefer JS,Picker MJ

    更新日期:1999-06-01 00:00:00

  • 2-Aminoindan and its ring-substituted derivatives interact with plasma membrane monoamine transporters and α2-adrenergic receptors.

    abstract:RATIONALE:Over the last decade, many new psychostimulant analogues have appeared on the recreational drug market and most are derivatives of amphetamine or cathinone. Another class of designer drugs is derived from the 2-aminoindan structural template. Several members of this class, including the parent compound 2-amin...


    pub_type: 杂志文章


    authors: Halberstadt AL,Brandt SD,Walther D,Baumann MH

    更新日期:2019-03-01 00:00:00

  • Effects of nicotine on body weight in rats with access to "junk" foods.

    abstract::The present experiment examined effects of nicotine on body weight of male and female rats when Oreo cookies, potato chips, laboratory chow, and water were available. Body weight and eating behavior were measured for 17-day periods before, during, and after nicotine or saline administration. There was an inverse relat...


    pub_type: 杂志文章


    authors: Grunberg NE,Popp KA,Winders SE

    更新日期:1988-01-01 00:00:00

  • Effects of diazepam on operant behavior in man.

    abstract::The effects of diazepam (10 mg orally) on the responding of normal human volunteers was studied in a procedure that involved the maintenance of operant behavior by monetary reinforcement and its suppression by monetary loss (punishment). Diazepam produced an antipunishment effect as shown by an increase in behavior su...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Carlton PL,Siegel JL,Murphree HB,Cook L

    更新日期:1981-01-01 00:00:00