Post-extinction fluoxetine treatment prevents stress-induced reemergence of extinguished fear.


RATIONALE:The post-extinction exposure of rats to a sub-conditioning procedure (SCP; i.e., retraining with a shock intensity that is too weak to induce by itself significant fear conditioning) has been reported to provoke the reemergence of extinguished fear. This phenomenon can be prevented by chronic fluoxetine treatment. OBJECTIVES:We sought to examine another potential inducer of fear reemergence, acute stress, in rats and determine whether fluoxetine prevents this phenomenon. METHODS:Because in previous studies fluoxetine was administered before extinction, we first analyzed its effect on the SCP-associated reemergence of auditory-cued conditioned fear in rats injected after extinction to avoid any interaction between fluoxetine and extinction learning. Next, we used the same protocol but replaced the SCP with acute stress. RESULTS:We found that the SCP and acute stress, which were carried out 3 weeks after fear extinction, similarly provoked the reemergence of extinguished fear in rats injected with vehicle during the 3-week period. In contrast, the animals treated with fluoxetine during this period behaved similarly to those not exposed to an inducer of fear reemergence. CONCLUSIONS:Our data establish acute stress as an inducer of fear reemergence. The results provide further support for the hypothesis that fluoxetine interfered with mechanisms that reactivated extinguished fear, even when administered after fear extinction.




Deschaux O,Zheng X,Lavigne J,Nachon O,Cleren C,Moreau JL,Garcia R




Has Abstract


2013-01-01 00:00:00












  • Fluoxetine blocks expression but not development of sensitization to morphine-induced oral stereotypy in rats.

    abstract:RATIONALE:Repeated high doses of morphine in the rat cause stereotypic gnawing behavior that can be re-expressed by a low dose of morphine weeks and even months after the initial treatment. The determination of the role of serotonin in this sensitized morphine-induced behavior has both empirical and theoretical relevan...


    pub_type: 杂志文章


    authors: Wennemer HK,Kornetsky C

    更新日期:1999-09-01 00:00:00

  • Neuroleptic-induced striatal dopamine receptor supersensitivity in mice: relationship to dose and drug.

    abstract::Clozapine and molindone administered to mice for 21 days did not elevate the density of striatal 3H-spiperone binding sites at doses clinically equivalent to 1.5 mg/kg haloperidol, which elevated binding by 29%. Thioridazine (25 mg/kg) elevated binding by 25%. It appears that clinically equivalent doses of clozapine a...


    pub_type: 杂志文章


    authors: Severson JA,Robinson HE,Simpson GM

    更新日期:1984-01-01 00:00:00

  • Melatonin in the afternoons of a gradually advancing sleep schedule enhances the circadian rhythm phase advance.

    abstract:RATIONALE:We test methods to advance (shift earlier) circadian rhythms without producing misalignment between rhythms and sleep. We previously tested (1) a gradually advancing sleep/dark schedule plus morning bright light and afternoon/evening melatonin and (2) the same sleep schedule with only morning bright light. No...


    pub_type: 杂志文章


    authors: Crowley SJ,Eastman CI

    更新日期:2013-02-01 00:00:00

  • Task-dependent effects of the antidepressant/antipanic drug phenelzine on memory.

    abstract::Phenelzine (PLZ) is a non-selective monoamine oxidase (MAO) inhibitor commonly used to treat depression and panic disorder. In addition to increasing levels of biogenic amines in the brain, PLZ elevates brain levels of the amino acid gamma-aminobutyric acid (GABA; Baker et al. 1991; present study). Given the extensive...


    pub_type: 杂志文章


    authors: Parent MB,Habib MK,Baker GB

    更新日期:1999-03-01 00:00:00

  • An IL-6 receptor antagonist attenuates postpartum anhedonia, but has no effect on anhedonia precipitated by subchronic stress in female rats.

    abstract:RATIONALE:Nearly 60-80% of women experience some form of sadness, anxiety, or anhedonia in the weeks following the birth of a child (Patel et al. 23(2):534-42, 2012; Degner 10: 359;j4692, 2017); however, the exact mechanisms that precipitate these changes in mood postpartum are still unknown. It is well-known that the ...


    pub_type: 杂志文章


    authors: Gomez J,Haas NA,Schwarz JM

    更新日期:2019-10-01 00:00:00

  • Ritanserin, a 5-HT2 receptor antagonist, does not modify ECT-induced prolactin release.

    abstract::The effect of pretreatment with ritanserin, a potent and selective serotonin-S2 (5-HT2) receptor antagonist, on the prolactin (PRL) response to electroconvulsive therapy (ECT) was studied in seven female patients suffering from major depressive disorder. They were given either ECT alone, or ECT after 10 or 20 mg ritan...


    pub_type: 杂志文章


    authors: Papakostas Y,Markianos M,Papadimitriou G,Stefanis C

    更新日期:1990-01-01 00:00:00

  • Pentagastrin has panic-inducing properties in obsessive compulsive disorder.

    abstract::The effects of the CCKB-receptor agonist pentagastrin, a synthetic analogue of the cholecystokinin tetrapeptide (CCK-4), were studied in seven patients suffering from obsessive compulsive disorder (OCD) and seven healthy controls. All subjects were challenged with an IV dose of 0.6 micrograms/kg pentagastrin or placeb...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: de Leeuw AS,Den Boer JA,Slaap BR,Westenberg HG

    更新日期:1996-08-01 00:00:00

  • Acute effects of methadone on EEG power spectrum and event-related potentials among heroin dependents.

    abstract::Methadone as the most prevalent opioid substitution medication has been shown to influence the neurophysiological functions among heroin addicts. However, there is no firm conclusion on acute neuroelectrophysiological changes among methadone-treated subjects as well as the effectiveness of methadone in restoring brain...


    pub_type: 杂志文章


    authors: Motlagh F,Ibrahim F,Rashid R,Shafiabady N,Seghatoleslam T,Habil H

    更新日期:2018-11-01 00:00:00

  • Neurochemical and behavioural investigations of the NMDA receptor-associated glycine site in the rat striatum: functional implications for treatment of parkinsonian symptoms.

    abstract::The glutamatergic cortico-striatal and subthalamo-entopeduncular pathways are both overactive in parkinsonism. Previous behavioural investigations have shown that intra-entopeduncular injection of either NMDA-site or glycine-site antagonists results in alleviation of parkinsonian symptoms, although injection of the fo...


    pub_type: 杂志文章


    authors: Carroll CB,Holloway V,Brotchie JM,Mitchell IJ

    更新日期:1995-05-01 00:00:00

  • Higher serotonin transporter occupancy after multiple dose administration of escitalopram compared to citalopram: an [123I]ADAM SPECT study.

    abstract:OBJECTIVES:Previous studies have investigated the occupancy of the serotonin reuptake transporter (SERT) after clinical doses of citalopram and other selective serotonin reuptake inhibitors. In the present study, the occupancies of SERT after multiple doses of escitalopram and citalopram were compared using the radioli...


    pub_type: 杂志文章,随机对照试验


    authors: Klein N,Sacher J,Geiss-Granadia T,Mossaheb N,Attarbaschi T,Lanzenberger R,Spindelegger C,Holik A,Asenbaum S,Dudczak R,Tauscher J,Kasper S

    更新日期:2007-04-01 00:00:00

  • Changes in the rate-increasing effects of d-amphetamine and pentobarbital by response consequences.

    abstract::Keypecking in one group of pigeons was maintained under schedules in which food was presented only when a specified number of responses was followed by a 30-s pause without a response. d-Amphetamine and pentobarbital increased low rates of responding (and, thus, decreased food presentation) only after initial injectio...


    pub_type: 杂志文章


    authors: Smith JB,McKearney JW

    更新日期:1977-07-18 00:00:00

  • Prevention and reversal of social stress-escalated cocaine self-administration in mice by intra-VTA CRFR1 antagonism.

    abstract:BACKGROUND:A history of brief intermittent social defeat stress can escalate cocaine self-administration and induce long-term adaptations in the mesolimbic dopamine system. Extra-hypothalamic corticotrophin releasing factor (CRF) has been shown to be closely associated with stress-induced escalation of drug use. How re...


    pub_type: 杂志文章


    authors: Han X,DeBold JF,Miczek KA

    更新日期:2017-09-01 00:00:00

  • Nicotinic-serotonergic drug interactions and attentional performance in rats.

    abstract:RATIONALE:Both central serotonergic and nicotinic systems play important roles in a variety of neurobehavioral functions; however, the interactions of these two systems have not been fully characterized. The current study served to determine the impact of a relatively selective 5-HT2A receptor antagonist, ketanserin, o...


    pub_type: 杂志文章


    authors: Rezvani AH,Caldwell DP,Levin ED

    更新日期:2005-05-01 00:00:00

  • Ketamine reduces temporal expectation in the rhesus monkey.

    abstract:RATIONALE:Ketamine, a well-known general dissociative anesthetic agent that is a non-competitive antagonist of the N-methyl-D-aspartate receptor, perturbs the perception of elapsed time and the expectation of upcoming events. OBJECTIVE:The objective of this study was to determine the influence of ketamine on temporal ...


    pub_type: 杂志文章


    authors: Brulé S,Herlin B,Pouget P,Missal M

    更新日期:2021-02-01 00:00:00

  • Cigarette demand and delayed reward discounting in nicotine-dependent individuals with schizophrenia and controls: an initial study.

    abstract:RATIONALE:The high prevalence of smoking and low cessation rates among individuals with schizophrenia and similar conditions are not well understood. Behavioral economics has been extensively applied to studying addictive behavior and may contribute to understanding smoking in this subpopulation. OBJECTIVES:This study...


    pub_type: 杂志文章


    authors: MacKillop J,Tidey JW

    更新日期:2011-07-01 00:00:00

  • Effects of a brisk walk on blood pressure responses to the Stroop, a speech task and a smoking cue among temporarily abstinent smokers.

    abstract::A review and meta-analysis by Hamer et al. (2006) showed that a single session of exercise can attenuate post-exercise blood pressure (BP) responses to stress, but no studies examined the effects among smokers or with brisk walking. Healthy volunteers (n=60), averaging 28 years of age and smoking 15 cigarettes daily, ...


    pub_type: 杂志文章,随机对照试验


    authors: Taylor A,Katomeri M

    更新日期:2006-01-01 00:00:00

  • Aggressive temperament predicts ethanol self-administration in late adolescent male and female rhesus macaques.

    abstract:RATIONALE:Anxiety and aggression are associated with ethanol self-administration, but these behaviors can serve as either risk factors for or consequences of heavy drinking in rodents and humans. Baseline levels of aggressive-like and anxious-like behavior in non-human primates have not yet been characterized in relati...


    pub_type: 杂志文章


    authors: McClintick MN,Grant KA

    更新日期:2016-12-01 00:00:00

  • Influence of caffeine on the liking of novel-flavored soda in adolescents.

    abstract:BACKGROUND:Soda manufacturers claim that caffeine is added to soda as a flavor enhancer, but many researchers have speculated that caffeine is added to increase the hedonic and reinforcing properties of the soda. Studies in adults have demonstrated that caffeine can condition flavor preferences when added to novel-flav...


    pub_type: 杂志文章,随机对照试验


    authors: Temple JL,Ziegler AM,Graczyk A,Bendlin A,O'Leary S,Schnittker YS

    更新日期:2012-09-01 00:00:00

  • Opioids for hedonic experience and dopamine to get ready for it.

    abstract:BACKGROUND AND RATIONALE:More than two decades ago, Wise proposed his "anhedonia hypothesis" to explain the role of dopamine in motivated behaviors. The hypothesis posits that dopamine mediates the pleasure experienced by reward obtainment. However, some experimental findings have contested this hypothesis and several ...


    pub_type: 杂志文章,评审


    authors: Barbano MF,Cador M

    更新日期:2007-04-01 00:00:00

  • Differential effects of dopaminergic agonists on food-reinforced operant behavior in the long-tailed macaque (Macaca fascicularis).

    abstract::Dopaminergic involvement in the regulation of operant behavior was examined by monitoring responding after administration of different dopaminergic agonists. A chain schedule of reinforcement was used to classify the effects of these agonists in long-tailed macaques (Macaca fascicularis). The schedule included the fol...


    pub_type: 杂志文章


    authors: Dooley DJ,Bowden DM

    更新日期:1983-01-01 00:00:00

  • Cognitive rehabilitation in schizophrenia: a quantitative analysis of controlled studies.

    abstract:RATIONALE:Cognitive rehabilitation is now recognized as an important tool in the treatment of schizophrenia, and findings in this area are emerging rapidly. There is a need for a systematic review of the effects of the different training programs. OBJECTIVES:To review quantitatively the controlled studies on cognitive...


    pub_type: 杂志文章,评审


    authors: Krabbendam L,Aleman A

    更新日期:2003-09-01 00:00:00

  • Restoration of brain myo-inositol levels in rats increases latency to lithium-pilocarpine seizures.

    abstract::Lithium pretreatment in rats potentiates the epileptogenic effects of pilocarpine and other cholinergic agonists. In order to determine if this effect of lithium could be reversed by myo-inositol, rats were pretreated with intracerebroventricular (ICV) injections of myoinositol, artificial CSF or L-chiro-inositol. Lit...


    pub_type: 杂志文章


    authors: Kofman O,Sherman WR,Katz V,Belmaker RH

    更新日期:1993-01-01 00:00:00

  • Subtle effects of ketamine on memory when administered following stimulus presentation.

    abstract:RATIONALE:N-methyl-D-aspartate (NMDA) receptor antagonists (e.g., PCP, ketamine) have been shown to impair learning/memory. Well documented in animal models, only limited research in humans has been reported. Findings to date are similar to results of animal studies; however, antagonists are typically administered befo...


    pub_type: 杂志文章,随机对照试验


    authors: LaPorte DJ,Blaxton TA,Michaelidis T,Robertson DU,Weiler MA,Tamminga CA,Lahti AC

    更新日期:2005-07-01 00:00:00

  • The plant-derived hallucinogen, salvinorin A, produces kappa-opioid agonist-like discriminative effects in rhesus monkeys.

    abstract:RATIONALE:Salvinorin A is the active component of the hallucinogenic plant Salvia divinorum. The potential mode of action of this hallucinogen was unknown until recently. A recent in vitro study detected high affinity and efficacy of salvinorin A at kappa-opioid receptors. It was postulated that salvinorin A would prod...


    pub_type: 杂志文章


    authors: Butelman ER,Harris TJ,Kreek MJ

    更新日期:2004-03-01 00:00:00

  • Piracetam elevates muscarinic cholinergic receptor density in the frontal cortex of aged but not of young mice.

    abstract::Chronic treatment (2 weeks) with piracetam (500 mg/kg, once daily PO) elevated m-cholinoceptor density in the frontal cortex of aged (18 months) female mice by about 30-40%, but had no effect on m-cholinoceptor density in the frontal cortex of young (4 weeks) mice. The effect of piracetam on m-cholinoceptor density as...


    pub_type: 杂志文章


    authors: Pilch H,Müller WE

    更新日期:1988-01-01 00:00:00

  • Sources of variation in locomotor activity and stereotypy in rats treated with d-amphetamine.

    abstract::Rats injected with doses of d-amphetamine 0--5.0 mg/kg were observed continuously in either an enclosed Y-maze or on an elevated Y-shaped platform. Patterns of increased walking and stereotypy were unaffected by the type of apparatus, but rearing remained totally suppressed at all dose levels on the elevated platform....


    pub_type: 杂志文章


    authors: Mumford L,Teixeira AR,Kumar R

    更新日期:1979-04-25 00:00:00

  • Attentional capture by alcohol-related stimuli may be activated involuntarily by top-down search goals.

    abstract::Previous research has found that the attention of social drinkers is preferentially oriented towards alcohol-related stimuli (attentional capture). This is argued to play a role in escalating craving for alcohol that can result in hazardous drinking. According to incentive theories of drug addiction, the stimuli assoc...


    pub_type: 杂志文章


    authors: Brown CRH,Duka T,Forster S

    更新日期:2018-07-01 00:00:00

  • Cocaine toxicity: concurrent influence of dopaminergic, muscarinic and sigma receptors in mediating cocaine-induced lethality.

    abstract::The concurrent influence of dopaminergic, sigma and muscarinic neurotransmitter systems in mediating cocaine-induced lethality is predicted by previous receptor binding results from our laboratories. The present results demonstrate that pharmacological manipulations of these predicted neurotransmitter systems alter th...


    pub_type: 杂志文章


    authors: Ritz MC,George FR

    更新日期:1997-02-01 00:00:00

  • Changes in morphine self-administration after tel-diencephalic lesions in rats.

    abstract::Rats were trained to bar-press for intravenous infusions of morphine sulfate during 1-h daily test sessions. Rates of morphine self-administration were enhanced by lesions of the frontal cortex and hippocampus and transiently reduced by lesions of the medial forebrain bundle and medial thalamus. Dose-response studies ...


    pub_type: 杂志文章


    authors: Glick SD,Cox RD

    更新日期:1978-05-31 00:00:00

  • GABA(B) receptor blockade in the hippocampus affects sensory and sensorimotor gating in Long-Evans rats.

    abstract:RATIONALE:Sensory and sensorimotor gating deficits are observed in schizophrenia. GABA(B) receptor deficiency is also detected in the hippocampus of schizophrenic patients. OBJECTIVES:The present study tested the hypothesis that GABA(B) receptors in the hippocampus contribute to paired-pulse gating of hippocampal audi...


    pub_type: 杂志文章


    authors: Ma J,Leung LS

    更新日期:2011-09-01 00:00:00