Abstract：
:The opioid antagonist effects of systemically administered nor-binaltorphimine (nor-BNI) were evaluated against the kappa agonists CI-977, U69,593, U50,488, ethylketocyclazocine (EKC), Mr2034 and bremazocine, the mu agonist morphine and the alkaloid delta agonist BW-373U86 in the acetic acid-induced writhing assay in mice. All eight agonists completely and dose-dependently inhibited writhing. Antagonism of CI-977 was apparent 1 h after administration of 32 mg/kg nor-BNI, peaking after 4 h and was maintained for at least 4 weeks; no antagonist effects of nor-BNI were apparent after 8 weeks. Nor-BNI (32 mg/kg) caused little or no antagonism of morphine or BW-373U86 at 1 h and none at 24 h after nor-BNI administration. Subsequently, dose-effect curves for CI-977, U50,488, U69,593, EKC, Mr2034 and bremazocine were determined 24 h after pretreatment with 3.2, 10 and 32 mg/kg nor-BNI. Pretreatment with 3.2 mg/kg nor-BNI produced significant antagonism of all six kappa agonists, suggesting that their antinociceptive effects were mediated at least in part by nor-BNI-sensitive kappa receptors. At higher doses, nor-BNI dose-dependently shifted the agonist dose-effect curves of CI-977, U50,488, U69,593 and bremazocine, but not those of EKC and Mr2034, suggesting that the latter compounds may be producing effects via nor-BNI-insensitive receptors. Mu receptor involvement was demonstrated following a 24 h pretreatment with 32 mg/kg beta-FNA in combination with nor-BNI, which significantly increased the degree of antagonism of Mr2034 and EKC from that seen with nor-BNI alone.2+ off
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Broadbear JH,Negus SS,Butelman ER,de Costa BR,Woods JHdoi
10.1007/BF02245071subject
Has Abstractpub_date
1994-07-01 00:00:00pages
311-9issue
3eissn
0033-3158issn
1432-2072journal_volume
115pub_type
杂志文章abstract：:Five elderly depressed patients were treated with amitriptyline (AT) and nortriptyline (NT) in turn, in a cross-over design. Steady-state plasma drug levels were compared with those calculated for eight healthy subjects of previous single-dose studies. Plasma clearances were on average about 2.5 times lower in the pat...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00436164
更新日期：1983-01-01 00:00:00
abstract：RATIONALE:Several recent studies have focused on glutamate modulating agents for symptoms relief in schizophrenia, especially negative symptoms which are resistant to conventional therapies. OBJECTIVES:We aimed to assess the efficacy and tolerability of riluzole, an anti-glutamate agent with neuroprotective properties...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-013-3261-z
更新日期：2014-02-01 00:00:00
abstract：:Chlordiazepoxide (5 and 10 mg/kg) and diazepam (2.5 mg/kg) reduced the latency to eat and enhanced feeding response to familiar food in a food-preference test. The increased feeding response resulted from an increased frequency of individual eating episodes (bouts) without significant change in the episode duration. E...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00426525
更新日期：1980-01-01 00:00:00
abstract：RATIONALE:Previous research has identified a number of factors that appear to moderate the behavioural response to glucose administration. These include physiological state, dose, types of cognitive tasks used and level of cognitive demand. Another potential moderating factor is the length of the fasting interval prior...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-011-2510-2
更新日期：2012-04-01 00:00:00
abstract：RATIONALE:It has recently been reported that chronic nicotine administration at subconvulsive doses causes seizures, a phenomenon referred to as kindling. Evidence points to the involvement of oxidative stress in pharmacological and electrical kindling, sex is known to influence the brain's response to nicotine. OBJEC...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-012-2799-5
更新日期：2013-01-01 00:00:00
abstract：:Behavioral performances of normotensive and hypertensive adult male baboons were tested before, during, and following chronic oral dosing with nifedipine. Performances during a five-color simultaneous match-to-sample task were measured during three dosing schedules (0.20, 0.68, and 1.14 mg/kg/day) and vehicle. Each do...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245802
更新日期：1990-01-01 00:00:00
abstract：RATIONALE:Cognitive rehabilitation is now recognized as an important tool in the treatment of schizophrenia, and findings in this area are emerging rapidly. There is a need for a systematic review of the effects of the different training programs. OBJECTIVES:To review quantitatively the controlled studies on cognitive...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-002-1326-5
更新日期：2003-09-01 00:00:00
abstract：:Previous work in this and another laboratory has shown that nicotine tablets improve the performance of a rapid information processing task and reduce the Stroop effect, whereas scopolamine has the opposite effects. The purpose of this study was to extend these previous findings by determining whether, when administer...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00432014
更新日期：1984-01-01 00:00:00
abstract：RATIONALE:Zotepine is an antipsychotic drug with proven efficacy for treatment of acute episodes of schizophrenia. Antipsychotic drugs also require to be effective in prevention of recurrence. OBJECTIVE:This trial was designed to compare the effects of zotepine and placebo in the prevention of recurrence of acute epis...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002130000452
更新日期：2000-06-01 00:00:00
abstract：:The cognitive deficits, particularly memory impairment, observed in association with organic brain damage caused by chronic alcohol ingestion, are consistent with the profile of benzodiazepine-induced amnesia. This study examined the cognitive capabilities of a group of heavy social drinkers (n = 11) and a group of lo...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02244897
更新日期：1993-01-01 00:00:00
abstract：RATIONALE:Several halogenated analogs of benztropine (BZT) have previously been characterized as potent DA uptake inhibitors with behavioral profiles that indicate diminished psychomotor stimulant effects relative to cocaine. In a previous study using a fixed-ratio 10 schedule, two chloro-analogs (3'-Cl-BZT and 4'-Cl-B...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130000616
更新日期：2001-04-01 00:00:00
abstract：:In mice, quipazine has shown several behavioral effects: It antagonizes hypothermia induced by a high dose of apomorphine without altering climbing or stereotyped behavior; it antagonizes oxotremorine-induced hypothermia without altering tremors or peripheral signs; and it increases the toxicity of yohimbine. These th...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00431273
更新日期：1980-01-01 00:00:00
abstract：RATIONALE:Humans typically self-administer cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC) together repeatedly (as in cannabis, cannabis extract, or Sativex®) to relieve pain. It has been suggested that one benefit of the drug combination may be decreased tolerance development. OBJECTIVE:The present study com...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-018-5036-z
更新日期：2018-11-01 00:00:00
abstract：RATIONALE:Medication and illicit drugs can have detrimental side effects which impair driving performance. A drug's impairing potential should be determined by well-validated, reliable, and sensitive tests and ideally be calibrated by benchmark drugs and doses. To date, no consensus has been reached on the issue of whi...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-013-3408-y
更新日期：2014-06-01 00:00:00
abstract：:The effect of the dopamine receptor antagonist haloperidol on the development of sensitization to ethanol-induced increases in locomotor activity was examined in DBA/2J mice. In Experiment 1, different groups of mice were given saline or ethanol (2 g/kg) immediately before each of four locomotor activity sessions (48-...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245821
更新日期：1995-08-01 00:00:00
abstract：RATIONALE:Clozapine is a unique antipsychotic with very low propensity to cause motor side effects. In contrast to most other antipsychotics that block more than 70% of dopamine D(2) receptors at therapeutic doses, clozapine occupies less than 70%. Furthermore, even at maximum occupancy, 70% is not exceeded. Several me...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-001-0967-0
更新日期：2002-02-01 00:00:00
abstract：RATIONALE:Depressive disorders are conditions that often require continuous treatment, and it is therefore important to evaluate the consequences of prolonged administration. There are few studies assessing cognitive functions of depressed patients after long-term use of antidepressants. OBJECTIVES:This study evaluate...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-005-0274-2
更新日期：2006-03-01 00:00:00
abstract：RATIONALE:Numerous substituted cathinone drugs have appeared in recreational use. This variety is often a response to legal actions; the scheduling of 3,4-methylenedioxypyrovalerone (MDPV; "bath salts") in the USA was followed by the appearance of the closely related drug α-pyrrolidinopentiophenone (alpha-PVP; "flakka"...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-015-3944-8
更新日期：2015-08-01 00:00:00
abstract：:It was the aim of the present study to determine the affinities of four neuroleptics and five antidepressants for histamine H3 receptors. In rat brain cortex membranes, the specifically bound [3H]-N alpha-methylhistamine was monophasically displaced by clozapine (pKi 6.15). The other drugs did not completely displace ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02247479
更新日期：1994-12-01 00:00:00
abstract：RATIONALE:(+)-HA-966, a partial agonist at the glycine/NMDA modulatory site, significantly reduced i.v. cocaine self-administration in a fixed-ratio (FR) schedule. Since this effect was observed studying only one dose of cocaine and considering the characteristic bell-shaped curve generated by cocaine in self-administr...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-003-1703-8
更新日期：2004-04-01 00:00:00
abstract：:Rats were trained on a fixed ratio 10, food-reinforced schedule to recognize a discriminative stimulus (DS) elicited by the selective serotonin (5-HT) reuptake inhibitor (SSRI), citalopram (2.5 mg/kg, IP). The preferential, high efficacy agonist at 5-HT2C receptors, Ro60-0175, dose-dependently generalized to citalopra...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050910
更新日期：1999-03-01 00:00:00
abstract：RATIONALE:Carrageenan-induced hyperalgesia is a widely used pain model in rodents. However, characteristics of carrageenan-induced hyperalgesia and effects of analgesic drugs under these conditions are unknown in nonhuman primates. OBJECTIVE:The aims of this study were to develop carrageenan-induced hyperalgesia in rh...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-013-3341-0
更新日期：2014-04-01 00:00:00
abstract：:Benztropine mesylate (Cogentin) and physostigmine salicylate (Antilirium), were tested for changes in tongue protrusions, retrusions, and swallowing acts in rats anesthetized with a 100 mg/kg IM injection of ketamine hydrochloride. These ketamine-induced linguopharyngeal events were monitored by means of a force displ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02180028
更新日期：1988-01-01 00:00:00
abstract：:2Beta-propanoyl-3beta-(4-tolyl)-tropane (PTT) is a cocaine analog which has been shown in rhesus monkeys to have cocaine-like discriminative stimulus effects and a long duration of action (>8 h), yet does not function as a reinforcer when substituted for cocaine in monkeys responding under a fixed-interval 5-min sched...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050549
更新日期：1998-03-01 00:00:00
abstract：:The purpose of this review was to establish in vivo apparent pA2 and pKB values for antagonism of the discriminative stimulus effects of benzodiazepine ligands, and to compare these values to those obtained from other behavioral procedures. Articles were chosen from the Medline data base from January 1976 to August 19...
journal_title：Psychopharmacology
pub_type： 杂志文章,meta分析
doi：10.1007/s002130050103
更新日期：1996-11-01 00:00:00
abstract：INTRODUCTION:Model psychosis is characterised by experimentally induced symptoms of withdrawal from reality, frequently accompanied by perceptual disturbances, thought disorders, delusional ideas and sometimes by hallucinations. These "altered states of consciousness" provide a long-standing and valid approach to enhan...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-009-1591-7
更新日期：2009-11-01 00:00:00
abstract：:the immediate posttrial injection of oxotremorine (0.250 mu Mol/kg, IP) can facilitate the retention of a passive-avoidance response in mice. After the administration of alfa-methyl-p-tyrosine methylester (alpha-MPT) by intracerebroventricular injection at doses that had no effect on retention (100 microgram, 10 micro...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00433098
更新日期：1980-01-01 00:00:00
abstract：RATIONALE:The beneficial effects of nicotinic acetylcholine receptor (nAChR) agonists on cognitive performance have been widely shown. Paradoxically, recent preclinical studies employing extremely low doses of nAChR antagonists have also found cognitive enhancement, perhaps pointing to a novel treatment mechanism for c...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-016-4443-2
更新日期：2017-01-01 00:00:00
abstract：RATIONALE:Chronic pain is becoming a more common medical diagnosis and is especially prevalent in older individuals. As such, prescribed use of opioids is on the rise, even though the efficacy for pain management in older individuals is unclear. OBJECTIVES:Thus, the present preclinical study assessed the effectiveness...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-013-3208-4
更新日期：2014-01-01 00:00:00
abstract：RATIONALE:Treatment of attention-deficit/hyperactivity disorder (ADHD) has for many years relied on psychostimulants, particularly various formulations of amphetamines and methylphenidate. These are central nervous system stimulants and are scheduled because of their abuse potential. Atomoxetine (atomoxetine hydrochlor...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-013-2986-z
更新日期：2013-03-01 00:00:00
