Abstract：
RATIONALE:Catecholamine transmission modulates numerous cognitive and reward-related processes that can subserve more complex functions such as cost/benefit decision making. Dopamine has been shown to play an integral role in decisions involving reward uncertainty, yet there is a paucity of research investigating the contributions of noradrenaline (NA) transmission to these functions. OBJECTIVES:The present study was designed to elucidate the contribution of NA to risk/reward decision making in rats, assessed with a probabilistic discounting task. METHODS:We examined the effects of reducing noradrenergic transmission with the α2 agonist clonidine (10-100 μg/kg), and increasing activity at α2A receptor sites with the agonist guanfacine (0.1-1 mg/kg), the α2 antagonist yohimbine (1-3 mg/kg), and the noradrenaline transporter (NET) inhibitor atomoxetine (0.3-3 mg/kg) on probabilistic discounting. Rats chose between a small/certain reward and a larger/risky reward, wherein the probability of obtaining the larger reward either decreased (100-12.5 %) or increased (12.5-100 %) over a session. RESULTS:In well-trained rats, clonidine reduced risky choice by decreasing reward sensitivity, whereas guanfacine did not affect choice behavior. Yohimbine impaired adjustments in decision biases as reward probability changed within a session by altering negative feedback sensitivity. In a subset of rats that displayed prominent discounting of probabilistic rewards, the lowest dose of atomoxetine increased preference for the large/risky reward when this option had greater long-term utility. CONCLUSIONS:These data highlight an important and previously uncharacterized role for noradrenergic transmission in mediating different aspects of risk/reward decision making and mediating reward and negative feedback sensitivity.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Montes DR,Stopper CM,Floresco SBdoi
10.1007/s00213-015-3904-3subject
Has Abstractpub_date
2015-08-01 00:00:00pages
2681-96issue
15eissn
0033-3158issn
1432-2072journal_volume
232pub_type
杂志文章abstract：:N-carbamoyl-2-(2,6-dichlorophenyl) acetamidine hydrochloride (LON 954) causes a reproducible rest tremor in mice, of rapid onset and short duration with no associated rigidity or akinesia and in the absence of any marked changes in body temperature or accompanying peripheral parasympathomimetic effects. This tremor ca...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00439104
更新日期：1977-04-29 00:00:00
abstract：:The effects of benzodiazepine (BZ) antagonists on operant behavior were examined in rats chronically administered a low dose of diazepam (DZ). The low maintenance dose of DZ (5 mg/kg twice daily) was selected as more closely associated with its anxiolytic effects than the higher treatment doses previously used to stud...
journal_title：Psychopharmacology
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doi：10.1007/BF02244103
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pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1007/s00213-003-1711-8
更新日期：2004-04-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 临床试验,杂志文章
doi：10.1007/BF00690931
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00423257
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pub_type： 杂志文章
doi：10.1007/BF00433050
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journal_title：Psychopharmacology
pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1007/BF02245109
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journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
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更新日期：2009-11-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
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doi：10.1007/BF00187245
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pub_type： 杂志文章
doi：10.1007/BF00432281
更新日期：1979-01-31 00:00:00
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更新日期：2006-04-01 00:00:00
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doi：10.1007/s00213-004-2060-y
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更新日期：2007-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：1984-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：1993-01-01 00:00:00
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