Abstract:
RATIONALE:Comorbidity with gambling disorder (GD) and alcohol use disorder (AUD) is well documented. OBJECTIVE:The purpose of our study was to examine the influence of genetic alcohol drinking tendency on reward-guided decision making behavior of rats and the impact of dopamine releaser D-amphetamine on this behavior. METHODS:In this study, Alko alcohol (AA) and Wistar rats went through long periods of operant lever pressing training where the task was to choose the profitable of two options. The lever choices were guided by different-sized sucrose rewards (one or three pellets), and the probability of gaining the larger reward was slowly changed to a level where choosing the smaller reward would be the most profitable in the long run. After training, rats were injected (s.c.) with dopamine releaser D-amphetamine (0.3, 1.0 mg/kg) to study the impact of rapid dopamine release on this learned decision making behavior. RESULTS:Administration of D-amphetamine promoted unprofitable decision making of AA rats more robustly when compared to Wistar rats. At the same time, D-amphetamine reduced lever pressing responses. Interestingly, we found that this reduction in lever pressing was significantly greater in Wistar rats than in AA rats and it was not linked to motivation to consume sucrose. CONCLUSIONS:Our results indicate that conditioning to the lever pressing in uncertain environments is more pronounced in AA than in Wistar rats and indicate that the reinforcing effects of a gambling-like environment act as a stronger conditioning factor for rats that exhibit a genetic tendency for high alcohol drinking.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Oinio V,Sundström M,Bäckström P,Uhari-Väänänen J,Kiianmaa K,Raasmaja A,Piepponen Pdoi
10.1007/s00213-018-4847-2subject
Has Abstractpub_date
2018-05-01 00:00:00pages
1361-1370issue
5eissn
0033-3158issn
1432-2072pii
10.1007/s00213-018-4847-2journal_volume
235pub_type
杂志文章abstract:RATIONALE:Abstinence from drug occurs in human addicts for several reasons, including the avoidance of adverse consequences. OBJECTIVES:To explore a model of drug use in the face of adverse consequences in rats through intermittent punishment of drug seeking and to investigate whether the ability to withhold seeking r...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-007-0805-0
更新日期:2007-09-01 00:00:00
abstract::The binding kinetics of tritiated quinuclidinyl benzilate (QNB) were studied in membrane preparations from human parotid and rabbit submandibular glands. Inhibition of 3H-QNB was then used to compare the anticholinergic activity of lofepramine, desipramine, imipramine and amitriptyline for muscarinic receptor in the s...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00172861
更新日期:1986-01-01 00:00:00
abstract:RATIONAL:It has been suggested that phosphodiesterase 5 inhibitors such as sildenafil may be effective in the treatment of negative symptoms of schizophrenia. OBJECTIVE:This study was designed to investigate the effect of sildenafil added to risperidone as augmentation therapy in patients with chronic schizophrenia an...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-010-2044-z
更新日期:2011-02-01 00:00:00
abstract::Monoamine neurotransmitter systems, along with cholinergic systems, are known to play important roles in cognition, and are disrupted in at least some patients with dementia of the Alzheimer type (DAT). This suggests that monoamine-enhancing drugs might ameliorate cognitive symptoms in certain patients with DAT. L-Dep...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00216016
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:Acute administration of selective serotonin and noradrenaline re-uptake blockers to healthy volunteers affects the processing of emotional information but it is not known if similar effects occur with antidepressants acting through other pharmacological mechanisms. Mirtazapine is a clinically established ant...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-008-1410-6
更新日期:2009-05-01 00:00:00
abstract::The effects of serotonergic manipulations on the escape interference engendered by exposure to inescapable shock were assessed. Consistent with the view that the behavioral interference was related to reductions of serotonin (5-HT), treatment with the 5-HT receptor blocker methysergide mimicked the effects of inescapa...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00181242
更新日期:1986-01-01 00:00:00
abstract:RATIONALE:Tryptophan depletion is used to reduce central serotonergic function and to investigate its role in psychiatric illness. Despite widespread clinical use, its effects on serotonin (5-HT) receptors have not been well characterized. OBJECTIVE:The aim of this study was to examine the effect of acute (ATD) and ch...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0635-5
更新日期:2007-03-01 00:00:00
abstract::Serotonergic mechanisms have been implicated in the pathophysiology of depression and in the neuropharmacology of antidepressant treatment. One measure of central serotonergic function is the prolactin (PRL) response to IV L-tryptophan (L-TRP). We used the L-TRP test to assess the role of serotonin in the mechanism of...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245291
更新日期:1992-01-01 00:00:00
abstract::The effects of six putative dopamine receptor agonists on exploratory behaviour in rats were assessed: pergolide, (+)- and (-)-3-PPP, bromocriptine, mesulergine and CQ 32-084. Behaviour was automatically recorded in a holeboard apparatus and the data were analysed by the novel multivariate statistical method of partia...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00217053
更新日期:1987-01-01 00:00:00
abstract:RATIONALE:Most adult smokers start smoking during their adolescence. This adolescent initiation may be due to multiple factors, but little evidence is available regarding whether their brains are differentially sensitive to the addictive effects of nicotine during adolescence. OBJECTIVE:To test the hypothesis that ado...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1758-6
更新日期:2004-07-01 00:00:00
abstract:RATIONALE:Intermittent footshock stress effectively reinstates extinguished heroin-, cocaine- and alcohol-taking behaviors, but not behaviors previously maintained by food reinforcers. Here we tested further the generality of the phenomenon of stress-induced reinstatement by determining the effect of footshock on reins...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050992
更新日期:1999-05-01 00:00:00
abstract:BACKGROUND AND RATIONALE:More than two decades ago, Wise proposed his "anhedonia hypothesis" to explain the role of dopamine in motivated behaviors. The hypothesis posits that dopamine mediates the pleasure experienced by reward obtainment. However, some experimental findings have contested this hypothesis and several ...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-006-0521-1
更新日期:2007-04-01 00:00:00
abstract::The predatory behavior of ferrets (Putorius putorius furo L.) consists mainly of instinctive behavioral patterns that are elicited by simple external stimuli. For the ferret, the time needed to catch and kill rats depends on the size of the rats in relation to that of the ferret. Killing success decreases with a relat...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427754
更新日期:1978-10-31 00:00:00
abstract:RATIONALE:A growing number of studies suggest that gamma-aminobutyric acid type-B (GABA(B)) receptor agonists reduce alcohol use and craving. OBJECTIVES:This study was designed to further clarify behavioral mechanism(s) by which GABA(B) agonists may decrease alcohol reinforcement. METHODS:Male C57BL/6 J mice were tra...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1769-3
更新日期:2004-07-01 00:00:00
abstract::The subtype of dopamine (DA) receptors mediating the yawning response to DA agonists was determined in rats. Yawning was elicited both by the mixed D1-D2 agonist apomorphine and by the specific D2 agonist LY 171555, but not by the selective D1 agonist SKF 38393. Both apomorphine- and LY 171555-induced yawning were ant...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00518186
更新日期:1987-01-01 00:00:00
abstract:RATIONALE:A cue-modulated startle test recently confirmed that smoking cues in smokers may not be withdrawal-like and aversive as traditionally believed. OBJECTIVE:Analogous tests were applied to alcohol cues in inpatient alcoholics. METHODS:Twenty-six withdrawn alcoholics (18 men) were examined. Alcohol-related pict...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000508
更新日期:2000-09-01 00:00:00
abstract::Although previous studies have shown that pharmacological agents, such as buprenorphine, and alternative nondrug reinforcers, such as money or sweetened solutions, reduce cocaine self-administration, few studies have examined the combined effects of these two approaches. The purpose of the present study was to evaluat...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246018
更新日期:1996-06-01 00:00:00
abstract::The central effects of acetylsalicylic acid (ASA) are discussed controversially. In animal models, it has been shown that ASA can interact with the central serotonergic and catecholaminergic neuronal system. However, the relevance of this interaction for humans is still unknown. We performed a study on the influence o...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002130050683
更新日期:1998-08-01 00:00:00
abstract:INTRODUCTION:The majority of individuals who suffer an episode of depression go on to experience recurrences. We have proposed, based upon the observation that reducing serotonin via acute tryptophan depletion (ATD) is more likely to induce negative mood in recovered depressed individuals than never depressed individua...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-009-1533-4
更新日期:2009-08-01 00:00:00
abstract:RATIONALE:Information is sparse on neurotransmitter deficiencies in frontotemporal dementia (FTD), in particular with reference to distinct histological subgroups and Alzheimer's disease (AD). OBJECTIVES:To evaluate in FTD with the major histologies, and compare with AD and controls, neurotransmission indices, as thes...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-007-0992-8
更新日期:2008-03-01 00:00:00
abstract::The alcohol-preferring AA rats have previously been shown to drink more solution containing the opioid etonitazene than the alcohol-avoiding ANA rats. The present experiments were initiated to see whether the line difference in opioid and alcohol intake would persist if an intravenous (i.v.) route of self-administrati...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02247335
更新日期:1996-06-01 00:00:00
abstract:RATIONALE:Nicotine can enhance attentional performance in humans, a property that may be of therapeutic utility. OBJECTIVES:To identify brain sites mediating nicotine-induced attentional enhancement. METHODS:Nicotine (0, 1, 2, 4 and 8 microg) was injected bilaterally into the dorsal hippocampus and the prelimbic area...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1438-6
更新日期:2003-07-01 00:00:00
abstract:INTRODUCTION:Recently we demonstrated that genetic or pharmacological suppression of the central ghrelin signaling system, involving the growth hormone secretagogue receptor 1A (GHS-R1A), lead to a reduced reward profile from alcohol. As the target circuits for ghrelin in the brain include a mesolimbic reward pathway t...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1907-7
更新日期:2010-09-01 00:00:00
abstract:RATIONALE:Only a small percentage of individuals seeking treatment for their marijuana use achieves sustained abstinence, suggesting more treatment options are needed. OBJECTIVES:We investigated the effects of baclofen (study 1) and mirtazapine (study 2) in a human laboratory model of marijuana intoxication, withdrawa...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1888-6
更新日期:2010-08-01 00:00:00
abstract:RATIONALE:The orexin/hypocretin system has recently been implicated in reward-seeking, especially for highly salient food and drug rewards. We reasoned that this system may be strongly engaged during periods of reward restriction, including food restriction. OBJECTIVES:This study examined the involvement of the orexin...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-012-2902-y
更新日期:2013-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Footshock stress reliably reinstates heroin seeking in rats, but the time course of the development of this effect following drug withdrawal is not known. Here we studied the effect of intermittent footshock stress on reinstatement of heroin seeking following different withdrawal periods (1-66 ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100748
更新日期:2001-06-01 00:00:00
abstract:RATIONALE:Cognitive rehabilitation is now recognized as an important tool in the treatment of schizophrenia, and findings in this area are emerging rapidly. There is a need for a systematic review of the effects of the different training programs. OBJECTIVES:To review quantitatively the controlled studies on cognitive...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-002-1326-5
更新日期:2003-09-01 00:00:00
abstract::These experiments examined the neurochemical mechanisms involved in the development and expression of place conditioning produced by heroin. Conditioned place preferences (CPP) lasting up to 8 weeks were obtained with doses of 50-1000 micrograms/kg heroin, using a regimen shown not to produce physical dependence. Nalo...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00442007
更新日期:1989-01-01 00:00:00
abstract::The administration of large doses of probenecid has been used to study the central nervous system metabolism of catecholamines and indoleamines in patients with affective disease. It has been reported that alterations of the binding of L-tryptophan to plasma albumin binding sites occur during probenecid administration...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00492369
更新日期:1977-08-16 00:00:00
abstract::In the conditioned reinforcement paradigm, animals learn a new instrumental response reinforced solely by conditioned reward (a stimulus that has previously been associated with primary reward). It has been shown that psychostimulants potentiate responding for conditioned reward and there is evidence that the nucleus ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244202
更新日期:1991-01-01 00:00:00