Abstract:
RATIONALE:Intermittent footshock stress effectively reinstates extinguished heroin-, cocaine- and alcohol-taking behaviors, but not behaviors previously maintained by food reinforcers. Here we tested further the generality of the phenomenon of stress-induced reinstatement by determining the effect of footshock on reinstatement of operant responding previously maintained by nicotine or palatable sucrose solutions. METHODS:Groups of rats were trained to self-administer either nicotine (0.03 mg/kg per infusion, 14 days) or sucrose (10 or 30% w/v, 14-20 days). After extinction of the nicotine- or the sucrose-reinforced behaviors for 5-15 days, the rats were exposed to intermittent footshock stress (5 and 15 min, 0.8 mA) during tests for reinstatement. RESULTS:Footshock reliably reinstated nicotine seeking after extinction of the drug-reinforced behavior. In contrast, the same parameters of footshock stress did not consistently reinstate operant responding previously maintained by sucrose solutions. CONCLUSIONS:These and previous data suggest that stressors may be more effective stimuli for reinstatement of behaviors previously maintained by drug reinforcers as compared with non-drug reinforcers.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Buczek Y,Lê AD,Wang A,Stewart J,Shaham Ydoi
10.1007/s002130050992subject
Has Abstractpub_date
1999-05-01 00:00:00pages
183-8issue
2eissn
0033-3158issn
1432-2072journal_volume
144pub_type
杂志文章abstract::Although previous studies have shown that pharmacological agents, such as buprenorphine, and alternative nondrug reinforcers, such as money or sweetened solutions, reduce cocaine self-administration, few studies have examined the combined effects of these two approaches. The purpose of the present study was to evaluat...
journal_title:Psychopharmacology
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更新日期:1982-01-01 00:00:00
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