Abstract:
:The effects of meperidine on operant behavioral thermoregulation were investigated using a convective thermal controller and mice trained to alternate at will the thermal-drive condition, changing it from an air flow of 15 degrees C to one of 45 degrees C, and vice versa. Administration of 15 mg/kg meperidine resulted in significantly lower response rates, a significantly larger fraction of time spent in one (mostly cold) drive condition, and significantly lower body temperatures than administration of saline. In a second experiment the animal was automatically returned to the hot-drive condition every 3 min unless it had been exposed to this condition in the previous 0.4 min although otherwise it remained free to alternative drive conditions at will. Under these conditions, meperidine-treated animals also spent significantly more time in cold drive and had significantly lower body temperatures than control animals, in spite of lower response rates. Pretreatment with 4.5 mg/kg tranylcypromine (4 h prior) did not significantly alter the effects of meperidine administration in either experiment.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Gessner PK,Clarke CCdoi
10.1007/BF00491979subject
Has Abstractpub_date
1979-09-01 00:00:00pages
59-63issue
1eissn
0033-3158issn
1432-2072journal_volume
65pub_type
杂志文章abstract:RATIONALE:Cocaine and opioids are often co-abused. As yet, however, there is no clear evidence that the drugs interact to make the mixture a more effective reinforcer. OBJECTIVE:The present study examined the relative reinforcing potency and maximum effectiveness of the cocaine-opioid combination in monkeys given a ch...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-2131-1
更新日期:2011-05-01 00:00:00
abstract:RATIONALE:Direct activation of the cannabinoid CB1 receptor in the dorsolateral periaqueductal gray (dlPAG) inhibits anxiety- and panic-related behaviours in experimental animals. It has remained unclear, however, whether the local endocannabinoid signalling is recruited as a protective mechanism against aversive stimu...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3793-x
更新日期:2015-05-01 00:00:00
abstract:RATIONALE:Previous studies indicate that the rewarding effect of D-1 dopamine receptor stimulation in nucleus accumbens (NAc) shell is greater in food-restricted (FR) than in ad libitum fed (AL) rats. The D-1 receptor is positively coupled to adenylyl cyclase and activates protein kinase A (PKA). OBJECTIVES:The purpos...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2602-z
更新日期:2012-06-01 00:00:00
abstract::A paradigm for assessing benzodiazepine receptor sensitivity was developed using intravenous midazolam in normal volunteers. After administration of incremental doses of midazolam, alterations in saccadic eye movement parameters and psychological self ratings were assessed. Significant changes included dose-dependent ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244431
更新日期:1991-01-01 00:00:00
abstract:RATIONALE:A substantial body of research suggests that the neuropeptide oxytocin promotes social affiliative behaviors in a wide range of animals including humans. However, its antiaggressive action has not been unequivocally demonstrated in male laboratory rodents. OBJECTIVE:Our primary goal was to examine the putati...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-3124-7
更新日期:2013-10-01 00:00:00
abstract:RATIONALE:Each year, over 300,000 individuals in the USA enter treatment for cannabis use disorder (CUD). The development of effective pharmacotherapy for CUD is a priority. OBJECTIVE:This placebo-controlled study examined the effects of zolpidem alone and in combination with nabilone on cannabis withdrawal and a labo...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-016-4298-6
更新日期:2016-07-01 00:00:00
abstract::Passive avoidance learning was significantly impaired by atropine (5 mg/kg, IP) or scopolamine (0.5 mg/kg), but not by methyl-atropine (5 mg/kg) or methyl-scopolamine (0.5 mg/kg), from postnatal day 15 on. In contrast, an improvement was observed, not significant at 11 days and significant at 13 days, probably due to ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00449124
更新日期:1982-01-01 00:00:00
abstract::In a shuttle-box self-stimulation paradigm, analgesic doses of morphine increase the amount of time a rat leaves rewarding brain stimulation on, without altering average OFF times. This paradigm may serve as a model for the euphoria induced by narcotic drugs and as a useful tool for evaluating the reinforcing effects ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426581
更新日期:1977-11-15 00:00:00
abstract:RATIONALE:Abstinence from drug occurs in human addicts for several reasons, including the avoidance of adverse consequences. OBJECTIVES:To explore a model of drug use in the face of adverse consequences in rats through intermittent punishment of drug seeking and to investigate whether the ability to withhold seeking r...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-007-0805-0
更新日期:2007-09-01 00:00:00
abstract:RATIONALE:Subthreshold smokers (who smoke < or =5 cigarettes/day) experience withdrawal symptoms, yet they smoke less than is required to maintain serum nicotine levels. OBJECTIVES:For study 1, our aim was to determine (1) if adult subthreshold smokers report withdrawal symptoms; (2) how they rate symptom severity; (3...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0497-x
更新日期:2006-10-01 00:00:00
abstract::Two experiments were conducted to test the hypothesis that tolerance to the hypothermic effect of ethanol fails to develop if rats are denied the unconditional stimulus represented by hypothermia. In both experiments, rats were injected with either ethanol (1.9 or 2.5 g/kg) or saline and given microwave hyperthermia (...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00175187
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:The main psychoactive component of cannabis, delta-9-tetrahydrocannabinol (THC), can impair driving performance. Cannabidiol (CBD), a non-intoxicating cannabis component, is thought to mitigate certain adverse effects of THC. It is possible then that cannabis containing equivalent CBD and THC will differenti...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-019-05246-8
更新日期:2019-09-01 00:00:00
abstract::After learning a light-cued, go-no go successive discrimination to criterion, male Sprague-Dawley rats received 0, 5, or 10 mg/kg chlordiazepoxide on six performance sessions, followed by two drug-recovery (saline) sessions. Chlordiazepoxide impaired discrimination performance in a dose-dependent manner, with animals ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00652237
更新日期:1986-01-01 00:00:00
abstract:RATIONALE:Antidepressants are known to modify human sleep patterns. OBJECTIVES:Duloxetine is a new antidepressant with a mechanism of action involving reuptake inhibition of both serotonin (5-HT) and norepinephrine (NE). In this study, the effects of two dosing regimens of duloxetine on sleep electroencephalography (E...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00213-004-1961-0
更新日期:2005-02-01 00:00:00
abstract::ApolipoproteinE (ApoE) genotype has recently been identified as a major risk factor for Alzheimer's disease (AD) but the mechanism(s) by which ApoE isoforms influence this disease remain unclear. Recent studies suggest that mice deficient in ApoE may exhibit impaired central cholinergic function. Since this neurotrans...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050329
更新日期:1997-07-01 00:00:00
abstract:RATIONALE:Buprenorphine is a low-efficacy mu opioid agonist that can reduce drug taking in opioid abusers; however, the mechanism by which buprenorphine modifies the actions of other drug taking and the consequences of repeated treatment with buprenorphine are not fully understood. OBJECTIVE:The purposes of this study...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-001-0943-8
更新日期:2002-03-01 00:00:00
abstract::Cigarette smokers have a wide variety of "tar" and nicotine yields to choose from in the current market, ranging from 0.5 mg "tar" and less than 0.05 mg nicotine to 27 mg "tar" and 1.8 mg nicotine by the Federal Trade Commission (FTC) method. To understand better the relationship between FTC nicotine yields and actual...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02246082
更新日期:1995-11-01 00:00:00
abstract::The performance of healthy volunteer subjects on an auditory latent inhibition (LI) paradigm was assessed following administration of a single oral dose of d-amphetamine or placebo. It was predicted that a low (5 mg), but not a high (10 mg), dose of d-amphetamine would disrupt LI. The prediction was supported with lef...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02245170
更新日期:1992-01-01 00:00:00
abstract::The benzodiazepines are typified by a profile of side effects which includes drowsiness, ataxia and incoordination. Ro 15-1788, an imidazodiazepine derivative, exhibits marked antagonism of the behavioural and biochemical effects of the benzodiazepines in animals and man. It is devoid of any behavioural activity in an...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00427969
更新日期:1983-01-01 00:00:00
abstract:RATIONALE:Phytocannabinoids are useful therapeutics for multiple applications including treatments of constipation, malaria, rheumatism, alleviation of intraocular pressure, emesis, anxiety and some neurological and neurodegenerative disorders. Consistent with these medicinal properties, extracted cannabinoids have rec...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2415-0
更新日期:2012-02-01 00:00:00
abstract::Rats exhibit profound individual differences in their propensity to ingest sugar and in their locomotor response to AMP. Intrinsic variation in the responsiveness of mesolimbic dopamine mechanisms has been suggested to account for these individual differences. In light of this overlap, it might be expected that indivi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244864
更新日期:1994-09-01 00:00:00
abstract::The serotonin 5-HT(3) receptor is thought to play a role in the reward pathway and drug abuse by modulating dopamine release within the mesolimbic pathway. Dopamine release stimulated by cocaine and methamphetamine is blocked by administration of 5-HT(3) receptor antagonists. Animal studies demonstrate that 5-HT(3) re...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100833
更新日期:2001-10-01 00:00:00
abstract:RATIONALE:Chronic stress and corticosterone have been shown to affect serotonin (5-HT) neurotransmission; however, the influence of stress on the activity of the dorsal raphe nucleus (DRN), the main source of 5-HT in the forebrain, is not well understood. In particular, it is unknown if and how stress modifies DRN 5-HT...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-5045-y
更新日期:2018-12-01 00:00:00
abstract:RATIONALE:Schizophrenia is characterized by a large variety of cognitive symptoms, among which information processing deficits have been extensively studied. So far, these aspects have been found to be remarkably stable and effective treatment is still lacking. Traditionally, information processing is subdivided into p...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-003-1684-7
更新日期:2004-06-01 00:00:00
abstract:INTRODUCTION:Alterations in protein kinase (PKA) protein levels have been implicated in the regulation of responses to and development of cocaine addiction. However, the contribution of differences in PKA intracellular cascade to the known sex differences in responses to cocaine is not well understood. This study exami...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1411-5
更新日期:2009-04-01 00:00:00
abstract:RATIONALE:Several antipsychotic drugs are metabolised by the polymorphic cytochrome P(450) CYP2D6. The impact of the polymorphism on the plasma levels and the occurrence of side effects have not been clearly established. OBJECTIVE:To investigate the impact of the CYP2D6 polymorphism on the steady-state plasma concentr...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1059-5
更新日期:2002-06-01 00:00:00
abstract:RATIONALE:Humans typically self-administer cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC) together repeatedly (as in cannabis, cannabis extract, or Sativex®) to relieve pain. It has been suggested that one benefit of the drug combination may be decreased tolerance development. OBJECTIVE:The present study com...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-5036-z
更新日期:2018-11-01 00:00:00
abstract::In a randomised, double-blind, parallel groups study, 40 patients referred for surgical removal of impacted third molars received either (a) temazepam 40 mg orally followed at 35 min by IV saline or (b) oral placebo followed by IV diazepam 10 mg (Diazemuls). Patients were divided into High-Anxious and Low-Anxious grou...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00652245
更新日期:1986-01-01 00:00:00
abstract:RATIONALE:The beneficial effects of psychostimulant drugs in the treatment of psychiatric disorders occur because they increase the extracellular dopamine concentration by inhibiting re-uptake of extracellular dopamine at dopamine transporters. However, the psychological effects at low dopamine transporter occupancy ha...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-016-4464-x
更新日期:2017-02-01 00:00:00
abstract:RATIONAL:Caloric restriction increases the risk of relapse in abstinent drug users. Hormones involved in the regulation of energy balance and food intake, such as leptin and ghrelin, are implicated in drug-related behaviors. OBJECTIVES:We investigated the role of leptin and ghrelin in the augmentation of heroin seekin...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-019-05415-9
更新日期:2020-03-01 00:00:00