Absence of central effects in man of the benzodiazepine antagonist Ro 15-1788.

Abstract:

:The benzodiazepines are typified by a profile of side effects which includes drowsiness, ataxia and incoordination. Ro 15-1788, an imidazodiazepine derivative, exhibits marked antagonism of the behavioural and biochemical effects of the benzodiazepines in animals and man. It is devoid of any behavioural activity in animals, except at very high doses. In the present study the effects of single rising oral doses of Ro 15-1788 on cognitive, psychomotor and subjective function in man have been assessed using a battery of psychometric tests designed to identify the sedative action of the benzodiazepines. At all doses up to 600 mg, Ro 15-1788 demonstrated none of the classical behavioural effects of the benzodiazepines.

journal_title

Psychopharmacology

authors

Darragh A,Lambe R,O'Boyle C,Kenny M,Brick I

doi

10.1007/BF00427969

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

192-5

issue

2

eissn

0033-3158

issn

1432-2072

journal_volume

80

pub_type

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