Abstract:
:The benzodiazepines are typified by a profile of side effects which includes drowsiness, ataxia and incoordination. Ro 15-1788, an imidazodiazepine derivative, exhibits marked antagonism of the behavioural and biochemical effects of the benzodiazepines in animals and man. It is devoid of any behavioural activity in animals, except at very high doses. In the present study the effects of single rising oral doses of Ro 15-1788 on cognitive, psychomotor and subjective function in man have been assessed using a battery of psychometric tests designed to identify the sedative action of the benzodiazepines. At all doses up to 600 mg, Ro 15-1788 demonstrated none of the classical behavioural effects of the benzodiazepines.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Darragh A,Lambe R,O'Boyle C,Kenny M,Brick Idoi
10.1007/BF00427969subject
Has Abstractpub_date
1983-01-01 00:00:00pages
192-5issue
2eissn
0033-3158issn
1432-2072journal_volume
80pub_type
临床试验,杂志文章,随机对照试验abstract::We have previously demonstrated that depletion of forebrain norepinephrine (NE) led to an attenuation of neophobia in a novel environment, as defined by a greater preference for novel food over familiar food. To study further the role of forebrain NE in neophobia we chronically infused noradrenergic receptor ligands o...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02253601
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abstract::Research was conducted to examine the ability of alcohol to impart conditioned reinforcement. Rats were allowed to self-administer solutions of either saline or alcohol (25, 50, and 100 mg/kg/infusion) by the intragastric route. Superimposed on the infusion interval was a buzzer (conditioned reinforcing stimulus). Tes...
journal_title:Psychopharmacology
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journal_title:Psychopharmacology
pub_type: 杂志文章
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abstract:RATIONALE:Although psilocybin has been used for centuries for religious purposes, little is known scientifically about its acute and persisting effects. OBJECTIVES:This double-blind study evaluated the acute and longer-term psychological effects of a high dose of psilocybin relative to a comparison compound administer...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Psychopharmacology
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journal_title:Psychopharmacology
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journal_title:Psychopharmacology
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journal_title:Psychopharmacology
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journal_title:Psychopharmacology
pub_type: 杂志文章
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journal_title:Psychopharmacology
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