Tolerance to hypothermia induced by ethanol depends on specific drug effects.

abstract：RATIONALE:Naturally low prepulse inhibition (PPI) in DBA/2 mice is increased by marketed antipsychotics and compounds acting at novel targets relevant to schizophrenia. Whether other mouse strains with naturally low PPI respond similarly and could be translational models of schizophrenia is unknown. OBJECTIVE:Baseline...

journal_title：Psychopharmacology

authors： Flood DG,Zuvich E,Marino MJ,Gasior M

更新日期：2011-06-01 00:00:00

abstract：RATIONALE:Recent studies have suggested that the salutary actions of clozapine in schizophrenia may be due to selective activation of M(1) muscarinic receptors by clozapine and/or its major active metabolite N-desmethylclozapine. OBJECTIVE:We systematically tested this hypothesis by screening a large number of psychoa...

journal_title：Psychopharmacology

authors： Davies MA,Compton-Toth BA,Hufeisen SJ,Meltzer HY,Roth BL

更新日期：2005-04-01 00:00:00

abstract：:Augmentation with low-dose fluvoxamine (50-100 mg/day) to antipsychotic treatment may improve the negative symptoms in schizophrenic patients, but involves a risk of drug-drug interaction. We studied the effects of fluvoxamine on plasma concentrations of haloperidol and reduced haloperidol, and their clinical symptoms...

journal_title：Psychopharmacology

authors： Yasui-Furukori N,Kondo T,Mihara K,Inoue Y,Kaneko S

更新日期：2004-01-01 00:00:00

abstract：RATIONALE:Neuroactive derivatives of steroid hormones, neurosteroids, can act on GABAA receptors (GABAARs) to potentiate the effects of GABA on these receptors. Neurosteroids become elevated to physiologically relevant levels under conditions characterized by increased steroid hormones. There is considerable evidence f...

journal_title：Psychopharmacology

authors： MacKenzie G,Maguire J

更新日期：2014-09-01 00:00:00

abstract：:After publication of this paper, the authors determined an error in Fig. 2C. ...

journal_title：Psychopharmacology

authors： Zhang B,Xiong F,Ma Y,Li B,Mao Y,Zhou Z,Yu H,Li J,Li C,Fu J,Wang J,Zhao X

更新日期：2019-07-01 00:00:00

abstract：RATIONALE:Memantine is a potential treatment for alcoholic patients, yet few studies investigate the effect of concurrent treatment with memantine and ethanol on aggression. We evaluated aggressive behavior following ethanol consumption and treatment with glutamatergic drugs to characterize interactions between these c...

journal_title：Psychopharmacology

authors： Newman EL,Chu A,Bahamón B,Takahashi A,Debold JF,Miczek KA

更新日期：2012-11-01 00:00:00

abstract：RATIONALE:Piper methysticum extract (kava kava) possesses numerous therapeutic properties, but it is unknown which of its principle constituents (kavalactones) subserve such effects. OBJECTIVES:This experiment sought to characterize the putative anxiolytic properties of P. methysticum extract and its six principle kav...

journal_title：Psychopharmacology

authors： Smith KK,Dharmaratne HR,Feltenstein MW,Broom SL,Roach JT,Nanayakkara NP,Khan IA,Sufka KJ

更新日期：2001-04-01 00:00:00

abstract：RATIONALE:Subthreshold smokers (who smoke < or =5 cigarettes/day) experience withdrawal symptoms, yet they smoke less than is required to maintain serum nicotine levels. OBJECTIVES:For study 1, our aim was to determine (1) if adult subthreshold smokers report withdrawal symptoms; (2) how they rate symptom severity; (3...

journal_title：Psychopharmacology

authors： Fernando WW,Wellman RJ,Difranza JR

更新日期：2006-10-01 00:00:00

abstract：RATIONALE:Several recent studies have focused on glutamate modulating agents for symptoms relief in schizophrenia, especially negative symptoms which are resistant to conventional therapies. OBJECTIVES:We aimed to assess the efficacy and tolerability of riluzole, an anti-glutamate agent with neuroprotective properties...

journal_title：Psychopharmacology

authors： Farokhnia M,Sabzabadi M,Pourmahmoud H,Khodaie-Ardakani MR,Hosseini SM,Yekehtaz H,Tabrizi M,Rezaei F,Salehi B,Akhondzadeh S

更新日期：2014-02-01 00:00:00

abstract：:It is commonly believed that repeated exposures diminish the pleasurable effects of drugs and hence that pleasure must have only a minor role in addiction. In six experiments with rats, repeated exposures to amphetamine, morphine, or cocaine were found to enhance the drug-induced rewarding effect as measured by condit...

journal_title：Psychopharmacology

authors： Lett BT

更新日期：1989-01-01 00:00:00

abstract：:The issue of whether tolerance develops to the motivational effects of opioids was addressed by use of an unbiased place preference conditioning procedure. Administration of the mu-opioid agonists morphine or fentanyl produced dose-related preferences for the drug-associated place in control rats. In contrast, the kap...

journal_title：Psychopharmacology

authors： Shippenberg TS,Emmett-Oglesby MW,Ayesta FJ,Herz A

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Partial dopamine receptor agonists have been proposed as candidate pharmacotherapies for cocaine dependence. OBJECTIVE:This 42-day, within-subject, human laboratory study assessed how maintenance on aripiprazole, a partial D(2) receptor agonist, influenced smoked cocaine self-administration, cardiovascular m...

journal_title：Psychopharmacology

authors： Haney M,Rubin E,Foltin RW

更新日期：2011-08-01 00:00:00

abstract：:The [14C]-2-deoxyglucose method was used to map the in vivo metabolic response of glucose to savoxepine, a novel tetracyclic cyano-dibenzoxepino-azepine. Savoxepine is reported to have higher affinity for dopamine (DA) receptors in the hippocampus than in the striatum and hence should have dose-dependent, anatomically...

journal_title：Psychopharmacology

authors： Cascella NG,Tarazi FI,Shirakawa O,Tamminga CA

更新日期：1994-03-01 00:00:00

abstract：RATIONALE:Nicotine and nicotinic agonists have been shown to improve attentional function. Nicotinic receptors are easily desensitized, and all nicotinic agonists are also desensitizing agents. Although both receptor activation and desensitization are components of the mechanism that mediates the overall effects of nic...

journal_title：Psychopharmacology

authors： Rezvani AH,Cauley M,Xiao Y,Kellar KJ,Levin ED

更新日期：2013-03-01 00:00:00

abstract：:Rats were trained to discriminate between two compound stimulus arrays that included exteroceptive (ES) and interoceptive (IS) stimulus components. The ES components were illumination and tactile cues, and the IS components were produced by d-amphetamine (A) or Na pentobarbital (P) treatment (drug versus drug discrimi...

journal_title：Psychopharmacology

authors： Duncan PM

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:Microinjections of ethanol and acetaldehyde into ventral tegmental area (VTA) produce locomotor activation in rats through mechanisms dependent on the mu-opioid receptors. However, it is not clear how these drugs can interact with these receptors. It has been hypothesized that salsolinol could be the responsi...

journal_title：Psychopharmacology

authors： Hipólito L,Sánchez-Catalán MJ,Zornoza T,Polache A,Granero L

更新日期：2010-03-01 00:00:00

abstract：:This paper examines noradrenergic hyperactivity in response to stress in the development of spontaneous recurrences of methamphetamine (MAP) psychosis, a phenomenon known as flashbacks, in studies of psychedelic drug use. We studied predictors of flashbacks in 36 subjects with flashbacks, along with 80 subjects with a...

journal_title：Psychopharmacology

authors： Yui K,Ishiguro T,Goto K,Ikemoto S

更新日期：1997-12-01 00:00:00

abstract：RATIONALE:Prepulse inhibition (PPI) of the startle reflex is a model of pre-attentional inhibitory function. The dopamine baseline in the nucleus accumbens plays a key role in PPI regulation as well as in the rewarding effects of cocaine. OBJECTIVES:The aim of this study was to evaluate the predictive ability of PPI t...

journal_title：Psychopharmacology

authors： Arenas MC,Navarro-Francés CI,Montagud-Romero S,Miñarro J,Manzanedo C

更新日期：2018-09-01 00:00:00

abstract：:In two experiments, phenobarbitone sodium (30 mg/kg) reliably enhanced water consumption and extended the duration of drinking in 24h water-deprived male rats. The opiate receptor antagonists naloxone (0.1-10 mg/kg) and naltrexone (0.1-10 mg/kg) both decreased water intake and reduced the duration of drinking. When th...

journal_title：Psychopharmacology

authors： Cooper SJ,McGivern H

更新日期：1983-01-01 00:00:00

abstract：RATIONALE:Atypical antipsychotic drugs are classically associated with lower propensity to extrapyramidal symptoms (EPS) and hyperprolactinemia than typical antipsychotic drugs. It has not been clarified why some atypical antipsychotic drugs, such as amisulpride, induce prolactin plasma concentration (PRL) elevation, b...

journal_title：Psychopharmacology

authors： Bressan RA,Erlandsson K,Spencer EP,Ell PJ,Pilowsky LS

更新日期：2004-09-01 00:00:00

abstract：:Neuroleptic-free schizophrenic patients received caerulein, a potent analogue of cholecystokinin octapeptide, in a fixed- and rising-dose schedule. In addition, neuroleptic-treated patients received a single dose of the peptide with a 4-week follow-up. No significant change in mental status was observed after any of t...

journal_title：Psychopharmacology

authors： Tamminga CA,Littman RL,Alphs LD,Chase TN,Thaker GK,Wagman AM

更新日期：1986-01-01 00:00:00

abstract：:Chronic tolerance to ethanol-induced sleep, motor impairment (moving belt test), and hypothermia were examined in two lines of rats that had been selectively bred for their different initial sensitivities to ethanol. In agreement with previous work (Mayer et al. 1982, 1983), the least-affected (LA) rats were found to ...

journal_title：Psychopharmacology

authors： Khanna JM,Lê AD,LeBlanc AE,Shah G

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Caffeine has a well-established effect on reaction times (RTs) but the neurocognitive mechanisms underlying this are unclear. METHODS:In the present study, 15 female participants performed an oddball task after ingesting caffeine or a placebo, and electroencephalographic data were obtained. Single-trial P3b...

journal_title：Psychopharmacology

authors： Saville CWN,de Morree HM,Dundon NM,Marcora SM,Klein C

更新日期：2018-03-01 00:00:00

abstract：RATIONALE:Carbon monoxide synthetized by inducible heme oxygenase (HO-1) exerts potent anti-inflammatory and antinociceptive effects during acute and neuropathic pain, but its role in the modulation of chronic inflammatory pain and the possible involvement of nitric oxide in this action remain unknown. OBJECTIVES AND ...

journal_title：Psychopharmacology

authors： Negrete R,Hervera A,Leánez S,Pol O

更新日期：2014-03-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:Dopamine (DA) agonists reliably disrupt prepulse inhibition (PPI) of the startle reflex in animals but less so in humans despite cross-species similarities in the neural regulation of PPI. This study examines whether individual variation in baseline PPI may account for the inconsistencies in DA...

journal_title：Psychopharmacology

authors： Bitsios P,Giakoumaki SG,Frangou S

更新日期：2005-10-01 00:00:00

abstract：RATIONALE:Numerous substituted cathinone drugs have appeared in recreational use. This variety is often a response to legal actions; the scheduling of 3,4-methylenedioxypyrovalerone (MDPV; "bath salts") in the USA was followed by the appearance of the closely related drug α-pyrrolidinopentiophenone (alpha-PVP; "flakka"...

journal_title：Psychopharmacology

authors： Aarde SM,Creehan KM,Vandewater SA,Dickerson TJ,Taffe MA

更新日期：2015-08-01 00:00:00

abstract：:Responding maintained under progressive ratio (PR) and fixed ratio (FR 160) schedules of IV saline or cocaine (0.01-4.0 mg/kg) injections was studied in baboons. Each injection was followed by a time-out period which was 3-h with the PR schedule and was either 3 or 12 with the FR schedule. On the PR schedule the ratio...

journal_title：Psychopharmacology

authors： Griffiths RR,Bradford LD,Brady JV

更新日期：1979-10-01 00:00:00

abstract：RATIONALE:While reserpine-induced oral movements (OM), an animal model of tardive dyskinesia, are more persistent in old than in adult rats, old animals present spontaneous OM, which are phenomenologically similar to those presented by reserpine-treated adult rats. We postulate that these OM may be the result of oxidat...

journal_title：Psychopharmacology

authors： Abílio VC,Vera JA Jr,Ferreira LS,Duarte CR,Carvalho RC,Grassl C,Martins CR,Torres-Leite D,Bignotto M,Tufik S,Ribeiro Rde A,Frussa-Filho R

更新日期：2002-06-01 00:00:00

abstract：INTRODUCTION:Marchigian Sardinian alcohol-preferring (msP) rats exhibit innate preference for alcohol along with anxious phenotype. In these animals, two single-nucleotide polymorphisms in position -1,836 and -2,097 from the first start codon of the CRF1-R transcript have been found. MATERIALS AND METHODS:Here, we exa...

journal_title：Psychopharmacology

authors： Cippitelli A,Ayanwuyi LO,Barbier E,Domi E,Lerma-Cabrera JM,Carvajal F,Scuppa G,Li H,Ubaldi M,Heilig M,Roberto M,Ciccocioppo R

更新日期：2015-03-01 00:00:00

abstract：:Animal and human studies have demonstrated that, depending upon the sequence of alcohol presentation, long-term memory of events can either be enhanced or diminished. In the present study a similar phenomenon is demonstrated in the neuronal excitability of slices of hippocampus from guinea pig brains. Alcohol given af...

journal_title：Psychopharmacology

authors： Oliver AP,Parker ES,Wyatt RJ

更新日期：1984-01-01 00:00:00