Abstract:
RATIONALE:Neuroactive derivatives of steroid hormones, neurosteroids, can act on GABAA receptors (GABAARs) to potentiate the effects of GABA on these receptors. Neurosteroids become elevated to physiologically relevant levels under conditions characterized by increased steroid hormones. There is considerable evidence for plasticity of GABAARs associated with altered levels of neurosteroids which may counteract the fluctuations in the levels of these allosteric modulators. OBJECTIVES:The objective of this review is to summarize the current literature on GABAAR plasticity under conditions characterized by alterations in neurosteroid levels, such as over the estrous cycle, during puberty, and throughout pregnancy and the postpartum period. RESULTS:The expression of specific GABAAR subunits is altered over the estrous cycle, at puberty, and throughout pregnancy and the postpartum period. Inability to regulate δ subunit-containing GABAARs throughout pregnancy and the postpartum period is associated with depression-like behavior restricted to the postpartum period. CONCLUSIONS:GABAAR plasticity associated with alterations in neurosteroid levels represents a homeostatic compensatory mechanism to maintain an ideal level of inhibition to offset the potentiating effects of neurosteroids on GABAergic inhibition. Failure to properly regulate GABAARs under conditions of altered neurosteroid levels may increase vulnerability to mood disorders, such as premenstrual syndrome (PMS), premenstrual dysphoric disorder (PMDD), and postpartum depression.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
MacKenzie G,Maguire Jdoi
10.1007/s00213-013-3423-zsubject
Has Abstractpub_date
2014-09-01 00:00:00pages
3333-42issue
17eissn
0033-3158issn
1432-2072journal_volume
231pub_type
杂志文章,评审abstract::Fluctuations in extracellular dopamine and DOPAC levels in nucleus accumbens septi (NAS) were monitored in 1-min microdialysis samples taken from rats engaged in intravenous cocaine self-administration. For four rats the dose per injection was fixed at 2.0 mg/kg; for four others the dose per injection was varied irreg...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246140
更新日期:1995-07-01 00:00:00
abstract::Rats were made hyperphagic by 6-hydroxydopamine (6-OHDA) injected bilaterally into the ventral midbrain; then they were restricted to a 6 h/day feeding schedule and tested for appetite suppression with amphetamine and fenfluramine in randomized order. Amphetamine anorexia was diminished while fenfluramine anorexia was...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426393
更新日期:1984-01-01 00:00:00
abstract::A total of 97 patients, who participated in two studies on the relationship between the clinical effect and plasma levels of imipramine and clomipramine, were examined for improvement curves by use of weekly ratings on the Hamilton Depression Scale (HDS). Although we confirmed that our six-item HDS subscale, in contra...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00427459
更新日期:1984-01-01 00:00:00
abstract::The role of the nucleus accumbens septi (ACB) and corpus striatum (CPU) in self-stimulation were investigated by injecting directly or indirectly acting stimulant drugs or a dopamine-(DA)-receptor blocking agent into each site bilaterally. d-Amphetamine (68 nmol) facilitated hypothalamic self-stimulation when injected...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426546
更新日期:1977-08-31 00:00:00
abstract::The effects of the benzomorphan antagonist Mr 2266 and the selective delta-antagonist ICI 154,129 on the body weight gain of 6-day-old suckling rat pups was observed. Mr 2266 significantly reduced body weight gain in these animals, though ICI 154,129 had no affect on this variable. These findings suggest that mu- and ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432046
更新日期:1984-01-01 00:00:00
abstract::Withdrawal was precipitated by naloxone at different intervals, up to 22.5 h, following a last maintenance injection in morphine-dependent rats. Different symptoms of withdrawal were found to be preeminent following different morphine-naloxone intervals. Locomotor activity, jumping, and writhing were precipitated most...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426773
更新日期:1977-10-20 00:00:00
abstract::The present study was conducted to determine whether methadone maintenance alters the pharmacodynamic effects of single doses of cocaine. Twenty-two current users of IV cocaine who were not seeking treatment for their illicit cocaine use participated while living on a research unit. Eleven were maintained on methadone...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02246276
更新日期:1996-01-01 00:00:00
abstract:RATIONALE:Sex differences in the dopaminergic response to psychostimulants could have implications for drug abuse risk and other psychopathology involving the dopamine system, but human data are limited and mixed. OBJECTIVES:Here, we sought to investigate sex differences in dopamine release after oral D-amphetamine ad...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-5083-5
更新日期:2019-02-01 00:00:00
abstract:RATIONALE:Elevated whole-blood serotonin (5-HT) is a robust biomarker in ~ 30% of patients with autism spectrum disorders, in which repetitive behavior is a core symptom. Furthermore, elevated whole-blood 5-HT has also been described in patients with pediatric obsessive-compulsive disorder. The 5-HT1B receptor is assoc...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05758-8
更新日期:2021-01-29 00:00:00
abstract::3,4-Methylenedioxymethamphetamine (MDMA) is a psychoactive phenylisopropylamine which is structurally similar to both amphetamine-related sympathomimetics and the hallucinogen, mescaline. MDMA produces pleasurable effects which include euphoria, and recent reports continue to demonstrate its widespread recreational us...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00212765
更新日期:1988-01-01 00:00:00
abstract:INTRODUCTION:The present study was designed to investigate the rewarding effects induced by tramadol and its active metabolite O-desmethyltramadol (M1) under a neuropathic pain-like state. RESULTS:In opioid receptor binding and G protein activation, we confirmed that M1, but not tramadol, showed mu-opioid receptor (MO...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1180-1
更新日期:2008-10-01 00:00:00
abstract:RATIONALE:Batteries of tests that are thought to measure different aspects of anxiety-related behaviour are used to characterise mice after genetic or pharmacological manipulation. However, because of the potentially confounding effects of repeated testing and natural intra-individual variations in behaviour over time,...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1873-0
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND AND RATIONALE:Nicotinic acetylcholine systems play major roles in cognitive function. Nicotine and a variety of nicotinic agonists improve attention, and nicotinic antagonist exposure impairs it. This study was conducted to investigate the effect of a novel nicotinic receptor agonist at α4β2 nicotinic recept...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-012-2712-2
更新日期:2012-10-01 00:00:00
abstract::Rats injected with doses of d-amphetamine 0--5.0 mg/kg were observed continuously in either an enclosed Y-maze or on an elevated Y-shaped platform. Patterns of increased walking and stereotypy were unaffected by the type of apparatus, but rearing remained totally suppressed at all dose levels on the elevated platform....
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431954
更新日期:1979-04-25 00:00:00
abstract::In the forced swimming-induced immobility (despair) test model, adenosine, and 2-chloroadenosine treatment prolonged the immobilization period in mice. Dipyridamole, which is known to inhibit adenosine uptake, potentiated the adenosine effect. The purinoceptor antagonists caffeine and theophylline blocked purine nucle...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00429665
更新日期:1985-01-01 00:00:00
abstract:RATIONALE:Although both contain behaviourally significant concentrations of caffeine, tea is commonly perceived to be a less stimulating drink than coffee. At least part of the explanation for this may be that theanine, which is present in tea but not coffee, has relaxing effects. There is also some evidence that thean...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-007-0938-1
更新日期:2008-01-01 00:00:00
abstract::Functional antagonists at the N-methyl-D-aspartate (NMDA) receptor complex produce anti-depressant-like actions in preclinical models. Thus, an injection of a glycine partial agonist (1-aminocyclopropanecarboxylic acid; ACPC), a competitive NMDA antagonist (2-amino-7-phosphonoheptanoic acid; AP-7) or a use-dependent c...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245261
更新日期:1992-01-01 00:00:00
abstract::Because of the increasing demand for refined techniques to record drug-induced motoric changes, we designed and evaluated a computer monitoring system with continuous measurement of different parameters of rat motor activity. This system is particularly useful for chronic drug studies because it can characterize patte...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432113
更新日期:1983-01-01 00:00:00
abstract::The effect of delta 9-tetrahydrocannabinol (THC) on the locomotor activity-stimulating action of morphine has been investigated in mice. THC (10 mg/kg) has been found to potentiate morphine-induced hyperactivity. On the other hand, the stimulating action of morphine on motor activity strongly diminished in mice render...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427650
更新日期:1980-01-01 00:00:00
abstract::A new benzamide, cis-N-(1-benzyl-2-methylpyrrolidin - 3 - yl) - 5 - chloro - 2 - methoxy - 4 - methylaminobenzamide (YM-09151-2) exhibited more potent and longer-lasting inhibitory effects on apomorphine-induced behaviours (stereotyped behaviour, emesis and hypothermia), and methamphetamine-induced stereotyped behavio...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00429198
更新日期:1981-01-01 00:00:00
abstract::The present dose-response study investigated the effects of the benzodiazepine oxazepam (Serax) on anxiety as measured by autonomic and self-report indices in a nonclinical sample. Given Fowles' (1980, 1988) theory that electrodermal activity primarily reflects the activity of the behavioral inhibition system (BIS) wh...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02244346
更新日期:1993-01-01 00:00:00
abstract:RATIONALE:3,4-methylenedioxymethamphetamine (MDMA, ecstasy) produces an acute release of 5-HT in the brain, together with increased locomotion and hyperthermia. OBJECTIVE:This study examined whether the acute functional changes of locomotor activity and body temperature are related to enhanced 5-HT release induced by ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1921-9
更新日期:2011-02-01 00:00:00
abstract::In rats with unilateral 6-hydroxydopamine (6-OHDA) lesions of the medial forebrain bundle, pretreatment with the D1 DA antagonists, SCH 23390 (7-chloro-8-hydroxy-2,3,4,5-tetrahydro-3-methyl-1-phenyl-1H-3-benzazepin e) and A66359 (1- 2-bromo-4,5-dimethoxybenzyl]-7-hydroxy-6-methoxy-2-methyl- 1,2,3,4 tetrahydroisoquinol...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246211
更新日期:1995-02-01 00:00:00
abstract:RATIONALE:The rapid membrane actions of neuroactive steroids, particularly via an enhancement of γ-aminobutyric acidA receptors (GABAARs), participate in the regulation of central nervous system excitability. Prior evidence suggests an inverse relationship between endogenous GABAergic neuroactive steroid levels and beh...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3618-y
更新日期:2014-09-01 00:00:00
abstract::Keypecking in one group of pigeons was maintained under schedules in which food was presented only when a specified number of responses was followed by a 30-s pause without a response. d-Amphetamine and pentobarbital increased low rates of responding (and, thus, decreased food presentation) only after initial injectio...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426485
更新日期:1977-07-18 00:00:00
abstract:RATIONALE:There is an emerging body of evidence that implicates a crucial role of γ-aminobutyric acid subtype A (GABAA) receptors in modulating the rewarding effects of a number of abused drugs. Modulation of GABAA receptors may therefore represent a novel drug-class independent mechanism for the development of abuse t...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-015-4155-z
更新日期:2016-02-01 00:00:00
abstract:RATIONALE:3,4-Methylenedioxymethamphetamine (MDMA) produces a long-term depletion of serotonin (5-HT) in the rat brain; this depletion may have some functional consequences. OBJECTIVE:The aim of the present study was to evaluate the acute effects of MDMA on the extracellular concentrations of dopamine and 5-HT, body t...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130051143
更新日期:1999-11-01 00:00:00
abstract::When injected IP, the M1 muscarinic receptor antagonist pirenzepine dose-dependently induced a deficit in passive avoidance learning in rats. This activity was optimal at 75 mg/kg injected 1 h before the acquisition session. The deficit induced by pirenzepine was antagonized by oxotremorine (0.03-0.3 mg/kg SC) and phy...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00444707
更新日期:1989-01-01 00:00:00
abstract:RATIONALE:The majority of pharmacotherapies proposed for cocaine dependence have been marginally effective and frequently have undesirable side effects. We recently demonstrated that short-term treatment with citicoline decreased self-reported desire to use cocaine in crack cocaine users. OBJECTIVE:The present study w...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002130100824
更新日期:2001-09-01 00:00:00
abstract:RATIONALE:Glucocorticoids have been shown to affect declarative memory, an explicit form of memory for facts and events operated by medial temporal lobe structures. Recent neuroimaging data suggest that the medial temporal lobe (including the hippocampus) is also active in implicit sequence learning. OBJECTIVES:The ai...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-010-2112-4
更新日期:2011-05-01 00:00:00