Abstract：
RATIONALE:Glucocorticoids have been shown to affect declarative memory, an explicit form of memory for facts and events operated by medial temporal lobe structures. Recent neuroimaging data suggest that the medial temporal lobe (including the hippocampus) is also active in implicit sequence learning. OBJECTIVES:The aim of the present study was to investigate whether implicit sequence learning may also be affected by glucocorticoid administration. METHODS:Oral cortisol (30 mg) was given to 29 healthy subjects whereas 31 control subjects received placebo. One hour after treatment all volunteers performed five consecutive blocks of a five-choice serial reaction time task by responding to colored lights by pressing buttons of the same color. The subjects responded without knowing to a quasi-randomized stimulus sequence, including higher-order sequential regularities (a combination of two colors that predicted the following target color). The reaction speed of every button-press (100 per block) was determined and difference scores were calculated as a proof of learning. RESULTS:Both groups showed significant implicit sequence learning throughout the experiment. However, we found an impaired learning performance of the cortisol group compared with the placebo group. Further analysis revealed that a delayed learning in the cortisol group occurred at the very beginning of the task. CONCLUSIONS:This study is the first human investigation indicating impaired implicit memory function after exogenous administration of the stress hormone cortisol. This effect may depend on hippocampus engagement in implicit sequence learning, but the involvement of other brain structures is also discussed.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Römer S,Schulz A,Richter S,Lass-Hennemann J,Schächinger Hdoi
10.1007/s00213-010-2112-4subject
Has Abstractpub_date
2011-05-01 00:00:00pages
33-40issue
1eissn
0033-3158issn
1432-2072journal_volume
215pub_type
杂志文章,随机对照试验abstract：RATIONALE:So-called atypical antipsychotics (AAPs) are associated with varying levels of weight gain and associated metabolic disturbances, which in patients with serious mental illness (SMI) have been linked to non-compliance and poor functional outcomes. Mechanisms underlying AAP-induced metabolic abnormalities are o...
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pub_type： 临床试验,杂志文章,随机对照试验
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