Abstract:
:In the forced swimming-induced immobility (despair) test model, adenosine, and 2-chloroadenosine treatment prolonged the immobilization period in mice. Dipyridamole, which is known to inhibit adenosine uptake, potentiated the adenosine effect. The purinoceptor antagonists caffeine and theophylline blocked purine nucleoside-induced enhancement of immobilization. Tricyclic antidepressants such as imipramine and desipramine, the MAO inhibitor tranylcypromine, and amphetamine, a psychostimulant, reversed purine nucleoside-induced immobility. On the other hand, quipazine, fluoxetine, and amitriptyline failed to reverse purine nucleosides-induced prolongation of immobility. None of the antidepressants in the doses investigated had any effect by themselves. Reserpine also prolonged forced swimming-induced immobility in mice. The antidepressants fluoxetine and quipazine, but not methylxanthine pretreatment, reversed reserpine-induced immobility in this test model. These results indicate that adenosine and 2-chloroadenosine probably reduce norepinephrine outflow through their action on presynaptic purinoceptors on noradrenergic neurons and thereby cause prolongation of immobility in animals.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Kulkarni SK,Mehta AKdoi
10.1007/BF00429665subject
Has Abstractpub_date
1985-01-01 00:00:00pages
460-3issue
4eissn
0033-3158issn
1432-2072journal_volume
85pub_type
杂志文章abstract:RATIONALE:Glucose administration may decrease desire to smoke in abstinent smokers. Moreover, glucose administration has been associated with improved performance on measures of attention in healthy humans but evidence remains modest. OBJECTIVE:The present study aimed to determine whether reported craving and nicotine...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00213-002-1035-0
更新日期:2002-05-01 00:00:00
abstract:RATIONALE:Intermittent footshock stress reliably reinstates extinguished alcohol-taking behavior in drug-free rats, but the neurochemical events involved in this effect are not known. OBJECTIVE:We studied here whether two main modulators of stress responses, corticotropin-releasing factor (CRF) and corticosterone, are...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000411
更新日期:2000-06-01 00:00:00
abstract::N-Methyl-D-aspartate (NMDA) antagonists induce psychotomimetic effects in humans that closely resemble negative and cognitive symptoms of schizophrenia. NMDA agonists, in contrast, may significantly ameliorate such symptoms. In rodents, phencyclidine (PCP) and other NMDA antagonists induce a hyperlocomotory syndrome t...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050168
更新日期:1997-01-01 00:00:00
abstract:RATIONALE:The gut microbiota is increasingly recognized as a potential mediator of psychiatric diseases. Depressed patients have been shown to have a different microbiota composition compared with healthy controls, and several lines of research now aim to restore this dysbiosis. To develop novel treatments, preclinical...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-5094-2
更新日期:2019-05-01 00:00:00
abstract:RATIONALE:Reduced serotonin neurotransmission is implicated in disorders of impulse control, but the involvement of serotonin in inhibitory processes in healthy human subjects remains unclear. OBJECTIVES:To investigate the effects of an acute manipulation of serotonin and genotype at a functional polymorphism in a gen...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-005-0104-6
更新日期:2005-11-01 00:00:00
abstract:RATIONALE:The endogenous oxytocin system has emerged as an inhibitor of drug-seeking and stress in preclinical models. OBJECTIVES:The goal of this study was to examine whether systemic oxytocin administration attenuated methamphetamine (METH)-seeking in rats pre-exposed to a predator odor threat. METHODS:In Experimen...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-015-4184-7
更新日期:2016-03-01 00:00:00
abstract::Human eyeblink conditioning, a relatively simple form of learning and memory, has previously been shown to be impaired by the central and peripheral anticholinergic scopolamine. The present study compared the behavioral effects of scopolamine with the benzodiazepine lorazepam and a peripherally active anticholinergic,...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02246273
更新日期:1995-12-01 00:00:00
abstract:INTRODUCTION:The objective of this study was to examine age-, hormone-, and sex-dependent differences to the behavioral effects of nicotine using place-conditioning procedures in female rats. METHODS:Animals received nicotine in their initially non-preferred side and saline on alternate days in their initially preferr...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-009-1607-3
更新日期:2009-10-01 00:00:00
abstract::Evaluation of the efficacy of antidepressant agents needs to take into account factors which increase the "effect size", such as dosage, treatment duration, the use of two-phase trials, and pattern analysis of responders. Although many patients are thought to receive inadequate doses of antidepressants, relatively few...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/BF02246244
更新日期:1992-01-01 00:00:00
abstract::This study investigated behavioural effects of very potent 5-HT reuptake inhibitors after acute treatment (cianopramine and citalopram), as well as after chronic treatment (cianopramine), in two behavioural models of anxiety: 1) the light/dark choice procedure in mice and 2) the elevated plus-maze test in rats. In add...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245224
更新日期:1994-01-01 00:00:00
abstract:RATIONALE:The occurrence of methamphetamine (METH) use by the smoking route is increasing. A nonhuman primate model for examining the reinforcing effects of smoked METH would be valuable for testing potential interventions for treating METH abuse disorders. OBJECTIVE:The purpose of the present study was to examine the...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0479-z
更新日期:2006-10-01 00:00:00
abstract::Selectively bred FAST mice are highly susceptible, while SLOW mice are less susceptible, to the locomotor stimulant effects of ethanol. Heritability estimates indicate that approximately 15% of the variance in the FAST lines is of additive genetic origin, while low susceptibility is ostensibly nonheritable. Inbreeding...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244259
更新日期:1991-01-01 00:00:00
abstract::In mice that were scored for the length of time they remained immobile in awkward postures (cataleptic) on an inclined wire grid, a large IP dose of pilocarpine (80 mg/kg) caused a clear catalepsy, which was prevented by both dopamine agonists that were tested, apomorphine (4 or 8 mg/kg, IP) and bromocriptine (8 mg/kg...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431769
更新日期:1985-01-01 00:00:00
abstract::Dose-dependent effects of intravenously administered lorazepam on haemodynamic fluctuations were studied by means of spectral analysis, in order to elucidate sympathetic and parasympathetic components in cardiovascular control during situations of rest and mental stress after benzodiazepine administration. In a double...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02245447
更新日期:1994-02-01 00:00:00
abstract:RATIONALE:Inhibition of glutamatergic N-methyl-D-aspartate (NMDA) receptors following the administration of NMDA receptor antagonists results in psychotic-like behaviour. Whereas it is known that pharmacological manipulation of dopaminergic and serotonergic pathways affect this drug-induced psychosis, a role for noradr...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000630
更新日期:2001-03-01 00:00:00
abstract::Male volunteer subjects smoked one marijuana cigarette containing 100, 200, or 250 micrograms/kg delta-9-tetrahydrocannabinol (THC) and were tested on three perceptual-motor performance measures related to driving. Performance was measured and blood samples were collected for 24 h after smoking. The covariation betwee...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00427321
更新日期:1985-01-01 00:00:00
abstract:RATIONALE:Cotreatment with clorgyline shifts the development of sensitization to the D2/D3 dopamine receptor agonist quinpirole from locomotion to mouthing, an effect apparently unrelated to the monoamine oxidase inhibition property of clorgyline. This phenomenon was demonstrated in rats examined in small activity cham...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0377-4
更新日期:2006-07-01 00:00:00
abstract:RATIONALE:The post-extinction exposure of rats to a sub-conditioning procedure (SCP; i.e., retraining with a shock intensity that is too weak to induce by itself significant fear conditioning) has been reported to provoke the reemergence of extinguished fear. This phenomenon can be prevented by chronic fluoxetine treat...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-012-2806-x
更新日期:2013-01-01 00:00:00
abstract::Two putative predictors of placebo response were studied in three samples of psychiatric outpatients. Two groups, 73 university medical center patients and 56 college health service patients, underwent 1 week of placebo treatment. A quasi-control group of 112 patients receiving no medication waited about 1 week before...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00433557
更新日期:1979-06-21 00:00:00
abstract:OBJECTIVE:Studies suggest that brain-derived neurotrophic factor (BDNF) plays an essential role in regulating memory-related neuroplasticity in the hippocampus. Type 2 diabetes (T2DM) is associated with impairment in many domains of cognitive function which may result from reduced BDNF; however, the correlation of BDNF...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-012-2942-3
更新日期:2013-05-01 00:00:00
abstract::Physostigmine (1.0mg) or placebo were administered intravenously over 1-h period to seven male normal volunteers beginning 35 min after sleep onset. The results indicate that physostigmine induced the onset of REM sleep but did not significantly alter the duration of individual REM sleep periods. Physostigmine signifi...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00426799
更新日期:1978-06-15 00:00:00
abstract:RATIONALE:Brain waves reflect collective behavior of neurons and provide insight into distributed network processing. Frontal and hippocampal theta oscillations (4-7 Hz) were linked to cognitive tasks and animal studies have suggested an involvement of glutamatergic neurotransmission in integrative frontal-hippocampal ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0397-0
更新日期:2006-07-01 00:00:00
abstract:RATIONALE:Cognitive rehabilitation is now recognized as an important tool in the treatment of schizophrenia, and findings in this area are emerging rapidly. There is a need for a systematic review of the effects of the different training programs. OBJECTIVES:To review quantitatively the controlled studies on cognitive...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-002-1326-5
更新日期:2003-09-01 00:00:00
abstract::The antagonist effects of clocinnamox were evaluated against opioid agonists, acting at mu, kappa and delta-receptors, in rhesus monkeys (n = 3-4) responding under a fixed-ratio 30 (FR 30) schedule for food delivery. Clocinnamox (0.032-0.1 mg/kg) dose-dependently antagonized fentanyl (0.001-0.32 mg/kg) after either a ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246641
更新日期:1996-02-01 00:00:00
abstract::Neonatal treatment with monoamine reuptake inhibitors results in a constellation of neurobehavioral alterations in adult rats that may model human depression. Since alterations in circadian rhythmicity have been reported in both depressed patients and in animal depression models, the present study examined the effects...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244777
更新日期:1994-06-01 00:00:00
abstract:BACKGROUND:Alcoholics report persistent alcohol craving that is heightened by cognitive cues, stressful situations, and abstinence. The role of endogenous cannabinoids in human alcohol craving--though long suspected--remains elusive. MATERIALS AND METHODS:We employed laboratory exposure to stress, alcohol cue, and neu...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-009-1518-3
更新日期:2009-07-01 00:00:00
abstract:RATIONALE:The startle reflex to a sudden intense acoustic pulse stimulus is attenuated if the pulse is shortly preceded by a weak prepulse stimulus. This represents a form of sensory gating, known as prepulse inhibition (PPI), observable across species. PPI is modulated by dopamine and readily disrupted by acute amphet...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-012-2819-5
更新日期:2013-01-01 00:00:00
abstract::Previous studies have shown that dihydropyridine (DHP) calcium channel blockers can potentiate yawning induced by apomorphine in rats. The present study was undertaken to examine whether or not this interaction was seen with other compounds that induce yawning or if it represented a specific interaction with dopaminer...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244401
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVES:Early onset of heroin use during adolescence might increase chances of later drug addiction. Prior work from our laboratory suggests, however, that adolescent male rats are actually less sensitive than adults to some enduring effects of heroin self-administration. In the present study, we tested two likely c...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-012-2847-1
更新日期:2013-02-01 00:00:00
abstract::Single doses of amantadine hydrochloride and placebo were administered in a double-blind cross-over design on separate days to ten actively craving cocaine abusers in treatment. Pharmacological treatment did influence cocaine craving, but amantadine was less effective than placebo. ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00439458
更新日期:1989-01-01 00:00:00