Low BDNF is associated with cognitive deficits in patients with type 2 diabetes.

abstract：RATIONALE:Exposure to a single session of uncontrollable inescapable shock (IS), but not to identical controllable escapable shock, produces a potentiation of morphine's rewarding properties that is unusual in that the stressor can be given a number of days before the drug administration in an environment quite differe...

journal_title：Psychopharmacology

authors： Will MJ,Der-Avakian A,Bland ST,Grahn RE,Hammack SE,Sparks PD,Pepin JL,Watkins LR,Maier SF

更新日期：2004-01-01 00:00:00

abstract：RATIONALE:Salvinorin A is the active component of the hallucinogenic plant Salvia divinorum. The potential mode of action of this hallucinogen was unknown until recently. A recent in vitro study detected high affinity and efficacy of salvinorin A at kappa-opioid receptors. It was postulated that salvinorin A would prod...

journal_title：Psychopharmacology

authors： Butelman ER,Harris TJ,Kreek MJ

更新日期：2004-03-01 00:00:00

abstract：:The effects of six putative dopamine receptor agonists on exploratory behaviour in rats were assessed: pergolide, (+)- and (-)-3-PPP, bromocriptine, mesulergine and CQ 32-084. Behaviour was automatically recorded in a holeboard apparatus and the data were analysed by the novel multivariate statistical method of partia...

journal_title：Psychopharmacology

authors： Ståhle L,Ungerstedt U

更新日期：1987-01-01 00:00:00

abstract：:Administration of the serotonin (5-HT)1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) facilitates the expression of masculine sexual behavior in male and female rats as well as in male rhesus monkeys and inhibits lordosis behavior in female rats. In the present study the effects of 8-OH-DPAT on ...

journal_title：Psychopharmacology

authors： Paredes RG,Kica E,Baum MJ

更新日期：1994-05-01 00:00:00

abstract：:First, it was confirmed that systemic injection of the neurotoxin 6-hydroxydopamine HBr (30 mg/kg IP) depleted noradrenaline levels in rat heart, but not centrally. Losses averaged 90% of control 1 day after injection, and 50% at 42 days. The same drug and dose was then administered to 50% of a group of rats which had...

journal_title：Psychopharmacology

authors： Salmon P,Stanford C,Gray JA

更新日期：1985-01-01 00:00:00

abstract：RATIONALE:In recent years, an increasing body of evidence points to the involvement of the glutamatergic system and specifically the glutamatergic ionotropic N-methyl-D-aspartate (NMDA) receptor in the pathophysiology of obsessive-compulsive disorder (OCD). OBJECTIVES:To test the role of NMDA receptors in compulsive b...

journal_title：Psychopharmacology

authors： Albelda N,Bar-On N,Joel D

更新日期：2010-05-01 00:00:00

abstract：OBJECTIVES:Recent studies using positron emission tomography (PET) have established the relationship between an intravenous dose of cocaine and the percentage occupancy of the dopamine transporter in humans, and have documented the requirement of more than 50% occupancy for perception of the "high". The present experim...

journal_title：Psychopharmacology

authors： Gatley SJ,Volkow ND,Gifford AN,Fowler JS,Dewey SL,Ding YS,Logan J

更新日期：1999-09-01 00:00:00

abstract：RATIONALE:A glutamate-dopamine interaction has been implicated in the psychosis-like effects of glutamate N-methyl- D-aspartate (NMDA) receptor antagonists, such as phencyclidine and ketamine. However, recent imaging studies addressing striatal glutamate-dopamine interaction directly in vivo in man have been controvers...

journal_title：Psychopharmacology

authors： Aalto S,Hirvonen J,Kajander J,Scheinin H,Någren K,Vilkman H,Gustafsson L,Syvälahti E,Hietala J

更新日期：2002-12-01 00:00:00

abstract：:2Beta-propanoyl-3beta-(4-tolyl)-tropane (PTT) is a cocaine analog which has been shown in rhesus monkeys to have cocaine-like discriminative stimulus effects and a long duration of action (>8 h), yet does not function as a reinforcer when substituted for cocaine in monkeys responding under a fixed-interval 5-min sched...

journal_title：Psychopharmacology

authors： Birmingham AM,Nader SH,Grant KA,Davies HM,Nader MA

更新日期：1998-03-01 00:00:00

abstract：RATIONALE:A previous study found that a 10-min bout of moderate intensity exercise reduced cigarette withdrawal symptoms and desire to smoke in sedentary smokers but the effect may have been due to participants focusing attention on physical activity rather than the activity itself. OBJECTIVES:This study examined the ...

journal_title：Psychopharmacology

authors： Daniel J,Cropley M,Ussher M,West R

更新日期：2004-07-01 00:00:00

abstract：:Transdermal nicotine has been shown to relieve nicotine withdrawal and to double smoking cessation rates compared to placebo in clinical trials. A 21 or 22 mg/day dose provides a steady state serum nicotine that is less than obtained from smoking. Limited information is available about higher nicotine patch doses. To ...

journal_title：Psychopharmacology

authors： Fredrickson PA,Hurt RD,Lee GM,Wingender L,Croghan IT,Lauger G,Gomez-Dahl L,Offord KP

更新日期：1995-12-01 00:00:00

abstract：:The effect of long-term lithium carbonate treatment on parameters of immediate, short-, and long-term memory was examined in a group of bipolar affectively ill patients. The lithium treatment group recalled significantly fewer words across trials on a verbal learning task than a group of bipolar affectively ill patien...

journal_title：Psychopharmacology

authors： Reus VI,Targum SD,Weingartner H,Post RM

更新日期：1979-05-08 00:00:00

abstract：:Psychopharmacological studies using caffeinated beverages or caffeine have rarely considered temporal effects on psychological and physiological function or the specific contribution of caffeine, hot water, or beverage type to the observed effects. The effect of 400 ml hot tea, coffee, and water consumption on systoli...

journal_title：Psychopharmacology

authors： Quinlan P,Lane J,Aspinall L

更新日期：1997-11-01 00:00:00

abstract：:We have previously obtained evidence that the mesoamygdaloid dopamine projection modulates the acquisition of a conditioned response (CR) elicited by presentation of a conditioned stimulus (CS) predicting the availability of a natural (sucrose) reward. This property was found to be dependent upon D3, but not D1 or D2,...

journal_title：Psychopharmacology

authors： Hitchcott PK,Phillips GD

更新日期：1998-12-01 00:00:00

abstract：:The title of this article is "Effect of a dual orexin receptor antagonist (DORA-12) on sleep and event-related oscillations in rats exposed to ethanol vapor during adolescence". ...

journal_title：Psychopharmacology

authors： Ehlers CL,Benedict J,Wills D,Sanchez-Alavez M

更新日期：2020-11-01 00:00:00

abstract：RATIONALE:Central CB1 cannabinoid receptors regulate anxiety-like and appetitive consummatory behaviors. Pharmacological antagonism/inverse-agonism of CB1 receptors increases anxiety and decreases appetitive behaviors; however, neither well-defined dose nor context dependence of these effects has been simultaneously as...

journal_title：Psychopharmacology

authors： Gamble-George JC,Conger JR,Hartley ND,Gupta P,Sumislawski JJ,Patel S

更新日期：2013-08-01 00:00:00

abstract：:Different groups of rats received combined or separate administration of different doses of piracetam (P1:100, P2:200, and P4:400 mg/kg) and choline (C1:100 and C2:200 mg/kg). Compared to control treatment, C1 significantly improved performance in a delayed alternation (DA) task, while P1, P2, P4 or P1C1 had no effect...

journal_title：Psychopharmacology

authors： Ennaceur A,Delacour J

更新日期：1987-01-01 00:00:00

abstract：RATIONALE:The startle reflex to a sudden intense acoustic pulse stimulus is attenuated if the pulse is shortly preceded by a weak prepulse stimulus. This represents a form of sensory gating, known as prepulse inhibition (PPI), observable across species. PPI is modulated by dopamine and readily disrupted by acute amphet...

journal_title：Psychopharmacology

authors： Peleg-Raibstein D,Hauser J,Llano Lopez LH,Feldon J,Gargiulo PA,Yee BK

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:The primary aim of this project was to examine the role of alcohol use in smoking lapse behavior, as alcohol consumption is a known risk factor for poor smoking cessation outcomes. MATERIALS AND METHODS:We have developed a novel human laboratory model to examine two primary aspects of alcohol-mediated tobacc...

journal_title：Psychopharmacology

authors： McKee SA,Krishnan-Sarin S,Shi J,Mase T,O'Malley SS

更新日期：2006-12-01 00:00:00

abstract：:This study describes specific behaviours in guinea-pigs after dopamine D-1 and D-2 receptor activation which differed to those described in other rodent species. Intraperitoneal (IP) administration of the dopamine D-2 receptor agonist quinpirole (1.5, 3 and 6 mg/kg) to guinea-pigs dose-dependently initiated locomotor ...

journal_title：Psychopharmacology

authors： Brent PJ

更新日期：1991-01-01 00:00:00

abstract：:A two flavour, unbiased, taste preference conditioning procedure was used to test for possible motivating effects of gamma 2-MSH. Three training trials failed to produce any significant effect with doses ranging from 2.4 to 40 micrograms/ICV infusion in drug-naive, non-operated or placebo-implanted rats. However, in r...

journal_title：Psychopharmacology

authors： Mucha RF,van Ree JM

更新日期：1989-01-01 00:00:00

abstract：:An experiment was carried out in the pigeon to assess the effects of sodium amylobarbitone (SAB) on memory, using a delayed pair comparison task. Performance was disrupted at all delays by doses of 10 and 20 mg/kg SAB and it was concluded that this effect was not due to perceptual impairment or stereotyped responding,...

journal_title：Psychopharmacology

authors： Hulme M,Sahgal A,Iversen SD

更新日期：1979-03-29 00:00:00

abstract：BACKGROUND:Delivering nicotine in the way smokers seek is likely to be the key factor in e-cigarette (EC) success in replacing cigarettes. We examined to what degree different types of EC mimic nicotine intake from cigarettes. METHODS:Twelve participants ('dual users' of EC and cigarettes) used their own brand cigaret...

journal_title：Psychopharmacology

authors： Hajek P,Przulj D,Phillips A,Anderson R,McRobbie H

更新日期：2017-03-01 00:00:00

abstract：:Administration of 10 mg/kg TRH to mice was found to reduce the sleep and hypothermia induced by 4.7 g/kg ethanol. However, TRH did not reduce the sleep of mice that were given gamma-hydroxybutyric acid (GHBA), baclophen, or aminooxyacetic acid (AOAA) in combination with 3 g/kg/ ethanol. TRH also failed to reverse the ...

journal_title：Psychopharmacology

authors： Cott J,Engel J

更新日期：1977-04-29 00:00:00

abstract：RATIONALE:Medication and illicit drugs can have detrimental side effects which impair driving performance. A drug's impairing potential should be determined by well-validated, reliable, and sensitive tests and ideally be calibrated by benchmark drugs and doses. To date, no consensus has been reached on the issue of whi...

journal_title：Psychopharmacology

authors： Jongen S,Vuurman E,Ramaekers J,Vermeeren A

更新日期：2014-06-01 00:00:00

abstract：:Research was conducted to examine the ability of alcohol to impart conditioned reinforcement. Rats were allowed to self-administer solutions of either saline or alcohol (25, 50, and 100 mg/kg/infusion) by the intragastric route. Superimposed on the infusion interval was a buzzer (conditioned reinforcing stimulus). Tes...

journal_title：Psychopharmacology

authors： Smith SG,Werner TE,Davis WM

更新日期：1977-08-16 00:00:00

abstract：RATIONAL:Caloric restriction increases the risk of relapse in abstinent drug users. Hormones involved in the regulation of energy balance and food intake, such as leptin and ghrelin, are implicated in drug-related behaviors. OBJECTIVES:We investigated the role of leptin and ghrelin in the augmentation of heroin seekin...

journal_title：Psychopharmacology

authors： D'Cunha TM,Chisholm A,Hryhorczuk C,Fulton S,Shalev U

更新日期：2020-03-01 00:00:00

abstract：RATIONALE:Decision-making is a complex cognitive process that is mediated, in part, by subregions of the medial prefrontal cortex (PFC). Decision-making is impaired in a number of psychiatric conditions including schizophrenia. Notably, people with schizophrenia exhibit reductions in GABA function in the same PFC areas...

journal_title：Psychopharmacology

authors： Paine TA,O'Hara A,Plaut B,Lowes DC

更新日期：2015-05-01 00:00:00

abstract：:The subjective, psychomotor, and physiological effects of analgesic doses of oral codeine and morphine were examined in 12 healthy volunteers. Subjects ingested placebo, morphine 20 or 40 mg, or codeine 60 or 120 mg in a randomized, double-blind, crossover design. The smaller and larger doses of each drug were putativ...

journal_title：Psychopharmacology

authors： Walker DJ,Zacny JP

更新日期：1998-11-01 00:00:00

abstract：:Amitriptyline and zimelidine significantly reduce the uptake of 5-HT into the blood platelets of depressive patients. The degree of inhibition is significantly correlated with the plasma drug level of amitriptyline. No significant relationship could be detected between the degree of inhibition of uptake and therapeuti...

journal_title：Psychopharmacology

authors： Coppen A,Rama Rao VA,Swade C,Wood K

更新日期：1979-05-25 00:00:00