Abstract:
RATIONALE:Reduced serotonin neurotransmission is implicated in disorders of impulse control, but the involvement of serotonin in inhibitory processes in healthy human subjects remains unclear. OBJECTIVES:To investigate the effects of an acute manipulation of serotonin and genotype at a functional polymorphism in a gene coding for the serotonin transporter (5-HTT) on an established measure of response inhibition. METHODS:Serotonin function was reduced by the acute tryptophan depletion (ATD) procedure in a double-blind, crossover design in 42 healthy subjects. The Stop Signal Task (SST) was administered 5-7 h after drink administration. The influences of 5-HTT polymorphism, gender and trait impulsivity were investigated. RESULTS:ATD was associated with significant depletion of plasma tryptophan levels but did not increase the stop signal reaction time in comparison to the balanced (placebo) amino acid mixture. Subjects possessing the short allele of the 5-HTT polymorphism were not more impulsive on the SST than subjects homozygous for the long allele under placebo conditions and were not disproportionately sensitive to the effects of ATD. There was no effect of gender or trait impulsivity on ATD-induced change. CONCLUSIONS:We find no support for the involvement of brain serotonin neurotransmission in this form of inhibitory control in healthy human subjects.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Clark L,Roiser JP,Cools R,Rubinsztein DC,Sahakian BJ,Robbins TWdoi
10.1007/s00213-005-0104-6subject
Has Abstractpub_date
2005-11-01 00:00:00pages
570-8issue
4eissn
0033-3158issn
1432-2072journal_volume
182pub_type
杂志文章,随机对照试验abstract:RATIONALE:Deep brain stimulation (DBS) has achieved substantial success as a treatment for movement disorders such as Parkinson's disease. The therapeutic efficacy and relative lack of serious side effects resulted in the expansion of DBS into the treatment of many other diseases, including obsessive-compulsive disorde...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-013-3214-6
更新日期:2013-10-01 00:00:00
abstract::The sensitivity of the dopaminergic hypothalamic pituitary system, as indicated by growth hormone (GH) release after apomorphine (0.5 mg SC), was studied in 11 chronic schizophrenic in-patients under long-term neuroleptic (NL) therapy and after 12 and 30 days' drug withdrawal. GH peak levels after a 12-day drug-free p...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00555228
更新日期:1984-01-01 00:00:00
abstract::Suriclone is a new anxiolytic drug belonging to the family of cyclopyrrolones. Although chemically entirely different from the benzodiazepines, it acts as a benzodiazepine agonist with very high affinity for the benzodiazepine receptors. In the present cross-over study, 33 out-patients with a diagnosis of neurotic anx...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00187246
更新日期:1987-01-01 00:00:00
abstract:INTRODUCTION:Understanding an individual's vulnerability to drug addiction has important implications for the development of effective personal treatment plans. Although theories acknowledge impulsive behaviour as a key component of drug addiction, little is known about the influence of trait impulsivity on an individu...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-3270-y
更新日期:2014-02-01 00:00:00
abstract:RATIONALE:Prospective memory pervades our daily lives and failures can have detrimental consequences. This ability to execute delayed intentions may be impacted by stress, yet few studies have examined these effects. Moreover, as many cannabis users report using cannabis to cope with stress, it is important to understa...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-019-5184-9
更新日期:2019-06-01 00:00:00
abstract:RATIONALE:Traditional remedies prepared from Ptychopetalum olacoides (PO) are used throughout the Amazon to alleviate age-related conditions. These formulas are mainly used by elders, and alleged effects may be related to the anticholinesterase properties identified in a standardized ethanol extract of this species [P....
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1272-y
更新日期:2009-01-01 00:00:00
abstract:RATIONALE:Repeated exposure to psychostimulant drugs causes a long-lasting increase in the psychomotor and reinforcing effects of these drugs and an array of neuroadaptations. One such alteration is a hypersensitivity of striatal activity such that a low dose of amphetamine in sensitized animals produces dorsal striata...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1100-4
更新日期:2008-05-01 00:00:00
abstract::A two flavour, unbiased, taste preference conditioning procedure was used to test for possible motivating effects of gamma 2-MSH. Three training trials failed to produce any significant effect with doses ranging from 2.4 to 40 micrograms/ICV infusion in drug-naive, non-operated or placebo-implanted rats. However, in r...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00634469
更新日期:1989-01-01 00:00:00
abstract::BALB/cJ, DBA/2J, and C57BL/6J mice were injected with caffeine and tested, in the five choice Yerkes-Thompson Bryant-Bovt Nitti apparatus for patterns discrimination, in two sets of experiments. In the first the patterns were opposite oriented oblique bars, in the second U-shaped figures, one opened toward the right, ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431632
更新日期:1977-03-16 00:00:00
abstract:RATIONALE:Thousands of adolescents start smoking daily but information on the effects of tobacco exposure on this age group is scarce. Moreover, the available animal models rely on the effects of nicotine, neglecting other neuroactive components of tobacco. OBJECTIVES:We investigated the effects of exposure of adolesc...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3801-1
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abstract::Three-hour sessions of differential reinforcement of low-rate behavior (DRL 45-s) in rats were used to investigate alprazolam, caffeine, and their interactions at the onset, peak and disappearance of serum alprazolam, while caffeine level remained constant. The dose-response curve (DRC) method of Pöch permitted an ext...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246346
更新日期:1996-07-01 00:00:00
abstract::Chronic nicotine infusion has been found in a series of studies in our laboratory to significantly improve choice accuracy of rats in the eight-arm radial maze. The current study was designed to compare the effects of chronic nicotine infusion on working and reference memory in a 16-arm radial maze. Nicotine was admin...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02805971
更新日期:1996-09-01 00:00:00
abstract:RATIONALE:Perphenazine, a classical antipsychotic drug, has the potential to induce extrapyramidal side effects (EPS). Dopaminergic and serotonergic pathways are involved in the therapeutic and adverse effects of the drug. OBJECTIVES:To evaluate the impact of polymorphisms in the dopamine D(2) and D(3) and serotonin 2...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-006-0622-x
更新日期:2007-03-01 00:00:00
abstract:RATIONALE:Interrelationships between the discriminative stimulus and reinforcing properties of psychoactive drugs and the way in which they may interact to control drug intake are unclear. Studies have shown that drug history can influence the expression of drug-produced behavioral effects. OBJECTIVE:The present study...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0364-9
更新日期:2006-06-01 00:00:00
abstract::Triadimefon is a triazole fungicide that produces hyperactivity in both mice and rats similar to that seen following administration of compounds with catecholaminergic activity (e.g., d-amphetamine). To determine whether the triadimefon-induced hyperactivity is due to an action on CNS catecholaminergic systems, we eva...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00439445
更新日期:1989-01-01 00:00:00
abstract:RATIONALE:Prepulse inhibition (PPI) and locomotor activity have been used to investigate the effects of antipsychotic and stimulant drugs and their underlying dopaminergic mechanisms. Whereas D2-like agonists consistently decreased PPI and increased locomotion in rats in previous studies, we recently reported that thes...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0511-3
更新日期:2007-04-01 00:00:00
abstract:RATIONALE:Repeated treatment with morphine has been shown to sensitize rats to its stimulant effects on motor activity and mesolimbic dopamine (DA) transmission. OBJECTIVES:The aim of this study is to investigate if morphine sensitization is associated to changes in the behavioral reactions to appetitive and aversive ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2220-9
更新日期:2011-08-01 00:00:00
abstract::Nine VA Medical Centers are participating in a 2-year double-blind placebo controlled study of antioxidant treatment for tardive dyskinesia (TD) conducted by the Department of Veteran Affairs Cooperative Studies Program. One of the principal outcome measures of this study is the score derived from the instrumental ass...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s002130050320
更新日期:1997-07-01 00:00:00
abstract::Lu 25-109 [5-(2-ethyl-2H-tetrazol-5-yl)-1,2,3,6-tetrahydro-1-methylpyridine] , has M agonistic and M2/M3 antagonistic effects at muscarinic receptors in vitro; a pharmacological profile that may be beneficial in treatment of Alzheimer's disease. In the present study, we compare functional in vivo effects of Lu 25-109 ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050615
更新日期:1998-06-01 00:00:00
abstract::6-Hydroxydopamine (6OH-DA) pretreatment increased the aggressive behavior induced by marihuana in REM sleep-deprived rats. Brain catecholamine assays revealed that 6OH-DA depleted popamine (DA) and norepinephrine (NE) to a different extent, increasing the DA/NE ratio. Intraventricular injection of NE significantly dec...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00423257
更新日期:1976-07-28 00:00:00
abstract::Rats chronically treated with increasing daily doses of delta 9-tetrahydrocannabinol (delta 9-THC) for up to 5 or 10 days exhibit a withdrawal-like behavioural response when challenged with clomipramine, a potent inhibitor of serotonin (5-hydroxytryptamine) reuptake, at the time when the next injection of delta 9-THC ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431112
更新日期:1981-01-01 00:00:00
abstract::The rabbit classical eyeblink conditioning paradigm was used to assess the effects of haloperidol on hippocampal function. Haloperidol disrupted hippocampal activity and conditioned responses (CRs) at low but not high conditioned stimulus (CS) intensities. The observed relationship of hippocampal activity and the CR s...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050237
更新日期:1997-04-01 00:00:00
abstract::A group of 14 schizophrenics who remained symptomatic after neuroleptic treatment received either 0.02 mcg/kg CCK-8 or saline placebo intravenously. Thereafter, 13 received the alternative infusion as a crossover treatment. A second group of 16 such patients received 0.04 mcg/kg CCK-8 or saline intravenously and, ther...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00690931
更新日期:1987-01-01 00:00:00
abstract:RATIONALE:The extent to which non-α4β2 versus α4β2* nAChRs contribute to the behavioral effects of varenicline and other nAChR agonists is unclear. OBJECTIVES:The purpose of this study was to characterize the discriminative stimulus effects of varenicline and nicotine using various nAChR agonists and antagonists to el...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-016-4514-4
更新日期:2017-03-01 00:00:00
abstract:RATIONALE:Dopamine innervation of the nucleus accumbens is thought to have a major role in the biological processes underlying cocaine self-administration. Recent data suggest that dopamine innervation of the ventral pallidum (VP) may also play an important role. OBJECTIVES:This experiment was initiated to assess extr...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000456
更新日期:2000-07-01 00:00:00
abstract:RATIONALE:A variety of behavioral procedures have been developed to assess cannabinoid activity in mice; however, the feasibility of establishing Delta(9)-THC as a discriminative stimulus in mice has not been documented. OBJECTIVE:One goal was to establish Delta(9)-THC as a discriminative stimulus in mice; after havin...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-007-0900-2
更新日期:2008-07-01 00:00:00
abstract::The objective of the present study was to determine whether the development of behavioral sensitization to apomorphine could be blocked by either D1 or D2 selective dopamine antagonists. In three experiments, male rats received 10-21 daily injections of a selective D1 (SCH 23390; 0 or 0.5 mg/kg IP) or D2 (sulpiride; 0...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244370
更新日期:1991-01-01 00:00:00
abstract::Haloperidol has recently been found to be metabolized to its pyridinium ion (HP+). This conversion of haloperidol to HP+ appears to be similar to the activation of the dopaminergic neurotoxin N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to N-methyl-4-phenyl pyridinium ion (MPP+). MPP+ is responsible for the dam...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246077
更新日期:1995-10-01 00:00:00
abstract:RATIONALE:Only a small percentage of individuals seeking treatment for their marijuana use achieves sustained abstinence, suggesting more treatment options are needed. OBJECTIVES:We investigated the effects of baclofen (study 1) and mirtazapine (study 2) in a human laboratory model of marijuana intoxication, withdrawa...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1888-6
更新日期:2010-08-01 00:00:00
abstract:OBJECTIVES:The present study investigates the effects of injections of a specific N-methyl-D-aspartic acid (NMDA) antagonist 3-[(R)-2-carboxypiperazin-4-yl]-propyl-1-phophonic acid (CPP) into the prefrontal cortex (PFC) on the extracellular concentrations of dopamine and acetylcholine in the nucleus accumbens (NAc) and...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1288-3
更新日期:2008-12-01 00:00:00